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基于决策树法分析在成年早期和中年期维持正常血压的因素：年轻人冠状动脉风险发展研究结果

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中华高血压杂志(中英文) 2022年第5期 500-500页

作者：袁源周卫郑武洪 Reges O Krefman AE hardy st Yano Y Muntner P Lloyd-Jones DM Allen NB

对于大多数人来说，血压与多种危险因素有关。本研究旨在应用决策树法确定与维持正常血压时间>30年的相关因素及各因素之间的相互作用，并揭示哪类人群维持正常血压的概率更高。方法：纳入中青年人冠状动脉危险因素研究（coronary arter...

对于大多数人来说，血压与多种危险因素有关。本研究旨在应用决策树法确定与维持正常血压时间>30年的相关因素及各因素之间的相互作用，并揭示哪类人群维持正常血压的概率更高。方法：纳入中青年人冠状动脉危险因素研究（coronary artery risk development in young adults study,CARDIA）中基线检查（Y0,1985-1986）时血压水平正常的年龄18～30岁参与者。结果：在参与者3 156人中，在随访期间维持正常血压水平1 132人（35.9%），血压升高2 024人（64.1%）。中年时期正常血压者与血压升高者间差异有统计学意义的因素包括正常范围内的收缩压、种族和体质量指数（body mass index,BMI）。

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中华高血压杂志(中英文) 2023年第1期 100-100页

作者： Akinyelure OP Hubbard D Sakhuja S hardy st Oparil S Cherrington AL Reynolds K Wozniak G Muntner P 林沁郑武洪

在过去1年中未就诊的高血压患者血压失控的可能性更大。本研究人员使用2013—2018年美国国家健康和营养调查数据(n=5985),检查了过去1年美国成人高血压患者未就诊的相关因素。高血压定义为收缩压≥140和/或舒张压≥90mm Hg(1mm Hg=0.133... 详细信息

在过去1年中未就诊的高血压患者血压失控的可能性更大。本研究人员使用2013—2018年美国国家健康和营养调查数据(n=5985),检查了过去1年美国成人高血压患者未就诊的相关因素。高血压定义为收缩压≥140和/或舒张压≥90mm Hg(1mm Hg=0.133k Pa)或使用抗高血压药物。通过自我报告获取受试者过去1年的就诊情况,发现7.0%的美国成年高血压患者在过去1年中未曾就诊。与过去1年曾就诊的患者相比,

关键词：成人高血压国家健康

Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells

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Cancer Communications 2024年第3期44卷 448-452页

作者： Donghai Xiong Zheng Yin Mofei Huang Yian Wang Micael hardy Balaraman Kalyanaraman stephen T Wong Ming You Center for Cancer Prevention Houston Methodist Neal Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Department of Systems Medicine and Bioengineering Houston Methodist Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Aix Marseille Univ Centre Nationaldela Recherche Scientifique(CNRS)Institut de Chimie Radicalaire(ICR)UnitéMixte de Recherche(UMR)7273MarseilleFrance Department of Biophysics Medical College of WisconsinMilwaukeeWisconsinUSA

Dear Editor,Atovaquone(ATO),a mitochondrial inhibitor,has anti-cancer effects[1].Based on ATO,we developed mitochondria-targeted atovaquone(Mito-ATO)that had even stronger anti-tumor efficacy than ATO[2].We syn-thesized Mito-ATO by attaching the bulky triphenylphos-phonium(TPP)group to ATO via a ten-carbon alkyl chain(Supplementary file of methods;Supplementary Figure S1).

关键词： metabolism immunity targeted

被2017美国心脏病学会/美国心脏协会高血压指南推荐进行动态血压监测的成年人的生活方式

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中华高血压杂志 2022年第6期 600-600页

作者： Cohen LP Hubbard D Colvin CL Jaeger BC Poudel B Abdalla M Langford A hardy st Sims M Lewis CE Muntner P Shimbo D 袁源郑武洪

2017美国心脏病学会/美国心脏协会高血压指南推荐，在3个月的生活方式调整后，对诊室收缩压/舒张压为130～159/80～99 mm Hg(1mm Hg=0.133kPa)的成年人进行动态血压监测以排除白大衣性高血压（white coat hypertension,WCH）；对诊室收...

2017美国心脏病学会/美国心脏协会高血压指南推荐，在3个月的生活方式调整后，对诊室收缩压/舒张压为130～159/80～99 mm Hg(1mm Hg=0.133kPa)的成年人进行动态血压监测以排除白大衣性高血压（white coat hypertension,WCH）；对诊室收缩压/舒张压为120～129/75～79 mm Hg的成年人进行动态血压监测以排除隐蔽性高血压（masked hypertension,MHT）。研究人员评估了符合上述诊室血压标准的个体中具有理想生活方式因素的比例。

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Epidemiological, Clinical, Therapeutic, and Evolutionary Aspects of Chronic End-stage Renal Failure in the Nephrology Department of the University Hospital of Brazzaville in 2023

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Open Journal of Nephrology 2024年第1期14卷 62-69页

作者： Gaël Honal Mahoungou Daniel Tony Eyeni Sinomono Éric Ngandzali-Ngabé Soraya Ntandou Francky Ambounou Précieux Ngoma Berline Ndinga Dalhia Mboungou Héléna Botokoto Bothard hardy Ibovi Richard Loumingou Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Nephrology University Hospital of Brazzaville Brazzaville Congo

Objective: Chronic end-stage renal failure is a major public health problem in developing countries and is poorly documented. The objective of this study was to describe the epidemiological, diagnostic, therapeutic, and evolutionary aspects of patients admitted for end-stage renal failure to the Department of Nephrology at the University Hospital of Brazzaville. Patients and Methods: This was a descriptive cross-sectional study collecting prospective data that took place over 10 months. We included 128 patients who were exhaustively identified. Sociodemographic, clinical, therapeutic and developmental data were collected using a standardized and pretested pre-established survey form. The EPI info software enabled the analysis and processing of the data. Results: We reported a male predominance with a sex ratio of 2.5. The median age was 50 years. The first cause found was diabetes (55%) followed by hypertension (46%). The majority of patients had a dialysis emergency and half could not be dialyzed for financial reasons. Conclusion: Our results highlighted that certain epidemiological parameters of end-stage renal failure are constantly changing, such as frequency, while others remain static, including the main etiologies, gender, and age. However, mortality continues to increase and deserves more attention.

关键词： ESRD Epidemiology Nephrology University Hospital of Brazzaville

Factors Associated with Mortality in Diabetic Patients with End-stage Renal Failure starting Emergency Hemodialysis

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Open Journal of Nephrology 2024年第1期14卷 17-24页

作者： Gaël Honal Mahoungou Daniel Tony Eyeni Sinomono Farel Elilié Mawa Ongoth Éric Ngandzali-Ngabé Nestor Andzouana Raissa Laure Mayanda Aymande Okoumou-Moko Francky Ambounou Précieux Ngoma Berline Ndinga Héléna Botokoto Bothard hardy Ibovi Richard Loumingou Department of Nephrology University Hospital of Brazzaville Brazzaville Congo Faculty of Health Sciences University Marien Ngouabi Brazzaville Congo Department of Metabolic Diseases University Hospital of Brazzaville Brazzaville Congo

Background: Diabetic nephropathy is the leading cause of end-stage chronic kidney disease with poor prognosis in resource-limited settings. This study aimed to determine factors associated with mortality in patients starting dialysis treatment for end-stage chronic renal disease in an emergency context. Patients and Methods: This was a retrospective study from January 2020 to December 2022 at CHU-B. Data from 79 diabetic patients requiring emergency dialysis were compared with those of 79 non-diabetic patients with an end-stage renal disease requiring emergency dialysis. Data were collected from the Nephrology Department registry. We studied their initial clinical and biological profiles and factors related to mortality. Results: Out of 545 compiled records, 79 diabetic chronic kidney disease patients needing dialysis were included (group 1). A control group of 79 non-diabetic chronic kidney disease patients requiring emergency dialysis was also included (group 2). The average age of patients was 53.5 ± 17 years, and the duration of diabetes at dialysis initiation was 14.8 ± 4.3 years. Twenty-three percent were hypertensive. Fifty-two percent of patients experienced intra-dialytic hypotension. Death occurred in 22% of patients. Results show that age (adjusted OR 1.955;CI: 1.025 - 1.086;p-value: Conclusion: Emergency dialysis in diabetics is associated with unfavorable outcomes in terms of mortality. Despite follow-up, renal involvement remains poorly explored, emphasizing the need for physician awareness.

关键词： Diabetic Nephropathy Emergency Dialysis Republic of the Congo

Transaction costs for collaboration in the watershed management of the Cuyahoga River Area of Concern

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Regional Sustainability 2022年第2期3卷 146-156页

作者： Scott Daniel hardy Ohio Sea Grant The Ohio State UniversityColumbus43212USA

This study examines the transaction costs of collaborative watershed management in the Cuyahoga River Area of Concern(AOC)—one of the 43 geographic areas designated by the *** Canada Great Lakes Water Quality Agreement(GLWQA),where significant impairment of beneficial uses has occurred as a result of human *** Cuyahoga River is located in Northeast Ohio,the *** flows through the City of Cleveland before draining into Lake Erie—one of the five Great Lakes of North *** watershed is degraded due to municipal and agricultural discharges,streambank erosion,and contamination from urban and industrial *** research explores how a diverse group of stakeholders convened under the Cuyahoga River AOC Advisory Committee to share information,coordinate activities,agree on activities that restore beneficial uses,and support strategic management *** this study,23 semi-structured interviews with members of the advisory committee were conducted between January 28,2020 and April 20,2020,with follow-up emails and phone calls as needed to corroborate information.A review of research articles and government documents supported the interviews,including United states Environmental Protection Agency(***)and Ohio Environment Production Agency(OEPA)reports on the GLWQA and Cuyahoga River Remedial Action Plans.A third source of data is from direct participant observation at quarterly meetings of the advisory committee during 2017–2020,binational AOC conferences in 2017 and 2019,and other professional events geared towards restoring the Cuyahoga River AOC in 2016–*** of this study include a set of recommendations to help guide group structure and decision-making processes,including(1)employing best available technology to organize AOC events and disseminate information;(2)supporting new members with an orientation and/or mentor to clearly define formal and informal committee rules;(3)assuring equal access to detailed information on managem

关键词： Environmental policy Watershed management Transaction costs Collaboration Sustainability Great Lakes

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Bridging the microstructural evolutions from slurry to porous electrode of a lithium-ion battery

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Journal of Energy Chemistry 2023年第9期84卷 329-334页

作者： Hamid Hamed Zoleikha Mirzaie Alamooti Ashutosh Agrawal Jan D'Haen An hardy Mohammadhosein Safari Institute for Materials Research(IMO-imomec) UHasseltMartelarenlaan 42B-3500 HasseltBelgium Energyville Thor Park 8320B-3600 GenkBelgium IMEC Division IMOMEC BE-3590Belgium

1. Introduction The porous electrodes are the crucial components of the modern electrochemical devices including lithium-ion batteries. The detailed configuration of the lithium-insertion, carbon black, and PVDF binder particles in a typical electrode of a lithium-ion cell has a significant impact on its energy and power density. A thinner electrode is desired to decrease the battery volume particularly for portable electronics and mobility applications.

关键词： density. lithium electrode

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Guest editorial:Molybdenum alloying:more than hardenability

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Advances in Manufacturing 2020年第1期8卷 1-2页

作者： hardy Mohrbacher NiobelCon bvba SchildeBelgium Department of Materials Engineering KU LeuvenLeuvenBelgium

Molybdenum is a transitional metal in the periodic table of elements where it ranks in position 42 in the 5th period and group VI *** a high melting point of 2623℃,molybdenum belongs to the so-called refractory ***,as pure metal it finds many applications where high temperatures are encountered during operation,for example in ***,nearly 80%of all molybdenum produced every year by the world’s mining industry is used as addition to iron and steel *** and alloy steels account for 40%of molybdenum use,followed by stainless steels(23%),tool steels and castings(both around 8%).

关键词： alloying alloy steel