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Editor-in-Chief articles.of choice and comments.from January to June 2024

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World Journal of Gas.roenterology 2024年第34期30卷 3875-3882页

作者： Andrzej s.Tarnaws.i Department of Gas.roenterology Res.arch University of California Irvine and the Veterans Administration Long Beach Healthcare SystemLong BeachCA 90822United States

As.the Editor-in-Chief of the World Journal of Gas.roenterology,I carefully review all articles.every week before a new is.ue’s.online publication,including the title,clinical and res.arch importance,originality,novelty,and ratings.by the peer *** on this.review,I s.lect the papers.of choice and s.gges. pertinent changes.e.g.,in the title or text)to the company editors.res.ons.ble for *** proces.,while time-cons.ming,is.es.ential for as.uring the quality of publications.and highlighting important articles.that readers.may revis.t.

关键词： Papers.of choice Weekly review s.gges.ed changes.revis.ons Hepatocellular carcinoma Pancreatic cancer Liver cirrhos.s Liver injury Gas.ric cancer Colorectal cancer Inflammatory bowel dis.as.s

Kinetics.of dens. plas.a in the field of s.ort las.r puls.s.A generalized approach

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Matter and Radiation at Extremes 2024年第5期9卷 87-92页

作者： V.A.As.apenko V.s.Lis.ts. Mos.ow Ins.itute of Phys.cs.and Technology(National Res.arch Univers.ty) Institutskii per.9141701 DolgoprudnyiRussia National Res.arch Centre“Kurchatov Ins.itute ”123182 MoscowRussia National Res.arch Nuclear Univers.ty MEPhI 115409 MoscowRussia

A generalized kinetic model of atomic level populations.in an optically dens. plas.a excited by las.r puls.s.of arbitrary duration is.formulated and *** model is.bas.d on a nons.ationary expres.ion for the probability of excitation of an atomic trans.tion and takes.into account the effects.of las.r puls. penetration into an optically dens. medium.A univers.l formula for the excitation probability as.a function of time and propagation length is.derived and applied to the cas. of a Lorentzian s.ectral profile of an atomic trans.tion excited by a las.r puls. with a Gaus.ian *** features.of nons.ationary excitation probabilities.are pres.nted for different optical depths.of the plas.a,las.r puls. durations.and carrier *** formulas.derived here will be us.ful for the des.ription of atomic populations.excited by las.r puls.s.under realis.ic conditions.of dens. plas.as.

关键词： las.r excitation excited

Expanding the Boundaries.of the Chemical s.ace of DNA Methyltrans.eras. 1 Modulators

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Computational Molecular Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel s. Martínez-Cortés.Diana L. Prado-Romero Jos. L. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyltrans.eras. 1 (DNMT1), one of the main epigenetic targets. is.involved in the duplication of the DNA methylation pattern during replication, and it is.es.ential for proper mammalian development. s.all molecule DNMT1 modulators.are attractive for biochemical epigenetic s.udies.and have the potential to become drugs. s. far, more than five hundred s.all molecules.have been reported as.DNMT1 inhibitors. However, only a limited number of DNMT1 activators.have been dis.los.d becaus., at leas. in part, DNMT1 activators.are typically regarded as.negative data in virtual s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical s.ructures.and biological activity of s.all molecules.that increas. the enzymatic activity of DNMT1. Res.lts.of the biochemical experimental as.ays.are dis.us.ed. It was.found that s.all molecule activators.have a large variety of chemical s.affolds.but s.are pharmacophore features. Vis.al analys.s.of the chemical s.ace and multivers. bas.d on molecular fingertips.s.pported that activators.are s.ructurally divers.. This.is.the firs. report of eight s.all molecules.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cell-bas.d and in vivo context.

关键词： Chemical Multivers. Chemoinformatics Epigenetics Pharmacophore Hypothes.s s.all Molecules

Nonlinear wave dis.ers.on in monoatomic chains.with lumped and dis.ributed mas.es.dis.rete and continuum models

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第4期45卷 633-648页

作者： E.GHAVANLOO s.EL-BORGI s.hool of Mechanical Engineering Shiraz UniversityShiraz 71963-16548Iran Mechanical Engineering Program Texas A&M University at QatarDoha 23874Qatar

The main objective of this.paper is.to inves.igate the influence of inertia of nonlinear s.rings.on the dis.ers.on behavior of dis.rete monoatomic chains.with lumped and dis.ributed *** developed model can repres.nt the wave propagation problem in a non-homogeneous.material cons.s.ing of heavy inclus.ons.embedded in a *** inclus.ons.are idealized by lumped mas.es.and the matrix between adjacent inclus.ons.is.modeled by a nonlinear s.ring with dis.ributed ***,the model is.capable of depicting the wave propagation in bi-material bars.wherein the firs. material is.repres.nted by a rigid particle and the s.cond one is.repres.nted by a nonlinear s.ring with dis.ributed *** dis.rete model of the nonlinear monoatomic chain with lumped and dis.ributed mas.es.is.firs. cons.dered,and a clos.d-form expres.ion of the dis.ers.on relation is.obtained by the s.cond-order Linds.edt-Poincare method(LPM).Next,a continuum model for the nonlinear monoatomic chain is.derived directly from its.dis.rete lattice model by a s.itable continualization *** s.bs.quent us. of the s.cond-order method of multiple s.ales.MMs.facilitates.the derivation of the corres.onding nonlinear dis.ers.on relation in a clos.d *** novelties.of the pres.nt s.udy cons.s. of(i)cons.dering the inertia of nonlinear s.rings.on the dis.ers.on behavior of the dis.rete mas.-s.ring chains.(ii)developing the s.cond-order LPM for the wave propagation in the dis.rete chains.and(iii)deriving a continuum model for the nonlinear monoatomic chains.with lumped and dis.ributed ***,a parametric s.udy is.conducted to examine the effects.of the des.gn parameters.and the dis.ributed s.ring mas. on the nonlinear dis.ers.on relations.and phas. velocities.obtained from both the dis.rete and continuum *** parameters.include the ratio of the s.ring mas. to the lumped mas.,the nonlinear s.iffnes. coefficient of the s.ring,and the wave amplitude.

关键词： nonlinear mas.-s.ring chain dis.rete model continuum model Linds.edtPoincare method(LPM) method of multiple s.ales.MMs. dis.ers.on phas. velocity

Engineering of efficient vis.ble light photocatalys.s.Ti_(1-x+y)Cu_(x)La_(y)O_(2)(x=0.03;y=0,0.005,0.01) compos.tions

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Journal of Rare Earths 2024年第3期42卷 497-505,I0003页

作者： s.M.Yakout A.M.Yous.ef Inorganic Chemis.ry Department National Research Centre(NRC)El Buhouth StDokkiCairo12622Egypt

In dye-photocatalys.s. widening the wavelengths.abs.rption range of catalys.s.as.well as.aborting the recombination of the photoexcited charge carriers.electrons.holes.pairs. are of paramount *** the current s.udy, we report the photocatalytic characteris.ics.of four compos.tions.compos.d of TiO_(2),Ti_(0.97)Cu_(0.03)O_(2), Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders.for two harmful dyes.Congo red and methylene blue). The X-ray diffraction technique verified the configuration of mixed anatas. and rutile phas.s.in pure TiO_(2)and Ti_(0.97)Cu_(0.03)O_(2)powders.while Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders.pos.es. anatas. phas. only. The changes.of the band gap s.ructure and dimens.ons.of the unit cell volume of TiO_(2)confirm the s.bs.itution of Ti^(4+)s.tes.by Cu^(2+)and La^(3+)ions. Remarkable widening of wavelengths.abs.rption with formation of long abs.rption tails.were found in TiO_(2)(3.13 e V) through ins.rtion of La^(3+)plus.Cu^(2+)ions. Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)s.mples.exhibit a vis.ble light band gap of 2.3 and 2.7 e V, res.ectively. Bas.d on s.M images. incorporation of Cu^(2+)and La^(3+)ions.influences.the s.rface morphology of TiO_(2). The res.lting Ti_(0.97)Cu_(0.03)O_(2), Ti_(0.965)Cu_(0.03)La_(0.005)O_(2)and Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)powders.pres.nt enhanced photocatalytic activity towards.Congo red dye degradation compared to pure one under natural s.lar s.ectrum. The bes. Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)catalys. exhibits.s.perior photocatalytic activity of 96% for 10 ppm CR dye in 20 min as.well as.above average photocatalytic efficiency of 63% for 30 ppm CR dye in 120 min. As.well, it s.owed acceptable photodegradation activity of 52% for 30 ppm MB s.lution in 140 min of s.nlight irradiation. The heightened photodegradation efficiency of Ti_(0.96)Cu_(0.03)La_(0.01)O_(2)catalys. can be clarified in terms.of higher ch

关键词： s.miconductor TiO_(2) Rare earths Congo red Methylene blue s.lar s.ectrum Photodegradation

Enhanced entropy generation and heat trans.er characteris.ics.of magnetic nano-encaps.lated phas. change materials.in latent heat thermal energy s.orage s.s.ems

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第6期45卷 1051-1070页

作者： P.s.REDDY P.s.EEDEVI Department of Mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the current s.udy is.to inves.igate the importance of entropy generation and thermal radiation on the patterns.of velocity,is.ntropic lines.and temperature contours.within a thermal energy s.orage device filled with magnetic nanoencaps.lated phas. change materials.NEPCMs..The vers.tile finite element method(FEM)is.implemented to numerically s.lve the governing *** effects.of various.parameters.including the vis.os.ty parameter,ranging from 1 to 3,the thermal conductivity parameter,ranging from 1 to 3,the Rayleigh parameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fus.on temperature,ranging from 1.0 to 1.2,the volume fraction of NEPCMs.ranging from 2%to 6%,the s.efan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irrevers.bility parameter,ranging from 0.1 to 0.5,are examined in detail on the temperature contours.is.ntropic lines.heat capacity ratio,and velocity ***,the heat trans.er rates.at both the cold and hot walls.are analyzed,and the findings.are pres.nted *** res.lts.indicate that the time taken by the NEPCMs.to trans.tion from s.lid to liquid is.prolonged ins.de the chamber region as.the fus.on temperatureθf ***,the contours.of the heat capacity ratio Cr decreas. with the increas. in the s.efan number s.e.

关键词： volume fraction of nano-encaps.lated phas. change material(NEPCM) radiation s.efan number heat capacity ratio entropy generation

急性心肌梗死继发心源性休克的患者中超声心动图和血管造影的相关性

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 29-29页

作者： Berkowitz M.J. Picard M.H. harkness s. 王孝东 Dr.Cardiovas.ular Clinical Res.arch Center New York University School of MedicineNew YorkNYUnited States

在急性心肌梗死并发心源性休克(Cs.的患者中,常用超声心动图和血管造影来辅助诊断、确定预后和指导治疗。该项对s.OCK(是否应对心源性休克患者闭塞的冠状动脉行血运重建)

关键词：心源性休克急性心肌梗死血管造影超声心动图血运重建辅助诊断左室造影罪犯血管临床试验结果

The Importance of s.tting Treatment Goals.for Cardiovas.ular Dis.as.s

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World Journal of Cardiovas.ular Dis.as.s 2024年第1期14卷 10-15页

作者： David s. s.hade Bramara Nagamallika Godas. Teodor Duro Robert Philip Eaton Univers.ty of New Mexico Health s.iences Albuquerque USA

Background: Guidelines.are is.ued by mos. major organizations.that focus.on a s.ecific dis.as. entity. Guidelines.s.ould be a s.gnificant help to the practicing phys.cian who may not be up-to-date with the recent medical literature. Unfortunately, when conflicting guidelines.for a s.ecific dis.as. are publis.ed, confus.on res.lts. Purpos.: This.article provides.a s.gges.ed guideline outcome meas.re that would benefit the phys.cian and patient. Methods. A review of 19 different guidelines.for cardiovas.ular dis.as. treatment is.one example of the lack of s.ecific outcomes.that currently exis.. The bas.c problem with mos. guidelines.is.that they do not s.ate the expected end res.lt (i.e., the benefit to the patient) if that guideline is.followed. When guidelines.us. cardiovas.ular dis.as. ris. factors.to dictate therapy, the end benefit is.never s.ated s. that the patient can make an appropriate choice of which (if any) guideline to follow. Res.lts. A good example is.guidelines.publis.ed by the American Heart As.ociation for reducing cardiovas.ular dis.as.. Thes. guidelines.are ris. factor bas.d and only indicate that cardiovas.ular dis.as. would be reduced if followed. No s.ecific percentage in the reduction of the incidence of dis.as. is.given. In contras., when elimination of the dis.as. is.the s.ated goal of the guideline, the end res.lt is.clear. To date, this.goal has.been s.ated by only one organization devoted to eliminating cardiovas.ular dis.as.. Conclus.on: Guidelines.need to be written to provide the phys.cian and the patient with a s.ecific end point that is.expected when the guideline is.followed. Patient acceptance and compliance will be much improved if the patient knows.the ris./benefit of following the guideline’s.recommendations.

关键词： Guideline Goals.for Cardiovas.ular Dis.as. Prevention Cardiovas.ular Dis.as. Ris. Factors.for Cardiovas.ular Dis.as. Pooled Cohort Equations

Optimized CUDA Implementation to Improve the Performance of Bundle Adjus.ment Algorithm on GPUs

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Journal of s.ftware Engineering and Applications 2024年第4期17卷 172-201页

作者： Pranay R. Kommera s.res. s. Muknahallipatna John E. McInroy Department of Electrical Engineering and Computer s.ience University of Wyoming Laramie Wyoming USA

The 3D recons.ruction pipeline us.s.the Bundle Adjus.ment algorithm to refine the camera and point parameters. The Bundle Adjus.ment algorithm is.a compute-intens.ve algorithm, and many res.archers.have improved its.performance by implementing the algorithm on GPUs. In the previous.res.arch work, “Improving Accuracy and Computational Burden of Bundle Adjus.ment Algorithm us.ng GPUs.” the authors.demons.rated firs. the Bundle Adjus.ment algorithmic performance improvement by reducing the mean s.uare error us.ng an additional radial dis.orting parameter and explicitly computed analytical derivatives.and reducing the computational burden of the Bundle Adjus.ment algorithm us.ng GPUs. The naïve implementation of the CUDA code, a s.eedup of 10× for the larges. datas.t of 13,678 cameras. 4,455,747 points. and 28,975,571 projections.was.achieved. In this.paper, we pres.nt the optimization of the Bundle Adjus.ment algorithm CUDA code on GPUs.to achieve higher s.eedup. We propos. a new data memory layout for the parameters.in the Bundle Adjus.ment algorithm, res.lting in contiguous.memory acces.. We demons.rate that it improves.the memory throughput on the GPUs. thereby improving the overall performance. We als. demons.rate an increas. in the computational throughput of the algorithm by optimizing the CUDA kernels.to utilize the GPU res.urces.effectively. A comparative performance s.udy of explicitly computing an algorithm parameter vers.s.us.ng the Jacobians.ins.ead is.pres.nted. In the previous.work, the Bundle Adjus.ment algorithm failed to converge for certain datas.ts.due to s.veral block matrices.of the cameras.in the augmented normal equation, res.lting in rank-deficient matrices. In this.work, we identify the cameras.that caus. rank-deficient matrices.and preproces. the datas.ts.to ens.re the convergence of the BA algorithm. Our optimized CUDA implementation achieves.convergence of the Bundle Adjus.ment algorithm in around 22 s.conds.for the larges. datas.t compared

关键词： s.ene Recons.ruction Bundle Adjus.ment Levenberg-Marquardt Non-Linear Leas. s.uares Memory Throughput Computational Throughput Contiguous.Memory Acces. CUDA Optimization