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A study of a slim compact piezo inertia actuator

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纳米技术与精密工程(英文) 2023年第3期6卷 1-9页

作者： Pingping Sun haozhen zhang Huan Yu School of Physics and Information Engineering Jiangsu Second Normal UniversityNanjing 211200China

Most previously reported inertia actuators suffer from the problems of low speed and large *** overcome these shortcomings,this study proposes a slim compact piezo inertia actuator based on the principle of stick–slip *** by the transverse motion of a cantilever beam forming part of a monolithic elastomer,this actuator achieves a high *** construction and basic operating principle of the actuator are discussed in *** finite element analysis software is employed to determine the appropriate geometry for the monolithic *** study the actuator’s mechanical characteristics,a prototype is fabricated and a series of experimental tests are *** to the results of these tests,the maximum velocity and maximum load force are about 24.03 mm/s and 1.96 N,respectively,and the minimum step size is about 0.47μ*** is shown that the inertia actuator based on a monolithic elastomer with a cantilever beam not only has a slim compact structure,but also exhibits good output characteristics.

关键词： Piezo actuator Stick-slip Monolithic elastomer Cantilever beam Transverse motion

TGF-β1/Smad信号通路在肺纤维化中的作用及中医药调控研究进展

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中药药理与临床 2024年第1期40卷 123-128页

作者：李红梅张旭辉武妍琳张皓珍马泉张元李世霞杨亚茹甘肃中医药大学兰州730000 甘肃中医药大学附属医院兰州730030

肺纤维化(Pulmonary fibrosis,PF)是呼吸系统疾病中一类极为复杂难治的疾病,PF患者诊断后生存期极短,死亡率高,故被称为“类肿瘤疾病”,严重危害着人类健康。临床上常用的抗肺纤维化的药物主要有糖皮质激素、吡非尼酮、尼达尼布、N-乙... 详细信息

肺纤维化(Pulmonary fibrosis,PF)是呼吸系统疾病中一类极为复杂难治的疾病,PF患者诊断后生存期极短,死亡率高,故被称为“类肿瘤疾病”,严重危害着人类健康。临床上常用的抗肺纤维化的药物主要有糖皮质激素、吡非尼酮、尼达尼布、N-乙酰半胱氨酸、等,但这些药物皆存在不良反应多、价格昂贵、疗效欠佳等诸多弊端。研究发现PF的病理过程十分复杂,涉及多种机制,但其确切机制尚不明确。因此,阐明其潜在机制,提出安全有效的靶向治疗策略,是目前临床上治疗PF亟待解决的问题。大量研究证实TGF-β1/Smad信号通路在肺纤维化的发展中发挥至关重要的作用。中医药在防治肺纤维化方面具有独特优势和良好前景,其中有不少中药或中药复方可靶向调节TGF-β1/Smad信号通路。本文就TGF-β1/Smad信号传导通路在肺组织纤维化中的调控作用以及近7年来中医药靶向调控TGF-β1/Smad信号传导通路防治肺纤维化研究进展作简要综述,以期为临床中医药防治肺纤维化提供理论支撑。

关键词：肺纤维化转化生长因子β1/Smad信号通路中医药调控研究进展

BiOBr/COF S-scheme photocatalyst for H_(2)O_(2) production via concerted two-electron pathway

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Journal of Materials Science & Technology 2023年第35期166卷 241-249页

作者： haozhen zhang Jingjing Liu Yong zhang Bei Cheng Bicheng Zhu Linxi Wang Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of Geosciences68 Jincheng StreetWuhan 430078China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Constructing step-scheme(S-scheme)heterojunctions has become a popular strategy for efficient pho-tocatalytic H_(2)O_(2) ***,we in situ grew BiOBr nanosheets(NSs)on a Schiff-base covalent organic framework(COF)with largeπ-conjugated structures to prepare S-scheme BiOBr/COF photocat-alysts for H_(2)O_(2) *** highest photocatalytic H_(2)O_(2) production performance of the composite sample constituting the S-scheme heterojunction is 3749μmol g−1 h−1,which was 1.85 and 27 times the rates of COF and BiOBr,*** construction of S-scheme heterojunction contributed to ef-ficient carrier transfer and separation in space and enhanced redox ***,the lying-down O_(2)-adsorption configuration on the COF surface favors the concerted two-electron O_(2) reduction process,which greatly reduced the reduction potential requirement for O_(2)-to-H_(2)O_(2) *** synergy be-tween the S-scheme heterojunction and the unique O_(2)-COF interaction boosted photocatalytic H_(2)O_(2) pro-duction activity.

关键词： S-scheme heterojunction Photocatalytic H_(2)O_(2)production Covalent organic frameworks Concerted two-electron O_(2)reduction O_(2)-adsorption configuration

Overexpression of Wheat TaELF3-1BL Delays Flowering in Arabidopsis

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Phyton-International Journal of Experimental Botany 2023年第1期92卷 79-90页

作者： Junsheng Sun haozhen zhang Mingxia zhang Sishen Li Yanrong An State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai’an271018China

EARLY FLOWERING 3(ELF3),a light zeitnehmer(time-taker)gene,regulates circadian rhythm and photoperiodic flowering in Arabidopsis,rice,and *** three orthologs of ELF3(TaELF3-1AL,TaELF3-1BL,and TaELF3-1DL)have been identified in wheat too,and one gene,TaELF3-1DL,has been associated with heading ***,the basic characteristics of these three genes and the roles of the other two genes,TaELF3-1BL and,TaELF3-1AL,remain ***,the present study obtained the coding sequences of the three orthologs(TaELF3-1AL,TaELF3-1BL,and TaELF3-1DL)of ELF3 from bread wheat and characterized them and investigated the role of TaELF3-1BL in *** sequence comparison revealed similarities among the three TaELF3 genes of wheat;however,they were different from the Arabidopsis ***-time quantitative PCR revealed TaELF3 expression in all wheat tissues tested,with the highest expression in young spikes;the three genes showed rhythmic expression patterns ***,the overexpression of the TaELF3-1BL gene in Arabidopsis delayed flowering,indicating their importance in *** overexpression of TaELF3-1BL in the Arabidopsis ELF3 nonfunctional mutant(elf3 mutant)eliminated its early flowering phenotype,and slightly delayed *** wild-type Arabidopsis overexpressing TaELF3-1BL demonstrated reduced expression levels of flowering-related genes,such as CONSTANS(AtCO),FLOWERING LOCUS T(AtFT),and GIGANTEA(AtGI).Thus,the study characterized the three TaELF3 genes and associated TaELF3-1BL with flowering in Arabidopsis,suggesting a role in regulating flowering in wheat *** findings provide a basis for further research on TaELF3 functions in wheat.

关键词： TaELF3 photoperiod flowering time Arabidopsis Triticum aestivum L

Self-assembled manganese phthalocyanine nanoparticles with enhanced peroxidase-like activity for anti-tumor therapy

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Nano Research 2022年第3期15卷 2347-2354页

作者： Jinghan Wang Shanqing Gao Xiao Wang haozhen zhang Xitong Ren Juewen Liu Feng Bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High efficiency Display and Lighting TechnologySchool of Materials Science and Engineeringand Collaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China Department of Chemistry Waterloo Institute for NanotechnologyWaterlooOntario N2L 3G1Canada Henan and Macquarie University Joint Centre for Biomedical Innovation School of Life SciencesHenan UniversityKaifeng 475004China

The use of functional nanoparticles as peroxidase-like(POD-like)catalyst has recently become a focus of research in cancer *** is a macrocyclic conjugated metal ligand,which is expected to achieve a high POD-like catalytic activity,generating free radicals and inhibiting the proliferation of cancer *** this paper,we synthesized phthalocyanine nanocrystals with different structures through noncovalent self-assembly confined within micro-emulsion droplets,and manganese phthalocyanine(MnPc)possessing a metal–N–C active center was used as the building *** nano-assemblies exhibit shape-dependent POD-like catalytic activities,because the emulsifier and MnPc co-mixed assembly reduced the close packing between MnPc molecules and exposed more active *** assembly had a water-dispersed nanostructure,which is conducive to accumulation at tumor sites through the enhanced permeability and retention effect(EPR).Because of a highly efficient microenvironmental response,the assembly showed higher catalytic activity only emerged under the acidic tumor-like microenvironment,but caused less damage to normal tissues in biomedical *** vivo and in vitro catalytic therapy tests showed excellent anti-tumor *** work explored a new way for the application of metal–organic macromolecules such as MnPc as nanozymes for catalytic tumor therapy.

关键词： self-assembly manganese phthalocyanine nanozymes peroxidase catalytic therapy

Engineered stem cells by emerging biomedical stratagems

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Science Bulletin 2024年第2期69卷 248-279页

作者： Jinglin Wang Xiaoxuan zhang Hanxu Chen haozhen Ren Min Zhou Yuanjin Zhao Department of Vascular Surgery.Nanjing Drum Tower Hospital Affliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Division of Hepatobiliary Surgery and Transplantation Surgery Department of General SurgeryNanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shenzhen Research Institute Southeast UniversityShenzhen 518038China

Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable *** the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical *** the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are *** optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell *** review offers a detailed analysis of engineered stem cells,including their clinical applications and potential for future *** begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(ipsCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molecular biology and biomaterial fields,and their application in biomedical ***,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications.

关键词： Stem cells Genetic modification Biomaterials Microfluidics Organ-on-a-chip Bioprinting

Preliminary build and application of a data analysis platform for coiled tubing steel strips

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Baosteel Technical Research 2022年第3期16卷 19-26页

作者： zhang haozhen zhang Chuanguo WANG Pengjian Research Institute Baoshan Iron&Steel Co.Ltd.Shanghai 201999China Products&Technique Management Department Baoshan Iron&Steel Co.Ltd.Shanghai 201900China

To solve the problems in the quality control and improvement of coiled tubing steel strips production, such as scattered and inefficient production data, difficult performance fluctuation factor analysis, complex multivariate statistical analysis, and low accuracy and difficulty in mechanical property prediction, an industrial data analysis platform for coiled tubing steel strips production has been preliminarily *** the premise and foundation of analysis, industrial data collection, storage, and utilization are realized by using multiple big data *** Django as the agile development framework, data visualization and comprehensive analyses are *** platform has functions including overview survey, stability analysis, comprehensive analysis(such as exploratory data analysis, correlation analysis, and multivariate statistics),precise steel strength prediction, and skin-passing process *** platform is helpful for production overviewing and prompt responding, laying a foundation for an in-depth understanding of product characteristics and improving product performance stability.

关键词： coiled tubing steel strips industrial big data data analysis platform prediction

Polysulfide regulation by defect-modulated Ta_(3)N_(5-x) electrocatalyst toward superior room-temperature sodium-sulfur batteries

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Science Bulletin 2024年第2期69卷 197-208页

作者： Zhen zhang Dan Luo Jun Chen Chuyin Ma Matthew Li Haoze zhang Renfei Feng Rui Gao haozhen Dou Aiping Yu Xin Wang Zhongwei Chen Department of Chemical Engineering Waterloo Institute for NanotechnologyUniversity of WaterlooWaterloo N2L 3G1Canada Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China South China Academy of Advanced Optoelectronics&International Academy of Optoelectronics at Zhaoqing South China Normal UniversityGuangzhou 510006China Chemical Sciences and Engineering Division Argonne National LaboratoryLemont 60439USA Canadian Light Source Saskatoon S7N 2V3Canada

Resolving low sulfur reaction activity and severe polysulfide dissolution remains challenging in metalsulfur *** by a theoretical prediction,herein,we strategically propose nitrogenvacancy tantalum nitride(Ta3N5-x)impregnated inside the interconnected nanopores of nitrogendecorated carbon matrix as a new electrocatalyst for regulating sulfur redox reactions in roomtemperature sodium-sulfur *** a pore-constriction mechanism,the nitrogen vacancies are controllably constructed during the nucleation of *** defect manipulation on the local environment enables well-regulated Ta 5d-orbital energy level,not only modulating band structure toward enhanced intrinsic conductivity of Ta-based materials,but also promoting polysulfide stabilization and achieving bifunctional catalytic capability toward completely reversible polysulfide ***,the interconnected continuous Ta3N5-x-in-pore structure facilitates electron and sodium-ion transport and accommodates volume expansion of sulfur species while suppressing their shuttle *** to these attributes,the as-developed Ta3N5-x-based electrode achieves superior rate capability of 730 mAh g-1 at 3.35 A g-1,long-term cycling stability over 2000 cycles,and high areal capacity over 6 mAh cm-2 under high sulfur loading of 6.2 mg *** work not only presents a new sulfur electrocatalyst candidate for metal-sulfur batteries,but also sheds light on the controllable material design of defect structure in hopes of inspiring new ideas and directions for future research.

关键词： Tantalum nitride Nitrogen defects Sodium-sulfur batteries Electrocatalysts Polysulfide conversion

Asymmetric side-chain engineering of organic semiconductor for ultrasensitive gas sensing

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Chinese Chemical Letters 2024年第3期35卷 428-433页

作者： Xiaoying Ma Xiaojuan Dai Lanyi Xiang Jiajun Chang Danfeng Zhi haozhen Zhao Zhenjie Ni Ye Zou Xike Gao Fengjiao zhang School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Binzhou Institute of Technology Binzhou 256606China

Molecular structure of organic semiconductor plays a critical role in determining the performance and functionality of organic electronic devices,by optimizing the electrical,optical and physicochemical *** alkyl chains are fundamental units in tailering the solubility and assemblability,among which the asymmetric properties have been reported as key element for controlling the packing motifs and intrinsic charge ***,we expanded the scope of molecular asymmetry dependent sensing features based on a new series of naphthalene diimides(NDI)-based derivatives substituted with a same branching alkyl chain but various linear-shaped alkyl chains(Cn-).A clear molecular stacking change,from head-to-head bilayer to head-to-tail monolayer packing model,is observed based on the features of anisotropic molecular interactions with the change in the chain *** importantly,a unique LUMO level shift of 0.17 eV is validated for NDI-PhC4,providing a record sensitivity up to 150%to 0.01 ppb ammonia,due to the desired molecular reactivity and device amplification *** results indicate that asymmetric side-chain engineering opens a route for breath healthcare.

关键词： Organic thin film transistor Asymmetric side chain Gas sensing Molecular stacking Energy level manipulating