检索结果-南通市图书馆

Bioguided Fractionation and Purification of Natural Bioactives Obtained from<i>Alpinia conchigera</i>Water Extract with Melanin Inhibition Activity

引用

Journal of Biomaterials and Nanobiotechnology 2013年第3期4卷 265-272页

作者： Zanariah binti Ujang Thavamanithevi Subramaniam Mazita Md Diah harmayumi binti wahid Badariah binti Abdullah Ahmad Hazri Bin Abd Rashid David Appleton 3Department of Pharmacology Faculty of Medicine University of Malaya Kuala Lumpur Malaysia Sime Darby Technology Centre Sdn. Bhd. UPM-MTDC Technology Centre III Universiti Putra Malaysia Serdang Malaysia. Industrial Biotechnol- ogy Research Centre SIRIM Bhd. No. 1 Persiaran Dato Menteri Shah Alam Malaysia Natural Product and Cosmetics Program SIRIM Bhd. No. 1 Persiaran Dato Menteri Shah Alam Malaysia

Crude extracts of Alpinia conchigera a species from the Malaysian Ginger (Zingiberaceae) family and its fractions obtained from various extraction methods were assayed for melanogenesis inhibition activity and cell viability. The crude extract obtained from the ethanolic extraction and the super critical fluid extraction did not exhibit significant melanin inhibition activity and was shown to be toxic to the melanocyte cells in comparison to the water extract. The crude aqueous extracts displayed melanin inhibition of 96.38 ± 1.60% and cell viability 109.90 ± 8.32% at a concentration of 500 μg/mL. Bioassay guided fractionation was performed on the water extracts to isolate the active compounds. The actives were identified as trans-cinnamaldehyde and chavicol glucopyranoside with both compound showing potent anti-melanogenesis activity. At 4.9 μg/ml, both trans-cinnamaldehyde and chavicol glucopyranoside gave 85% inhibition of melanin formation in vitro with 77% and 97% cell viability respectively. In comparison, kojic acid, a known skin lightening agent showed 90.0% inhibition at 100 μg/mL. The bioactive composition comprising the extract, active fraction, purified compounds or mixture thereof of Alpinia conchigera may be used for cosmetic and pharmaceutical applications, particularly for the purposes of reducing skin pigmentation.

关键词： Alpinia Conchigera Preparatory HPLC Fractionation Chavicol Glucopyranoside Trans Cinnamaldehyde Anti-Melanogenesis Activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：