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Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

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International j.urnal of Mechanical System Dynamics 2023年第1期3卷 48-57页

作者： harry j.Carpenter Mergen H.Ghayesh Anthony C.Zander Peter j.Psaltis School of Electrical and Mechanical Engineering University of AdelaideAdelaideSouth AustraliaAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research Institute(SAHMRI)AdelaideSouth AustraliaAustralia Adelaide Medical School University of AdelaideAdelaideSouth AustraliaAustralia Department of Cardiology Central Adelaide Local Health NetworkAdelaideSouth AustraliaAustralia

In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)*** one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its *** can include the unique dynamical factors present in the coronary *** investigate the impact of these dynamical factors,we study an idealized artery model with sequential *** transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary *** compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI *** suggest that the motion of the artery can impact downstream patterns in both divergence and *** magnitude is also decreased by up to 57%due to motion in some *** divergence patterns varied most significantly between simulations over the systolic period,the time of the largest *** investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

关键词： computational fluid dynamics divergence fluid–structure interaction topology wall shear stress

One decade(2011–2020)of European agricultural water stress monitoring by MSG-SEVIRI:workflow implementation on the Virtual Earth Laboratory(VLab)platform

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International j.urnal of Digital Earth 2022年第1期15卷 730-747页

作者： Bagher Bayat Carsten Montzka Alexander Graf Gregory Giuliani Mattia Santoro harry Vereecken Institute of Bio-and Geosciences:Agrosphere (IBG-3) Forschungszentrum Jülich GmbHJülichGermany Institute for Environmental Sciences EnviroSPACE labUniversity of GenevaGenevaSwitzerland Institute of Atmospheric Pollution Research National Research Council of Italy (CNR)Sesto FiorentinoItaly

Cloud computing facilities can provide crucial computing support for processing the time series of satellite data and exploiting their spatio-temporal information ***,dedicated efforts are still required to develop workflows,executable on cloud-based platforms,for ingesting the satellite data,performing the targeted processes,and generating the desired *** this study,an operational workflow is proposed,based on monthly Evaporative Stress Index(ESI)anomaly,and implemented in cloud-based online Virtual Earth Laboratory(VLab)platform,as a demonstration,to monitor European agricultural water *** this end,daily time-series of actual and reference evapotranspiration(ETa and ET0),from the Spinning Enhanced Visible and Infrared Imager(SEVIRI)sensor,were used to execute the proposed workflow successfully on *** execution of the workflow resulted in obtaining one decade(2011–2020)of European monthly agricultural water stress maps at 0.04˚spatial resolution and corresponding stress reports for each *** support open science,all the workflow outputs are stored in GeoServer,documented in GeoNetwork,and made available through *** enables creating a dashboard for better visualization of the results for *** results from this study demonstrate the capability of VLab platform for water stress detection from time series of SEVIRI-ET data.

关键词： ET SEVIRI ESI water stress workflow Europe VLab demonstration

Design and guidance of a multi-active debris removal mission

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Astrodynamics 2023年第4期7卷 383-399页

作者： Minduli C.Wij.yatunga(B) Roberto Armellin harry Holt Laura Pirovano Aleksander A.Lidtke Te Pūnaha Atea–Space Institute The University of AucklandAuckland 1010New Zealand Astroscale j.pan Inc. 1-16-4-16 KinshiSumida-kuTokyoJapan

Space debris have become exceedingly dangerous over the years as the number of obj.cts in orbit continues to *** debris removal(ADR)missions have gained significant interest as effective means of mitigating the risk of collision between obj.cts in *** study focuses on developing a multi-ADR mission that utilizes controlled reentry and *** mission comprises two spacecraft:a Servicer that brings debris to a low altitude and a Shepherd that rendezvous with the debris to later perform a controlled reentry.A preliminary mission design tool(PMDT)was developed to obtain time and fuel optimal traj.ctories for the proposed mission while considering the effect of j.,drag,eclipses,and duty *** PMDT can perform such traj.ctory optimizations for multi-debris missions with computational time under a *** guidance schemes are also studied,taking the PMDT solution as a reference to validate the design methodology and provide guidance solutions to this complex mission profile.

关键词： active debris removal(ADR) traj.ctory design optimization autonomous guidance low-thrust electric propulsion △u-law guidance Q-law guidance

Telaprevir/boceprevir era: From bench to bed and back

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World j.urnal of Gastroenterology 2012年第43期18卷 6183-6188页

作者： Maikel P Peppelenbosch harry LA j.nssen Robert j.de Knegt Department of Gastroenterology and Hepatology Erasmus MC-University Medical Center 3015 CE Rotterdam The Netherlands

Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field.

关键词：治疗丙型肝炎病毒实验室丝氨酸蛋白酶抑制剂病毒感染利巴韦林组合使用 HCV

Variation in the plant-mediated methane transport and its importance for methane emission from intact wetland peat mesocosms

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j.urnal of Plant Ecology 2013年第4期6卷 298-304页

作者： Gurbir S.Bhullar Peter j.Edwards harry Olde Venterink Institute of Integrative Biology ETH ZurichUniversitätstrasse 168092 ZurichSwitzerland

Aims and Methods Vascular plants are known to influence the production,transport and oxidation of methane in wetland soils,but these processes are not well *** plants grown in intact peat cores,we compared the influence upon methane emissions of 20 forb and graminoid species from European *** measured plant-mediated transport of methane(conduit or chimney effect)using a novel agar-sealing technique that prevented methane exchange from the bare soil to the *** Findings the plant-mediated transport(chimney effect)represented between 30%and almost 100%of the total methane flux,with graminoids exhibiting greater internal transport than *** general,plants with less dense root tissues and a relatively larger root volume exhibited a larger chimney *** species(12 out of 20)signif-icantly reduced methane emissions compared to bare soil and only one species,Succisa pratensis,increased *** suggest that characterising vegetation in terms of plant functional traits and plant processes offers an effective method for estimating methane emis-sions from ***,we found no correlation between the magnitude of the chimney effect and the overall influence of different plant species on methane *** introducing a useful tool to study plant-mediated transport,this work suggests that characterising vegetation in terms of functional traits could improve estimates of methane emissions from wetlands,which in turn could help in designing mitigation strategies.

关键词： functional group graminoid forb agar-sealing conduit gas transportreceived

Quantitative Trait Loci Analysis Identifies a Prominent Gene Involved in the Production of Fatty Acid-Derived Flavor Volatiles in Tomato

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Molecular Plant 2018年第9期11卷 1147-1165页

作者： Karolina Garbowicz Zhongyuan Liu Saleh Alseekh Denise Tieman Mark Taylor Anastasiya Kuhalskaya Itai Ofner Dani Zamir harry j. Klee Alisdair R. Fernie Yariv Brotman Max-Planck-lnstitute of Molecular Plant Physiology Potsdam-Golm Germany Horticultural Sciences Plant Innovation Center University of Florida Gainesville FL USA Center of Plant System Biology and Biotechnology 4000 Plovdiv Bulgaria Department of Life Sciences Ben-Gurion University of the Negev Beersheba Israel Robert H. Smith Institute of Plant Sciences and Genetics Faculty of Agriculture Hebrew University of Jerusalem Rehovot 7610001 Israel These authors contributed equally to this article

To gain insight into the genetic regulation of lipid metabolism in tomato, we conducted metabolic trait loci （mQTL） analysis following the lipidomic profiling of fruit pericarp and leaf tissue of the Solanum pennellii introgression lines （IL）. To enhance mapping resolution for selected fruit-specific mQTL, we profiled the lipids in a subset of independently derived S. pennellii backcross inbred lines, as well as in a nearsogenic sub-iL population. We identified a putative lecithin：cholesterol acyltransferase that controls the levels of several lipids, and two members of the class III lipase family, LIP1 and LIP2, that were associated with decreased levels of diacylglycerols （DAGs） and triacylglycerols （TAGs）. Lipases of this class cleave fatty acids from the glycerol backbone of acylglycerols. The released fatty acids serve as precursors of flavor volatiles. We show that LIP1 expression correlates with fatty acid-derived volatile levels. We further confirm the function of LIP1 in TAG and DAG breakdown and volatile synthesis using transgenic plants. Taken together, our study extensively characterized the genetic architecture of Upophilic compounds in tomato and demonstrated at molecular level that release of free fatty acids from the glycerol backbone can have a maj.r impact on downstream volatile synthesis.

关键词： lipidomics lipids lipase volatile FA-VOC Z-4-decenal

Comparison of smoothness-constrained and geostatistically based cross-borehole electrical resistivity tomography for characterization of solute tracer plumes

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Water Science and Engineering 2016年第4期9卷 274-286页

作者： Andreas Englert Andreas Kemna j.n-feng Zhu j.n Vanderborght harry Vereecken Tian-Chyi j.Yeh Institute of Geology Mineralogy and GeophysicsRuhr University Bochum Department of Geophysics Steinmann InstituteUniversity of Bonn Kentucky Geological Survey University of Kentucky Agrosphere Institute for Bio- and Geosciences(IBG-3)Forschungszentrum Jlich GmbH Department of Resources Engineering National Cheng Kung University Department of Hydrology and Water Resources The University of Arizona

Experiments using electrical resistivity tomography(ERT) have shown promising results in reducing the uncertainty of solute plume characteristics related to estimates based on the analysis of local point measurements *** explore the similarities and differences between two cross-borehole ERT inversion approaches for characterizing salt tracer plumes,namely the classical smoothness-constrained inversion and a geostatistically based approach,we performed two-dimensional synthetic *** assumptions about the solute transport model and the electrical forward and inverse model allowed us to study the sensitivity of the ERT inversion approaches towards a variety of basic conditions,including the number of boreholes,measurement schemes,contrast between the plume and background electrical conductivity,use of a priori knowledge,and point *** results show that geostatistically based and smoothness-constrained inversions of electrical resistance data yield plume characteristics of similar quality,which can be further improved when point measurements are incorporated and advantageous measurement schemes are *** expected,an increased number of boreholes included in the ERT measurement layout can highly improve the quality of inferred plume characteristics,while in this case the benefits of point conditioning and advantageous measurement schemes *** ERT inversion approaches are similarly sensitive to the noise level of the data and the contrast between the solute plume and background electrical conductivity,and robust with regard to biased input parameters,such as mean concentration,variance,and correlation length of the *** sophisticated inversion schemes have recently become available,in which flow and transport as well as electrical forward models are coupled,these schemes effectively rely on a relatively simple geometrical parameterization of the hydrogeological ***,we believe that standard uncoupled ER

关键词： Electrical resistivity tomography Inversion technique Solute tracer plume Synthetic experiment Plume characteristics

Testing experimentally the effect of soil resource mobility on plant competition

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j.urnal of Plant Ecology 2014年第3期7卷 276-286页

作者： Stefanie Wilberts Matthias Suter Nina Walser Peter j.Edwards harry Olde Venterink Dieter Ramseier Department of Biology/Chemistry Division of EcologyUniversity of OsnabrückBarbarastrasse 13Osnabrück 49076Germany Forage Production and Grassland Agroscope Reckenholz-TänikonReckenholzstrasse 1918046 ZurichSwitzerland Institute of Integrative Biology ETH ZurichUniversitätstrasse 16Zürich 8092Switzerland Plant Biology and Nature Management Vrije Universiteit BrusselPleinlaan 21050 BrusselsBelgium

Aims The volume of soil beyond a plant’s roots from which that plant is able to acquire a particular nutrient depends upon the mobility of that nutrient in the *** this reason it has been hypothesized that the strength of competitive interactions between plants vary with soil nutrient *** aimed to provide an experimental test of this *** We devised two experimental systems to investigate specifically the effect of nutrient transport rates upon intraspecific *** the first,the exchange of rhizosphere water and dissolved nutrients between two connected pots,each containing one plant,was manipulated by alternately raising and lowering the *** the second experiment,the roots systems of two competing plants were separated by partitions of differing porosity,thereby varying the plants’access to water and nutrients in the other plant's *** this second experiment,we also applied varying amounts of nutrients to test whether higher nutrient input would reduce competition when competition for light is avoided,and applied different water levels to affect nutrient concentrations without changing nutrient *** findings In both experiments,lower mobility reduced competitive effects on plant biomass and on relative growth rate(RGR),as *** the second experiment,however,competition was more intense under high nutrient input,suggesting that low nutrient supply rates reduced the strength of the superior *** effects on RGR were only evident under the low water level,suggesting that under lower nutrient concentrations,competitive effects might be less *** together,our results provide the first direct experimental evidence that a reduction in nutrient mobility can reduce the intensity of competition between plants.

关键词： belowground competition nutrient transport soil water relative growth rate