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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Redescription of Cobitis longipectoralis Zhou, 1992 (Cypriniformes: Cobitidae) from late early Miocene of East China

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science China Earth sciences 2010年第7期53卷 945-955页

作者： CHANG Mee-mann Key Laboratory of Evolutionary systematics of Vertebrates Institute of Vertebrate Paleontology and Palaeoanthropology Chinese Academy of Sciences

Here we revise a fossil cobitid species ■Cobitis longipectoralis Zhou, 1992, based mainly on a well-preserved specimen collected recently from the taxon’s type locality of the late early Miocene of shanwang, shandong Province, East China. The new specimen, along with those collected by Zhou, enables us to provide an emended diagnosis and more detailed description of the species by focusing on the characters such as the structures of the suborbital spine and the presence and shape of the lamina circularis at the base of the second pectoral fin ray in adult males, the presence of a frontoparietal fontanelle, and a quad- rate-metapterygoid fenestra, etc. The long pectoral fin, initially considered by Zhou as the most important character of the spe- cies, however, turns out to be not diagnostic for the species. ■Cobitis longipectoralis Zhou, 1992 is not only the most informative and best-preserved early cobitid fossil known thus far but also the only and earliest cobitid fossil from East Asia.

关键词： Cobitis longipectoralis late early Miocene East China

A new Eocene catostomid (Teleostei: Cypriniformes) from northeastern China and early divergence of Catostomidae

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science China Earth sciences 2009年第2期52卷 189-202页

作者： CHANG Mee-mann Key Laboratory of Evolutionary systematics of Vertebrates Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences

A new Eocene catostomid genus and species,Plesiomyxocyprinus arratiae, is described from Huadian, Jilin Province, northeastern China. The materials include a nearly complete skeleton, dozens of pharyngeal bones with teeth, and a number of disarticulated bones. The new articulated specimen is large-sized and deep-bodied, with an estimated standard length of ca. 300 mm and body depth of 156 mm or about half of its standard length. The assignment of the fish to the Catostomidae is based on its falciform pharyngeal bone with one row of numerous (more than 50) compressed teeth, and the bone is much smaller than in cyprinids, especially given the size of the fish. The new fish distinguishes itself from all known catostomids (both extinct and extant) in its long anal fin with four unbranched and 17-18 branched rays, and its extremely short caudal peduncle that is only about one fourth of its depth. Plesiomyxocyprinus arratiae resembles the Eocene-Oligocene transpacific-distributed Amyzon in many general skeletal characters. However, it shows a few characters uniquely shared with the Recent catostomid Myxocyprinus asiaticus. Those include a very long dorsal fin with about 50 branched fin rays, the end of dorsal fin rays being close to the caudal fin base, and anal rays stretching posteriorly beyond the base of caudal fin. It is the first fossil catostomid that shows a close relationship to the endemic Myxocyprinus now living in the Yangtze River and Minjiang River, China. The discovery of Plesiomyxocyprinus arratiae, along with two previously described possible catostomid genera Jianghanichthys and Vasnetzovia, may indicate that the divergence of the Catostomidae started much earlier, in the middle Eocene or earlier, on the western side of the Pacific than on its eastern side.

关键词： a new catostomid genus Eocene northeastern China early divergence

Pliocene cyprinids (Cypriniformes,Teleostei) from Kunlun Pass Basin,northeastern Tibetan Plateau and their bearings on development of water system and uplift of the area

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science China Earth sciences 2010年第4期53卷 485-500页

作者： CHANG Mee-mann Key Laboratory of Evolutionary systematics of Vertebrates Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of Sciences

Here described are the cyprinid fossils from the Pliocene Lower Member of Qiangtang Formation of the Kunlun Pass Basin,northeastern Tibetan Plateau,collected at a locality 4769 m above the sea level(asl).The materials consist of numerous disarticulated and incomplete bones as well as thousands of pharyngeal teeth,fin rays,and *** fossils were referred to the genus Gymnocypris,lineage schizothoracini,family Cyprinidae;the lineage schizothoracini;and the family Cyprinidae *** schizothoracini is a freshwater fish group endemic to the Tibetan Plateau and its surrounding *** workers on living schizothoracins regarded that Gymnocypris belongs to the highly specialized grade of the group,colonizing higher altitudes than other members of the *** species are so far unequivocally assigned to the genus,i.e.,*** and ***,and they are inhabiting Qinghai Lake and the waters on both north(the Golmud River) and south(upper reach of the Yellow River) sides of the East Kunlun Mountain,*** abundant fossil schizothoracins occur in the Kunlun Pass Basin on the southern slope of the East Kunlun Mountain(at 4769 m asl),close to the present Golmud River,indicating comparatively rich waters in the area and possible connections between the water systems on north and south sides of the East Kunlun Mountain during the *** also suggests a more humid climate in the area during the Pliocene than it is *** presence of the highly specialized schizothoracin Gymnocypris may also imply less amplitude of uplift(approximately 1000 m) in the area since the Pliocene than previously proposed.

关键词： Gymnocypris schizothoracini Pliocene Kunlun Pass Basin of northeastern Tibetan Plateau development of water system uplift of the area

spontaneous closure of stoma

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Gastroenterology Report 2016年第4期4卷 325-327,I0003页

作者： Narendra Pandit harjeet singh Hemanth Kumar Rajesh Gupta G.R.Verma Division of surgical Gastroenterology Department of General surgery Post Graduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Intestinal loop stoma is a common surgical procedure performed for various benign and malignant abdominal problems,but it rarely undergoes spontaneous closure,without surgical *** male patients presented to our emergency surgical department with acute abdominal *** of them was diagnosed as having rectosigmoid perforation and underwent diversion sigmoid loop colostomy after primary closure of the *** other was a known case of carcinoma of the rectum who had already undergone low anterior resection with covering loop ileostomy;the patient underwent second loop ileostomy,this time for complicated intestinal *** our surprise,both the loop colostomy and ileostomy closed spontaneously at 8 weeks and 6 weeks,respectively,without any *** stoma closure is a rare and interesting *** exact etiology for spontaneous closure remains unknown,but it may be hypothesized to result from slow retraction of the stoma,added to the concept of a tendency towards spontaneous closure of enterocutaneous fistula.

关键词： ileostomy colostomy spontaneous closure of stoma

Potential of Essential Oils as Alternative Permeation Enhancers for Transdermal Delivery

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 258-269页

作者： Jayshree Mahanty sofi Haamid Rasheed sudhir Kumar harjeet singh Alok sharma Department of Pharmacognosy ISF College of PharmacyMogaPunjab CCRAs Ministry of AYUSHJhansiUttar PradeshIndia

Transdermal drug delivery plays a significant part in the drug delivery system when compared to other routes of drug *** function of the stratum corneum(sC)is a ***,numerous methods have been thrived to improve the perforation of drugs across the *** most effective method is to use enhancers since these agents enhance skin *** penetration enhancers like essential oils demonstrate higher enhancement activity and are more widely accepted than synthetic penetration *** potential in the expansion and interaction with the sC intercellular lipids has led to an increasing interest in these oils as penetration *** article gives an overview of a few essential oils,including their mode of action and important parameters for permeation *** present work can provide essential oils as alternative enhancers,and this could be useful in transdermal administration.

关键词： Essential oil natural permeation enhancers skin stratum corneum transdermal drug delivery