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Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification

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World journal of Gastrointestinal Pathophysiology 2020年第3期11卷 64-77页

作者： Mireia Lopez-Siles Xavier Aldeguer Miriam Sabat-Mir Mariona Serra-Pagès Sylvia H Duncan harry j flint L jesús Garcia-Gil Margarita Martinez-Medina Laboratory of Molecular Microbiology Biology DepartmentUniversitat de GironaGirona 17003Spain Department of Gastroenterology Hospital Universitari Dr.Josep TruetaGirona 17007Spain Department of Gastroenterology Hospital Santa CaterinaSalt 17190Spain GoodGut SL Girona 17003Spain Microbiology Group Rowett Institute of Nutrition and HealthUniversity of AberdeenAberdeen AB252ZDUnited Kingdom

BACKGROUND The challenges for inflammatory bowel disease(IBD)diagnostics are to discriminate it from gut conditions with similar symptoms such as irritable bowel syndrome(IBS),to distinguish IBD subtypes,to predict disease progression,and to establish the risk to develop colorectal cancer(CRC).Alterations in gut microbiota have been proposed as a source of information to assist in IBD *** prausnitzii(***),its phylogroups,and Escherichia coli(***)have been reported as potential biomarkers,but their performance in challenging IBD diagnostic situations remains *** hypothesize that bacterial biomarkers based in these species may help to discriminate these conditions of complex *** To evaluate the usefulness of indices calculated from the quantification of these species as biomarkers to aid in IBD *** A retrospective study of 131 subjects(31 controls(H);45 Crohn’s disease(CD),25 ulcerative colitis(UC),10 IBS,and 20 CRC patients)was performed to assess the usefulness of bacterial biomarkers in ***,the performance of biomarkers in faeces was studied in 29 stool samples(19 CD,10 UC).Relative abundances of total ***(FP),its phylogroups(PHGI and PHGII),and ***(E)quantification were determined by *** were combined to calculate the FP-E index,the PHGI–E index and the PHGII-E *** accuracy to discriminate among conditions was measured by the area under the receiver operating characteristic curve(AUC).RESULTS In biopsies,FP-E index was good for discriminating IBS from CD(AUC=0.752)while PHGII-E index was suitable for discriminating IBS from UC(AUC=0.632).The FP-E index would be the choice to discriminate IBD from CRC,especially from all UC subtypes(AUC≥0.875),regardless of the activity status of the *** between UC patients that had the longest disease duration and those with CRC featured slightly lower AUC *** differentiation in IB

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Diagnostic tests Faecalibacterium prausnitzii Escherichia coli Irritable bowel syndrome Colorectal cancer

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Significance of using isolated footing technique for resi- dential construction on expansive soils

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 123-129页

作者： harry FAR Deacon flint Centre for Built Infrastructure Research School of Civil and Environmental Engineering University of Technology Sydney (UTS)Australia

Expansive soils cause problems with the founding of lightly loaded structures in many parts of the world. Foundation design for expansive soils is one of the most discussed and problematic issues in Australia as expansive soils were responsible for billions of dollars＇ worth of damage to man-made structures such as buildings and roads. Several studies and reports indicate that one of the most common and least recognized problems causing severe structural damage to houses lies in expansive soils. In this study, a critical review has been carried out on the current Australian standards for building on expansive soils and they are compared with some techniques that are not included in the current Australian standards for residential slabs and footings. Based on the results of this review, the most effective and economical method has been proposed for construction of footings on all site classifications without restriction to 75mm of characteristic movement. In addition, it has become apparent that as design procedures for footings resting on sites with extreme characteristic movements are not included in the current Australian standards, there is a strong need for well-developed and simplified standard design procedures for characteristic soil movement of greater than 75mm to be included into the Australian Standards.

关键词： expansive soils residential slabs isolated footings Australian Standards

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Downscaling future climate scenarios to fine scales for hydrologic and ecological modeling and analysis

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Ecological Processes 2012年第1期1卷 109-123页

作者： Lorraine E flint Alan L flint U.S.Geological Survey Placer Hall6000 J St.SacramentoCA 95819USA

Introduction:Evaluating the environmental impacts of climate change on water resources and biological components of the landscape is an integral part of hydrologic and ecological investigations,and the resultant land and resource management in the twenty-first *** of both climate and simulated hydrologic parameters on ecological processes are relevant at scales that reflect the heterogeneity and complexity of *** present,simulations of climate change available from global climate models[GCMs]require downscaling for hydrologic or ecological ***:Using statistically downscaled future climate projections developed using constructed analogues,a methodology was developed to further downscale the projections spatially using a gradient-inverse-distancesquared approach for application to hydrologic modeling at 270-m spatial ***:This paper illustrates a methodology to downscale and bias-correct national GCMs to subkilometer scales that are applicable to fine-scale environmental *** scenarios were chosen to bracket the range of future emissions put forth by the Intergovernmental Panel on Climate ***-scale applications of downscaled datasets of ecological and hydrologic correlations to variation in climate are ***:The methodology,which includes a sequence of rigorous analyses and calculations,is intended to reduce the addition of uncertainty to the climate data as a result of the downscaling while providing the fine-scale climate information necessary for ecological *** results in new but consistent data sets for the US at 4 km,the southwest US at 270 m,and California at 90 m and illustrates the utility of fine-scale downscaling to analyses of ecological processes influenced by topographic complexity.

关键词： downscaling climate change spatial scale scenarios

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Fine-scale hydrologic modeling for regional landscape applications:the California Basin Characterization Model development and performance

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Ecological Processes 2013年第1期2卷 254-274页

作者： Lorraine E flint Alan L flint james H Thorne Ryan Boynton Water Resources Discipline U.S.Geological SurveyPlacer Hall6000 J StreetSacramentoCA 95819-6129USA Information Center for the Environment University of CaliforniaDavisCA95616USA

Introduction:Resource managers need spatially explicit models of hydrologic response to changes in key climatic drivers across variable landscape *** demonstrate the utility of a Basin Characterization Model for California(CA-BCM)to integrate high-resolution data on physical watershed characteristics with historical or projected climate data to predict watershed-specific hydrologic ***:The CA-BCM applies a monthly regional water-balance model to simulate hydrologic responses to climate at the spatial resolution of a 270-m *** model has been calibrated using a total of 159 relatively unimpaired watersheds for the California ***:As a result of calibration,predicted basin discharge closely matches measured data for validation *** CA-BCM recharge and runoff estimates,combined with estimates of snowpack and timing of snowmelt,provide a basis for assessing variations in water *** important output variable,climatic water deficit,integrates the combined effects of temperature and rainfall on site-specific soil moisture,a factor that plants may respond to more directly than air temperature and precipitation *** outputs are calculated for each grid cell,allowing results to be summarized for a variety of planning units including hillslopes,watersheds,ecoregions,or political ***:The ability to confidently calculate hydrologic outputs at fine spatial scales provides a new suite of hydrologic predictor variables that can be used for a variety of purposes,such as projections of changes in water availability,environmental demand,or distribution of plants and *** we present the framework of the CA-BCM model for the California hydrologic region,a test of model performance on 159 watersheds,summary results for the region for the 1981–2010 time period,and changes since the 1951–1980 time period.

关键词： Water balance Basin models Watershed hydrology Climate change Downscaling Basin characterization model

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Sensory sacrifices when we mass-produce mass produce

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Horticulture Research 2016年第1期3卷 167-172页

作者： Kevin M Folta harry j Klee Horticultural Sciences Department Plant Innovation Center and The Graduate Program for Plant Molecular and Cellular BiologyUniversity of FloridaGainesville32606FLUSA

Plant breeders have been extremely successful at driving genetic improvements in ***,‘improvements’are truly a question of *** the last one-hundred years most plant genetic innovations have been driven by industry *** fruits,heavier yields,uniformity,increased resistance to disease and better shipping quality are just a few of the traits that have ensured profits on the farm and affordable food for ***,these milestones have come at the expense of sensory qualities,which have been sacrificed in exchange for practical production *** a base of industry-sufficient genetics,today’s breeders can now turn to the consumer for guidance in defining critical *** approaches to plant breeding start with the analysis of consumer preferences,and then merge them with modern genomics and analytical chemistry *** result is the next generation of crops that meet supply chain demands while presenting improvements in flavor,nutrition,color,aroma and *** review analyzes the approach of consumer-assisted selection as it has been applied to tomato and strawberry,two complementary annual crops that have been intensively bred to meet industry *** breeding efforts start with the consumer,with the objective of reclaiming lost sensory qualities.

关键词： crops breeding driving

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Characterizing drought in California:new drought indices and scenario-testing in support of resource management

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Ecological Processes 2018年第1期7卷 1-13页

作者： Lorraine E.flint Alan L.flint john Mendoza julie Kalansky F.M.Ralph U.S.Geological Survey 6000 J.StSacramentoCA 95819USA Sonoma County Water Agency 404 Aviation Dr.Santa RosaCA 95403USA Scripps Institution of Oceanography 9500 Gilman Dr.La JollaCA 92093USA

Introduction:California’s recent drought(2012–2016)has implications throughout the state for natural resource management and adaptation planning and has generated many discussions about drought characterization and *** study characterizes drought conditions with two indices describing deficits in natural water supply and increases in landscape stress developed on the basis of water balance modeling,at a fine spatial scale to assess the variation in conditions across the entire state,and provides an in-depth evaluation for the Russian River basin in northern California to address local resource management by developing extreme drought scenarios for consideration in planning and ***:We employed the USGS Basin Characterization Model to characterize drought on the basis of water supply(a measure of recharge plus runoff)and landscape stress(climatic water deficit).These were applied to the state and to the Russian River basin where antecedent soil moisture conditions were evaluated and extreme drought scenarios were developed and run through a water management and reservoir operations model to further explore impacts on water ***:Drought indices indicated that as of the end of water year 2016 when reservoirs were full,additional water supply and landscape replenishment of up to three average years of precipitation in some locations was needed to return to normal *** soil conditions in the Russian River were determined to contribute to very different water supply results for different years and were necessary to understand to anticipate proper watershed response to *** drought scenarios manifested very different kinds of drought and recovery and characterization helps to guide the management response to ***:These scenarios and indices illustrate how droughts differ with regard to water supply and landscape stress and how long warm droughts recover much more slowly than short very dry dro

关键词： California drought Russian River Water supply Basin Characterization Model

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Cross-scale modeling of surface temperature and tree seedling establishment in mountain landscapes

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Ecological Processes 2013年第1期2卷 313-327页

作者： john R Dingman Lynn C Sweet Ian McCullough Frank W Davis Alan flint janet Franklin Lorraine E flint Earth Research Institute University of California Santa BarbaraSanta BarbaraCA 93106USA U.S.Geological Survey California Water Science CenterSacramentoCA 95819USA Bren School of Environmental Science&Management University of California Santa BarbaraSanta BarbaraCA93106USA School of Geographical Sciences and Urban Planning Arizona State UniversityTempeAZ85287USA

Introduction:Estimating surface temperature from above-ground field measurements is important for understanding the complex landscape patterns of plant seedling survival and establishment,processes which occur at heights of only several ***,future climate models predict temperature at 2 m above ground,leaving ground-surface microclimate not well ***:Using a network of field temperature sensors and climate models,a ground-surface temperature method was used to estimate microclimate variability of minimum and maximum *** lapse rates were derived from field temperature sensors and distributed across the landscape capturing differences in solar radiation and cold air drainages modeled at a 30-m spatial ***:The surface temperature estimation method used for this analysis successfully estimated minimum surface temperatures on north-facing,south-facing,valley,and ridgeline topographic settings,and when compared to measured temperatures yielded an R2 of 0.88,0.80,0.88,and 0.80,*** surface temperatures generally had slightly more spatial variability than minimum surface temperatures,resulting in R2 values of 0.86,0.77,0.72,and 0.79 for north-facing,south-facing,valley,and ridgeline topographic ***-Poisson regressions predicting recruitment of Quercus kelloggii(black oak)seedlings from temperature variables were significantly improved using these estimates of surface temperature compared to air temperature modeled at 2 ***:Predicting minimum and maximum ground-surface temperatures using a downscaled climate model coupled with temperature lapse rates estimated from field measurements provides a method for modeling temperature effects on plant *** methods could be applied to improve projections of species’range shifts under climate *** of complex topography can provide intricate microclimates that may allow species to redistribute locally as climate

关键词： Black oak Climate change Generalized linear models Microclimate Topography Spatial scale Surface temperature

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A review on molten sulfate salts induced hot corrosion

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journal of Materials Science & Technology 2021年第31期90卷 243-254页

作者： Shanshan Hu harry Finkle Xingbo Liu Mechanical&Aerospace Engineering Department Benjamin M.Statler College of Engineering&Mineral ResourcesWest Virginia UniversityMorgantownWV 26506-6106USA C.Eugene Bennett Department of Chemistry West Virginia UniversityMorgantownWV 26506USA

Hot corrosion has been extensively observed in various high temperature applications,which might cause large economic *** deepen the insight and understanding of hot corrosion,herein,we provide a detailed discussion on hot corrosion induced by molten sulfate salt,in which Na_(2)SO_(4)is the main chemical *** hot corrosion is triggered and sustained by the negative solubility gradient of protective oxide from the oxide/salt interface to salt/gas *** this work,we reviewed several key factors,including temperature,gas composition,molten salt composition,alloy element and external stress,influencing the hot corrosion of alloy beneath the molten *** application of anti-corrosion coating seems to be the most effective and commercial mothed to mitigate hot ***,the progress of the development of effective coatings,e.g.,Ni-Cr coatings,aluminide coatings,silicide coatings and MCrAlY(X)coatings,has also been summarized.

关键词： Hot corrosion Molten sulfate salts Protective oxide layer Dissolution Anti-corrosion coatings

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Synchronization of home departure and arrival times in dual earner households with children:Panel regression model of time gaps

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journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 504-513页

作者： Bilin Han harry Timmermans Urban Planning Group Eindhoven University of Technology

Organizing schedules and allocating time to different activities is always a challenge in dual-earner households,especially when they have *** may need to link their schedule to those of their children to allow them escorting their children to school or to take care or be with their children at *** paper reports the results of an analysis of the degree of synchronization of home departure and arrival times in dual earner households with children,where the degree of synchronization is defined as the gap between departure and arrival times of a parent and *** activity-travel diary data of different household members,a random parameters regression model is estimated to examine differences in time gaps in home departure and arrival times between parents and children as a function of gender,day of the week,age of the youngest child,and other socio-demographic *** results of the analysis provide insight into factors influencing the degree of synchronization and coordination of double activity-travel scheduling decisions in households with *** indicate that gender,number of children in the household,age of the youngest child,travel within or outside peak hours,day of the week,transport mode used for the work commute and household income level significantly affect time gaps,especially arrival time gaps.

关键词： Home departure and arrival times Synchronization Time gap Dual-earner households Random parameters panel regression model

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Early glaciological and Quaternary Geology cooperation

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Advances in Polar Science 2021年第4期32卷 275-280页

作者： harry ZILLIACUS University of Helsinki Faculty of Science Finland

The article depicts the author’s experiences of Glaciology and Quaternary Geology research between Finland and the People’s Republic of *** focus is on a visit to a glaciological station in Tianshan in *** climate is continental displaying warming-up and increased precipitation since the end of the 1980’*** data collected here is of utmost importance when analysing the future development of the *** associations to the historic Silk Roads are made having implications on the Belt and Road strategy launched by the *** to problems of sea and lake ice,Finland and the *** have found issues of mutual interest resulting in continuing cooperation in the Arctic and in ice-covered areas of *** forms of bilateral collaboration such as university education and training have evolved encompassing coming generations.

关键词： glaciers geomorphology Tianshan climate change the Belt and Road

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