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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 465-472页

作者： Priyanka Gupta Neeraj Kumar Ravindra Kumar Garg hardeep singh malhotra Imran Rizvi Rajesh Verma Praveen Kumar Sharma Ravi Uniyal Shweta Pandey Amita Jain Parul Jain Department of Neurology King George’s Medical UniversityLucknowIndia Department of Microbiology King George’s Medical UniversityLucknowIndia

Objective:To identify the clinical,laboratory,and radiological markers that could predict a positive GeneXpert result in patients suspected of tuberculous ***:In this prospective,observational study,patients with tuberculous meningitis were systematically *** clinical,laboratory[including cerebrospinal fluid(CSF)microscopy,culture,and GeneXpert],and neuroimaging factors were *** participants were administered anti-tuberculous treatment and corticosteroids.A six-month follow-up was done to evaluate the ***:Of the 116 patients studied,54(46.6%)tested positive for GeneXpert,while 62(53.4%)were *** cranial nerve involvement(OR 3.71,95%CI 1.052-13.09,P=0.04)and the presence of basal exudates on neuroimaging(OR 5.22,95%CI 2.03-13.42,P=0.001)emerged as independent predictive factors for a positive GeneXpert result.A positive CSF GeneXpert result(P=0.002)and drug resistance(P=0.004)were significantly linked to adverse ***,a high score on the Medical Research Council stageⅢ(OR 5.64,95%CI 1.18-26.87,P=0.03)and elevated CSF cell counts(OR 1.002,95%CI 1.00-1.001,P=0.03)were identified as independent predictors of poor ***:Third cranial nerve involvement and the presence of basal exudates were significant indicators of a positive GeneXpert *** stageⅢdisability and elevated CSF cell counts predicted poor outcomes.

关键词： Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Ziehl-Neelsen staining GeneXpert

Disseminated cysticercosis presenting with bilateral proptosis: A case report

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Asian Pacific Journal of Tropical Medicine 2019年第7期12卷 337-338页

作者： Ravindra Kumar Garg Neeraj Kumar Imran Rizvi hardeep singh malhotra Department of Neurology King George’s Medical University Uttar Pradesh

Rationale: Disseminated cysticercosis is characterized by presence of cysts in multiple body organs, like brain, skin, eyes, muscles and rarely heart and *** concerns: A 22-year-old man presented with bilateral proptosis of 1-year duration. He also had two episodes of cysticercosis encephalitis. In the second episode of encephalopathy, the patient ***: Disseminated ***: Corticosteroids(Initially intravenous dexamethasone 0.4 mg/kg/day for 2 weeks, followed by oral prednisolone 1.0 mg/kg/day).Outcomes: The patient died of cysticercosis encephalitis approximately 2 months ***: Disseminated cysticercosis in our case presented only with proptosis as he had very heavy infestation of the brain and eyes. Heavy larval infestation in a patient with disseminated cysticercosis can be life-threatening.

关键词： Neurocysticercosis Cysticercosis encephalitis Proptosis

Experimental Investigation of Thermal Performance of Novel Finned Radiators for Automotive Cooling System

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Journal of Thermal Science 2024年第5期33卷 1726-1743页

作者： singh hardeep TING David S-K READER Graham ESHTIAGHI Nicky ICHIYANAGI Mitsuhisa SUZUKI Takashi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan

This research investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with straight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the design of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins remains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3D printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,Microchannel Water Air Radiator with fin height 10.5 mm(MCWAR10.5)depicted a higher heat transfer rate amongst the *** comparison to Straight Water Air Radiator with fin height 9.5 mm(SWAR9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin surface area analysis,microchannel radiator(MCWAR3.2)illustrates lower heat dissipation than Helical radiator(HWAR138)but higher than HWAR134 and Straight radiator(SWAR6).The examination of pumping loss indicated that the Micro-channel radiator outperformed helical radiators due to its lower pressure *** average pressure loss for Micro-channel radiators was 0.74 kPa,making it 1.2 times higher than that of a straight radiator(0.62 kPa),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3D printing

Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA BISHNOI NEHA RAINA MEGHNA AMRITA singh PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR hardeep singh TULI MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

MIMO-WiMAX system incorporated with diverse transformation for 5G applications

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Frontiers of Optoelectronics 2019年第3期12卷 296-310页

作者： Lavish KANSAL Vishal SHARMA Jagjit singh malhotra IKG Punjab Technical University JalandharIndia Department of Electronics & Communication Engineering SBSSTCFerozepurIndia Department of Electronics and Communication Engineering DAVIETJalandharIndia Affiliated to IKG Punjab Technical University JalandharPunjabIndia

Wireless systems and standards are now progressing toward the implementation of fifth generation (5G) to combat with an expected and explosive growth of demands of wireless services in future. Consequently, wireless interoperability for microwave access (WiMAX) with orthogonal frequency division multiplexing (OFDM) technology at its physical layer is being utilized for the uplink and downlink transmission to afford the high spectral efficiency in fading environments. However, the 5G implementation requires additional improvements to meet the futuristic stress. This work proposes an innovative solution that combines WiMAX system with multiple input multiple output (MIMO) technology to meet the required elevated data rates as desired by the growing application needs of 5G. MIMO is capable to fulfil the vision of 5G to realize a huge number of base stations equipped with a large number of terminals to be served in the same time-frequency resource without severe inter-user interference. Furthermore, the proposed system is demon- strated incorporation with discrete wavelet transform (DWT), and fractional Fourier transforms (FrFTs) in the physical layer of the WiMAX system. The evaluated outcomes exemplify a considerable improvement in bit error rate (BER) performance in contrast with the earlier reported work.

关键词： wireless interoperability for microwave access (WiMAX) orthogonal frequency division multiplexing (OFDM) multiple input multiple output (MIMO) fast Fourier transform (FFT) discrete wavelet transform (DWT) fractional Fourier transform (FrFT)

Big data analytics for retail industry using MapReduce-Apriori framework

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Journal of Management Analytics 2020年第3期7卷 424-442页

作者： Neha Verma Dheeraj malhotra tinder singh Vivekananda Institute of Professional Studies GGSIPUDelhiIndia Sant Baba Bhaag singh niversity JalandharIndia

Presently,retailing has changed its face from unordered stacked traditional stores to beautifully decorated and appropriately managed merchandise stores or shopping malls with excellent ambiance and ***,these stores try to accommodate all needed items for daily use or rarely required items under the same ***,the primary challenge for today’s retailer is that the modern customer is quality and brands conscious as well as compare for services provided to them by different outlets at the comfort of home with a single ***,customers prefer to purchase from E-Commerce websites instead of physically visiting a retail store,which leads to the downfall in the sales of retailers which become a serious threat to ***,retailers are required to work sincerely towards their customer expectations by providing all their needed goods under the same ***,the objective of this paper is to assist retail business owners to recognize the purchasing needs of their customers and hence to entice customers to physical retail stores away from competitor E-Commerce *** paper employs a systematic research methodology based on association rule mining deployed over Map-Reduce based Apriori association mining and Hadoop based intelligent cloud architecture to determine useful buying patterns from purchase history of previous customers,in order to assist retail business *** finding acknowledges that the traditional mining algorithms have not progressed to support big data analysis as required by current retail businesses *** job of finding unknown association rules from big data requires a lot of resources such as memory and processing ***,traditional mining systems are inadequate to provide support for partial failure support,extensibility,scalability ***,this study aims to implement and develop MapReduce based Apriori(MR-Apriori)algorithm in the form of Intelligent Retail Mining Tool *** Tool

关键词： Big data retail analytics MR-Apriori algorithm map-reduce market basket analysis association mining IRM tool

A Comprehensive Review of Animal Models for Coronaviruses: SARSCoV-2, SARS-CoV, and MERS-CoV

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Virologica Sinica 2020年第3期35卷 290-304页

作者： Ashutosh singh Rahul Soloman singh Phulen Sarma Gitika Batra Rupa Joshi hardeep Kaur Amit Raj Sharma Ajay Prakash Bikash Medhi Department of Pharmacology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

The recent outbreak of coronavirus disease(COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has already affected a large population of the world. SARS-CoV-2 belongs to the same family of severe acute respiratory syndrome coronavirus(SARS-CoV) and Middle East respiratory syndrome coronavirus(MERSCoV). COVID-19 has a complex pathology involving severe acute respiratory infection, hyper-immune response, and coagulopathy. At present, there is no therapeutic drug or vaccine approved for the disease. There is an urgent need for an ideal animal model that can reflect clinical symptoms and underlying etiopathogenesis similar to COVID-19 patients which can be further used for evaluation of underlying mechanisms, potential vaccines, and therapeutic strategies. The current review provides a paramount insight into the available animal models of SARS-CoV-2, SARS-CoV, and MERS-CoV for the management of the diseases.

关键词： Coronaviruses SARS MERS COVID-19 Animal model

Biochar applications influence soil physical and chemical properties,microbial diversity,and crop productivity:a meta-analysis

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Biochar 2022年第1期4卷 1055-1071页

作者： hardeep singh Brian K.Northup Charles W.Rice P.V.Vara Prasad Department of Agronomy Kansas State University2002 Throckmorton Plant Sciences Center1712 Claflin RoadManhattanKS 66506USA United States Department of Agriculture-Agricultural Research Service Grazinglands Research LaboratoryEl-RenoOK 73036USA

Biochar is a widely known soil *** we synthesize the available information on influence of biochar application on different soil properties and crop productivity using *** data on influence of biochar applications on different soil physical,chemical,microbial properties,and crop productivity were extracted from literature and statistically *** on selection criteria,59 studies from the literature published between 2012 and 2021 were selected for the *** were developed between effect size of biochar application on different soil properties and crop *** of biochar increased soil pH,cation exchange capacity,and organic carbon by 46%,20%,and 27%,respectively,with greater effects in coarse and fine-textured *** on chemical properties were variable among biochar prepared from different *** physical properties,biochar application reduced bulk densities by 29%and increased porosity by 59%.Biochar prepared at higher pyrolytic temperatures(>500℃)improved bulk density and porosity to greater extents(31%and 66%,respectively).Biochar prepared at lower pyrolytic temperatures(<500℃)had a greater effect on microbial diversity(both bacterial and fungal),with more diverse bacterial populations in medium and coarse textured soils,while fungal diversity increased in fine textured *** applications increased crop productivity only in fine and coarse textured *** effect size of biochar application on crop productivity was correlated with responses to physical properties of *** meta-analysis highlighted the need to conduct long-term field experiments to provide better explanations for changes in biochar properties as it undergoes aging,its longer-term effects on soil properties,and timing of re-application of different biochars.

关键词： Biochar Crop productivity Microbial diversity Soil physical properties Soil chemical properties

Exploring Design Level Class Cohesion Metrics

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Journal of Software Engineering and Applications 2010年第4期3卷 384-390页

作者： Kuljit Kaur hardeep singh Department of Computer Science and Engineering Guru Nanak Dev University Amritsar India.

In object oriented paradigm, cohesion of a class refers to the degree to which members of the class are interrelated. Metrics have been defined to measure cohesiveness of a class both at design and source code levels. In comparison to source code level class cohesion metrics, only a few design level class cohesion metrics have been proposed. Design level class cohesion metrics are based on the assumption that if all the methods of a class have access to similar para-meter types then they all process closely related information. A class with a large number of parameter types common in its methods is more cohesive than a class with less number of parameter types common in its methods. In this paper, we review the design level class cohesion metrics with a special focus on metrics which use similarity of parameter types of methods of a class as the basis of its cohesiveness. Basically three metrics fall in this category: Cohesion among Methods of a Class (CAMC), Normalized Hamming Distance (NHD), and Scaled NHD (SNHD). Keeping in mind the anomalies in the definitions of the existing metrics, a variant of the existing metrics is introduced. It is named NHD Modified (NHDM). An automated metric collection tool is used to collect the metric data from an open source software program. The metric data is then subjected to statistical analysis.

关键词： Design Metrics Class Cohesion Metrics Cohesion among Methods of a Class Normalized Hamming Distance Scaled NHD

Impact of geographical and seasonal temperature on sperm parameters in Indian men who were partners in subfertile couples-A retrospective analysis

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Asian pacific Journal of Reproduction 2022年第4期11卷 175-182页

作者： Yogita Dogra Neeta singh Neena malhotra Reeta Mahey Vanamail Perumal Department of Obstetrics and Gynaecology Kamla Nehru State HospitalIndira Gandhi Medical CollegeShimla-Himachal PradeshIndia Department of Obstetrics and Gynaecology AIIMSNew DelhiIndia Statistics and Demography Department of Obstetrics and GynaecologyAIIMSNew DelhiIndia

Objective:To evaluate the impact of seasonal and geographical temperature on sperm parameters in Indian men who were partners in subfertile ***:A retrospective review of the records of semen analysis from January 2009 to December 2017 that was performed as part of primary evaluation of infertile couple was *** values of various semen parameters were compared between seasons using one-way analysis of variance test followed by Bonferroni pair wise post-hoc comparison *** Pearson correlation coefficient was applied to measure the correlation between age,sperm parameters and annual temperature/*** logistic regression analysis was further carried out to identify significant variables contributing to normal progressive motility of ***:A total of 3433 reports of semen samples were *** was no significant seasonal variation in the mean volume,concentration,and total motility levels(P>0.05)except the mean values of progressive motility(P<0.001).The mean values of progressive motility during pre-monsoon were significantly higher compared to the corresponding values during monsoon and autumn seasons(P<0.01).In all the seasons,total motility had significant positive correlation with sperm concentration and progressive motility(P<0.05).Pre-monsoon emerged as the significant favourable season to get normal progressive motility level(OR 1.32,95%CI 1.04-1.68)compared to *** chances of getting normal progressive motility reduced due to longer abstinence period(OR 0.87,95%CI 0.80-0.93).When the temperature was more than 28℃,the likelihood of getting normal progressive motility decreased(OR 0.70,95%CI 0.51-0.95).Conclusions:The progressive motility of sperms significantly decreases from pre-monsoon to autumn with recovery towards winter,which substantiates the effect of rising temperature on the progressive motility of *** is clinically important to counsel infertile patients,so that they can plan their treat

关键词： Infertility Seasonal variations Sperm Progressive motility Geographical temperature