检索结果-南通市图书馆

World Journal of Clinical Oncology 2014年第3期5卷 299-310页

作者： haroon a hussain Amanda J Harvey Brunel Institute for Cancer Genetics and Pharmacogenomics Biosciences Brunel University (London)

There have been significant improvements in the detection and treatment of breast cancer in recent decades. However, there is still a need to develop more effective therapeutic techniques that are patient specific with reduced toxicity leading to further increases in patients' overall survival; the ongoing progress in understanding recurrence, resistant and spread also needs to be maintained. Better understanding of breast cancer pathology, molecular biology and progression as well as identification of some of the underlying factors involved in breast cancer tumourgenesis and metastasis has led to the identification of novel therapeutic targets. Over a number of years interest has risen in breast tumour kinase(Brk) also known as protein tyrosine kinase 6; the research field has grown and Brk has been described as a desirable therapeutic target in relation to tyrosine kinase inhibition as well as disruption of its kinase independent activity. This review will outline the current "state of play" with respect to targeted therapy for breast cancer, as well as discussing Brk's role in the processes underlying tumour development and metas-tasis and its potential as a therapeutic target in breast cancer.

关键词： Breast tumour kinase Protein tyrosine kinase 6 Breast neoplasms Targeted molecular therapy Intracellular signaling peptides and proteins Protein kinase inhibitors

Analysis of Eigenvalues for Molecular Structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第10期73卷 1225-1236页

作者： Muhammad haroon Aftab Kamel Jebreen Mohammad Issa Sowaity Muhammad hussain Department of Mathematics and Statistics The University of LahoreLahore54000Pakistan Department of Mathematics An-Najah National UniversityNablusP400Palestine Department of Mathematics Palestince Polytechnic UniversityHebronP766Palestine Department of Mathematics Comsats University IslamabadLahore CampusLahore54000Pakistan

In this article,we study different molecular structures such as Polythiophene network,PLY(n)for n=1,2,and 3,Orthosilicate(Nesosilicate)SiO4,Pyrosilicates(Sorosilicates)Si2O7,Chain silicates(Pyroxenes)(SiO3)n,and Cyclic silicates(Ring Silicates)Si3O9 for their cardinalities,chromatic numbers,graph variations,eigenvalues obtained from the adjacency matrices which are square matrices in order and their corresponding characteristics *** convert the general structures of these chemical networks in to mathematical graphical *** transform the molecular structures of these chemical networks which are mentioned above,into a simple and undirected planar graph and sketch them with various techniques of *** matrices obtained from these simple undirected graphs are *** also label the molecular structures by assigning different *** graphs have also been studied for *** a connected graph,the eigenvalue that shows its peak point(largest value)obtained from the adjacency matrix has multiplicity ***,the gap between the largest and its smallest eigenvalues is interlinked with some form of“connectivity measurement of the structural graph”.We also note that the chemical structures,Orthosilicate(Nesosilicate)SiO4,Pyrosilicates(Sorosilicates)Si2O7,Chain silicates(Pyroxenes)(SiO3)n,and Cyclic silicates(Ring Silicates)Si3O9 generally have two same *** matrices have great importance in the field of computer science.

关键词： Vertex degree edges eigenvalues characteristics polynomials adjacency matrices graphical model genetics polythiophene silicates

An Approximation for the Entropy Measuring in the General Structure of SGSP_(3)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第12期73卷 4455-4463页

作者： Zeeshan Saleem Muftiand Muhammad hussain Kamel Jebreen Muhammad haroon Aftab Mohammad Issa Sowaity Zeeshan Saleem Mufti Muhammad hussain Biostatistics and Clinical Research Department University Hospital LariboisièreAP-HPUniversite’de ParisParis75010France Department of Mathematics An-Najah National UniversityNablusP400Palestine Department of Mathematics Palestine Technical University-KadoorieHebronP766Palestine Department of Mathematics and Statistics the University of LahoreLahore54000Pakistan Department of Mathematics Palestine Polytechnic UniversityHebronP766Palestine Department of Mathematics COMSATS University IslamabadLahore campusLahore54000Pakistan

In this article,we calculate various topological invariants such as symmetric division degree index,redefined Zagreb index,VL index,first and second exponential Zagreb index,first and second multiplicative exponential Zagreb indices,symmetric division degree entropy,redefined Zagreb entropy,VL entropy,first and second exponential Zagreb entropies,multiplicative exponential Zagreb *** take the chemical compound named Proanthocyanidins,which is a very useful polyphenol in human’s *** are very beneficial for one’s *** chemical compounds are extracted from grape *** are tremendously anti-inflammatory.A subdivision formof this compound is presented in this *** compound named subdivided grape seed Proanthocyanidins is abbreviated as SGSP_(3).This network SGSP_(3),is converted and modeled into its mathematical graphical formation with the support of the latest mathematical *** have also developed many closed formulas for the measurement of entropy for the general chemical structure of the subdivided grape seed Proanthocyanidins *** achieved outcomes can be correlated with the chemical version of SGSP_(3) to get a better understanding of its biological as well as physical features.

关键词： Symmetric division degree redefined Zagreb VL index exponential multiplicative Zagreb subdivided grape seed Proanthocyanidins graphical model genetics entropy

Aspergillus tubingensis Causes Leaf Spot of Cotton (Gossypium hirsutum L.) in Pakistan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2020年第1期89卷 103-109页

作者： Maria Khizar Urooj haroon Musrat Ali Samiah Arif Iftikhar hussain Shah Hassan Javed Chaudhary Muhammad Farooq hussain Munis Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabadPakistan Department of Plant Sciences School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghaiChina

Cotton(Gossypium hirsutum L.)is a key fiber crop of great commercial *** phytopathogens decimate crop production by causing various *** July-August 2018,leaf spot symptoms were recurrently observed on cotton leaves in Rahim Yar Khan,Pakistan and adjacent *** leaf samples were collected and plated on potato dextrose agar(PDA)*** agent of cotton leaf spot was isolated,characterized and identified as Aspergillus tubingensis based on morphological and microscopic *** identification of pathogen was done on the comparative molecular analysis of CaM andβ-tubulin gene *** analysis of both sequenced genes showed 99%similarity with ***’s postulates were followed to confirm the pathogenicity of the isolated *** plants were inoculated with fungus and similar disease symptoms were *** was re-isolated and identified to be identical to the inoculated *** our knowledge,this is the first report describing the involvement of *** in causing leaf spot disease of cotton in Pakistan and around the world.

关键词： Aspergillus tubingensis CaM gene Koch’s postulates cotton

Improved Hybrid Deep Collaborative Filtering Approach for True Recommendations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第3期74卷 5301-5317页

作者： Muhammad Ibrahim Imran Sarwar Bajwa Nadeem Sarwar haroon Abdul Waheed Muhammad Zulkifl Hasan Muhammad Zunnurain hussain Department of Computer Science The Islamia University of BahawalpurBahawalpurPakistan Department of Computer Science Bahria University Lahore CampusLahorePakistan Software Engineering Department Faculty of ITUniversity of Central PunjabLahorePakistan Faculty of Computer Science and Information Technology Universiti Putra MalaysiaSelangorMalaysia

Recommendation services become an essential and hot research topic for researchers *** data such asReviews play an important role in the recommendation of the *** was achieved by deep learning approaches for capturing user and product information from a short ***,such previously used approaches do not fairly and efficiently incorporate users’preferences and product *** proposed novel Hybrid Deep Collaborative Filtering(HDCF)model combines deep learning capabilities and deep interaction modeling with high performance for True *** overcome the cold start problem,the new overall rating is generated by aggregating the Deep Multivariate Rating DMR(Votes,Likes,Stars,and Sentiment scores of reviews)from different external data sources because different sites have different rating scores about the same product that make confusion for the user to make a decision,either product is truly popular or *** proposed novel HDCF model consists of four major modules such as User Product Attention,Deep Collaborative Filtering,Neural Sentiment Classifier,and Deep Multivariate Rating(UPA-DCF+NSC+DMR)to solve the addressed *** results demonstrate that our novel model is outperforming state-of-the-art IMDb,Yelp2013,and Yelp2014 datasets for the true top-n recommendation of products using HDCF to increase the accuracy,confidence,and trust of recommendation services.

关键词： Neural sentiment classification user product attention deep collaborative filtering multivariate rating artificial intelligence

Fast Processing of Optical Fringe Movement in Displacement Sensors Without Using an ADC

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonic Sensors 2013年第3期3卷 241-245页

作者： Babar hussain Taj MUHAMMAD Muhammad REHAN haroon AMAN Muhammad ASLAM Masroor IKRAM M. Yasin Akhtar RAJA National Institute of Lasers and Optronics P. O. 45650 Islamabad Pakistan Pakistan Institute of Engineering and Applied Sciences P. O. 45650 Islamabad Pakistan Department of ECE EPIC Building UNC Charlotte 9201 University City Blvd. Charlotte NC 28223-000

An interferometer based optical sensor for displacement measurement is reported. This method requires quite simple signal processing as well as least electronic components. Referring to this technique, two photodiodes spatially shifted by 90 degrees were used. The output of photodiodes was converted into rectangular signals which were extracted in LabVIEW using the data acquisition card without using an analog to digital converters （ADC）. We have also processed the signals in C＋＋ after acquiring via parallel port. A Michelson interferometer configuration was used to produce linear fringes for the detection of displacements. The displacement less than 100nm could be measured using this technique.

关键词： Fast signal processing optical displacement sensor direction detection Michelson interferometer

Simultaneous synthesis of bimetallic@3D graphene electrocatalyst for HER and OER

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2021年第2期15卷 305-315页

作者： Nabi ULLAH Meng XIE Shahid hussain Waleed YASEEN Sayyar Ali SHAH Bashir Adegbemiga YUSUF Chidinma Judith OLUICBO haroon Ur RASHEED Yuanguo XU Jimin XIE School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China School of Pharmacy Jiangsu UniversityZhenjiang 212013China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Currently,the exploration of ultimate energy sources is a hot investigation area for researchers due to the swift diminution of fossil fuels and environmental pollution produced by the ignition of these fossil fuels[1-5].Hydrogen is an ideal alternative energy carrier and is considered to solve such problems due to its high energy density,sustainability,recyclability,and zero COx emission[6-9].

关键词： synthesis catalyst energy

Why more research needs to be done on echinococcosis in Pakistan

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2017年第1期6卷 786-790页

作者： haroon Ahmed Shahzad Ali Muhammad Sohail Afzal Abid Ali Khan Hamid Raza Zaheer hussain Shah Sami Simsek Department of Biosciences COMSATS Institute of Information Technology(CIIT)Park RoadChak ShahzadIslamabadPakistan Department of Parasitology Faculty of Veterinary MedicineUniversity of Firat23119ElazigTurkey Department of Wildlife and Ecology University of Veterinary and Animal SciencesLahorePakistan Department of Chemistry School of ScienceUniversity of Management and Technology(UMT)LahorePakistan School of Science University of Management and Technology(UMT)LahorePakistan

Background:Echinococcosis has a worldwide geographical distribution with endemic foci on every inhabited *** to the frequent outbreaks in different parts of Pakistan in the recent past,echinococcosis is being described as a neglected tropical disease and is considered one of the most neglected parasitic diseases in the *** endemic regions,predominantly settings with limited resources,there are high numbers of echinococcosis patients,as these communities do not have access to appropriate *** Pakistan,there are limited reports on *** disease is prevalent in human and livestock,but this has not been sufficiently explored *** is an agricultural country and due to the disease’s zoonotic mode of transmission,there is a dire need of future research on *** present paper is an effort to highlight the importance of echinococcosis in ***:There is a dire need for future research on echinococcosis in Pakistan as very few investigations had been carried out on this topic thus *** prevalence of the disease in neighbouring countries highlights that Pakistan might be at severe risk of this zoonotic infection and further supports the need for more *** Pakistan,the majority of the population lives in rural areas with limited acess to proper hygienic/sanitary *** conditions favour the outbreak of diseases such as *** limited available data could result in higher outbreaks in the future,and thus cause the already weak healthcare system to *** country has a meagre annual budget for health,which is being spent on known infections such as polio,dengue fever and hepatic viral infections.A proper surveillance system for echinococcosis is required across the country as treatment is usually expensive,complicated and may require extensive surgery and/or prolonged drug *** of new/novel drugs and other treatment modalities receives very little,if any,***

关键词： Pakistan Echinococcosis Neglected tropical diseases Research