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Third time re-irradiation of liver metastasis with robotic radiosurgery: a case series

Hepatoma Research 2019年第7期5卷 1-8页

作者： Debnarayan Dutta Sathiya Krishnamoorthy Rupa Das Ram Madhavan haridas nair RaghavendraHolla Amrita Institute of Medical Sciences and Research Centre KochiKerala 682041India Department of Radiation Oncology Global HospitalChennai 600035India

Re-irradiation(Re-RT)in liver tumours is rarely reported owing to poor tolerance of liver and high incidence of radiation induced liver disease *** based robotic radiosurgery allows to deliver high dose radiation to the liver tumour and restricts the dose to healthy uninvolved liver,thereby increasing the potential for *** to radiation is low for entire liver and hence re-radiation is a *** the other hand,as regenerative potential of hepatocytes is rapid,replacement of necrotic liver tissue occurs with regenerated *** regenerated hepatocytes are radiation na?ve,do not have"memory"of radation therapy treatment and hence have potential of *** are reporting a series of two breast cancer patients presented with liver oligometastasis treated with fiducial based CyberKnife system(CK).Both the patients were treated multiple times with CK and had long-term survival(>2 years)without any clinical features of radiation induced liver *** selected patients are suitable for multiple sessions of CK for liver lesions with long-term outcome.

关键词： Liver lesions re-radiation robotic radiosurgery

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Role of Nutrients Input Pattern on the Growth Dynamics of Common Freshwater Microalgal Community

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American Journal of Plant Sciences 2015年第15期6卷 2481-2491页

作者： Chandrasekharan nair Aneesh Ajit haridas Vattackatt Balakrishnan Manilal Process Engineering and Environmental Technology Division National Institute for Interdisciplinary Science and Technology (NIIST-CSIR) Thiruvananthapuram India

Most of the microalgae present in aquatic systems competed for the same available inorganic nutrients. The successful competitors would eventually dominate the rest because of their adaptive advantageous. Based on this premise, it was important to understand the effect of nutrients input rate on microalgal species-diversity and population. This was investigated in batch experiments of 14 days with pond water samples having natural ecosystem by varying nutrients dosing pattern under natural day light. Nutrients were supplied as single dose and multiple doses to the fresh water microalgal culture of fresh water. Prominent growth of many microalgal species was the key result of multiple dosing of nutrients compared to single or concentrated dosing of nutrients. Simulation towards oligotrophic condition was supporting the diverse population of microalgae. Whereas in the experiments with higher dosing of nutrients in one or two times had dominant growth of two or three microalgae and higher growth of heterotrophic bacteria. This condition resembled the eutrophic or hyper-eutrophic condition of water. This study thus showed the influence of the nutrients supply pattern on the growth and diversity of microalgae in freshwater and the nutrients added on eight, ten and twelve consecutive days from first day were considered as the effective nutrient addition pattern to promote maximum microalgal population present in a freshwater system.

关键词： Microalgae Species-Diversity Eutrophic Oligotrophic

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Culturing of Autoflocculating Microalgal Consortium in Continuous Raceway Pond Reactor

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American Journal of Plant Sciences 2015年第15期6卷 2472-2480页

作者： Chandrasekharan nair Aneesh Faisal Mullalayam Vattackatt Balakrishnan Manilal Ajit haridas Process Engineering and Environmental Technology Division National Institute for Interdisciplinary Science and Technology (NIIST-CSIR) Thiruvananthapuram India

The goal of this study was to develop a self-settling microalgal consortium in raceway pond reactor (RPR). Experiments were carried out with cultures that developed without additional seeding, but naturally promoted by process conditions in a raceway pond reactor. The changes in microalgal communities and total biomass under nitrogen and phosphorous limitations were studied in both batch and continuous systems. At the steady state batch had the population of 46% Euglena sp., 16% Closterium sp., 14% Chlorella sp., 14% Scenedesmus sp. and 10% Ankistrodesmus sp. with a maximum biomass of 900 mg/L. In order to get self-settling microalgal consortium, the operation was changed to continuous continuous mode with the aid of a specially designed settler for daily harvest and recycling of the biomass. Grazing fauna could be controlled by managing reduced liquid and solid retention time. At steady-state condition, an autofloculating and self-settling consortium was developed which had mainly Fragilaria sp., Scenedesmus sp., and filamentous Ulothrix sp. The maximum biomass concentration obtained was 140 mg/L. The presence of neutral lipid droplets in the consortium was identified by staining with Nile Red. Development of the lipid rich consortium could be a suitable method for producing biofuel.

关键词： Self-Settling Microalgal Consortium Raceway Pond Reactor Autoflocculating

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