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Journal of Clinical and Translational Hepatology Has Been Indexed in SCIE: A Milestone towards a Greater Academic Goal

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 357-358页

作者： harry hua-xiang xia George Y.Wu Hong Ren Department of Gastroenterology First Affiliated HospitalGuangdong Pharmaceutical UniversityGuangzhouGuangdongChina Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Institute for Viral Hepatitis Department of Infectious DiseasesThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina

On November 10, 2020, the Editorial Office received a no-tification letter from Clarivate Analytics stating that Journal of Clinical and Translational Hepatology (JCTH) had been selected to be included in citation indexes in the Web of Science, and that articles published in JCTH after December 30, 2017 will be listed in some of the most influential and widely used databases in the world, including Current Con-tents/Clinical Medicine, Science Citation Index Expanded (SCIE), Essential Science Indicators, and Journal Citation Reports Science.

关键词： SCIE Academic Miles

Hair regrowth following fecal microbiota transplantation in an elderly patient with alopecia areata: A case report and review of the literature

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World Journal of Clinical Cases 2019年第19期7卷 3074-3081页

作者： Wen-Rui Xie xiao-Ya Yang harry hua-xiang xia Li-Hao Wu Xing-xiang He Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Physiology Guangzhou Health Sciences CollegeGuangzhou 510180Guangdong ProvinceChina

BACKGROUND Alopecia areata is a hair loss disease associated with genetics,autoimmunity,and other *** is an intriguing link between alopecia areata and gut *** microbiota transplantation(FMT)has been recommended to treat Clostridium difficile(previously known as Clostridioides difficile)infection,and has also shown potentials in the treatment of inflammatory bowel disease,irritable bowel syndrome,and non-alcohol fatty liver *** SUMMARY An 86-year-old man,with a history of sigmoid colon carcinoma,suffered from recurrent abdominal pain and distension,and diarrhea for six months,with *** admission,he was also diagnosed with *** physical examination,the patient presented with a 1.5 cm×2.0 cm alopecia areata on his right *** to the negative results of laboratory testing,capsule endoscopy,and colonoscopy,the patient was diagnosed with noninfectious diarrhea,depressive disorder,and patchy alopecia *** that noninfectious diarrhea in the elderly patient was mainly caused by gut dysbiosis,he was given six rounds of *** diarrhea improved remarkably one month after FMT,with improved appetite and disappearance of abdominal pain,distension,and depressive ***,he reported new hair growth on the affected region of his scalp,with some of his white hair gradually turning to black,without taking any other therapies for alopecia areata before and after *** FMT might act as a potential therapy for patients who suffer from alopecia *** and well-designed studies are required to confirm the role of FMT in alopecia areata.

关键词： Fecal microbiota transplantation Alopecia areata Gut microbiota Autoimmune disease Psychopathogenesis Case report

Ascitic Fluid Analysis in the Differential Diagnosis of Ascites:Focus on Cirrhotic Ascites

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Journal of Clinical and Translational Hepatology 2014年第1期2卷 58-64页

作者： Lin-Lin huang harry hua-xiang xia Sen-Lin Zhu Department of Gastroenterology the First Affiliated Hospital Sun Yat-sen University Guangzhou China Novartis Pharmaceuticals Corporation East Hanover NJ USA

Ascites is the pathologic accumulation of fluid within the peritoneal *** many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differential *** concept of transudate versus exudate,as determined by total protein measurements,is outdated and the use of serumascites albumin gradient as an indicator of portal hypertension is more *** dehydrogenase (LDH),vascular endothelial growth factor (VEGF),and other tumor markers can be helpful in distinguishing between malignant and benign *** and adenosine deaminase levels may support a diagnosis of tuberculous disease,and amylase level may indicate a diagnosis of *** the specificity and sensitivity of laboratory results,accurate diagnosis should be based on both laboratory data and clinical iudgment.

关键词： Ascitic fluid analysis Differential diagnosis Ascites Cirrhosis

Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial

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Current Medical Science 2021年第6期41卷 1087-1095页

作者： Li-hao WU Zhi-ning YE Ping PENG Wen-rui XIE Jia-ting XU Xue-yuan ZHANG harry hua-xiang xia Xing-xiang HE Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080China Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080China Guangzhou Eighth People's Hospital Guangzhou 510060China

Objective:Coronavirus disease 2019(COVTD-19)is often accompanied by gastrointestinal symptoms,which are related to gut microbiota dysbiosis(GMD).Whether washed microbiota transplantation(WMT)is an effective treatment for COV1D-19 patients suspected of having GMD by restoring the gut microbiota is *** study is designed to explore the efficacy and safety of WMT in COVID-19 patients suspected of having ***:This is a randomized,multicenter,single-blind prospective ***-19 patients suspected of having GMD will be randomly divided to receive routine treatment only or to receive routine treatment and *** frequency of WMT will be once a day for three consecutive *** and imaging examinations will be performed at admission,1 and 2 weeks after treatment,and on the day of *** a telephone follow-up will be conducted at 1st week,2nd week,and 6th month after *** clinical efficacy and safety of WMT in COVD-19 patients suspected of having GMD and the effects of WMT on the organ function,homeostasis,inflammatory response,intestinal mucosal barrier function,and immunity of the patients will be ***:By following the proposed protocol,WMT is expected to be efficacious and safe for the treatment of COVID-19 patients suspected of having GMD,and the therapeutic effect is expected to be associated with improvement of the intestinal mucosal barrier function,inflammatory response,and ***:The findings from this study may offer a new approach for the prevention and treatment of COVID-19 patients suspected of having GMD.

关键词： COVID-19 SARS-Cov-2 virus gut microbiota microbiome dysbiosis washed microbiota transplantation

Chemoprevention of gastric cancer: current status

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Chinese Medical Journal 2003年第1期116卷 5-10页

作者： harry hua-xiang xia Benjamin Chun-Yu Wong Shiu-Kum Lam Department of Medicine Department of MedicineDepartment of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong SAR ChinaThe University of Hong Kong Queen Mary Hospital Hong Kong SAR ChinaThe University of Hong Kong Queen Mary Hospital Hong Kong SAR China

The development of gastric cancer is a multi-factor process. In addition to genetic factors, environmental factors including smoking, low gastric acidity, excessive intake of salt or salty food and low consumption of fresh fruits and vegetables all contribute to the development of gastric cancer. Of particular interest, epidemiological and experimental studies have demonstrated that Helicobacter pylori (H. pylori) infection is causally linked to gastric cancer. Most studies using micronutrient supplementation have failed to demonstrate any preventive effect against the development of gastric cancer. The use of non-steroidal anti-inflammatory drugs has been consistently observed to protect against the development of gastric cancer. Recently, eradication of H. pylori infection by a chemopreventative approach is being studied in a number of trials. Studies using precancerous lesions as an end point of the treatment have produced conflicting and mostly negative results. Trials using cancer as an end point are being cautiously carried out in high-risk populations, and will provide the definitive answer to this important question. In the end, vaccination may be proven to be the optimal strategy in human for the management of H. pylori infection and prevention of gastric cancer.

关键词： chemoprevention gastric cancer Helicobacter pylori

Association between Helicobacter pylori and gastric cancer:current knowledge and future research

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World Journal of Gastroenterology 1998年第2期4卷 1-4页

作者： xia HH harry hua-xiang xia, Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW 2751, Australia

ＡｓｓｏｃｉａｔｉｏｎｂｅｔｗｅｅｎＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉａｎｄｇａｓｔｒｉｃｃａｎｃｅｒ：ｃｕｒｅｎｔｋｎｏｗｌｅｄｇｅａｎｄｆｕｔｕｒｅｒｅｓｅａｒｃｈＨａｒｙＨｕａＸｉａｎｇＸｉａＳｕｂｊｅｃｔ... 详细信息

ＡｓｓｏｃｉａｔｉｏｎｂｅｔｗｅｅｎＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉａｎｄｇａｓｔｒｉｃｃａｎｃｅｒ：ｃｕｒｅｎｔｋｎｏｗｌｅｄｇｅａｎｄｆｕｔｕｒｅｒｅｓｅａｒｃｈＨａｒｙＨｕａＸｉａｎｇＸｉａＳｕｂｊｅｃｔｈｅａｄｉｎｇｓｓｔｏｍａｃｈｎｅ...

关键词： stomach neoplasms/etiology stomach neoplasms/epidemiology stomach neoplasms/prevention and control DNA mutation Helicobacter pylori  helicobacter infection

Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease

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World Journal of Gastroenterology 2021年第6期27卷 513-522页

作者： Ya-Mei Zheng xian-Yun Chen Jie-Yi Cai Yu Yuan Wen-Rui Xie Jia-Ting Xu harry hua-xiang xia Min Zhang Xing-xiang He Li-Hao Wu Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityResearch Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong ProvinceGuangzhou 510030Guangdong ProvinceChina Department of Science and Education The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510030Guangdong ProvinceChina Department of Epidemiology and Health Statistics Guangdong Pharmaceutical UniversityGuangzhou 510220Guangdong ProvinceChina

BACKGROUND The pathogenesis of gastroesophageal reflux disease(GERD)is closely associated with the intestinal bacteria composition and their *** To investigate whether washed microbiota transplantation(WMT)improves symptoms of nonerosive reflux disease(NERD)with proton pump inhibitor(PPI)*** Patients with recurrent NERD and PPI dependency at the First Affiliated Hospital of Guangdong Pharmaceutical University from 2017 to 2018 were included and divided into a WMT or PPI group treated with PPI with/without *** endpoint was NERD symptom frequency evaluated 1 mo after WMT using reflux disease questionnaire(RDQ)and GERD questionnaire(GERDQ)scores,remission time,PPI dose,and the examination of intestinal mucosal barrier *** In the WMT(n=15)and PPI(n=12)groups,the total remission rate at 1 mo after treatment was 93.3%vs 41.7%.Compared with the PPI group,the WMT group showed better results in GERDQ(P=0.004)and RDQ(P=0.003)and in remission months(8 vs 2,P=0.002).The PPI dose was reduced to some extent for 80%of patients in the WMT group and 33.3%in the PPI *** 24 patients,intestinal mucosal barrier function was examined before treatment,and changes in the degree of damage were observed in 13 of these patients after *** one of the 15 patients had minor side effects,including a mushy stool two or three times a day,which resolved on their own after 1 *** This study is the first to demonstrate that WMT may be safe and effective for relieving NERD symptoms and reducing PPI dependency and recurrence.

关键词： Nonerosive reflux disease Washed microbiota transplantation Proton pump inhibitor dependency Intestinal bacteria Lipopolysaccharide Small intestinal bacterial overgrowth

Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells

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World Journal of Gastroenterology 2005年第13期11卷 1946-1950页

作者： harry hua-xiang xia Shiu Kum Lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg Benjamin Chun-Yu Wong Department of Medicine Institute of Molecular Biology Department of Molecular Microbiology

AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cag pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro. METHODS: A cytotoxic wild-type H pylori strain (TN2), its three isogenic mutants (TN2Δcag,TN2ΔcagA and TN2ΔcagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/ cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45, were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter. RESULTS: The wild-type strain and the isogenic mutants, TN2ΔcagA and TN2ΔcagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2Δcag did not increase the release of MIF at any of the four ratios. 3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2ΔcagA and TN2ΔcagE, but not from the mutant TN2Δcag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared. CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric ep

关键词： H pylori MIF PAI

Journal of Clinical and Translational Hepatology Receives Its First Impact Factor(4.108)and CiteScore(6.7)

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 453-455,F0003页

作者： harry hua-xiang xia George Y.Wu Hong Ren Department of Gastroenterology First Affiliated HospitalGuangdong Pharmaceutical UniversityGuangzhouGuangdongChina Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarm-ingtonCTUSA Institute for Viral Hepatitis Department of Infectious DiseasesThe Second Affiliated Hospital of Chong-qing Medical UniversityChongqingChina

We are pleased to announce that Journal of Clinical and Translational Hepatology(JCTH)has received its first impact factor-4.108-in the Journal Citation Report released by Clarivate Analytics on June 30,*** now ranks 42nd among 92 journals in the Gastroenterology and Hepatology category and is in the second quartile(Q2)in the category(Fig.1).Moreover,JCTH has also received its first CiteScore-6.7-released by Elsevier on June 4,2021 and ranks 16th among 62 hepatology journals according to that evaluation system(Fig.2).

关键词： Clinical category Hepa