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Ethnocultural heritage of the North-Eastern Caucasus as a factor of eco-tourism development

Journal of Mountain Science 2024年第8期21卷 2810-2824页

作者： Zaburaeva Khava sh. Complex Research Institute named after Kh.I.Ibragimov of the Russian Academy of Sciences Grozny 366002Russia

The North-East Caucasus is a multi-ethnic mountain macroregion with a rich cultural heritage,insufficiently studied in the context of the ecotourism *** fill this gap and identify promising directions of environmentally safe forms of tourism,the author used in-depth review of modern literature to investigate the features of ecological tourism and the problems of preserving ethno-cultural heritage,and used historical and comparative-geographical methods to analyze the development of the tangible and intangible cultural heritage of the indigenous peoples of the North-Eastern Caucasus in different historical periods and to identify the geographical peculiarities of the distribution of historical and cultural monuments(tower buildings),pilgrimage sites and centers of traditional crafts and *** part of the planned expeditions,the author personally visited some historical monuments and handicraft centers for a deeper study of ethno-cultural *** cartographic method made it possible to visualize the *** results of the research show that the ethnocultural heritage of the North-East Caucasus is formed by material(historical and cultural monuments)and immaterial elements of culture(language,customs,traditions,ethnic identification)of those peoples,who live *** ethnocultural heritage is considered as the most important factor in the development of the tourism *** is revealed that this region has a large potential for development in various areas of *** highest concentration of religious buildings focused in mountainous *** tower structures were erected in mountainous and high-altitude *** ancient times to the present day there have been preserved various types of crafts and trades(pottery,metalworking,burka making,jewelry making,carpet weaving,gold embroidery,wood and stone carving,etc.),which can become objects of *** ethnocultural heritage of the North-East Caucasus needs to be preserved a

关键词： Mountainous districts Sustainable development Prospects Stone Towers Folk crafts

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FPGA Accelerators for Computing Interatomic Potential-Based Molecular Dynamics Simulation for Gold Nanoparticles:Exploring Different Communication Protocols

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Computers, Materials & Continua 2024年第9期80卷 3803-3818页

作者： Ankitkumar patel Srivathsan Vasudevan Satya Bulusu Department of Electrical Engineering Indian Institute of Technology IndoreIndore453552India Department of Chemistry Indian Institute of Technology IndoreIndore453552India

Molecular Dynamics(MD)simulation for computing Interatomic Potential(IAP)is a very important High-Performance Computing(HPC)*** simulation on particles of experimental relevance takes huge computation time,despite using an expensive high-end *** computing,a combination of the Field Programmable Gate Array(FPGA)and a computer,is proposed as a solution to compute MD simulation *** such heterogeneous computation,communication between FPGA and Computer is *** such MD simulation,explained in the paper,is the(Artificial Neural Network)ANN-based IAP computation of gold(Au_(147)&Au_(309))*** simulation calculates the forces between atoms and the total energy of the chemical *** work proposes the novel design and implementation of an ANN IAP-based MD simulation for Au_(147)&Au_(309) using communication protocols,such as Universal Asynchronous Receiver-Transmitter(UART)and Ethernet,for communication between the FPGA and the host *** improve the latency of MD simulation through heterogeneous computing,Universal Asynchronous Receiver-Transmitter(UART)and Ethernet communication protocols were explored to conduct MD simulation of 50,000 *** this study,computation times of 17.54 and 18.70 h were achieved with UART and Ethernet,respectively,compared to the conventional server time of 29 h for Au_(147) *** results pave the way for the development of a Lab-on-a-chip application.

关键词： Ethernet hardware accelerator heterogeneous computing interatomic potential(IAP) MDsimulation peripheral component interconnect express(PCIe) UART

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Optimization of gas lift system for well performance improvement in Asmari formation:A techno-economic perspective

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Petroleum Research 2024年第1期9卷 115-124页

作者： hari Sreenivasan Jash patel Dev Jain Setu patel Isaac Wilson shanker Krishna Drilling Cementing&Stimulation(DCS)Research CentreDepartment of Petroleum EngineeringSchool of Energy Technology(SoET)Pandit Deendayal Energy University(PDEU)Knowledge CorridorRaysanGandhinagarGujarat382426India

Well productivity in the Asmari carbonate formation of southwest Iran has decreased in recent years as a result of production *** production rate must be maintained below 1500 STB/day to prevent water *** this study,a gas lift well is modeled using data from one of the producing wells of this *** analysis is performed using lift-gas injection rates and wellhead pressures at different reservoir pressures and water cut conditions to optimize *** aspects are considered to optimize the artificial gas injection rates at different tubing head pressures and water cut *** the lift-gas injection rate from 0.4 MMscf/day to 1 MMscf/day enhances the oil production rate by 37.71%and 43.89%for 10%and 30%water cut conditions,*** injection rates of 5.2 MMscf/day and 5.4 MMscf/day are determined to be economically optimal for 30%water cut with tubing head pressures of 260 psig and 270 psig,respectively.

关键词： Production enhancement Artificial lift Gas lift Asmari carbonate formation Techno-economic analysis Well productivity

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Predictive active control of building structures using LQR and artificial intelligence

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 489-502页

作者： Nirmal S.Mehta Vishisht Bhaiya K.A.patel Ehsan Noroozinejad Farsangi Department of Civil Engineering SVNIT SuratGujarat 395007India Urban Transformations Research Centre Western Sydney UniversityNSWAustralia

This study presents a neural network-based model for predicting linear quadratic regulator(LQR)weighting matrices for achieving a target response *** on the expected weighting matrices,the LQR algorithm is used to determine the various responses of the *** responses are determined by numerically analyzing the governing equation of motion using the state-space *** training a neural network,four input parameters are considered:the time history of the ground motion,the percentage reduction in lateral displacement,lateral velocity,and lateral acceleration,Output parameters are LQR weighting *** study the effectiveness of an LQR-based neural network(LQRNN),the actual percentage reduction in the responses obtained from using LQRNN is compared with the target percentage ***,to investigate the efficacy of an active control system using LQRNN,the controlled responses of a system are compared to the corresponding uncontrolled *** trained neural network effectively predicts weighting parameters that can provide a percentage reduction in displacement,velocity,and acceleration close to the target percentage *** on the simulation study,it can be concluded that significant response reductions are observed in the active-controlled system using ***,the LQRNN algorithm can replace conventional LQR control with the use of an active control system.

关键词： active control system linear quadratic regulator artificial neural networks state-space approach response effectiveness factor resilience

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Colorimetric Sensor for Detection of Tabun Mimic Diethyl Cyanophosphonate

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Journal of Analysis and Testing 2024年第3期8卷 374-384页

作者： Madhu Bala Dheeraj Pandey Nikita patel sheetal Yadav Abha Sharma Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research RaebareliTransit Campus

Herein,a colorimetric chemosensor （probe 7） was designed and synthesized for sensing diethyl cyanophosphonate （DCNP）,a Tabun nerve agent *** sensitive,selective,fast response and photostable probe 7 in dimethylsulfoxide （DMSO）responded to DCNP at low concentrations with visual naked eye color change from pink to pale yellow and displayed unresponsive behaviour against various interferences except for copper ions,which can be di?erentiated by adding ethylene diamine where the yellow color persisted in the case of DCNP but turned to pink in the case of copper ***,the yellow aqueous solution of probe 7 at pH 10 and 12 turned colorless against the response of *** limit of detection（LOD） of probe 7 was found to be 50 nmol/L in an aqueous basic solution at pH 10 for the detection of *** formation of the cyclized product was elucidated by1H and31P NMR nuclear magnetic resonance (1H NMR,31P NMR),Fourier transform infrared spectroscopy （FTIR）,and high-resolution mass spectrometry （HRMS） ***?lter paper and silica plate loaded with probe 7 were fabricated for real-time and on-site detection of DCNP.

关键词： Chemosensor Colorimetric Fluorescence Tabun mimic

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Enhancing Canola Yield and Photosynthesis under Water Stress with Hydrogel Polymers

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1623-1645页

作者： Elham A.Badr Gehan sh.Bakhoum Mervat sh.Sadak Ibrahim Al-Ashkar Mohammad Sohidul Islam Ayman El Sabagh Magdi T.Abdelhamid Field Crops Research Department National Research CentreCairo12622Egypt Botany Department National Research CentreCairo12622Egypt Plant Production Department College of Food and Agriculture SciencesKing Saud UniversityRiyadh12271Saudi Arabia Department of Agronomy Hajee Mohammad Danesh Science and Technology UniversityDinajpur5200Bangladesh Department of Field Crops Faculty of AgricultureSiirt UniversitySiirt56100Turkey Department of Agronomy Faculty of AgricultureKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Research Centers Montana State UniversityBozemanMT 59717USA

While Egypt’s canola production per unit area has recently grown,productivity remains low,necessitating increased *** are water-absorbent polymer compounds that can optimize irrigation schedules by increasing the soil’s ability to retain ***,twoﬁeld experiments were conducted to examine hydrogel application to sandy soil on canola growth,biochemical aspects,yield,yield traits,and nutritional quality of yielded seeds grown under water deﬁcit stress *** experiments were conducted by arranging a split-plot layout in a randomized complete block design(RCBD)with three times replications of each *** water stress at 75%or 50%of crop evapotranspiration(ETc)lowered chlorophyll a,chlorophyll b,caro-tenoids,and total pigments content,indole-3-acetic acid,plant development,seed yield,and oil and total carbo-hydrates of seed yield,hydrogel treatment enhanced all of the traits mentioned ***,hydrogel enhanced to gather compatible solutes(proline,amino acids,total soluble sugars),phenolics content in leaves,seed protein,and crop water productivity,which increased while the plants were under water *** results revealed that the full irrigation(100%ETc)along with hydrogel compared to water-stressed(50%ETc)led to enhanced seed yield(kg ha^(-1)),Oil(%),and Total carbohydrates(%)of rapeseed by 57.1%,11.1%and 15.7%,***,under water-stressed plots with hydrogel exhibited enhancement by 10.0%,3.2%and 5.1%in seed yield(kg ha^(-1)),oil(%),and total carbohydrates(%)of rapeseed by 57.1%,11.1%and 15.7%,respec-tively compared to *** a result,the use of hydrogel polymer will be a viable and practical solution for increasing agricultural output under water deﬁcit stress situations.

关键词： Hydrogel oil osmolytes rapeseed yield water stress

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Hepatocellular carcinoma presenting as an extrahepatic mass:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2241-2252页

作者： Wei Kelly Wu Krutika patel Chandrasekhar Padmanabhan Kamran Idrees Department of Surgery Vanderbilt University Medical CenterNashvilleTN 37232United States Department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Division of Surgical Oncology and Endocrine Surgery Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States

BACKGROUND Hepatocellular carcinoma(HCC)is a primary liver tumor generally diagnosed based on radiographic *** disease is typically associated with increased tumor diameter,multifocality,and vascular *** report a case of a patient who presented with extrahepatic HCC metastasis to a portocaval lymph node with occult hepatic primary on computed tomography(CT).We review the literature for cases of extrahepatic HCC presentation without known hepatic lesions and discuss strategies to differentiate between metastatic and ectopic *** SUMMARY A 67-year-old male with remotely treated hepatis C was referred for evaluation of an enlarging portocaval,mixed cystic-solid *** CT evaluations demonstrated steatosis,but no cirrhosis or liver *** ultrasound demonstrated a normal-appearing pancreas,biliary tree,and *** needle aspiration yielded atypical *** differential diagnosis included duodenal or pancreatic cyst,lymphoproliferative cyst,stromal or mesenchymal lesions,nodal involvement from gastrointestinal or hematologic malignancy,or duodenal gastrointestinal stromal *** review by a multidisciplinary tumor board,the patient underwent open surgical resection of a 5.2 cm×5.5 cm retroperitoneal mass with pathology consistent with moderately-differentiated *** resonance imaging(MRI)subsequently demonstrated a 1.2 cm segment VIII hepatic lesion with late arterial enhancement,fatty sparing,and intrinsic T1 *** fetoprotein was 23.3 ng/*** patient was diagnosed with HCC with portocaval nodal ***:We surveyed the literature for HCC presenting as extrahepatic masses without history of concurrent or prior intrahepatic *** identified 18 cases of extrahepatic HCC ultimately found to represent metastatic lesions,and 30 cases of extrahepatic HCC found to be primary,ectopic *** Hepatocellular carcinoma can seldomly present with extrahepatic metastasis in the setting of

关键词： Extrahepatic Metastasis Portocaval Lymph node Case report

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Synergistic Swarm Optimization Algorithm

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2557-2604页

作者： Sharaf Alzoubi Laith Abualigah Mohamed Sharaf Mohammad sh.Daoud Nima Khodadadi Heming Jia Faculty of Computer Sciences and Informatics Amman Arab UniversityAmman11953Jordan Computer Science Department Al Al-Bayt UniversityMafraq25113Jordan Department of Electrical and Computer Engineering Lebanese American UniversityByblos13-5053Lebanon Hourani Center for Applied Scientific Research Al-Ahliyya Amman UniversityAmman19328Jordan MEU Research Unit Middle East UniversityAmman11831Jordan Applied Science Research Center Applied Science Private UniversityAmman11931Jordan School of Computer Sciences Universiti Sains MalaysiaPulau Pinang11800Malaysia School of Engineering and Technology Sunway University MalaysiaPetaling Jaya27500Malaysia Department of Industrial Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia College of Engineering Al Ain UniversityAbu Dhabi112612United Arab Emirates Department of Civil and Architectural Engineering University of MiamiCoral Gables1251USA School of Information Engineering Sanming UniversitySanming365004China

This research paper presents a novel optimization method called the Synergistic Swarm Optimization Algorithm(SSOA).The SSOA combines the principles of swarmintelligence and synergistic cooperation to search for optimal solutions efficiently.A synergistic cooperation mechanism is employed,where particles exchange information and learn from each other to improve their search *** cooperation enhances the exploitation of promising regions in the search space while maintaining exploration ***,adaptive mechanisms,such as dynamic parameter adjustment and diversification strategies,are incorporated to balance exploration and *** leveraging the collaborative nature of swarm intelligence and integrating synergistic cooperation,the SSOAmethod aims to achieve superior convergence speed and solution quality performance compared to other optimization *** effectiveness of the proposed SSOA is investigated in solving the 23 benchmark functions and various engineering design *** experimental results highlight the effectiveness and potential of the SSOA method in addressing challenging optimization problems,making it a promising tool for a wide range of applications in engineering and *** codes of SSOA are available at:https://***/matlabcentral/fileexchange/153466-synergistic-swarm-optimization-algorithm.

关键词： Synergistic swarm optimization algorithm optimization algorithm metaheuristic engineering problems benchmark functions

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Design,optimization,and characterization of an in-situ pore-forming system for controlled delivery of paliperidone

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Medicine in Novel Technology and Devices 2024年第1期21卷 71-79页

作者： Priya Pate Bhumi Ladani Gayatri patel Ramanbhai patel College of Pharmacy Charotar University of Science and TechnologyCHARUSAT–CampusChanga388421AnandGujaratIndia

The purpose of the current investigation was to develop a pharmaceutical equivalent osmotic drug delivery formulation of Paliperidone(PLD)in the form of controlled porosity osmotic pump tablets(CPOT)in order to keep the drug's steady state concentration in the *** helps to achieve the greatest therapeutic benefit with the fewest side *** the purpose of identifying various formulation attributes,preliminary trials were *** design was used to study the influence of seven input factors namely drug to polymer ratio,polymer 1(HPMC K100 M)to polymer 2(HPMC K15M),drug to total osmogens,coating level,amount of pore former,concentration of ethyl cellulose and amount of plasticizer on dependent variable similarity factor(f2).Utilizing the Minitab 17,data analysis was *** similarity factor(f2)was computed using the osmotic tablet reference product INVEGA®.The findings demonstrate that each of the seven independent variables significantly affects the similarity *** optimized batch,both core and coated tablets showed acceptable pharmaco-technical *** release profile of the optimized batch tablets was found to be similar to that of reference product with good zero-order release *** release was observed through the channels formed by in-situ pores on tablet surface performed using *** the results it can be concluded that prepared CPOT of PLD was found pharmaceutical equivalent with commercial product which is cost effective and fully compliance with cGMP.

关键词： Controlled release pH-independent release Similarity factor Pharmaceutical equivalent Reference product

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Therapeutic nucleic acids in regenerative medicine and tissue repair

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Nano Research 2024年第10期17卷 8942-8976页

作者： Qimanguli Saiding Duotian Qin Soohwan An Dylan Neal patel Muhammad Muzamil Khan Na Kong Wei Tao Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA

In the vanguard of biomedical innovation,regenerative medicine emerges as a transformative paradigm,concentrating its efforts on rectifying tissue deficits and functional aberrations in patients through the strategic augmentation of endogenous cellular *** to this approach is nucleic acid therapy,which offers a novel pathway for tissue regeneration by modulating key signaling *** one of the most effective ways to regulate cell function,nucleic acids are crucial for various tissue regeneration;however,their in vivo therapeutic applications face substantial challenges,including nuclease degradation,cell membrane impermeability,and targeted intracellular ***-based gene delivery systems offer a solution for stable and localized drug delivery by enabling the controlled overexpression of therapeutic nucleic acids,producing functional regulatory *** review presents examples of nucleic acid applications in regenerative medicine,highlighting the synergy between nucleic acids and biomaterial *** underlines the importance of nucleic acid delivery techniques,the choice of therapeutic nucleic acids,and biomaterials for advancing tissue *** latest developments in designing nucleic acid biomaterial-based delivery vehicles are explored,the mechanism of nucleic acids in tissue regeneration is elucidated,and their limitations are discussed while considering future directions for the clinical translation of nucleic acid-based therapeutics.

关键词： tissue repair nucleic acids biomaterials delivery systems regenerative medicine

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