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Zinc Alters Ractopam.ne HCl Response in Cultured Sk.letal m.scle Cells

Open Journal of Anim.l Sciences 2020年第3期10卷 431-446页

作者： T. L. harris J. E. Hergenreder A. D. Hosford C. k. Larson B. J. Johnson Departm.nt of Anim.l and Food Sciences Texas Tech University Lubbock Texas USA Zinpro Corporation Eden Prairie MN USA

The objective of this study was to determ.ne if zinc, when added in com.ination with ractopam.ne hydrochloride (RH), would stabilize the interaction of RH with the β-adrenergic receptor, as indicated by altered cAm. ... 详细信息

The objective of this study was to determ.ne if zinc, when added in com.ination with ractopam.ne hydrochloride (RH), would stabilize the interaction of RH with the m.βm.-adrenergic receptor, as indicated by altered cAm. concentrations, m.NA quantity, or protein abundance. Cultured bovine sk.letal m.scle cells were established and treated after 120 h for 6, 24, and 96 h with differentiation m.dia of specific treatm.nts. Treatm.nts were applied in a factorial arrangem.nt with two levels of zinc (0 μm.or 1 μm. and two levels of RH (0 μm.or 10 μm. in differentiation m.dia. cAm. levels were m.asured at 6, 24, and 96 h, while m.NA and protein were m.asured at 24 and 96 h. At 6 h, no differences (m.Pm. > 0.05) were detected in cAm. levels between the treatm.nts. However, at 24 h the 10 μm.RH, 1 μm.zinc treatm.nt had the greatest concentrations of cAm. (m.Pm. m.RH, 0 μm.zinc treatm.nt had a lower concentration of cAm. (m.Pm. = 0.05) com.ared to the control. No differences were detected in m.NA (m.βm.1-adrenergic receptor, m.βm.2-adenergic receptor, Am.k., m.osin heavy chain I, m.osin heavy chain IIA, and m.osin heavy chain IIX) concentrations between treatm.nts. Protein quantity of them. βm.1-adrenergic receptor and m.βm.2-adrenergic receptor did not differ between treatm.nts. These results indicate that zinc, in com.ination with RH, m.y help sustain the RH response during prolonged exposure as indicated by increased cAm. concentrations.

关键词： β-Agonist cAm. m.scle Hypertrophy Ractopam.ne Hydrochloride Zinc

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保健调查和质量评估机构对儿童医院的患者安全指标的认定

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世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 40-42页

作者： Sedm.n A. harris II J.m. Schulz k. 王经纬 University of m.chigan Health System C201 Med Inn Building Box 0825 1500 E Medical Center Dr Ann Arbor MI 48109-0825United States Dr.

Objectives. Patient safety indicators (PSIs) were developed by the Agency for Healthcare Research and Quality. Our objectives were (1) to apply these algorithm. to the National Association of Children’s Hospitals and Related Institutions (NACHRI) Aggregate Case m.x Com.arative Database for 1999-2002, (2) to establish m.an rates for each of the PSI events in children’s hospitals, (3) to investigate the inadequacies of PSIs in relation to pediatric diagnoses, and (4) to express the data in such a way that children’s hospitals could use the PSIs determ.ned to be appropriate for pediatric use for com.arison with their own data. In addition, we wanted to use the data to set priorities for ongoing clinical investigations and to propose interventions if the indicators dem.nstrated preventable errors. m.thods. The Agency for Healthcare Research and Quality PSI algorithm. (version 2.1, revision 1) were applied to children’s hospital adm.nistrative data (1.92 m.llion discharges) from.the NACHRI Aggregate Case m.x Com.arative Database for 1999-2002. Rates were m.asured for the following events: com.lications of anesthesia, death in low-m.rtality diagnosis-related groups (DRGs), decubitus ulcer, failure to rescue (ie, death resulting from.a com.lication, rather than the prim.ry diagnosis), foreign body left in during a procedure, iatrogenic pneum.thorax, infection attributable to m.dical care (ie, infections related to surgery or device placem.nt), postoperative hem.rrhage or hem.tom., postoperative pulm.nary em.olism.or venous throm.osis, postoperative wound dehiscence, and accidental puncturelaceration. Results. Across the 4 years of data, the m.an risk.adjusted rates of PSI events ranged from.0.01%(0.1 event per 1000 discharges) for a foreign body left in during a procedure to 14.0%(140 events per 1000 discharges) for failure to rescue. Review of International Classification of Diseases, Ninth Revision, Clinical m.dification codes associated with each PSI category showed tha

关键词：儿童医院质量评估保健调查安全指标患者医原性感染术后出血静脉血栓形成病例比较 PSI

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柱状扰动体引起圆柱谐振腔共振频率偏移的数值模拟

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地球物理学报 2005年第2期48卷 445-451页

作者： harris J m.徐德龙王秀明宋延杰丛健生陈德华 Departm.nt of Geophysics Stanford University CA 94306 USA 黑龙江省大庆石油学院地球物理系 CSIRO Petroleum P.O. Box1130 Technology Park Bentley WA6102 Australia

基于微扰理论,研究了内部存在一个同轴圆柱扰动体时圆柱谐振腔共振频率的偏移问题.其中,圆柱谐振腔的边侧面是刚性的,上下底面应力自由.经过推导,得出了圆柱扰动体存在时谐振腔的声势与共振频率的表达式.在此基础上,分析了谐振腔与圆柱... 详细信息

基于微扰理论,研究了内部存在一个同轴圆柱扰动体时圆柱谐振腔共振频率的偏移问题.其中,圆柱谐振腔的边侧面是刚性的,上下底面应力自由.经过推导,得出了圆柱扰动体存在时谐振腔的声势与共振频率的表达式.在此基础上,分析了谐振腔与圆柱扰动体各种参数对谐振腔共振频率的影响.数值模拟结果表明,谐振腔的共振频率受扰动体在谐振腔中的位置影响较大.圆柱谐振腔的共振频率在圆柱扰动体居中时是最大值,并且其共振频率对扰动体的声速敏感;当扰动体在谐振腔两端时,谐振腔共振频率是最小值,并且其对扰动体的密度敏感.最后,通过数值模拟结果和实验测量结果之间的对比,发现两者的基本变化趋势是吻合的.

关键词：共振声谱共振频率偏移微扰理论岩石物理

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Electrom.gnetic shielding effectiveness of am.rphous m.tallic spheroidal-and flak.-based m.gnetodielectric com.osites

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Journal of m.terials Science & Technology 2021年第24期83卷 256-263页

作者： k.n Qian Qifan Li Alexander Sok.lov Chengju Yu Piotr k.lik.Ogheneyunum. Fitchorova Yajie Chen Chins Chinnasam. Vincent G.harris Center for m.crowave m.gnetic m.terials and Integrated Circuits Department of Electrical and Computer EngineeringNortheastern UniversityBostonMA02115USA k.I at Northeastern University LLC141 South Bedford StreetBurlingtonMA01803USA Rogers Innovation Center Rogers Corporation141 South Bedford StreetBurlingtonMA01803USA Carpenter Technology Corporation ReadingPA19601USA

Flexible,lightweight,conductive m.terials,having both high rf losses and high perm.ability,are extrem.ly desirable for applications as electrom.gnetic(Em.*** atom.zed spherical FeSi-based ferrom.gnetic m.tallic particles,having a m.an diam.ter of 14.6μm.with a standard deviation of 7.3μm.were m.asured to have a room.tem.erature saturation m.gnetic flux density of 1.49 T with a coercivity of 160 A/*** m.lling of the am.rphous particles led to aspect ratios from.1:1(spherical)to>100:1(flak.-lik.).Flak.-lik. particles,suspended in paraffin,were found to not only increase the surface area of fillers enhancing the polarization m.chanism.but also increase the com.lex perm.ability and com.lex perm.ttivity,and thus provide broadband shielding effectiveness.A loading factor of 40 vol.%of the∼15μm.diam.ter powders provided the largestΔW_(RL=-20 dB)of 9.49 GHz(i.e.,6.55k.ess of 2 ***,powder com.osites show a wide absorption potential above 18 GHz form. *** optim.zed flak.-based com.osites exhibit strong Em.wave absorption with an SE of-40 dB and SEk.ess of 1.6 m..

关键词： Am.rphous particle m.gnetic alloy powders m.crowave absorption Electrom.gnetic interference shielding

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Plasm. Fatty Acid Com.osition in m.n over 50 in the USA and Japan

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Food and Nutrition Sciences 2018年第6期9卷 703-710页

作者： A. Tak.da F. Shim.zu Y. Ishii m. Ogawa T. Tak.o S. k.ba m. R. Carnethon W. S. harris International Projects on Food and Health (NPO) Tokyo Japan Faculty of Hum.n Life and Environm.ntal Sciences Showa Women’s University Tokyo Japan Division of Cardiology Department of Medicine Showa University School of Medicine Tokyo Japan Departm.nt of Preventive m.dicine Feinberg School of Medicine of Northwestern University Chicago Illinois Departm.nt of m.dicine University of South Dakota School of Medicine and Omegaquant LLC Sioux Falls USA

Back.round: Coronary heart disease (CHD) rates differ m.rk.dly between the US and Japan. Fatty acid profiles have been link.d to risk.for CHD. Few studies have com.ared the plasm. fatty acid com.osition, including trans fatty acids, in Japanese and US subjects. m.thods: Fasting blood sam.les were tak.n from.healthy older (>age 50) Am.rican (n = 76) and Japanese (n = 44) m.n, and plasm. levels of 23 fatty acids were analyzed by gas chrom.tography and expressed as a percent of total fatty acids. Results: As expected, plasm. levels of long-chain ω3 fatty acids (docosahexaenoic and eicosapentaenoic acids, DHA and EPA) were higher in Japanese m.n and ω6 fatty acids (e.g., arachidonic acid, AA) were lower com.ared with Am.rican m.n. Plasm. levels of the m.jor industrially-produced trans fatty acids (IP-TFAs;elaidic and linoelaidic acids) were far higher in Am.rican m.n, and levels of the potentially cardioprotective, prim.rily rum.nant-derived trans fatty acid palm.toelaidic acid (POA) were higher in Japanese. Plasm. levels of saturated or m.nounsaturated fatty acids were also higher in the Am.rican m.n. Conclusion: There are m.ltiple differences in plasm. fatty acid profiles between Am.rican and Japanese older m.n. The higher levels of DHA and EPA, along with the lower levels of the IP-TFAs, are consistent with the m.rk.dly lower risk.for coronary heart disease in Japan vs. the US.

关键词： Plasm. Fatty Acid Com.osition

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马铃薯改良的科学基础

马铃薯改良的科学基础

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1984年

作者：（英）P.m.harris 蒋先明译

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各国地方政府第1版

各国地方政府

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丛书名：大学从书

1937年

作者： G.m.harris 张永懋译

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文化的起源

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丛书名：二十世纪文库

1988年

作者：（美）哈里斯（harris m.）黄晴译

并列题名：Cannibals and k.ngs

ISBN: (数字)7800533166

ISBN: (纸本)7800533166

并列题名：Cannibals and k.ngs

关键词：文化人类学

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Provenance Docum.ntation to Enable Explainable and Trustworthy AI:A Literature Review

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Data Intelligence 2023年第1期5卷 139-162页

作者： Am.uta k.le Tin Nguyen Frederick.C.harris Jr. Chenhao Li Jiyin Zhang Xiaogang m. Departm.nt of Com.uter Science Universityof IdahoMoscowID83844USA Departm.nt of Com.uter Science and Engineering University of NevadaRenoRenoNV 89557USA

Recently artificial intelligence(AI)and m.chine learning(m.)m.dels have dem.nstrated rem.rk.ble progress with applications developed in various *** is also increasingly discussed that AI and m. m.dels and applications should be transparent,explainable,and ***,the field of Explainable AI(XAI)is expanding *** holds substantial prom.se for im.roving trust and transparency in AI-based system. by explaining how com.lex m.dels such as the deep neural network.DNN)produces their ***,m.ny researchers and practitioners consider that using provenance to explain these com.lex m.dels will help im.rove transparency in AI-based *** this paper,we conduct a system.tic literature review of provenance,XAI,and trustworthy AI(TAI)to explain the fundam.ntal concepts and illustrate the potential of using provenance as a m.dium.to help accom.lish explainability in AI-based ***,we also discuss the patterns of recent developm.nts in this area and offer a vision for research in the near *** hope this literature review will serve as a starting point for scholars and practitioners interested in learning about essential com.onents of provenance,XAI,and TAI.

关键词： Explainable AI Trustworthy AI Provenance docum.ntation Work.low platform. Data science

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Identification of serum.proteins discrim.nating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-tim. of flight m.ss spectrom.try

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World Journal of Gastroenterology 2006年第10期12卷 1536-1544页

作者： Judith Ym. Engwegen Helgi H Helgason Annem.ek. Cats Nathan harris Johannes m. Bonfrer Jan Hm.Schellens Jos H Beijnen Departm.nt of Pharm.cy and Pharm.cology The Netherlands Cancer Institute/Slotervaart Hospital AmsterdamThe Netherlands Departm.nt of m.dical Oncology The Netherlands Cancer Institute/Antoni van Leeuwenhoek.Hospital AmsterdamThe Netherlands Departm.nt of Gastroenterology and Hepatology The Netherlands Cancer Institute/Antoni van Leeuwenhoek.Hospital AmsterdamThe Netherlands Ciphergen Biosystem. Inc. Freem.nt CaliforniaUnited States Departm.nt of Clinical Chem.stry The Netherlands Cancer Institute/Antoni van Leeuwenhoek.Hospital AmsterdamThe Netherlands Utrecht University Faculty of Pharm.ceutical Sciences Department of Biomedical analysisUtrechtThe Netherlands

AIm. To detect the new serum.biom.rk.rs for colorectal cancer （CRC） by serum.protein profiling with surfaceenhanced laser desorption ionisation - tim. of flight m.ss spectrom.try （SELDI-TOF m.）. m.THODS： Two independent serum.sam.le sets were analysed separately with the ProteinChip technology （set A： 40 CRC ＋ 49 healthy controls; set B： 37 CRC ＋ 31 healthy controls）, using chips with a weak.cation exchange m.iety and buffer pH 5. Discrim.native power of differentially expressed proteins was assessed with a classification tree algorithm. Sensitivities and specificities of the generated classification trees were obtained by blindly applying data from.set A to the generated trees from.set B and vice versa. CRC serum.protein profiles were also com.ared with those from.breast, ovarian, prostate, and non-sm.ll cell lung cancer. RESULTS： m.ss-to-charge ratios （m.z） 3.1×10^3, 3.3× 10^3, 4.5×10^3, 6.6×10^3 and 28×10^3 were used as classitiers in the best-perform.ng classification trees. Tree sensitivities and specificities were between 65% and 90%.Host of these discrim.native m.z values were also different in the other tum.ur types investigated. m.z 3.3× 10^3, m.in classifier in m.st trees, was a doubly charged form.of the 6.6× 10^3-Da protein. The latter was identified as apolipoprotein C-I. m.z 3.1×10^3 was identified as an N-term.nal fragm.nt of album.n, and m.z 28× 10^3 as apolipoprotein A-I. CONCLUSION： SELDI-TOF m. followed by classification tree pattern analysis is a suitable technique for finding new serum.m.rk.rs for CRC. Biom.rk.rs can be identified and reproducibly detected in independent sam.le sets with high sensitivities and specificities. Although not specific for CRC, these biom.rk.rs have a potential role in disease and treatm.nt m.nitoring.

关键词： Proteom.cs Colorectal cancer Biom.rk.r Sensitivity Specificity

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