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Effect of 1%brinzolamide and 0.5%timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 851-854页

作者： Kemal rnek Nesrin byktortop Nurgl rnek Reyhan Ogurel Inci Elif Erbahceci Zafer Onaran Department of Ophthalmology School of MedicineKinkkale University

AIM:To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure(IOP)after cataract ***:The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens *** scheduled for phacoemulsification were assigned to 1 of 2 *** treatment group received 1 drop of brinzolamide-timolol fixed combination immediately after surgery,and the control group received no *** IOP was measured preoperatively and at 2h and 24h ***:The mean IOP change was lower in the treatment group than in the control group at 2h *** difference between the mean IOP values of the two groups at 2h postoperatively was found to be statistically ***-four hours after the surgery,the mean IOP change was still higher in the control group when compared to the treatment ***:The fixed combination brinzolamidetimolol can effectively reduce IOP after cataract surgery.

关键词： brinzolamide timolol cataract surgery

Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 78-82页

作者： Cavit l Kahraman Dinler O■uz Hasdemir Oktay büyüka■ik Güler bu■dayci Department of General Surgery Abant Izzet Baysal University Medical School Department of biochemistry Abant Izzet Baysal University Medical School

bACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal *** this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute ***:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal *** first group had only acute pancreatitis and served as the *** pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic ***:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic ***:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis.

关键词： pineal gland acute pancreatitis melatonin oxidative damage

Content-based similarity for 3D model retrieval and classification

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Progress in Natural Science:Materials International 2009年第4期19卷 495-499页

作者： Ke Lüa, Ning He b, Jian Xue a a College of Computing & Communication Engineering, Graduate University of Chinese Academy of Sciences, Yuquan Road 19(A), beijing 100049, China b School of Mathematical Science, Capital Normal University, beijing 100037, China College of Computing & Communication Engineering Graduate University of Chinese Academy of Sciences Yuquan Road 19(A) Beijing 100049 China School of Mathematical Science Capital Normal University Beijing 100037 China

With the rapid development of 3D digital shape information, content-based 3D model retrieval and classification has become an important research area. This paper presents a novel 3D model retrieval and classification algorithm. For feature representation, a method combining a distance histogram and moment invariants is proposed to improve the retrieval performance. The major advantage of using a distance histogram is its invariance to the transforms of scaling, translation and rotation. based on the premise that two similar objects should have high mutual information, the querying of 3D data should convey a great deal of information on the shape of the two objects, and so we propose a mutual information distance measurement to perform the similarity comparison of 3D objects. The proposed algorithm is tested with a 3D model retrieval and classification prototype, and the experimental evaluation demonstrates satisfactory retrieval results and classification accuracy.

关键词： 3D model Retrieval and classification Content-based 3D model retrieval Similarity comparison

A Connecticut Yankee in King Arthur's court

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A Connecticut Yankee in King Arthur's court

The Role of Toxicology in Evaluating Marketing Applications for Prescription Drug Products in the United States

作者： Mark Twain edited by Henry b. Wonham.

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毒理学杂志 2005年第A3期19卷 169-170页

作者： Kenneth L Hastings P.H. D.A.b.T. Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Dr.Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration

In the United States, in order to market a prescription drug product studies need to be conducted to demonstrate safety and efficacy.

关键词：毒物学临床应用处方药代谢产物

The trumpet of the swan

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The trumpet of the swan

Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy ——a hypothesis

作者： E.b. White pictures by Edward Frascino.

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Asian Pacific Journal of Tropical biomedicine 2017年第11期7卷 1041-1045页

作者： Kaviyarasi Renu V.G.Abilash P.b.Tirupathi Pichiah Thabassum Akthar Syeda Sankarganesh Arunachalam School of biosciences and Technology VIT University Department of Animal Science School of Life Sciences Bharathidasan University Department of biotechnology Kalasalingam University

Diabetic cardiomyopathy is one of the life threatening complications of diabetes. A number of animal models are being used for studying diabetic cardiomyopathy. In laboratory animal models, induction of cardiomyopathy happens in two stages: first being the induction of diabetic condition and the second being the induction of cardiomyopathy by prolonging diabetic condition. It takes a longer time to develop diabetes with the limited success rate for development of cardiomyopathy. Adriamycin is an effective anticancer drug limited by its major side-effect cardiomyopathy. A number of features of Adriamycin treatment mimics diabetes. We postulate that Adriamycin-induced cardiomyopathy might be used as a model system to study diabetic cardiomyopathy in rodents since a number of features of both the cardiomyopathies overlap. Left ventricular hypertrophy, systolic and diastolic dysfunction, myofibrillar loss, and fibrosis are hallmarks of both of the cardiomyopathies. At the molecular level, calcium signaling, endoplasmic reticulum stress, advance glycation endproduct activation, mitochondrial dysfunction,inflammation, lipotoxicity and oxidative stress are similar in both the *** signature profile of both the cardiomyopathies shares commonalities. In conclusion,we suggest that Adriamycin induced cardiomyopathic animal model can be used for studying diabetic cardiomyopathy and would save time for researchers working on cardiomyopathy developed in rodent using the traditional method.

关键词： Cardiomyopathy Diabetes Animal model for cardiomyopathy Adriamycin Diabetic cardiomyopathy

Morbidity and mortality of coagulase-negative staphylococcal sepsis in very-low-birth-weight infants

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World Journal of Pediatrics 2018年第3期14卷 269-273页

作者： Joseph b.Cantey Kelsey R.Anderson Ram R.Kalagiri Lea H.Mallett Department of Pediatrics University of Texas Health Science Center San Antonio7703 Floyd Curl DriveSan AntonioTX 78229USA Texas A&M Health Science Center College of Medicine BryanTXUSA Texas A&M Health Science Center Baylor/Scott&White HealthTempleTXUSA

background Coagulase-negative staphylococci (CoNS) are the most common cause of late-onset sepsis in the neonatal intensive care unit (NICU) and usually require vancomycin treatment. Our objective was to determine whether CoNS are associated with neonatal morbidity and mortality. Methods This was a retrospective cohort study of very-low-birth-weight (VLbW, ≤ 1500 g) infants from 1989 to 2015. Exclusion criteria were major congenital anomaly or death within 72 h. CoNS was considered a pathogen if recovered from ≥ 2 cultures, or 1 culture if treated for ≥ 5 days and signs of sepsis were present. Logistic regression was used to exam-ine factors associated with morbidity and mortality. Results Of 2242 VLbW infants, 285 (12.7%) had late-onset sepsis. CoNS (125, 44%),Staphylococcus aureus (52, 18%), and Escherichia coli (36, 13%) were the most commonly recovered organisms. In multivariate analysis, CoNS sepsis was not associated with mortality (OR 0.6 (95% CI 0.2-2.6)), but sepsis with other organisms was (OR 4.5 (95% CI 2.6-8.0))CoNS sepsis was associated with longer hospitalization but not risk for bronchopulmonary dysplasia, intraventricular hem-orrhage, or retinopathy of prematurity. Conclusion CoNS sepsis was not associated with mortality or morbidities other than length of stay. These findings support vancomycin-reduction strategies in the NICU.

关键词： Morbidity Mortality Neonate Sepsis

Effect of Doping of Ti and C on Crystallization and Magnetic Properties of NdPrFeb Thick Melt-Spun Ribbons

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稀有金属材料与工程 2012年第2期41卷 212-214页

作者： Peng Haijun[a] Zhang Maocai[b] bao Xiaoqian[b] [a] National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous Metals Beijing 100088 China [b] State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

结晶化过程和 NdPrFeb 厚带子的磁性上的 Ti 和 C 增加的效果被调查。结果证明 Ti 做压制形成(Nd， Pr ) 2Fe23b3 亚稳的阶段并且显著地精制合金和增加 coercivity 的谷物。在 Ti 和 C 的合作增加的情况中， coercivity 被减少，但是顽... 详细信息

结晶化过程和 NdPrFeb 厚带子的磁性上的 Ti 和 C 增加的效果被调查。结果证明 Ti 做压制形成(Nd， Pr ) 2Fe23b3 亚稳的阶段并且显著地精制合金和增加 coercivity 的谷物。在 Ti 和 C 的合作增加的情况中， coercivity 被减少，但是顽磁与 C 内容增加被提高。Jr=0.88 T 的磁性， Hcj=618 kA/m 并且(bH ) max=109.8 kJ/m3 被完成在(Nd0.4Pr0.6 ) 在最佳的退火以后的 9Fe72Ti4b11C4 带子。

关键词：稀有金属材料金属材料工程 TA2M