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Nano Research 2024年第8期17卷 7027-7038页

作者： Wenan Cai Yuichiro tanaka Xing Zhu Teruhisa Ohno Department of Applied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu 804-8550Japan College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi’an 710021China

Polymer carbon nitride(PCN)is widely used in ***,pristine PCN has disadvantages such as insufficient visible light absorption and low photogenerated carrier separation efficiency that greatly limited the photocatalytic *** a non-toxic metal,gallium has the potential to solve the defects of *** ions coordinated with nitrogen in carbon nitride to form Ga-N active sites and improved the photocatalytic *** doped potassium ions form a transmission channel for charge redistribution and transfer between adjacent layers,which is beneficial for better separation of photoexcited *** this study,a series of PCN co-doped with gallium and potassium(Ga-K-PCN)were *** experimental results indicated photocatalytic generation of hydrogen peroxide proceeds through the 2e−oxygen reduction reaction ***,Nyquist plots and photocurrent results further proved that the presence of Ga-N sites and potassium ion doping could significantly improve the separation/transfer of intra-planar and interlayer charge carriers and thus enhance photocatalytic *** Ga10-K3-PCN photocatalysts promoted yield of H_(2)O_(2),with reactivity at 28.2μmol/(g·h)and solar-to-chemical conversion efficiency at 0.64%,surpassed that of a typical photo-catalyst based on PCN(0.18%).

关键词： photocatalysis gallium oxygen reduction reaction H_(2)O_(2) production

Cardiac mapping of electrical impedance tomography by means of a wavelet model

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World Journal of Cardiovascular Diseases 2013年第7期3卷 464-470页

作者： harki tanaka Neli Regina Siqueira Ortega Andre Hovnanian Carlos Roberto Ribeiro de Carvalho Marcelo Britto Passos Amato Center of Engineering Modelling and Applied Social Sciences Federal University of ABC Sao Paulo Brazil Center of Fuzzy Systems in Health School of Medicine University of Sao Paulo Sao Paulo Brazil Respiratory Intensive Care Unit Hospital das Clínicas School of Medicine University of Sao Paulo Sao Paulo Brazil

To improve the identification of cardiac regions in Electrical impedance tomography (EIT) pulmonary perfusion images, a model of wavelet transform was developed. The main goal was to generate maps of the heart using EIT images in a controlled animal experiment using a healthy pig and in two human volunteers. The model was capable of identifying the heart regions, demonstrated robustness and generated satisfactory results. The pig images were compared to perfusion images obtained using injection of a hypertonic solution and achieved an average area of the ROC curve of 0.88. The human images were qualitatively compared with Computerized Tomography scan (CT-scan) images.

关键词： Electrical Impedance Tomography Heart Image Analysis Image Segmentation Wavelet

Fabrication of Mie-resonant silicon nanoparticles using laser annealing for surface-enhanced fluorescence spectroscopy

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Microsystems & Nanoengineering 2024年第2期10卷 133-141页

作者： Tatsuya Fukuta Ryo Kato Takuo tanaka Taka-aki Yano Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon nanostructures with unique Mie resonances have garnered considerable attention in the field of ***,we present a simple and efficient method for the fabrication of silicon(Si)nanoparticle substrates using continuous-wave(CW)laser *** resulting silicon nanoparticles exhibit Mie resonances in the visible region,and their resonant wavelengths can be precisely ***,laser-annealed silicon nanoparticle substrates show a 60-fold enhancement in *** tunable and fluorescence-enhancing silicon nanoparticle platform has tremendous potential for highly sensitive fluorescence sensing and biomedical imaging applications.

关键词： nanoparticles annealing resonant

Metabolomics in liver diseases: A novel alternative for liver biopsy?

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World Journal of Hepatology 2024年第1期16卷 12-16页

作者： Yasuo tanaka Department of Gastroenterology National Center for Global Health and MedicineTokyo 162-8655Japan

Hepatitis C virus(HCV)remains a significant public health problem as it can cause acute and chronic *** HCV infection is a major cause of liver fibrosis,and evaluation of liver fibrosis is essential because the prognosis of patients with chronic HCV infection is closely related to the stage of *** fibrosis is traditionally evaluated based on pathological analysis of biopsy specimens,which is considered the gold ***,liver biopsy is invasive and susceptible to sampling error and inter-and intraobserver variation in pathological interpretation;it is also ***,noninvasive diagnostic investigations have been developed,including the use of fibrotic markers,scoring systems based on routine blood tests,and transient elastography with magnetic resonance imaging or ***,metabolomics,an emerging technology,has been used to detect the fibrosis *** this editorial,I comment on the article titled“Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways”by Ferrasi et al published in the recent issue of the World Journal of Hepatology.I discuss previous studies on the use of metabolome analysis for the diagnosis of HCV-related liver fibrosis and the potential development of biopsy-free diagnostic techniques.

关键词： Metabolomics Hepatitis C virus Liver fibrosis Liver cirrhosis Serum biomarker

Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi tanaka Hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第3期32卷 463-476页

作者： Hur SUN MASANORI KAWANO TATSUYA IWASAKI ICHRO ITONAGA YUTA KUBOTA HROSHI TSUMURA KAZUHRO tanaka Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(OS)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined OS cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the OS cell line,the expression of TCF7L1 decreased,the proliferation of OS cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/S transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of OS xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in OS cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Hyperacute experimental model of rat lung transplantation using a coronary shunt cannula

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World Journal of Transplantation 2024年第2期14卷 155-161页

作者： Munehisa Takata Yusuke tanaka Daisuke Saito Shuhei Yoshida Isao Matsumoto Department of Thoracic Surgery Kanazawa UniversityKanazawa 920-8641IshikawaJapan

BACKGROUND Lung transplantation is a well-established treatment of end-stage lung disease.A rodent model is an inexpensive way to collect biological data from a living model after lung ***,mastering the surgical technique takes time owing to the small organ *** To conduct rat lung transplantation using a shunt cannula(SC)or modified cannula(MC)and assess their *** Rat lung transplantation was performed in 11 animals in the SC group and 12 in the MC *** devised a method of rat lung transplantation using a coronary SC for coronary artery bypass surgery as an anastomosis of pulmonary arteri-ovenous vessels and *** same surgeon performed all surgical proce-dures in the donor and recipient rats without using a magnifying *** success rate of lung transplantation,operating time,and PaO2 values were com-pared after 2-h reperfusion after *** Ten and 12 lungs were successfully transplanted in the SC and MC groups,*** the SC group,one animal had cardiac arrest within 1 h after reperfusion owing to bleeding during pulmonary vein *** opera-ting time for the removal of the heart-lung block from the donor and preparation of the left lung graft was 26.8±2.3 and 25.7±1.3 min in the SC and MC groups,respectively(P=0.21).The time required for left lung transplantation in the recipients was 37.5±2.8 min and 35.9±1.4 min in the SC and MC groups,respectively(P=0.12).PaO2 values at 2 h after reperfusion were 456.2±25.5 and INTRODUCTION Lung transplantation is a well-established treatment of end-stage lung *** immune and non-immune mech-anisms in lung transplantation are highly complex,and post-transplant complications such as infections and primary and chronic lung allograft dysfunction must be reduced to improve ***,there is a need for immunological and pathophysiological analyses using animal lung transplantation *** rat lung transplantation model was f

关键词： Lung transplantation Rat Shunt cannula Modified cannula Reperfusion

New strategy for boosting cathodic performance of low temperature solid oxide fuel cells via chlorine doping

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Nano Research 2024年第9期17卷 8086-8094页

作者： ShaoHua Xu Hao Qiu Shanshan Jiang Jingjing Jiang Wei Wang Xiaomin Xu Wei Kong tanaka Dennis Chivurugwi Arkadii Proskurin Daifen Chen Chao Su School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China Institute of Analysis and Testing Beijing Academy of Science and TechnologyBeijing 100089China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWA6102Australia Admiral Makarov National University of Shipbuilding Heroiv Ukrainy av.9Mykolaiv54025Ukraine

To enhance the performance and widespread use of solid oxide fuel cells(SOFCs),addressing the low-temperature(<650℃)electrochemical performance and operational stability issues of cathode materials is ***,we propose an innovative approach to enhance oxygen ion mobility and electrochemical performance of perovskite oxide by substituting some oxygen sites with chlorine *** designed SrTa_(0.1)Fe_(0.9)O_(3-δ-x)Clx(x=0.05 and 0.10)exhibits improved performance compared to SrTa_(0.1)Fe_(0.9)O_(3-δ)(STF).SrTa_(0.1)Fe_(0.9)O_(2.95-δ)Cl_(0.05)(STFCl0.05)shows the lowest area-specific resistance(ASR)value on Sm0.2Ce0.8O1.9(SDC)*** 600℃,STFCl0.05 achieves an ASR value of 0.084Ω·cm^(2),and a single cell with STFCl0.05 reaches a higher peak power density(PPD)value(1143 mW·cm^(-2))than that with STF(672 mW·cm^(-2)).Additionally,besides exhibiting excellent oxygen reduction reaction(ORR)activity at lower temperatures,the STFCl0.05 cathode demonstrates good CO_(2)tolerance and operational *** cell operation lasts for 150 h,and single cell operation endures for 720 h without significant performance *** chlorine doping approach effectively enhances ORR activity and stability,making STFCl0.05 a promising cathode material for low-temperature SOFCs.

关键词： low-temperature solid oxide fuel cells(LT-SOFCs) oxygen reduction reaction(ORR) CO_(2)tolerance chlorine doping

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN MASANORI KAWANO TATSUYA IWASAKI ICHIRO ITONAGA YUTA KUBOTA HIROSHI TSUMURA KAZUHIRO tanaka Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Euler Product Expressions of Absolute Tensor Products of Dirichlet L-Functions

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Advances in Pure Mathematics 2024年第6期14卷 451-486页

作者： Hidenori tanaka Shin-ya Koyama Department of Biomedical Engineering Toyo University Saitama Japan Department of Mechanical Engineering Toyo University Saitama Japan

In this paper, we calculate the absolute tensor square of the Dirichlet L-functions and show that it is expressed as an Euler product over pairs of primes. The method is to construct an equation to link primes to a series which has the factors of the absolute tensor product of the Dirichlet L-functions. This study is a generalization of Akatsuka’s theorem on the Riemann zeta function, and gives a proof of Kurokawa’s prediction proposed in 1992.

关键词： Dirichlet L-Function Absolute Tensor Product (Kurokawa Tensor Product) Euler Product