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Nanoemulsion for delivery of anticancer drugs

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Cancer Advances 2022年第16期5卷 1-7页

作者： Virender Kumar Vandana Garg harish dureja Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtakHaryana 124001India

Cancer refers to a collection of diseases that have abnormal cell growth as their *** inability of cytotoxic agents to distinguish between rapidly dividing healthy cells and rapidly multiplying cancerous cells produces the most notorious adverse effects of cytotoxic anticancer *** an essential tool in nanotechnology,nanoemulsions have therapeutic and clinical ***,nanoemulsions are considered to be one of the most feasible nano-carriers for delivering lipophilic antineoplastic agents with targeted *** addition to solving water-solubilization issues,these formulations deliver specific targeting to cancer cells and might even be developed to overcome multi-drug *** overcome the problems associated with conventional drug delivery systems,such as low bioavailability and noncompliance.A review of nanoemulsion in cancer therapeutics is presented here to shed light on the current position of this technology.

关键词： nanoemulsion cancer targeted delivery cytotoxic agents nano-carriers

An update review on drug repurposing for COVID-19

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TMR Pharmacology Research 2022年第3期2卷 12-20页

作者： Virender Kumar Vandana Garg harish dureja Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak(Haryana)124001India

The COVID-19 global health disaster has caused more than two million deaths ***,a new therapeutic molecule has not been developed for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as of *** a result,some medications that had been previously authorized for use against SARS-CoV-2 could now be given to COVID-19 *** use of medications to treat COVID-19 is discussed in this *** report also discusses the lessons learned when using combination therapy,convalescent plasma therapy,immunotherapeutic molecules,and therapeutic molecules to treat COVID-19 *** beneficial outcomes were noted with anti-viral therapy and *** COVID-19 medicine and vaccination have undergone 9,037 clinical trials since July *** may be possible to provide COVID-19 patients with a successful outcome through the short-term repurposing of an existing *** evaluation of potential antiviral molecules can thus lead to more clinical trials being initiated.

关键词： COVID-19 SARS-CoV-2 antiviral molecules repurposing drugs treatment immunotherapeutic molecules

Ananas comosus loaded nanoemulsion a promising therapeutic approach for cancer

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Cancer Advances 2022年第17期5卷 1-11页

作者： Virender Kumar Vandana Garg harish dureja Department of Pharmaceutical Sciences Maharshi Dayanand UniversityHaryana 124001India

Cancer has a major impact on society across the *** are different strategiessuch as chemotherapy,radiotherapy,surgical intervention,and immunotherapy for ***-a-days,phytochemicals are gaining a lot of interest for their chemopreventiveaction in treatment of *** investigations demonstrated that extract/bioactivecompounds from *** resulting in reduction of inflammatory cytokines release andproliferation of T-cell was also *** in treatment of cancer nanoemulsion of *** have ben *** the basis of previous literature,we have postulated thatnanoemulsion of *** may be beneficial because of its safety and efficacy profile.

关键词： inhibited cancer emulsion

Role of traditional herbal medicine in the treatment of malaria

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TMR Modern Herbal Medicine 2022年第4期5卷 9-16页

作者： Virender Kumar Vandana Garg harish dureja Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtakHaryana 124001India

Malaria is one of the world's major public health concerns and numerous medicinal plants are commonly used for treating *** health care uses medicinal plants widely,but no scientific documentation is available and,there is a growing risk of losing this ***,this study aims to document the traditional use of medicinal plants in treating malaria and related *** this review,numerous herbal medicines for antimalarial potential are *** literature survey was done using keywords i.e.,malaria,herbal,herbal,traditional use,antimalarial,quinine,artemisinin,and traditional medicine by using PubMed,Science Direct,Google Scholar,and HINARI *** review discusses the life cycle of the malarial parasite,what makes you attractive to mosquitoes,and the role of traditional herbal medicine in malaria.

关键词： Artemisinin Antimalarial Herbal Malaria Quinine

Efficient Finite Difference WENO Scheme for Hyperbolic Systems withNon-conservativeProducts

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Communications on Applied Mathematics and Computation 2024年第2期6卷 907-962页

作者： Dinshaw S.Balsara Deepak Bhoriya Chi-Wang Shu harish Kumar Physics Department University of Notre DameNotre DameUSA ACMS Department University of Notre DameNotre DameUSA Division of Applied Mathematics Brown UniversityProvidenceUSA Department of Mathematics Indian Institute of TechnologyDelhiIndia

Higher order finite difference weighted essentially non-oscillatory(WENO)schemes have been constructed for conservation *** multidimensional problems,they offer a high order accuracy at a fraction of the cost of a finite volume WENO or DG scheme of the comparable *** makes them quite attractive for several science and engineering ***,to the best of our knowledge,such schemes have not been extended to non-linear hyperbolic systems with non-conservative *** this paper,we perform such an extension which improves the domain of the applicability of such *** extension is carried out by writing the scheme in fluctuation *** use the HLLI Riemann solver of Dumbser and Balsara(***.304:275-319,2016)as a building block for carrying out this *** of the use of an HLL building block,the resulting scheme has a proper supersonic *** use of anti-diffusive fluxes ensures that stationary discontinuities can be preserved by the scheme,thus expanding its domain of the *** new finite difference WENO formulation uses the same WENO reconstruction that was used in classical versions,making it very easy for users to transition over to the present *** conservation laws,the new finite difference WENO is shown to perform as well as the classical version of finite difference WENO,with two major advantages:(i)It can capture jumps in stationary linearly degenerate wave families exactly.(i)It only requires the reconstruction to be applied *** examples from hyperbolic PDE systems with non-conservative products are shown which indicate that the scheme works and achieves its design order of the accuracy for smooth multidimensional *** Riemann problems and several novel multidimensional problems that are drawn from compressible Baer-Nunziato multiphase flow,multiphase debris flow and twolayer shallow water equations are also shown to document the robustness of the *** some

关键词： Hyperbolic PDEs Numerical schemes Non-conservative products Stiff source terms Finite difference WENO

An updated review of pineapple and its bioactive compounds in breast cancer

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Cancer Advances 2023年第5期6卷 1-5页

作者： Virender Kumar Davinder Kumar Vandana Garg harish dureja Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtakHaryana 124001India.

Women are more likely than men to develop cancer of the *** breast cancer drugs are highly toxic,and treatment can cause side *** is imperative to find safe alternative medicines in the pursuit of a cure for breast *** extract of pineapple contains cysteine proteases known as *** general,pineapples are regarded as safe *** the fruit,stem,and of pineapples,bromelain is produced by multiple *** well as reducing the growth of tumors locally,bromelain severely impaired the cytotoxicity of monocytes in the immune system in the fight against ***,we investigated pineapple’s possible mechanisms of action and its bioactive compounds in breast cancer.

关键词： Ananas comosus proteinases bromelain pineapple plant phototherapeutic applications

Pharmacological potential of Manilkara zapota(L.)***(Sapodilla):a narrative review

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Journal of Traditional Chinese Medicine 2024年第2期44卷 403-407页

作者： Priyanka Sharma Aakash Deep harish Kumar Nitin Bansal Sanjiv Kumar Arun Davinder Kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001India

Herbal medicine is safe and effective in treating various *** herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health *** plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological *** genus Manilkara contains 135 plants around the *** overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)***(***),also known as *** has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.

关键词： herbal medicine Manilkara zapota phytoconstituents pharmacological activity review

Morphological and molecular description of a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,India

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 226-234页

作者： Prasanta Saini harish Kumar Shah Mathew Jessu Sonia T Tom Anns KP Amju ICMR-Vector Control Research Centre(Field Station) KottayamKeralaIndia

Objective:To report a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,***:A systematic sandfly survey was conducted in the Thrissur and Kollam districts of Kerala,India using mechanical aspirators,light and sticky traps,both indoor and outdoor habitats,for a period of one *** acid barcoding of samples was performed targeting mitochondrial cytochrome oxidase I(COI)gene and sequence generated was subjected to phylogenetic ***:Sergentomyia(Neophlebotomus)ashwanii,a new sandfly species is recorded and described in this communication.A single row of 10-12 pointed teeth in the cibarium with 4-6 small denticles or fore-teeth are the key characteristics that is distinctive from other members of the subgenus *** COI barcode followed by phylogenetic analysis of the nucleotide sequence confirms that specimens of the species belong to the same taxonomic group while the genetic distance(14.2%)with the congeners established it to be a different ***:The Western Ghats'being an important biodiversity hotspot and has dearth of systematic entomological surveys on *** current study tried to fill the void and also report a new sandfly species.

关键词： Sergentomyia(Neophlebotomus)ashwanii COI barcode Western Ghats Phlebotomine sandflies

Comprehensive review on ethnomedicinal, phytochemistry and pharmacological profile of Ficus Religiosa L.

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1052-1057页

作者： Rahul Rawat harish Kumar Neetu Singh Aakash Deep Balasubramanian Narasimhan Surender Singh Yadav Sanjiv Kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal University Department of Botany Maharshi Dayanand University Faculty of Pharmaceutical Sciences Maharshi Dayanand University

Ficus religiosa L.(F. religiosa) or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family. Though the tree has pan-tropical distribution but originally it is indigenous to the Indian subcontinent and Indochina region. Popularly the tree is named "Pepal or bodhi tree". Traditionally, it is practiced for the treatment of asthma, nose bleeding, heart disorders, diabetes, wound healing, ear problems, constipation, hyperlipidemia, gonorrhea, ulcers and infectious disorders. Chemical analysis demonstrated the presence of numerous bioactives including tannins, phenols, saponins, sugars, alkaloids, methionine, terpenoids, flavonoids, glycosides, proteins, separated amino acids, essential and volatile oils and steroids etc., which are probably responsible for its diverse pharmacological actions. The present work is an attempt to compile up-to-date comprehensive information on F. religiosa that covers its taxonomy, ethnomedicinal importance, phytochemistry, pharmacological attributes and clinical trials. Keeping in mind the various health attributes of F. religiosa, future research can be aimed at in-depth elucidation of the structure-function relationship and multifactorial signalings pathways.

关键词： Ficus religiosa clinical trials ethnomedicine health benefits pharmacology phytoconstituents