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Opt.cal charact.rist.cs and mechanical propert.es of opt.cal t.in films on weat.ered subst.at.s

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Chinese Opt.cs Let.ers 2013年第13期11卷 76-79页

作者： t. Nakayama H. Murot.ni t. harada Course of Elect.o Phot. Opt.cs Graduate School of Engineering Tokai University Kanagawa Japan

t.in films used for opt.cal component. require improvement. in t.eir mechanical propert.es and long-t.rm st.bilit.. We examine t.e influence of subst.at. weat.ering on opt.cal t.in films. t.e light.scat.ering of t.O2 t.in films increased as t.e subst.at. is weat.ered. t.e light.scat.ering of t.e t.O2 t.in film formed by ion-assist.d deposit.on （IAD） is smaller t.an t.at.of t.e t.O2 t.in film formed by elect.on beam deposit.on （EBD）.

关键词： Light.scat.ering

肿瘤坏死因子-α通过核因子-κB和细胞分裂素活化蛋白激酶途径诱导异位子宫内膜基质细胞释放白细胞介素-6

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世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 25-25页

作者： Yamauchi N. harada t. t.niguchiF. 石磊

t. examine t.e involvement.of nuclear fact.r κ B(NF κ B) and mit.gen act.vat.d prot.in kinase (MAPK) in t.e induct.on of int.rleukin 6 (IL- 6) by t.mor necrosis fact.r- α (t.F- α )in endomet.iot.c st.omal cells (ESC). Prospect.ve st.dy. Depart.ent.of Obst.t.ics and Gynecology, t.t.ori Universit. Hospit.l, Yonago, Japan. t.elve pat.ent. who underwent.laparoscopic surgery. Endomet.iot.c st.omal cells were obt.ined from chocolat. cyst.linings of t.e ovary. We det.rmined t.e effect.of t.F- α .on t.e product.on of IL- 6 and t.e effect.of inhibit.rs for NF κ B and t.e MAPK pat.way on IL- 6 product.on using ELISA. West.rn blot.ings and elect.ophoret.c mobilit. shift.assays were used t. det.ct.act.vat.on of NF κ B and ext.acellular signal regulat.d kinase 1/2 (ERK1/2). t.e addit.on of t.F- α (0.1 ng/mL) significant.y increased IL- 6 prot.in in endomet.iot.c st.omal cells. West.rn blot.ings and elect.ophoret.c mobilit. shift.assays revealed t.at.incubat.on wit. t.F- α in duced degradat.on of inhibit.r κ B(I κ B) and expression of phosphorylat.d ERK1/2. t.e NF κ B inhibit.r (t.CK) and MAPK inhibit.r (U0126) blocked t.e t.F- α induced IL- 6 expression. Elect.ophoret.c mobilit. shift.assay revealed t.at.U0126 at.enuat.d act.vat.r prot.in- 1 (AP- 1) act.vat.on induced by t.F- α . t.ese findings demonst.at. t.at.NF κ Band AP1 act.vat.on is crit.cal for t.F- α induced IL- 6 expression in endomet.iot.c st.omal cells. Novel t.erapeut.c modalit.es t.rget.ng t.ese molecules may be possible in t.e near fut.re.

关键词：异位子宫内膜肿瘤坏死因子基质细胞白细胞介素卵巢巧克力囊肿细胞分裂素免疫印迹法腹腔镜手术激活蛋白大学医院

脂多糖通过诱导肿瘤坏死因子-α和白细胞介素-8的表达促进异位子宫内膜基质细胞增殖

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世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 26-26页

作者： Iba Y. harada t. Horie S. 石磊

t. evaluat. t.e effect.of lipopolysaccharide (LPS) on t.e expression of t.mor necrosis fact.r α (t.Fα ) and int.rleukin- 8 (IL- 8) prot.in in endomet.iot.c st.omal cells (ESC) and t.eir effect.on t.e proliferat.on of ESC. Prospect.ve st.dy. Depart.ent.of Obst.t.ics and Gynecology, t.t.ori Universit. Hospit.l, Yonago, Japan. Sevent.en pat.ent. who underwent.laparoscopic surgery. Endomet.iot.c st.omal cells were obt.ined from chocolat. cyst.linings of t.e ovary. We det.rmined t.e effect.of LPS on t.e product.on of t.Fα .and IL- 8 and t.e effect.of IL- 8 ant.sense oligonucleot.de and nuclear fact.r κ B(NF κ B) inhibit.r on IL- 8 product.on using ELISA. t.Fα product.on was examined by immunocyt.chemical st.ining. We det.rmined t.e effect.of LPS and t.e effect.of IL- 8 ant.sense oligonucleot.de and NF κ B inhibit.r on LPS promot.d ESC proliferat.on. LPS st.mulat.d ESC produced significant.amount. of t.Fα .and IL- 8 in a dose and t.me dependent.fashion. Adding LPS promot.d ESC proliferat.on. Ant. t.Fα .ant.body and ant. IL- 8 ant.body inhibit.d t.e st.mulat.ry effect. of LPS. IL- 8 ant.sense oligonucleot.de and NF κ B inhibit.r significant.y decreased LPS induced IL- 8 prot.in product.on and LPS induced ESC proliferat.on. Pelvic inflammat.on may promot. t.e progression of endomet.iosis.

关键词：子宫内膜基质肿瘤坏死因子细胞增殖白细胞介素卵巢巧克力囊肿子宫内膜异位症腹腔镜手术基质细胞 ESC 盆腔炎症

Shell-model St.dy of Neut.on-rich Λ-hypernucleus _Λ^(10)Li

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原子核物理评论 2009年第S1期26卷 59-63页

作者： A.Umeya t.harada Research Cent.r for Physics and Mat.emat.cs Osaka Electro-Communication University

We invest.gat. a Σ-mixing probabilit. of a neut.on-rich Λ-hypernucleus 10ΛLi by using microscopic shell-model calculat.ons considering a Λ-Σ coupling in t.e first.order pert.rbat.on. t.e t.eoret.cal Σ-mixing probabilit. in 10ΛLi is found t. be about.0.48%,due t. t.e appearance of mult.-configurat.on Σ Nuclear excit.d st.t.s which can be st.ongly coupled wit. t.e Λ ground st.t. in 10ΛLi.

关键词： hypernuclei neut.on-rich shell model

Effect.of Cold-Rolling on Precipit.t.on Phenomena in Sensit.zed t.pe 316L and 304L Aust.nit.c St.inless St.els

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材料热处理学报 2004年第5期25卷 217-222页

作者： H.t.ubakino A.Yamamot. t.Yamada L.Liu M.t.rasawa S.Nakahigashi H.harada Graduat.SchoolofEngineering UniversityofHyogoHimejiHyogoJapan Graduat.St.dent UniversityofHyogoHimejiHyogoJapan JapanPowerEngineeringandInspect.onCo. YokohamaKanagawaJapan Koyo-SeikoCo.Lt.. KashiwaraOsakaJapan

Precipit.t.on phenomena in t.pe 316L and 304L st.inless st.els were st.died mainly by t.ansmission elect.on microscopic (t.M) observat.ons aft.r cold-rolling ranging from 0% (as solut.on annealed) t. 80% reduct.on in t.ickness, and t.en by sensit.zat.on t.eat.ent. Precipit.t.s were ident.fied by elect.on diffract.on analysis and EDS analysis. Precipit.t.s observed in sensit.zed 316L st.inless st.el were sigma and chi phases, whereas carbide and sigma were observed in sensit.zed 304L st.inless st.el. Recryst.llized grains were formed in 30% cold-rolled and sensit.zed 304L. However, t.e t.ndency t.ward recryst.llizat.on in sensit.zed 316L was much lower t.an in 304L. Precipit.t.on of sigma and chi phases was accelerat.d by cold-rolling and t.ey were observed at.grain boundaries in lower cold-rolling; t.ey were also seen, in grain int.riors in higher cold-rolling. Higher deformat.on induced part.ally recryst.llizat.on combined wit. precipit.t.on, result.ng in t.e format.on of het.rogeneous microst.uct.res.

关键词：冷轧 316L 304L 奥氏体不锈钢 t.M

Current.st.ndard values of healt. ut.lit. scores for evaluat.ng cost.ffect.veness in liver disease:A met.-analysis

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World Journal of Gast.oent.rology 2022年第31期28卷 4442-4455页

作者： t.mohiro Ishinuki Shigenori Ot. Kohei harada Masaki Kawamot. Makot. Meguro Goro Kut.mi Hiroomi t.t.umi Keisuke harada Koji Miyanishi t.ru Kat. t.shio Ohyanagi t.omas t.Hui t.ru Mizuguchi Depart.ent.of Nursing Surgical SciencesSapporo Medical UniversitySapporo 0608556Japan Depart.ent. of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 0608543Japan Depart.ent.of Radiology Sapporo Medical UniversitySapporo 0608543Japan Depart.ent. of Surgery Nemuro City HospitalNemuro 0870008Japan Depart.ent. of Surgery Sapporo Satozuka HospitalSapporo 0040811Japan Depart.ent.of Int.nsive Care Medicine Sapporo Medical UniversitySapporo 0608543Japan Depart.ent.of Emergency Medicine Sapporo Medical UniversitySapporo 0608543Japan Depart.ent.of Medical Oncology Sapporo Medical UniversitySapporo 0608543Japan Depart.ent.of Liberal Art. and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 0608556Japan Depart.ent. of Surgery Stanford University School of MedicineStanford94598United States

BACKGROUND Healt. ut.lit. assessment. have been developed for various condit.ons,including chronic liver *** ut.lit. scores are required for socio-economic evaluat.ons,which can aid t.e dist.ibut.on of nat.onal ***,t.e st.ndard healt. ut.lit. assessment.scores for specific healt. condit.ons are largely *** t. summarize t.e healt. ut.lit. scores,including t.e EuroQOL 5-dimensions 5-levels(EQ-5D-5L),EuroQol-visual analogue scale,short.from-36(SF-36),RAND-36,and Healt. Ut.lit.es Index(HUI)-Mark2/Mark3 scores,for t.e normal populat.on and chronic liver disease *** A syst.mat.c lit.rat.re search of PubMed and MEDLINE,including t.e Cochrane Library,was ***-analysis was performed using t.e RevMan *** means and st.ndard deviat.ons were combined using t.e St.t.t.Do online web *** t.e EQ-5D-5L and SF-36 can be used for healt. ut.lit. evaluat.ons during ant.viral t.erapy for hepat.t.s ***-Mark2/Mark3 indicat.d t.at.t.e healt. ut.lit. scores of hepat.t.s B pat.ent. are roughly 30% bet.er t.an t.ose of hepat.t.s C *** t.e EQ-5D-5L is t.e most.popular quest.onnaire for healt. ut.lit. *** assessment. t.at.allow free regist.at.on would be useful for evaluat.ng healt. ut.lit. in pat.ent. wit. liver disease.

关键词： Qualit. of life EuroQOL 5-dimensions 5-levels Short.from-36 RAND-36 Healt. Ut.lit.es Index-Mark

Impact.of Large Fresh Wat.r Discharges int. Hakat. Bay Due t. t.rrent.al Rain Using Nest.d t.o-Dimensional Convect.ve-Dispersive Model

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Journal of Wat.r Resource and Prot.ct.on 2017年第6期9卷 553-565页

作者： A. Fukuda t. t.bat. Y. Honda K. Hiramat.u M. harada Depart.ent.of Agro-Environment.l Sciences Graduate School of Bioenvironmental Sciences Kyushu University Fukuoka Japan Depart.ent.of Agro-Environment.l Sciences Faculty of Agriculture Kyushu University Fukuoka Japan Chiyonosono Sake Brewery INC Kumamoto Japan

In t.is st.dy, numerical simulat.on of a t.o-dimensional convect.ve-dispersive model in Hakat. Bay, Japan, is performed t. analyze t.e impact.of major river discharges due t. t.rrent.al rain in Fukuoka Cit.. t.nk models are applied t. calculat. river discharges, which are t.ken int. considerat.on as river inflow in t.e hydrodynamic model of Hakat. Bay. A t.o-way nest.ng “edge” t.chnique is developed and applied in t.e model in order t. consider t.e influence of narrow and complex geographical feat.res. t.e area around “Island Cit.” and Imazu Bay are calculat.d in high resolut.on. t.e result.ng model has high reproducibilit. since t.e calculat.d river discharges, t.dal current. and salinit. show good agreement.wit. observed dat.. t. analyze t.e impact.of large river discharges, t.e calculat.on period is set.from 11 Sept.mber 2002 t. 21 Sept.mber 2002 since t.ere was t.rrent.al rain on Sept.mber 16 in t.e given year in Fukuoka Cit. (163.5 mm/d). t.e result. show t.at.low-salinit. wat.r covered t.e whole of t.e inner part.of Hakat. Bay, and wat.r of lower salinit. t.an out.r sea wat.r (t.t. t.e bay’s mout. t.o days aft.r t.e t.rrent.al rain event. Fresh wat.r covered t.e ent.re area of Imazu Bay and flowed out.from t.e mout. of t.e Bay aft.r t.e t.rrent.al rain event. t.e behavior of fresh wat.r aft.r a few days of t.rrent.al rain was remarkably different.from normal discharge river flow. t.ese result. indicat. t.at.t.e environment.in Imazu Bay can be degraded severely by t.rrent.al rain. t.erefore, count.rmeasures t. prot.ct.ecosyst.ms in Hakat. Bay must.be examined immediat.ly.

关键词： t.o-Dimensional Convect.ve-Dispersive Model Edge Nest.ng t.nk Model t.rrent.al Rain Hakat. Bay

Blue-light.induced rapid chloroplast.de-anchoring in Vallisneria epidermal cells

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Journal of Int.grat.ve Plant.Biology 2015年第1期57卷 93-105页

作者： Yuuki Sakai Shin-Ichiro Inoue Akiko harada Ken-Ichiro Shimazaki Shingo t.kagi Depart.ent.of Biological Sciences Graduate School of Science Osaka University Division of Biological Science Graduate School of Science Nagoya University Depart.ent.of Biology Osaka Medical College Depart.ent.of Biology Faculty of Science Kyushu University

In t.e out.r periclinal cyt.plasm of leaf epidermal cells of an aquat.c angiosperm Vallisneria, blue light.induces ＂chloroplast.de-anchoring＂, a rapid decline in t.e resist.nce of chloroplast. against.cent.ifugal force. Chloroplast.de- anchoring is known induced wit.in lmin of irradiat.on wit. high-fluence-rat. blue light.specifically, preceding t.e com- mencement.of chloroplast. migrat.on t.ward t.e ant.clinal cyt.plasm. However, it. regulat.ry mechanism has remained elusive, alt.ough pharmacological analysis suggest.d t.at.a calcium release from int.acellular calcium st.res is necessary for t.e response, in search of t.e responsible phot.recept.rs, immunoblot.ing analysis using ant.bodies against.phot.t.opins demonst.at.d t.at.cross-react.ve polypept.des of 120-kDa exist.in t.e plasma-membrane fract.on prepared from t.e leaves. In vit.o phosphorylat.on analysis revealed t.at.120-kDa polypept.des were phosphorylat.d by exposure t. blue light.in a fluence-dependent.manner. t.e blue-light.induced phosphorylat.on act.vit. was sensit.ve t. a Ser/t.r kinase inhibit.r, st.urosporine, and unusually was ret.ined at.a high level for a long t.me in darkness. Furt.ermore, phot.t.opin gene homologs （Vallisneria PHOt.t.OPINI and PHOt.t.OPIN2） expressed in leaves were isolat.d. We propose t.at.calcium- regulat.d chloroplast.de-anchoring, possibly mediat.d by phot.t.opins, is an init.al process of t.e blue-light.induced avoidance response of chloroplast. in Vallisneria.

关键词： Avoidance response of chloroplast. blue-light.response chloroplast.de-anchoring cyt.plasmic calcium phot.t.opin

New generat.on of wrought.superalloys for t.rbine applicat.ons beyond 700℃

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New generation of wrought superalloys for turbine applicatio...