检索结果-南通市图书馆

维普期刊数据库

Ablation techniques for primary and metastatic liver tumors

在线全文

学校读者我要写书评

暂无评论

World journal of Hepatology 2016年第3期8卷 191-199页

作者： Michael j Ryan jonathon Willatt Bill S Majdalany Ania Z Kielar Suzanne Chong julie A Ruma Amit pandya Department of Radiology University of Michigan Department of Radiology University of Ottawa

Ablative treatment methods have emerged as safe and effective therapies for patients with primary and secondary liver tumors who are not surgical candidates at the time of *** article reviews the current literature and describes the techniques,complications and results for radiofrequency ablation,microwave ablation,cryoablation,and irreversible electroporation.

关键词： Liver Ablation Hepatocellular carcinoma Metastasis Radiofrequency Microwave Cryoablation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

灵活更新固件——IoT设备的关键

中国电子商情(基础电子) 2017年第8期 38-40页

作者： hardik Patel Microchip Technology存储器产品部

物联网(IoT)设备正迅速引入各大市场,从家用电器到医疗设备,再到汽车,应用范围十分广泛。制造商必须通过不断创新和灵活地采用或集成新技术来领先于竞争对手。为了满足新功能的需求和新法规的要求,设计人员必须将灵活性纳入其产品中,以... 详细信息

物联网(IoT)设备正迅速引入各大市场,从家用电器到医疗设备,再到汽车,应用范围十分广泛。制造商必须通过不断创新和灵活地采用或集成新技术来领先于竞争对手。为了满足新功能的需求和新法规的要求,设计人员必须将灵活性纳入其产品中,以适应不断发展的

关键词：扇区擦写闪存 NOR SST 扇段存储器存贮器计算机 IoT 固件代码块擦除

Enhanced osseointegration of drug eluting nanotubular dental implants: An in vitro and in vivo study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第10期28卷 432-447页

作者： Pankaj Chauhan Alok Srivastava Pooja Bhati Manish Chaturvedi Vinay Patil Sriram Kunnoth Nisha Kumari Vedpal Arya Madhur pandya Mohit Agarwal Smiti Bhardwaj Farrukh Faraz Sanjay Chauhan Mahesh Verma Veena Koul Naresh Bhatnagar Homi Bhabha Cancer Hospital and Research Centre VizagAndhra PradeshIndia Centre for Biomedical Engineering Indian Institute of Technology DelhiIndia Department of Mechanical Engineering Indian Institute of Technology DelhiIndia Mechanical&Automation Engineering Indira Gandhi Delhi Technical University for WomenNew DelhiIndia Rajasthan Technical University Kota RajasthanIndia Applied Mechanics Indian Institute of Technology DelhiIndia National University of Singapore Singapore Department of Periodontics Maulana Azad Institute of Dental SciencesNew DelhiIndia Rajasthan Dental College and Hospital JaipurRajasthanIndia Department of Prosthodontics Maulana Azad Institute of Dental SciencesNew DelhiIndia

Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially available Titanium (Ti) dental implants, the bioactivity of Ti is still low. Thus, to achieve both biological and therapeutic activity on titanium surfaces, surface modification techniques such as titanium nanotubes have been studied as nanotube surfaces can hold therapeutic drugs and molecules. The main aim of the present research work is to study the early osseointegration around the novel Simvastatin drug eluting nanotubular dental implant. In the present research, the titanium nanotubes were fabricated on the screw-shaped dental implant surface and the Simvastatin drug was loaded into the nanotubes using the ultrasonication dip method. In vitro and In vivo studies were carried out on the modified dental implants. In vitro cell culture study reported enhanced osteogenic activity on the drug-loaded nanotube surface implants. The in vivo animal studies were evaluated by micro-CT, histopathology, and reverse torque removal analysis methods. The test results showed faster osseointegration with the strong interface on the Simvastatin drug-loaded implant surface at 4 weeks of healing as compared to the control implants.

关键词： Titanium Biocompatibility Simvastatin Nanotube Micro CT Histopathology Nanoscale

MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2016年第2期9卷 245-260页

作者： Kamaldeep S. Virdi Yashitola Wamboldt hardik Kundariya john D. Laurie Ido Keren K.R. Sunil Kumar Anna Block Gilles Basset Steve Luebker Christian Elowsky Philip M. Day johnna L. Roose Terry M. Bricker Thomas Elthon Sally A. Mackenzie School of Biological Sciences Department of Agronomy and Horticulture University of Nebraska Lincoln NE 68588 USA Center for Biotechnology University of Nebraska Lincoln NE 68588 USA Department of Biological Sciences Louisiana State University Baton Rouge LA 70803 USA These authors contributed equally to this article

As metabolic centers, plant organelles participate in maintenance, defense, and signaling. MSH1 is a plant- specific protein involved in organeUar genome stability in mitochondria and plastids. Plastid depletion of MSH1 causes heritable, non-genetic changes in development and DNA methylation. We investigated the rash I phenotype using hemi-complementation mutants and transgene-null segregants from RNAi suppres- sion lines to sub-compartmentalize MSH1 effects. We show that MSH1 expression is spatially regulated, specifically localizing to plastids within the epidermis and vascular parenchyma. The protein binds DNA and localizes to plastid and mitochondrial nucleoids, but fractionation and protein-protein interactions data indicate that MSH1 also associates with the thylakoid membrane. Plastid MSH1 depletion results in variegation, abiotic stress tolerance, variable growth rate, and delayed maturity. Depletion from mitochon- dria results in 7%-10% of plants altered in leaf morphology, heat tolerance, and mitochondrlal genome sta- bility. MSH1 does not localize within the nucleus directly, but plastid depletion produces non-genetic changes in flowering time, maturation, and growth rate that are heritable independent of MSH 1. MSH1 deple- tion alters non-photoactive redox behavior in plastids and a sub-set of mitochondrially altered lines. Ectopic expression produces deleterious effects, underlining its strict expression control. Unraveling the complexity of the MSH1 effect offers insight into triggers of plant-specific, transgenerational adaptation behaviors.

关键词： Thylakoid protein Organellar DNA binding MSH1 Epigenetic variation

Multi-omic Microbiome Profiles in the Female Reproductive Tract in Early Pregnancy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Microbes & Diseases 2019年第2期1卷 49-60页

作者： Sophonie jean Bernice Huang hardik I.Parikh David j.Edwards j.Paul Brooks Naren Gajenthra Kumar Nihar U.Sheth Vishal Koparde Ekaterina Smirnova Snehalata Huzurbazar Philippe H.Girerd Dayanjan S.Wijesinghe jerome F.StraussIII Myrna G.Serrano jennifer M.Fettweis Kimberly K.jefferson Gregory A.Buck Department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVA Department of Statistical Sciences and Operations Research Virginia Commonwealth UniversityRichmondVA Supply Chain Management and Analytics School of BusinessVirginia Commonwealth UniversityRichmondVA Life Sciences Virginia Commonwealth UniversityRichmondVA DNAnexus Inc. Mountain ViewCA Frederick National Laboratory for Cancer Research FrederickMD Department of Biostatistics Virginia Commonwealth UniversityRichmondVA Department of Statistics University of WyomingLaramieWY Obstetrics and Gynecology Virginia Commonwealth UniversityRichmondVA Pharmacotherapy and Outcomes Science Virginia Commonwealth UniversityRichmondVA Department of Computer Science Virginia Commonwealth UniversityRichmondVA.

The vaginal microbiome likely influences host signaling compounds within the reproductive tract,including pro-inflammatory signals,which may play an important role during *** lactobacilli are associated with positive pregnancy outcome,whereas bacterial vaginosis,a dysbiosis of the vaginal microbiome,is associated with an increased risk of adverse pregnancy outcomes including preterm *** the host response could be predicted based on the taxonomic composition of the vaginal microbiome,particularly early in pregnancy,then those predictions could potentially be used to personalize intervention methods to reduce preterm birth and other adverse *** this proof of principle study,we apply multivariate strategies to analyze 16S rRNA-based taxonomic surveys in conjunction with targeted immuno-proteomic and lipidomic data from vaginal samples from 58 women enrolled in the Multi-Omic Microbiome Study-Pregnancy Initiative during early *** between the vaginal microbiome and the vaginal lipidome have not been previously *** from this study reveal significant multiple pairwise associations between microbial taxa,specific eicosanoids and sphingomyelins,and *** the biologic significance of these associations is not yet known,these results support the utility of such multi-omic approaches as a means to predict the impact of the microbiome on the host.

关键词： vaginal microbiome preterm birth multi-omics metagenomics cytokine profiles lipidomics

Simultaneous bilateral shoulder and bilateral central acetabular fracture dislocation： What to do？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese journal of Traumatology 2016年第1期19卷 59-62页

作者： hardik Sheth Abhijeet Ashok Salunke Ramesh Panchal jimmy Chokshi G.I. Nambi Saranjeet Singh Amit Patel Ranu Sheth Pramukswami Medical College Anand. Gujrat. India

Musculoskeletal injuries following seizures have a high morbidity and mortality. These injuries are often missed and the diagnosis is delayed due to a lack of clinical suspicion and appropriate investigations. We report a case of 72 years old male with simultaneous bilateral central acetabular fracture dislocation and bilateral posterior shoulder fracture dislocation secondary to an epileptic seizure. Present study high- lights the significance of clinical suspicion and clinico-radiological evaluation for diagnosis of a rare injury following episode of seizures. Simultaneous fracture dislocation of all four limbs treated with a holistic approach can lead to a good functional recovery. Surgical management with open reduction and internal fixation is preferred and replacement arthroplasty should be reserved for cases with implant failure and elderly patients.

关键词： Epilepsy Seizures Acetabulum Fracture Dislocation Shoulder

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

美国产品责任、安全与信息法概要

宏观质量研究 2015年第1期3卷 72-80页

作者：萨钦.潘迪亚刘璐李俊美国康涅狄格大学法学院对外经济贸易大学法学院

美国规范产品伤害风险的法律主要包括产品责任法、产品安全法和信息法。其中,产品安全法和产品责任法各成体系,分别作用于防止损害的发生和强制已经发生损害的产品生产者和销售者承担责任。产品信息机制方面的法律意在帮助消费者在做出... 详细信息

美国规范产品伤害风险的法律主要包括产品责任法、产品安全法和信息法。其中,产品安全法和产品责任法各成体系,分别作用于防止损害的发生和强制已经发生损害的产品生产者和销售者承担责任。产品信息机制方面的法律意在帮助消费者在做出购买或使用决定时充分、准确地了解产品安全状况及产品质量信息。文章对三者分别进行了介绍并指出:这些法律共同致力于赔偿危险产品对人造成的损害、抑制危险产品的销售行为、帮助消费者避免购买或以低价购买不安全产品或劣质产品。

关键词：美国产品责任法产品安全法产品信息

维普期刊数据库

Suppression of osteosarcoma progression by engineered lymphocyte-derived proteomes

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第4期10卷 1641-1656页

作者： Kexin Li Xun Sun Hudie Li Hailan Ma Meng Zhou Kazumasa Minami Keisuke Tamari Kazuhiko Ogawa Pankita Hpandya MReza Saadatzadeh Melissa AKacena Karen EPollok Bai-Yan Li Hiroki Yokota Department of Pharmacology School of PharmacyHarbin Medical UniversityHarbinHeilongjiang 150081China Department of Biomedical Engineering Indiana University Purdue University IndianapolisIndianapolisIN 46202USA Department of Radiation Oncology Osaka University Graduate School of MedicineSuitaOsaka 565-0871Japan Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA Department of Pediatrics Indiana University School of MedicineIndianapolisIN 46202USA Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisIN 46202USA Indiana Center for Musculoskeletal Health Indiana University School of MedicineIndianapolisIN 46202USA

Cancer cells tend to develop resistance to chemotherapy and enhance aggressive-ness.A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic *** on this strategy,induced tumor-suppressing cells(iTSCs)have been generated from tumor cells and mesenchymal stem ***,we examined the possi-bility of generating iTSCs from lymphocytes by activating PKA signaling for suppressing the pro-gression of osteosarcoma(OS).While lymphocyte-derived CM did not present anti-tumor capabilities,the activation of PKA converted them into *** PKA conversely gener-ated tumor-promotive *** a mouse model,PKA-activated CM suppressed tumorinduced bone *** analysis revealed that moesin(MSN)and calreticulin(Calr),which are highly expressed intracellular proteins in many cancers,were enriched in PKA-activated CM,and they acted as extracellular tumor suppressors through CD44,CD47,and *** study presented a unique option for cancer treatment by generating iTSCs that secret tumor-suppressive proteins such as MSN and *** envision that identifying these tu-mor suppressors and predicting their binding partners such as CD44,which is an FDA-approved oncogenic target to be inhibited,may contribute to developing targeted protein therapy.

关键词： Calreticulin Lymphocytes Moesin Osteosarcoma PKA Proteome

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUARK GLUON TAGGING