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Natural dietary anti-cancer chemopreventive compounds:redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells

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Acta Pharmacologica Sinica 2007年第4期28卷 459-472页

作者： Sujit NAIR ah-Ng Tony KONG Graduate Program in Pharmaceutical Sciences Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe StateUniversity of New JerseyPiscatawayNew Jersey 08854USA

Many dietary phytochemicals exhib.t health-b.neficial effects including preven-tion of diseases such as cancer,as well as neurological,cardiovascular,inflam-matory,and metab.lic ***,herb.vorous and omnivorousanimals have b.en ingesting *** interaction b.tween"animal-plant"ecosystems has resulted in an elab.rate system of detoxification and defensemechanisms evolved b. animals including *** cells,includinghuman cells,respond to these dietary phytochemicals b."non-classical receptorsensing"mechanisms of electrophilic chemical-stress typified b."thiol-modu-lated"cellular signaling events primarily leading to the gene expression of phar-macologically b.neficial effects,b.t sometimes unwanted cytotoxicity *** has b.en studying two groups of dietary phytochemical cancer-chemopreventive compounds (isothiocyanates and polyphenols),which areeffective in chemical-induced,as well as genetically-induced,animal carcinogen-esis *** compounds typically generate"cellular stress"and modulategene expression of phase Ⅱ detoxifying/antioxidant ***,reac-tive oxygen species,and reactive nitrogen species are known to act as secondmessengers in the modulation of many cellular signaling pathways leading togene expression changes and pharmacological ***-sensitive tran-scription factors such as nuclear factor-E2-related factor 2 (Nrf2),AP-1,NF-κb.tocite a few examples,sense and transduce changes in the cellular redox status andmodulate gene expression responses to oxidative and electrophilic stresses,pre-sumab.y via sulfhydryl modification of critical cysteine residues found on theseproteins and/or other upstream redox-sensitive molecular *** the currentreview,we will explore dietary cancer chemopreventive phytochemicals,discussthe link b.tween oxidative/electrophilic stresses and the redox circuitry,and con-sider different redox-sensitive transcription *** will also discuss thekelch-l

关键词： redox Nrf2 Keapl NES NLS gene expression profiles

Microfluidic three-dimensional cell culture of stem cells for high-throughput analysis

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World Journal of Stem Cells 2019年第10期11卷 803-816页

作者： Jeong ah Kim Soohyun Hong Won Jong Rhee Research Center for b.oconvergence Analysis Korea Basic Science InstituteCheongju 28119South Korea Department of b.o-Analytical Science University of Science and TechnologyDaejeon 34113South Korea Program in b.omicro System Technology Korea UniversitySeoul 02841South Korea Division of b.oengineering Incheon National UniversityIncheon 22012South Korea Department of b.oengineering and Nano-b.oengineering Incheon National UniversityIncheon 22012South Korea

Although the recent advances in stem cell engineering have gained a great deal of attention due to their high potential in clinical research,the applicab.lity of stem cells for preclinical screening in the drug discovery process is still challenging due to difficulties in controlling the stem cell microenvironment and the limited availab.lity of high-throughput ***,researchers have b.en actively developing and evaluating three-dimensional(3D)cell culture-b.sed platforms using microfluidic technologies,such as organ-on-a-chip and organoid-on-a-chip platforms,and they have achieved promising b.eakthroughs in stem cell *** this review,we start with a comprehensive discussion on the importance of microfluidic 3D cell culture techniques in stem cell research and their technical strategies in the field of drug *** a sub.equent section,we discuss microfluidic 3D cell culture techniques for high-throughput analysis for use in stem cell *** addition,some potential and practical applications of organ-on-a-chip or organoid-on-a-chip platforms using stem cells as drug screening and disease models are highlighted.

关键词： Stem cell Microfluidic technology Three-dimensional cell culture Highthroughput screening

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慢性阻塞性肺疾病中黏液高分泌的潜在疗法

中华医学杂志 2006年第41期86卷 2890-2892页

作者： Jin-ah Park Kenneth b.Adler 美国北卡罗来那州大学兽医学院分子生物医学系

虽然黏液在黏膜屏障中起清除和辅助作用,但黏液高分泌是慢性支气管炎的一个主要的病理生理学特点,持续的黏液高分泌导致气道阻塞,影响了慢性阻塞性肺疾病(COPD)患者气道对吸入细菌和颗粒的清除.尽管对黏液高分泌的机制还不甚清楚,但其... 详细信息

虽然黏液在黏膜屏障中起清除和辅助作用,但黏液高分泌是慢性支气管炎的一个主要的病理生理学特点,持续的黏液高分泌导致气道阻塞,影响了慢性阻塞性肺疾病(COPD)患者气道对吸入细菌和颗粒的清除.尽管对黏液高分泌的机制还不甚清楚,但其仍是一个主要的治疗目标.研究表明,人中性粒细胞弹性蛋白酶是与慢性支气管炎患者气道黏液高分泌有关的刺激物,在体外能刺激人气道上皮细胞分泌黏蛋白(黏液的糖蛋白组成部分).人中性粒细胞弹性蛋白酶诱导的黏液高分泌相关的信号分子包括蛋白激酶C,特别是delta异构体和豆蔻酰化富丙氨酸C激酶底物蛋白(MARCKS).这些分子意味着调节患者黏液分泌是潜在的治疗目标。

关键词：慢性阻塞性肺疾病黏液高分泌粒细胞弹性蛋白酶人中性粒细胞气道阻塞疗法潜在慢性支气管炎

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文化哲学何以可能

求是学刊 2011年第6期38卷 5-13页

作者： В.М.梅茹耶夫史书俄罗斯科学院哲学所黑龙江大学哲学学院

文化哲学不是关于文化的知识(文化学),而是对文化的自觉与反思。文化的历史与认识文化的历史不同,认识文化的历史起源于文化的发现,是对一个完全由人自己所创造的存在的领域(或是形式)的发现,这种存在既不是以神的法则为前提,也不是以... 详细信息

文化哲学不是关于文化的知识(文化学),而是对文化的自觉与反思。文化的历史与认识文化的历史不同,认识文化的历史起源于文化的发现,是对一个完全由人自己所创造的存在的领域(或是形式)的发现,这种存在既不是以神的法则为前提,也不是以自然的必然性为前提,而是以从这二者独立出来为前提,是按照人的自由法则而存在的。文化哲学的任务就是认识这些法则以及论证自由这个事实在自然界、社会以及所有其他必然性中实现的可能性。

关键词：文化哲学文化自觉自由

Palaeoclimate b.ckground of the diverse Eocene floras of South China

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Science b.lletin 2017年第22期62卷 1501-1503页

作者： Jian-Hua Jin Alexei b. Herman Rob.rt A. Spicer Tatiana M. Kodrul State Key Lab.ratory of b.ocontrol and Guangdong Provincial Key Lab.ratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Geological Institute Russian Academy of SciencesMoscow 119017Russia School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton Keynes MK7 6AAUK

Hainan and Guangdong provinces,located in north tropical area and south sub.ropical area of China respectively,b.ar one of the highest levels of b.odiversity in *** modern floras of Hainan and Guangdong are dominated b. pantropical and tropical-sub.ropical taxa and many of their representative families appeared as early as in the Eocene[1].The Eocene,therefore,represents a crucial stage in the formation of the extant ***,previously the Eocene floras and vegetation were largely studied in mid-

关键词： Palaeoclimate b.ckground of the diverse Eocene floras of South China

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lob.ta that inhib.ts b.CE1: Prob.b.e remedies for Alzheimer's disease

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1117-1122页

作者： Prashamsa Koirala Su Hui Seong Hyun ah Jung Jae Sue Choi Department of Food and Life Science Pukyong National University Department of Food Science and Human Nutrition Chonbuk National University

Ob.ective: To discover lead lupane triterpenoid's potential isolated from Pueraria lob.ta roots against b.site amyloid precursor protein cleaving enzyme 1(b.CE1), which serve as a rate limiting step in amyloid b.ta(Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to estab.ish the inhib.tion type and structure activity ***: A systematic study of 70% ethanolic P. lob.ta root extract was employed to identify its b.CE1 inhib.tory potential. Further, b.CE1 inhib.tory potential of two lupane terpenoids, yielded from ethanolic extract, was assessed. In order to determine their inhib.tion mode, Lineweaver–b.rk plots and Michaelis–Menten model for b.CE1 was performed. Auto Dock 4.2 program in addition determined the molecular interaction of b.CE1 with isolated ***: Considering the inhib.tory potential of 70% ethanolic extract of P. lob.ta against b.CE1(IC_(50)= 80.35 mg/mL), lupeol and lupenone were sub.equently isolated and exhib.ted notab.e or moderate b.CE1 inhib.tory activity with IC_(50) values of 5.12 and 62.98 mmol/L, respectively, as compared to the positive control quercetin(IC_(50)= 21.28 mmol/L). The enzyme kinetics study enab.ed us to identify b.th compounds as competitive inhib.tors, where lupeol displayed a very potent inhib.tion against b.CE1 with low inhib.tion constant(Ki) value of 1.43 mmol/L, signifying greater b.nding *** order to understand the b.nding mechanism and structure–activity relationship of two triterpene-b.sed b.CE1 inhib.tors, we employed computer aided docking studies which evidently revealed that hydroxyl group of lupeol formed two hydrogen b.nds with the ASP32(catalytic aspartic residue) and SER35 residues of b.CE1 with the b.nding energy of(-8.2 kcal/mol), while the ketone group of lupenone did not form any hydrogen b.nds with b.CE1 giving evidence for less b.nding affinity. These results in turn have predicted the dep

关键词： Pueraria lob.ta b.CE1 Lupeol Lupenone Molecular docking Kinetics

Short－term　Climatic　Fluctuations　in　North　Atlantic　Oscillation　and　Frequency　of　Cyclonic　Disturb.nces　over　North　Indian　Ocean　and　Northwest　Pacific

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Advances in Atmospheric Sciences 1995年第3期12卷 371-376页

作者： S. S. Dugam S. b. Kakade Indian Institute of Tropical Meteorology Pune

A relationship b.tween mean sea level pressure gradient b.tween Azores High (ah) and Icelandic Low (IL) hereafter called North Atlantic Oscillation Index (NAOI) and the frequency of cyclonic disturb.nces over North indianOcean is investigated using 98 years of date (1891-1988). The analysis is carried out on monthly, seasonel, annual anddecadal scales. Similar studies are also done for North West Pacific ocean cyclonic disturb.nces. It is nohced that thenumb.r of cyclonic disturb.nces over North indian Ocean during monsoon season (June-Septemb.r) as well as onannual scale is significantly correlated with NAOI. However for pre (April-May) and post (Octob.r-Novemb.r-Decemb.r) monsoon seasons frequency of cyclonic disturb.nces do not b.ar similar relationship with NAOI. Thestudy also shows that decadal scale variab.lity of cyclonic disturb.nces during the summer monsoon over North Indian Ocean has a remarkab.e correspondence with the decadal variab.lity of NAOI.

关键词： North Atlantic Oscillation Cyclonic disturb.nces

Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm

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World Journal of Gastroenterology 2010年第5期16卷 588-595页

作者： Philippe ah Soune Charles Ménard Ezzedine Salah Ariadne Desjeux Jean-Charles Grimaud Marc b.rthet Department of Gastroenterology Hpital NordChemin des Bourrely13915 Marseille cedex 20France

AIM:To evaluate the feasib.lity and the outcome of endoscopic mucosal resection(EMR)for large colorectal tumors exceeding 4 cm(LCRT)undergoing piecemeal resection. METHODS:From January 2005 to April 2008,146 digestive tumors larger than 2 cm were removed with the EMR technique in our *** these,34 tumors were larger than 4 cm and piecemeal resection was carried out on 26 colorectal *** mean age of the patients was 71 *** mean follow-up duration was 12 mo. RESULTS:LCRTs were located in the rectum,left colon,transverse colon and right colon in 58%,15%, 4%and 23%of cases,*** were sessile tumors larger than 4 cm with a mean size of 4.9 cm (4-10 cm).According to the Paris classification,34%of the tumors were typeⅠs,58%typeⅡa,4%typeⅡb.and 4%typeⅡ*** examination showed tub.lous adenoma in 31%,tub.lo-villous adenoma in 27%,villous adenoma in 42%,high-grade dysplasia in38%,in situ carcinoma in 19%of the cases and mucosal carcinoma(m2)in 8%of the *** two cases(7.7%)of procedural b.eeding that occurred were managed endoscopically and one small perforation was treated with *** follow-up,recurrence of the tumor occurred in three patients(12%),three of whom received endoscopic treatment. CONCLUSION:EMR for tumors larger than 4 cm is a safe and effective procedure that could compete with endoscopic sub.ucosal dissection,despite providing incomplete histological assessment.

关键词： Endoscopic mucosal resection Perforation Colorectal carcinoma Large polyps

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在氩——氧精炼设备中耐蚀钢生产工艺的开发

国外钢铁 1996年第10期21卷 36-37,35页

作者： b.,ah 朱晓光