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Induction of osteoblast differentiation in human adipose derived stem cells by lanthanum ions

Journal of Rare Earths 2014年第11期32卷 1080-1088页

作者： harini d Indra R Rajaram A Rama Rajaram department of Biochemistry Central Leather Research Institute department of Biophysics Central Leather Research Institute

Adipose derived stem cells represent a readily available source of adult stem cells for various biomedical applications. In this study, the proliferation and osteogenic differentiation potential of lanthanum nitrate（La3＋） on human adipose derived mesenchymal stem cells（hAdSCs） were investigated for the first time and compared with that of dexamethasone（dex）. Our results provided evidence that La3＋ at 50 μmol/L concentration promoted proliferation of hAdSCs upto 2.4 fold when treated for 21 d in dMEM medium. Treatment of hAdSCs with La3＋ containing osteogenic induction medium（α-MEM with ascorbic acid and β-glycerophosphate） for 7 d resulted in higher calcium deposition than that in the presence of dex（0.1 μmol/L） as shown by Alizarin red S and von Kossa staining. Scanning electron micrographs also showed more extracellular matrix mineralization in the presence of La3＋. After 7 d of treatment with La3＋（10 μmol/L） the expression of RunX2, osteopontin（OP） and osteocalcin（OC） increased 3.4, 5.5 and 2.7 fold respectively. Our results provided evidence that in the presence of La3＋ osteogenic differentiation occurred earlier than that in the presence of dex.

关键词： hAdSCs lanthanum osteoblast differentiation genes calcium deposition SEM RunX2 rare earths

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A Comparative Analysis of Quantitative Metrics of Root Architecture

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Plant Phenomics 2021年第1期3卷 65-85页

作者： harini Rangarajan Jonathan P.Lynch department of Plant Science The Pennsylvania State UniversityUniversity ParkPA 16802USA

High throughput phenotyping is important to bridge the gap between genotype and *** methods used to describe the phenotype therefore should be robust to measurement errors,relatively stable over time,and most importantly,provide a reliable estimate of elementary phenotypic *** this study,we use functional-structural modeling to evaluate quantitative phenotypic metrics used to describe root architecture to determine how they fit these *** results show that phenes such as root number,root diameter,and lateral root branching density are stable,reliable measures and are not affected by imaging method or *** aggregating multiple phenes such as total length,total volume,convex hull volume,and bushiness index estimate different subsets of the constituent phenes;they however do not provide any information regarding the underlying phene *** of phene aggregates are not unique representations of underlying constituent phenes:multiple phenotypes having phenes in different states could have similar aggregate *** growth angle is an important phene which is susceptible to measurement errors when 2d projection methods are *** that aggregate phenes which are complex functions of root growth angle and other phenes are also subject to measurement errors when 2d projection methods are *** results support the hypothesis that estimates of phenes are more useful than metrics aggregating multiple phenes for phenotyping root *** propose that these concepts are broadly applicable in phenotyping and phenomics.

关键词： aggregate projection estimates

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Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease:Potential therapeutic implications

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Hepatobiliary & Pancreatic diseases International 2023年第4期22卷 437-438页

作者： Stergios A Polyzos Jannis Kountouras Athanasios d Anastasilakis Evangelos Terpos First Laboratory of Pharmacology Medical SchoolAristotle University of ThessalonikiThessalonikiMacedoniaGreece Second Medical Clinic Aristotle University of ThessalonikiIppokration HospitalThessalonikiMacedoniaGreece department of Endocrinology 424 General Military HospitalThessalonikiMacedoniaGreece department of Clinical Therapeutics School of MedicineNational and Kapodestrian University of AthensAthensGreece

To the Editor:We read with considerable interest the paper of Shree harini and Ezhilarasan,summarizing the possible pathophysiological connections between the modulators of canonical Wnt/β-catenin pathway and nonalcoholic fatty liver disease(NAFLd)[1].The au-thors supported with evidence that Wnt/β-catenin signaling contributes to hepatic homeostasis by regulating hepatic development,regeneration and *** also supported that dysregula-tion of modulators of Wnt/β-catenin signaling is not only impli-cated in the development of NAFLd,but also in its progression to nonalcoholic steatohepatitis(NASH),hepatic fibrosis and hepato-cellular carcinoma(HCC).

关键词： hepatic NAFLd nonalcoholic

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用蚕丝打印器官

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环球科学 2019年第23期 15-15页

作者：哈里尼·巴拉特张哲(翻译) 不详

蚕丝中的蛋白质可用于3d打印技术。目前有很多研究团队都在测试蚕丝蛋白,希望以它为原料实现3d打印人体组织、移植物甚至器官。这种方法比以胶原蛋白为原料的传统方法更便宜。印度阿萨姆邦的研究人员正在研究如何使用当地的蚕丝实现这... 详细信息

蚕丝中的蛋白质可用于3d打印技术。目前有很多研究团队都在测试蚕丝蛋白,希望以它为原料实现3d打印人体组织、移植物甚至器官。这种方法比以胶原蛋白为原料的传统方法更便宜。印度阿萨姆邦的研究人员正在研究如何使用当地的蚕丝实现这一目标。

关键词：蚕丝蛋白胶原蛋白阿萨姆邦移植物研究团队蛋白质

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