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World Journal of Gastroenterology 2021年第6期27卷 513-522页

作者： Ya-mei Zheng Xian-Yun Chen Jie-Yi Cai Yu Yuan Wen-Rui Xie Jia-Ting Xu harry hua-Xiang Xia Min Zhang Xing-Xiang he Li-hao Wu Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityResearch Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong ProvinceGuangzhou 510030Guangdong ProvinceChina Department of Science and Education The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510030Guangdong ProvinceChina Department of Epidemiology and health Statistics Guangdong Pharmaceutical UniversityGuangzhou 510220Guangdong ProvinceChina

BACKGROUND The pathogenesis of gastroesophageal reflux disease(GERD)is closely associated with the intestinal bacteria composition and their *** To investigate whether washed microbiota transplantation(WMT)improves symptoms of nonerosive reflux disease(NERD)with proton pump inhibitor(PPI)*** Patients with recurrent NERD and PPI dependency at the First Affiliated hospital of Guangdong Pharmaceutical University from 2017 to 2018 were included and divided into a WMT or PPI group treated with PPI with/without *** endpoint was NERD symptom frequency evaluated 1 mo after WMT using reflux disease questionnaire(RDQ)and GERD questionnaire(GERDQ)scores,remission time,PPI dose,and the examination of intestinal mucosal barrier *** In the WMT(n=15)and PPI(n=12)groups,the total remission rate at 1 mo after treatment was 93.3%vs 41.7%.Compared with the PPI group,the WMT group showed better results in GERDQ(P=0.004)and RDQ(P=0.003)and in remission months(8 vs 2,P=0.002).The PPI dose was reduced to some extent for 80%of patients in the WMT group and 33.3%in the PPI *** 24 patients,intestinal mucosal barrier function was examined before treatment,and changes in the degree of damage were observed in 13 of these patients after *** one of the 15 patients had minor side effects,including a mushy stool two or three times a day,which resolved on their own after 1 *** This study is the first to demonstrate that WMT may be safe and effective for relieving NERD symptoms and reducing PPI dependency and recurrence.

关键词： Nonerosive reflux disease Washed microbiota transplantation Proton pump inhibitor dependency Intestinal bacteria Lipopolysaccharide Small intestinal bacterial overgrowth

Measurements of heat Treatment Effects on Bovine Cortical Bones by Nanoindentation and Compression Testing

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Journal of Biomaterials and Nanobiotechnology 2012年第1期3卷 105-113页

作者： mei-ling Lau Kin-tak Lau harry Ku Debes Bahattacharyya Yan-dong Yao Centre for Advanced Composite Materials Department of Mechanical Engineering The University of Auckland Auckland New Zealand Centre of Excellence in Engineered Fibre Composites Faculty of Engineering and Surveying University of Southern Queensland Toowoomba Australia Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong China

heat treatment of bone is one of the reliable and simple sterilization methods to overcome the risk of rejection and disease transfer from allograft and xenograft, in particular for the prevention of human immunodeficiency virus (hIV) infection. however, the mechanical property of the micro-structural level after heat treatment is not well characterized. To address this issue, this study was carried out to compare the localized mechanical properties of micro-structural tissue with those at the global structural level. Nanoindentation technique has been well accepted as an accurate technique to measure mechanical property of small and heterogeneous specimen nondestructively, as well as the complex bio-material of micro-structural level, often with a resolution of better than 1 μm. In this study, nanoindentation was conducted to measure the localised elastic modulus and hardness values of bones at temperature of 23°C (room temperature – non-heated sample), 90°C and 150°C, respectively. All experiments were conducted at room temperature (~23°C). The elastic modulus (E) and nanoindentation hardenss (h) values in the longitudinal direction of bones heated at 150°C were recorded as 23.43 GPa and 0.73 GPa, respectively;as in transverse direction, the E and h values were 12.77 GPa and 0.54 GPa, respectively. It showed significant increases of 44% and 43% in the longitudinal direction as compared to those of the non heat-treated bones. In addition, E and h values in transverse direction also showed increases of 23% and 38%, respectively as compared to those of the non heat-treated bones. Furthermore, heat-treated bones at 90°C in longitudinal direction also appeared to have significant increases of 18% and 31% in E and h values, respectively. however, the E and h values in transverse direction increase only by 0.4% and 12.8%, respectively. In addition, compressive test is employed to measure the global stiffness (E) of the bone samples. When heated at 150°C, the bone specime

关键词： Bone heat Treatment Nanoindentation Mechanical Properties BSE and EDX

Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration

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Neuroscience Bulletin 2013年第2期29卷 177-188页

作者： Feng mei S.Y.Christin Chong Jonah R.Chan Department of Neurology Program in Neuroscience and the MS Research GroupUniversity of California

The differentiation of and myelination by oligodendrocytes （OLs） are exquisitely regulated by a series of intrinsic and extrinsic mechanisms. As each OL can make differing numbers of myelin segments with variable lengths along similar axon tracts, myelination can be viewed as a graded process shaped by inhibitory/ inductive cues during development. Myelination by OLs is a prime example of an adaptive process determined by the microenvironment and architecture of the central nervous system （CNS）. In this review, we discuss how myelin formation by OLs may be controlled by the heterogeneous microenvironment of the CNS. Then we address recent findings demonstrating that neighboring OLs may compete for available axon space, and highlight our current understanding of myelin-based inhibitors of axonal regeneration that are potentially responsible for the reciprocal dialogue between OLs and determine the numbers and lengths of myelin internodes. Understanding the mechanisms that control the spatiotemporal regulation of myelinogenic potential during development may provide valuable insight into therapeutic strategies for promoting remyelination in an inhibitory microenvironment.

关键词： differentiation myelin nogo-A LINGO-l semaphorin ephrin netrin-1

Entrapped single tungstate site in zeolite for cooperative catalysis of olefin metathesis with Br?nsted acid site

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Entrapped single tungstate site in zeolite for cooperative c...

照亮两种不同戏剧传统的差异与共性——论说《1616:莎士比亚和汤显祖的中国》

中国化学会第三届中国能源材料化学研讨会

作者： Pu Zhao Lin Ye Zhenyu Sun Benedict T.W.Lo harry Woodcock Chen huang Chiu Tang Angus I.Kirkland Donghai mei S.C.Edman Tsang Wolfson Catalysis Centre Department of ChemistryUniversity of Oxford Department of Materials University of Oxford Diamond Light Source Ltd. Harwell Science and Innovation Campus Physical and Computational Sciences Directorate & Institute for Integrated Catalysis Pacific Northwest National LaboratoryPO Box 999

＜正＞Industrial olefin metathesis catalysts generally suffer from low reaction rates and require harsh reaction conditions for moderate *** is due to their inability to prevent metathesis active sites（MASs） from aggregation and their intrinsic poor adsorption and activation of olefin ***,isolated tungstate species as single molecular MASs are immobilized inside zeolite pores by Br?nsted acid sites（BASs） on the inner surface.

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艺术百家 2016年第5期32卷 11-14,74页

作者：孙玫中央大学中国文学系

1616年,英国的莎士比亚、中国的汤显祖先后离开了人世。400年前,这两位文豪的辞世显然还只是各自孤立的事件。20世纪,是研究中国戏曲的学者们把这两位文学巨匠联系在了一起。今年恰逢莎士比亚、汤显祖逝世四百周年,各种纪念活动纷至沓来... 详细信息

1616年,英国的莎士比亚、中国的汤显祖先后离开了人世。400年前,这两位文豪的辞世显然还只是各自孤立的事件。20世纪,是研究中国戏曲的学者们把这两位文学巨匠联系在了一起。今年恰逢莎士比亚、汤显祖逝世四百周年,各种纪念活动纷至沓来,其中有一本英文著作格外值得注目和留意。以出版莎士比亚丛书以及"哈利·波特"系列而闻名的英国的布鲁姆斯伯里出版公司,于年初出版发行了《1616:莎士比亚和汤显祖的中国》(1616:Shakespeare and Tang Xianzu’s China)。该书荟集了来自不同国度的十位研究戏曲和十位莎学的专家学者的研究成果,通过研究汤、莎去了解他们各自所处的、非常不同的戏剧世界,而不是要将汤显祖和莎士比亚作一简单的、平行的对照。所以,该书的范围并不局限于汤显祖和莎士比亚这两位伟大的剧作家,还包括了当年剧作家之间的交往、剧场和艺人等诸多方面。

关键词：戏曲艺术汤显祖莎士比亚晚明英国伊丽莎白时代

美国现实社会变迁的一面镜子——解读约翰·厄普代克的小说《兔子》四部曲

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辽宁师范大学学报（社会科学版） 2007年第1期30卷 100-102页

作者：蔡殿梅辽宁师范大学外国语学院辽宁大连116029

约翰.厄普代克是美国20世纪下半叶最著名的现实主义小说家之一,是美国“垮掉的一代”的重要代表,被评论家称为“社会历史变化的准确记录者”。他的小说《兔子》四部曲,生动形象地描述了哈里这个普普通通美国人家庭的兴起与衰败,成功地... 详细信息

约翰.厄普代克是美国20世纪下半叶最著名的现实主义小说家之一,是美国“垮掉的一代”的重要代表,被评论家称为“社会历史变化的准确记录者”。他的小说《兔子》四部曲,生动形象地描述了哈里这个普普通通美国人家庭的兴起与衰败,成功地塑造了“兔子”哈里这样一个置身于美国现实社会中的典型形象,系统而全面地展现了半个世纪以来美国社会的分崩离析和精神颓废等现实,从而加深了人们对美国当代现实生活真实状况的认识,是20世纪美国现实社会变迁的真实写照。

关键词： “兔子”哈里堕入歧途无奈挣扎信仰危机死于无聊社会变迁

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2004少儿图书出版综述

湖南科技学院学报 2005年第10期26卷 77-80页

作者：李蓉梅北京师范大学文学院北京100875

2004年中国少儿图书出版原创几乎与引进平分秋色。原创小说,童话,卡通,百科都取得了很大成功。青春文学成为各社重头戏,马小跳超越哈利·波特,哪吒成就了国产动漫传奇,红色经典成为一道亮丽的风景。尽管如此,原创仍面临引进的严峻挑战... 详细信息

2004年中国少儿图书出版原创几乎与引进平分秋色。原创小说,童话,卡通,百科都取得了很大成功。青春文学成为各社重头戏,马小跳超越哈利·波特,哪吒成就了国产动漫传奇,红色经典成为一道亮丽的风景。尽管如此,原创仍面临引进的严峻挑战。引进图书中,魔幻,侦探,图画书占了很大比例。魔幻,侦探吸引了大量读者。目前,图画书市场还是引进版的天下。

关键词：少儿图书出版原创引进少儿图书出版引进版红色经典图画书原创魔幻侦探读者

迷惘的爱情——透视海明威《乞力马扎罗的雪》中男女主人公之爱情观

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玉林师范学院学报 2005年第1期26卷 48-51页

作者：李光梅玉林师范学院外语系副教授广西玉林537000

“迷惘的一代”作家、诺贝尔文学奖得主欧内斯特·海明威以他非凡的才华和真实的情感写出了一部部几乎是美国文学史上最优秀的小说。短篇小说《乞力马扎罗的雪》是其中之一。海明威的短篇小说《乞力马扎罗的雪》充分反映了美国20世纪20... 详细信息

“迷惘的一代”作家、诺贝尔文学奖得主欧内斯特·海明威以他非凡的才华和真实的情感写出了一部部几乎是美国文学史上最优秀的小说。短篇小说《乞力马扎罗的雪》是其中之一。海明威的短篇小说《乞力马扎罗的雪》充分反映了美国20世纪20年代理想破灭、精神空虚与孤独的“迷惘一代”的坎坷命运。笔者通过对美国战后的一代人的精神危机,着重从男女主人公在动荡的历史背景下对爱情的态度与追求截然不同出发,分析了海伦的无私给予、哈利的麻木索取;海伦的温柔体贴、哈利的冷酷无情;指出是战争毁了人们的理想与爱情,战后的和平与繁荣亦无法抚平他们心灵上的创伤;小说中男女主人公都曾想与命运抗争,最终都以失败告终。高大、宏伟、洁白无暇的乞力马扎罗山被哈得看作是“上帝的庙殿”,但对于海伦却是渴望而不可及的地方。透过《乞力马扎罗的雪》中无望与无爱的“爱情”,海明威激起了我们对战争的痛恨与谴责、对自由与和平的追求、对爱情的珍惜及对妇女前途、命运的探索。

关键词：迷惘的一代迷惘的爱情乞力马扎罗的雪

失败的抗争者:《兔子,跑吧!》中兔子的人格与行为分析

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天津外国语学院学报 2006年第2期13卷 66-70页

作者：索金梅郝蕴志南开大学外国语学院英语系天津300071

约翰.厄普代克(John Updike)的成名之作《兔子,跑吧!》中的男主人公兔子一直是个颇有争议的人物。结合了当时的社会背景,从兔子的心理、性格出发,用弗洛伊德主义理论和精神分析法对其人格和行为进行分析,认为兔子对生活的抗争和对幸福... 详细信息

约翰.厄普代克(John Updike)的成名之作《兔子,跑吧!》中的男主人公兔子一直是个颇有争议的人物。结合了当时的社会背景,从兔子的心理、性格出发,用弗洛伊德主义理论和精神分析法对其人格和行为进行分析,认为兔子对生活的抗争和对幸福的追求之所以失败,除了有当时社会、历史及价值观方面的原因,自身存在的弱点,如自恋、幼稚、缺乏自我调整能力也是使其最终成为悲剧性人物的重要因素。

关键词：美国中产阶级男性精神分析法人格与行为