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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli Guo Chikako harada Takayuki harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

MAVEN observation of magnetosonic waves in the Martian magnetotail region

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Earth and Planetary Physics 2024年第2期8卷 317-325页

作者： ShangChun Teng JiCheng Sun JiaWei Gao Y.harada Markus Fraenz DeSheng Han State key Laboratory of Marine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China MNR key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geophysics Kyoto UniversityKyotoJapan Max-Planck-Institute for Solar System Research GoettingenGermany

Magnetosonic waves are an important medium for energy transfer in collisionless space *** waves have been widely investigated in the upstream of the bow shock at *** waves are believed to originate from pickup ions or reflected *** utilizing MAVEN spacecraft data,we have observed the occurrence of quasi-perpendicularly propagating magnetosonic emissions near the proton gyrofrequency in the Martian magnetotail *** plasma waves are associated with a significant enhancement of proton and oxygen *** excited magnetosonic waves could possibly heat the protons through resonance and facilitate the ionospheric plasma *** results could be helpful to better understand the Mars’magnetospheric dynamics and offer insights into possible energy redistribution between waves and plasma in the Martian nightside magnetosphere.

关键词： Martian magnetotail region magnetosonic waves proton escape

Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto Shinji Oe koichiro Miyagawa Yuichi Honma Masaru harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

Nitrogen-based fertilizers differentially affect protist community composition in paddy field soils

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Soil Ecology Letters 2024年第3期6卷 35-44页

作者： Seda Ozer Bodur Solomon Oloruntoba Samuel kazuki Suzuki Naoki harada Rasit Asiloglu Graduate School of Science and Technology Niigata UniversityNiigataJapan Department of Plant and Microbial Biology North Carolina State UniversityRaleighNCUSA Institute of Science and Technology Niigata UniversityNiigataJapan

Protists are one of the most diverse and dominant microbial groups and they play critical roles in the soil *** nitrogen fertilizers have a profound impact on protist communities,still less is known about how different nitrogen fertilizer types affect protist community composition in different soil *** we investigated the effects of six inorganic nitrogen fertilizers(urea,ammonium nitrate,ammonium sulfate,potassium nitrate,ammonium chloride,and diammonium hydrogen phosphate)and an organic fertilizer(a mixture of rice husk and cow manure)on protist community composition in three paddy field soils using a high-throughput sequencing *** effect of the fertilizers on the functional groups of protists,namely consumers(predators and decomposers),photoautotrophs,and parasites(plant pathogens and animal parasites)was also *** results showed that nitrogen fertilizers had distinctive effects on the beta diversity of the protists,while we also observed that the same fertilizer had slightly different effects depending on the soil *** and Rhizaria were the most affected protist taxonomical groups,while predatory protists were the main functional groups that were affected by nitrogen *** forest analysis showed that most of the fertilizer-affected protists were predators,among which Cercozoa was the most affected *** conclusion,our results provide important insights into the impact of nitrogen fertilizers on soil protist communities.

关键词： nitrogen fertilizer bottom-up paddy field predatory protist soil protist community

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接触性和内吸性抑芽剂的效果比较

接触性和内吸性抑芽剂的效果比较

256层螺旋CT低剂量对比剂低管电压高管电流扫描方案在肾功能衰竭病人腹部动态增强扫描中的临床应用

2004年CORESTA会议第58届烟草科学研究会议

作者： harada k. MORI k. HIROSE E. 孙希芳日本鹿儿岛烟叶技术中心日本鹿儿岛烟叶技术中心日本鹿儿岛烟叶技术中心

＜正＞2004年,日本决定把所有MH（马来酰肼）系列即内吸性抑芽剂更换成接触性抑芽剂。据报道,用接触性抑芽剂抑制腋芽比用MH对产量和品质的影响小,因而对主要接触性抑芽剂癸基醇和MH这两类药剂的抑芽效果在烤烟上进行了研究。癸基醇分6...

＜正＞2004年,日本决定把所有MH（马来酰肼）系列即内吸性抑芽剂更换成接触性抑芽剂。据报道,用接触性抑芽剂抑制腋芽比用MH对产量和品质的影响小,因而对主要接触性抑芽剂癸基醇和MH这两类药剂的抑芽效果在烤烟上进行了研究。癸基醇分6次施,抑芽率在94%,抑芽效果优于MH。

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国际医学放射学杂志 2012年第1期 72-73页

作者： T.Nakaura k.Awai N.Maruyama N.Takata I.Yoshinaka k.harada 李琼 Department of Diagnostic Radiology Amakusa Medical CenterKameba 854-1AmakusaKumamoto 863-0046Japan

目的探讨256层螺旋CT低剂量对比剂低管电压高管电流腹部动态增强扫描方案的临床应用的可行性。材料与方法本前瞻性研究获机构审查委员会批准,并获得了病人的知情同意书。此研究共纳入151例病人,其中估算肾小球滤过率(eGFR)大于或等于60m... 详细信息

目的探讨256层螺旋CT低剂量对比剂低管电压高管电流腹部动态增强扫描方案的临床应用的可行性。材料与方法本前瞻性研究获机构审查委员会批准,并获得了病人的知情同意书。此研究共纳入151例病人,其中估算肾小球滤过率(eGFR)大于或等于60mL·min-1·1.73m-2的117例

关键词：扫描方案低剂量对比剂低管电压管电流肾功能衰竭肾衰肾疾病螺旋动态增强扫描病人腹部躯干临床应用 CT

Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato Yuya Miyasaka Yasuhito Hagiwara Natsuko Yano Hiroko Akamatsu Mayumi harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACkGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

局部外用δ-氨基酮戊酸光动力疗法成功治疗良性皮肤淋巴组织增生

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 48-48页

作者： Takeda H kaneko T harada k 刘艳 Department of Dermatology Hirosaki University School of Medicine 5 Zaifu-ChoHirosaki Aomori 036-8562 JapanDr

Background: Photodynamic therapy (PDT) using topical δ-aminolevulinic acid (ALA) has been used for nonmelanoma skin cancers, including malignant cutaneous T-cell lymphomas. Moreover, PDT has been tried for benign inflammatory or infectious skin lesions. Objective: To evaluate the effects of ALA-PDT on skin lesions of lymphadenosis benigna cutis (LABC). Patients and Methods: Two 16-year-old females with solitary and infiltrated nodules were treated 5 times with topical ALA-PDT. Results: Both patients responded well and showed dramatic clinical an d histopathological improvement without visible scars. Conclusion: The results c onfirm that topical ALA-PDT is an effective and safe modality for the treatment of LABC, and that such treatment may be cosmetically beneficial.

关键词： δ-氨基酮戊酸黑色素瘤浸润性结节淋巴瘤感染性

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日本心血管疾病患者的安宁疗护及启示

中华护理杂志 2024年第5期59卷 533-539页

作者：彭梦云原田奈穂子齋藤信也岡山大学保健学研究科日本岡山市7008558 岡山大学医学部保健学科日本岡山市7008558

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高... 详细信息

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高患者及家庭成员的生活质量。该文介绍了日本心血管疾病患者安宁疗护的发展历程、规模及需求、团队成员及协作、介入时间、评估与筛查、服务内容与流程、质量评价及困境等,提出对国内心血管疾病患者实施安宁疗护的启示,为开展心血管疾病患者的安宁疗护提供借鉴。

关键词：心血管疾病安宁疗护姑息护理