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The dorsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen Martínez-Padilla Lourdes Sánchez-Salido Anne Baron-Van Evercooren Beatriz García-díaz Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONANd) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain Sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe and chronic condition widely found in the general *** reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in *** the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical ***,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells(satellite glial cells and inflammatory cells)and factors(cytokines,neurotrophic factors and genetic factors)that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic *** importantly,we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines dorsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies satellite glial cells sensory neurons

A New Multiobjective Particle Swarm Optimization Using Local displacement and Local Guides

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Open Journal of Optimization 2024年第2期13卷 31-49页

作者： Saïd Charriffaini Rawhoudine Abdoulhafar Halassi Bacar Laboratoire des Mathmatiques Statistiques Informatique et Applications (LMSIA) Dpartement des Mathmatiques Physique-Chimie et Informatique Facult des Sciences et Techniques Universit des Comores Moroni Comoros

This paper introduces a novel variant of particle swarm optimization that leverages local displacements through attractors for addressing multiobjective optimization problems. The method incorporates a square root distance mechanism into the external archives to enhance the diversity. We evaluate the performance of the proposed approach on a set of constrained and unconstrained multiobjective test functions, establishing a benchmark for comparison. In order to gauge its effectiveness relative to established techniques, we conduct a comprehensive comparison with well-known approaches such as SMPSO, NSGA2 and SPEA2. The numerical results demonstrate that our method not only achieves efficiency but also exhibits competitiveness when compared to evolutionary algorithms. Particularly noteworthy is its superior performance in terms of convergence and diversification, surpassing the capabilities of its predecessors.

关键词： Particle Swarm Optimization Multiobjective Optimization Attractor-Based displacement Square root distance Crowding distance

Nav1.7调节软骨细胞并作为骨关节炎的治疗靶点

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中国疼痛医学杂志 2024年第6期30卷 404-406页

作者： Fu W Vasylyev d Bi Y 戈家宜(译) 刘兴君(校) 不详南通大学药学院

骨关节炎(osteoarthritis,OA)是常见的关节疾病。目前还没有能够同时防止关节退化和减少疼痛的治疗方法。有证据表明软骨细胞中存在电压门控钠通道(voltage gated sodium channels,VGSCs),但它们在软骨细胞和OA中的表达和功能仍不清楚... 详细信息

骨关节炎(osteoarthritis,OA)是常见的关节疾病。目前还没有能够同时防止关节退化和减少疼痛的治疗方法。有证据表明软骨细胞中存在电压门控钠通道(voltage gated sodium channels,VGSCs),但它们在软骨细胞和OA中的表达和功能仍不清楚。该研究发现,Nav1.7作为一个与OA相关的VGSCs,人OA软骨细胞以0.1~0.15个/μm2和350~525个通道/细胞的密度表达功能性Nav1.7。在通过基因操作抑制Nav1.7的一系列小鼠模型上发现,表达在背根神经节(dorsal root ganglion,dRG)神经元中的Nav1.7参与疼痛的调控,而表达在软骨细胞中的Nav1.7调节OA进程。使用选择性或临床常用的泛Nav通道阻断剂,可显著改善结构性关节损伤,并减轻OA疼痛。Nav1.7阻断剂调节细胞内Ca2+信号和软骨细胞的分泌组,进而影响软骨细胞生物学和OA进程。该研究证实,Nav1.7为一个新发现的、在软骨细胞表达的OA相关VGSCs,可作为具有双重靶点特性的用于治疗OA和镇痛的非阿片类镇痛药。

关键词：骨关节炎软骨细胞关节疾病基因操作背根神经节治疗靶点关节损伤电压门控钠通道

深部未发现天然气资源——美国地质调查局对本土的评价

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天然气地球科学 2001年第4期12卷 40-47页

作者： T.dyman J.Schmoker d.root 郑军卫美国地质调查局

介绍了美国地质调查局(USGS)对美国深部未发现天然气的评价方法及评价结果,简要比较了USGS评价结果与其它评价机构评价的差异,列出了美国深部天然气资源评价工作的发展方向。

关键词：深部气天然气资源常规远景区美国

Structure of the 40S ribosomal subunit of Plasmodium falciparum by homology and de novo modeling

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Acta Pharmaceutica Sinica B 2017年第1期7卷 97-105页

作者： harrison Ndung'u Mwangi Peter Wagacha Peterson Mathenge Fredrick Sijenyi Francis Mulaa Center for Biotechnology and Bioinformatics Chiromo CampusUniversity of Nairobi.HEP Bioinformatics Consultants Ltd. department of Computing Informatics University of Nairobi dNA Software Inc. department of Biochemistry Riverside DriveChiromo CampusUniversity of Nairobi

Generation of three dimensional structures of macromolecules using in silico structural modeling technologies such as homology and de novo modeling has improved dramatically and increased the speed by which tertiary structures of organisms can be generated. This is especially the case if a homologous crystal structure is already available. High-resolution structures can be rapidly created using only their sequence information as input, a process that has the potential to increase the speed of scientific discovery. In this study, homology modeling and structure prediction tools such as RNA123 and SWISS–MOdEL were used to generate the 40 S ribosomal subunit from Plasmodium falciparum. This structure was modeled using the published crystal structure from Tetrahymena thermophila, a homologous eukaryote. In the absence of the Plasmodium falciparum 40 S ribosomal crystal structure, the model accurately depicts a global topology, secondary and tertiary connections, and gives an overall root mean square deviation(RMSd) value of 3.9 ? relative to the template's crystal structure. deviations are somewhat larger in areas with no homology between the templates. These results demonstrate that this approach has the power to identify motifs of interest in RNA and identify potential drug targets for macromolecules whose crystal structures are unknown. The results also show the utility of RNA homology modeling software for structure determination and lay the groundwork for applying thisapproach to larger and more complex eukaryotic ribosomes and other RNA-protein complexes. Structures generated from this study can be used in in silico screening experiments and lead to the determination of structures for targets/hit complexes.

关键词： Ribosome 40S subunit RNA structure Plasmodium falciparum 3d modeling de novo Homology

Multi-regional observations and validation of the M_(3)ocean tide

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中国科学:地球科学英文版 2023年第10期66卷 2265-2277页

作者： Adam Thomas dEVLIN Jiayi PAN déborah IdIER School of Geography and Environment Jiangxi Normal UniversityNanchang330022China Cooperative Institute for Marine and Atmospheric Research School of Ocean and Earth Science and TechnologyUniversity of Hawai’i at MānoaHonoluluHI96822USA department of Oceanography University of Hawai’i at MānoaHonoluluHI96822USA The Chinese University of Hong Kong Hong Kong999077China Key Laboratory of Poyang Lake Wetland and Watershed Research of Ministry of Education Nanchang330022China BRGM Orléans45060France

Improved determinations of the oft-ignored third-degree ocean tides can yield better accuracy for tidal predictions,numerical model solutions,and *** only a small part of tidal range,these components can be larger at certain coastal locations due to shelf resonances and other ***,we discuss observations of the M3lunar terdiurnal tide using 9-year windowed tidal harmonic analyses at 157 tide gauges compares to a global assimilation model(TPXO9v5a),with a focus on the Western Pacific and the European ***9v5a does well in estimating the observed M_(3)amplitudes and phase lags in most regions,though determinations in coastal zones and in morphologically complex areas are coarse and often *** also employ a shallow-water model(MARS)on the European Shelf,which can yield localized improvement over *** five subregions of the European Shelf,regional root-mean-squared-errors(RMSEs)are lower(and thus a better fit)at three locations for TPXO for amplitudes,and three for phase lags,with MARS simulations being a better fit in the other *** also show that some locations have experienced significant long-term increases and/or decreases in the M_(3)amplitude over time,likely related to resonance changes under sea level rise(SLR)which can modulate the oceanic response to astronomical *** hypothesis is explored for Europe using the MARS model by applying various sea level rise scenarios,showing that the directionality(positive or negative)of the long-term changes in M_(3)amplitudes over time match the model results for more than half of our validation stations.

关键词： Third-degree tides M_(3)tide Altimetry Numerical simulation Sea level rise

Challenges in determination of microscopic degree of cleanliness in ultra-clean gear steels

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Journal of Iron and Steel Research(International) 2022年第10期29卷 1583-1600页

作者： d.Fuchs T.Tobie K.Stahl Gear Research Center(FZG) Technical University of Munich85748 GarchingGermany

Shot-peened,case-hardened gears can fail in the tooth root due to crack initiation below the surface of the steel ***,the crack is initiated at a non-metallic inclusion in the center of a so-called *** failure type can lead to a reduced endurance fatigue limit of the *** is for this reason that,over the last decade,much effort has been invested by steel manufacturers to reduce the non-metallic inclusion content of gear steels so as to mitigate or even completely prevent such crack *** ultra-clean gear steels were achieved by various measures in the steel production ***,as a result,the remaining non-metallic inclusions are inhomogeneously distributed in the steel volume in terms of both size and ***,due to the inhomogeneity of ultra-clean steels,the question arose if the values derived according to the standards are still representative of ultra-clean steel *** results show that the standards can still be applied,but more effort must be *** determine the degree of cleanliness,six microsections are currently evaluated according to steel test specification(SEP)1571,method *** is shown that an examination of 24 microsections starting from size class 0 seems beneficial to get more reliable and comparable results of the degree of cleanliness of these ultra-clean gear *** addition,it is shown that a high degree of cleanliness has been achieved for all steel batches investigated with the measures taken in the steel production process.

关键词： degree of cleanliness Non-metallic inclusion Evaluation of inclusion SEP 1571 dIN 50602 Ultrasonic immersion testing Ultra-clean gear steel Gear

Integrating vegetation indices and geo-environmental factors in GIS-based landslide-susceptibility mapping:using logistic regression

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Journal of Mountain Science 2022年第2期19卷 477-492页

作者： Himasha d.ABEYSIRIWARdANA Pattiyage I.A.GOMES department of Civil Engineering Faculty of EngineeringSri Lanka Institute of Information TechnologyMalabe 101115Sri Lanka

This study aimed to assess the potential of in-situ measured soil and vegetation characteristics in landslide susceptibility ***,data for eight independent variables,i.e.,soil moisture content,soil organic content,compaction of soil(soil toughness),plant root strength,crop biomass,tree diameter at knee height,Shannon Wiener Index(SWI)for trees and herbs was assembled from field tests at two historic landslide locations:Aranayaka and Kurukudegama,Sri *** economical,finer resolution database was obtained as the field tests were not *** logistic regression(LR)analysis showed that soil moisture content,compaction of soil,SWI for trees and herbs were statistically significant at Pd to test for *** values(d the absence of multicollinearity between four independent variables in the LR *** Operating Characteristics(ROC)curve and Confusion Metrix(CM)methods were used to validate the *** ROC analysis,areas under the curve of Success Rate Curve and Prediction Rate Curve were 84.5% and 96.6%,respectively,demonstrating the model’s excellent compatibility and *** to the CM,the model demonstrated a 79.6% accuracy,63.6% precision,100% recall,and a F-measure of 77.8%.The model coefficients revealed that the vegetation cover has a more significant contribution to landslide susceptibility than soil ***,the susceptibility map,which was then classified as low,medium,and highly susceptible areas based on the natural breaks(Jenks)method,was generated using geographical information systems(GIS)*** the historic landslide locations fell into the high susceptibility ***,validation of the model and inspection of the susceptibility map indicated that the in-situ soil and vegetation characteristics used in the model could be employed to demarcate historical landslide patches and identify landslide susceptibl

关键词： Landslide Susceptibility Slope stability GIS Logistic regression Area under the curve Confusion Metrix

Effects of root Growth of deep and Shallow rooting Rice Cultivars in Compacted Paddy Soils on Subsequent Rice Growth

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Rice science 2023年第5期30卷 459-472,I0022-I0024页

作者： Md.dhin ISLAM Adam H.PRICE Paul d.HALLETT School of Biological Sciences University of AberdeenSt Machar DrAberdeen AB243UUthe United Kingdom Faculty of Agriculture Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur-1706Bangladesh

Rice is often grown as multiple seasons in one year,alternating between flooded and upland systems.A major constraint,introduced from the flooded system,is a plough pan that may decrease rooting depth and productivity of follow-on upland *** penetrating the plough pan under flooded rice system can leave a legacy of weaker root growth *** rooting rice cultivars could have a bigger impact,but no direct evidence is *** explore whether a deep rather than a shallow rooting rice cultivar grown in a flooded cropping cycle benefited deeper root growth of follow-on rice in an upland,reduced tillage cropping cycle,a simulated flooded paddy in greenhouse was planted with deep(Black Gora) and shallow(IR64) rooting cultivars and a plant-free *** plough pans were made in between the topsoil and subsoil to form different treatments with no plough pan(0.35 MPa),soft plough pan(1.03 MPa) and hard plough pan(1.70 MPa).After harvest of this ‘first season’ rice,the soil was drained and undisturbed to simulate zero-tillage upland and planted rice cultivar BRRI dhan *** overall root length density(RLd),root surface area,the numbers of root tips and branching of BRRI dhan 28 did not vary between plough pan and no plough pan *** with the shallow rooting rice genotype,the deep rooting rice genotype as ‘first season’ crop produced 19% greater RLd,34% greater surface area and 29% more branching of BRRI dhan 28 in the *** the topsoil,however,BRRI dhan 28 had 28% greater RLd,35% greater surface area and 43% more branching for the shallow rather than deep rooting genotype planted in the ‘first season’.The results suggested that rice cultivar selection for a paddy cycle affects root growth of a follow-on rice crop grown under no-till,with benefits to subsoil access from deep rooting cultivars and topsoil proliferation for shallow rooting cultivars.

关键词： plough pan root growth biopores crop rotation Oryza sativa preceding crop zero-tillage