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Is it necessary to stop glucagon-like peptide-1 receptor agonists prior to endoscopic procedure? A retrospective study

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World Journal of Gastroenterology 2024年第26期30卷 3221-3228页

作者： Haider Ghazanfar Nismat Javed Abeer Qasim Franklin Sosa Faryal Altaf Shazia Khan Jaydeep Mahasamudram Abhilasha Jyala Sameer Datta Kandhi Dongmin Shin Nikhitha Mantri haozhe sun Siddarth Hanumanthu Harish Patel Jasbir Makker Bhavna Balar Anil Dev Sridhar Chilimuri Division of Gastroenterology Department of Internal MedicineBronxCare Health SystemIcahn School of Medicine at Mount SinaiBronxNY 10457United States Department of Internal Medicine BronxCare Health SystemIcahn School of Medicine at Mount SinaiBronxNY 10457United States

BACKGROUND Glucagon-like peptide-1 receptor agonists(GLP-1 RA)are effective in diabetes and obesity,reducing hyperglycemia by increasing insulin release and delaying gastric emptying.However,they can cause gastroparesis,raising concerns about aspiration during procedures.Recent guidelines advise discontinuing GLP-1 RA before surgery to reduce the risk of pulmonary aspiration.AIM To evaluate the effect of GLP-1 RAs on gastric residual contents during endosco-pic procedures.METHODS A retrospective chart review at BronxCare Health System,New York,from January 2019 to October 2023,assessed gastric residue and aspiration in GLP-1 RA patients undergoing endoscopic procedures.Two groups were compared based on dietary status before the procedure.Data included demographics,symptoms of gastroparesis,opiate use,hemoglobin A1c,GLP-1 agonist indication,endo-scopic details,and aspiration occurrence.IBM SPSS was used for analysis,cal-culating means,standard deviations,and applying Pearson’s chi-square and t-tests for associations,with P<0.05 as being significant.RESULTS During the study,306 patients were included,with 41.2%on a clear liquid/low residue diet and 58.8%on a regular diet before endoscopy.Most patients(63.1%)were male,with a mean age of 60±12 years.The majority(85.6%)were on GLP-1 RAs for diabetes,and 10.1%reported digestive symptoms before endoscopy.Among those on a clear liquid diet,1.5%had residual food at endoscopy compared to 10%on a regular diet,which was statistically significant(P=0.03).Out of 31 patients with digestive symptoms,13%had residual food,all from the regular diet group(P=0.130).No complications were reported during or after the procedures.CONCLUSION The study reflects a significant rise in GLP-1 RA use for diabetes and obesity.A 24-hour liquid diet seems safe for endoscopic procedures without aspiration.Patients with upper gastrointestinal symptoms might have a higher residual food risk,though not statistically significant.Further research is needed to assess risks based on diabetes duration,gast

关键词： Glucagon-like peptide-1 agonists Gastroparesis Endoscopic procedures Residual food Complications

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3D Model Construction and Ecological Environment Investigation on a Regional Scale Using UAV Remote Sensing

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Intelligent Automation & Soft Computing 2023年第8期37卷 1655-1672页

作者： Chao Chen Yankun Chen Haohai Jin Li Chen Zhisong Liu haozhe sun Junchi Hong Haonan Wang Shiyu Fang Xin Zhang School of Geography Science and Geomatics Engineering Suzhou University of Science and TechnologySuzhou215009China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of ScienceBeijing100101China School of Information Engineering Zhejiang Ocean UniversityZhoushan316022China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan316022China China Aero Geophysical and Remote Sensing Center for Natural Resources Beijing100083China

The acquisition of digital regional-scale information and ecological environmental data has high requirements for structural texture,spatial res-olution,and multiple parameter categories,which is challenging to achieve using satellite remote sensing.Considering the convenient,facilitative,and flexible characteristics of UAV(unmanned air vehicle)remote sensing tech-nology,this study selects a campus as a typical research area and uses the Pegasus D2000 equipped with a D-MSPC2000 multi-spectral camera and a CAM3000 aerial camera to acquire oblique images and multi-spectral data.Using professional software,including Context Capture,ENVI,and ArcGIS,a 3D(three-dimensional)campus model,a digital orthophoto map,and multi-spectral remote sensing map drawing are realized,and the geometric accuracy of typical feature selection is evaluated.Based on a quantitative remote sensing model,the campus ecological environment assessment is performed from the perspectives of vegetation and water body.The results presented in this study could be of great significance to the scientific management and sustainable development of regional natural resources.

关键词： Unmanned air vehicle multi-spectral camera oblique photography 3D model construction ecological environment investigation regional scale

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恢复梯度上华中亚热带森林生物多样性、林分因子及功能特性对生物量、生产力的影响

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Journal of Plant Ecology 2022年第2期15卷 385-398页

作者： Wenhao Miao Shupeng Ma Zhiwen Guo haozhe sun Xuemei Wang Yueming Lyu Xiangping Wang School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China

草地群落上进行的控制实验大都发现生物多样性对生态系统功能有显著促进作用。然而,在天然林中,多样性与林分因子、群落功能特性的相对作用大小仍存在争议。本文在森林恢复梯度上,研究这3类因素对生物量和生产力的相对影响。我们在湖北... 详细信息

草地群落上进行的控制实验大都发现生物多样性对生态系统功能有显著促进作用。然而,在天然林中,多样性与林分因子、群落功能特性的相对作用大小仍存在争议。本文在森林恢复梯度上,研究这3类因素对生物量和生产力的相对影响。我们在湖北神农架设置了处于不同恢复阶段的24块(600 m2)亚热带森林样地,计算了林分生物量和生产力。选择5个关键的植物功能性状,并计算了群落的功能多样性(功能丰富度、功能均匀度和功能离散度)和性状的加权平均值(CWM)。使用一般线性模型(GLMs)、变异分离等方法探究林分因子(密度、林龄、群落最大树高等)、功能特性、物种和功能多样性对生物量和生产力的相对重要性。研究结果表明,随着森林恢复,林分生物量和生产力显著增加,群落物种丰富度显著增加,而功能离散度显著降低。变异分离结果表明,多样性对生物量和生产力的单独效应不显著,但可能通过与林分因子和功能特性的协同效应来影响生物量和生产力。总体而言,我们发现林分因子对亚热带森林生物量和生产力的影响最大,功能特性显著影响生产力,但不影响生物量。这些结果说明,在森林经营中,调整林分结构和群落物种特性是提高森林碳储量和固碳潜力的有效途径。

关键词： BEF(生物多样性和生态系统功能) 功能特性恢复阶段林分因子亚热带森林

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开环易位聚合制备液晶聚合物的研究进展

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复旦学报（自然科学版） 2024年第2期63卷 155-168,I0001页

作者：孙浩哲江凤翔韦嘉俞燕蕾复旦大学材料科学系上海200433 复旦大学义乌研究院浙江义乌322000

液晶聚合物(LCP)兼具液晶的各向异性和聚合物良好的力学性能,在传感器、检测器和柔性执行器等领域具有广阔的应用前景。开环易位聚合(ROMP)具有活性聚合特征、反应条件温和与官能团耐受性高的特点,可以精确调控液晶聚合物的分子量和分... 详细信息

液晶聚合物(LCP)兼具液晶的各向异性和聚合物良好的力学性能,在传感器、检测器和柔性执行器等领域具有广阔的应用前景。开环易位聚合(ROMP)具有活性聚合特征、反应条件温和与官能团耐受性高的特点,可以精确调控液晶聚合物的分子量和分子结构,是液晶聚合物研究中一种常用的合成方法。本文整理了近年来报道的由开环易位聚合制备液晶聚合物的研究,并从材料的构-效关系和功能开发两方面对这些研究进行了介绍。在构-效关系研究方面,分别介绍了液晶均聚物与液晶共聚物中的不同结构参数对材料性质的影响;在材料功能开发方面,介绍了液晶聚合物在光致形变、形状记忆效应、光子晶体和图案化薄膜等应用领域的研究成果。最后,展望了开环易位聚合制备液晶聚合物未来的发展方向。

关键词：液晶聚合物开环易位聚合构-效关系功能聚合物

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风光互补发电制氢耦合合成氨系统的配置分析

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洁净煤技术 2024年第5期30卷 38-45页

作者：龚思琦杨洋李初福白祝洽孙浩哲张晓方许明北京低碳清洁能源研究院北京102211 国华(宁夏)新能源有限公司宁夏银川750001 国华能源投资有限公司北京100007

将可再生能源制氢与传统化工过程结合实现电-氢-化耦合,不仅可提高可再生能源的利用消纳,还有利于化工过程的绿色低碳转型。针对电-氢-化耦合系统中存在的可再生能源波动性与化工过程稳定性需求的矛盾,建立了大规模风光互补发电制氢-储... 详细信息

将可再生能源制氢与传统化工过程结合实现电-氢-化耦合,不仅可提高可再生能源的利用消纳,还有利于化工过程的绿色低碳转型。针对电-氢-化耦合系统中存在的可再生能源波动性与化工过程稳定性需求的矛盾,建立了大规模风光互补发电制氢-储氢-合成氨系统的配置模型,基于西北地区典型风光发电曲线研究风光配比、制氢容量、制氢最小负荷和氢气储罐体积等关键参数对系统运行的影响规律,并分析系统的全年运行特性。计算结果表明:当风光配比为8∶3且制氢容量与风光平均输出功率接近时,可在较小储罐体积工况下降低网电补充。制氢最小负荷降低和储罐体积增加有利于降低网电补充,有望实现系统纯绿电运行。当系统参数配置为风光配比8∶3、制氢容量400 MW、制氢最小负荷20%和氢气储罐体积100000 m^(3)时,全年平均网电补充比例在5%左右。对系统8760 h的模拟结果表明,制氢装置的负荷调节可减缓系统受风光发电波动的影响,通过储氢装置的进一步缓冲,可实现合成氨装置在50%~110%负荷的连续运转。

关键词：可再生能源制氢合成氨绿氨系统模拟

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Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality

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World Journal of Clinical Cases 2021年第29期9卷 8749-8762页

作者： Diana Ronderos Alaa Mabrouk Salem Omar Hafsa Abbas Jasbir Makker Ahmed Baiomi haozhe sun Nikhitha Mantri Yongsun Choi Ked Fortuzi Dongmin Shin Harish Patel Sridhar Chilimuri Department of Internal Medicine BronxCare Hospital CenterBronxNY 10457United States Department of Cardiology Mount Sinai Morning SideNew YorkNY 10023United States Division of Gastroenterology Department of MedicineBronxCare Health SystemBronxNY 10457United States

BACKGROUND There is little evidence about the association of pre-existing hepatitis C infection(HCV)with outcomes in patients with coronavirus disease 2019(COVID-19).AIM To assess the prevalence of history of HCV among patients with COVID-19 and to study the relationship of in-hospital mortality in relation with other predictors of poor outcomes in the presence or absence of COVID-19 induced acute liver injury.METHODS In a retrospective single-center study design,1193 patients with COVID-19 infection were studied.Patients were then classified into those with and without a history of HCV,50(4.1%)and 1157(95.9%)respectively.RESULTS Multivariate cox-regression models showed that age,HCV,D-Dimer,and ferritin were the only predictors of in-hospital mortality.Acute liver injury and fibrosis score(Fib-4 score)were not different between both groups.Multivariate coxregression model for liver profile revealed that aspartate aminotransferase/alanine aminotransferase ratio,Fib-4 score,and HCV were predictors of inhospital mortality.After propensity score matching HCV was the only predictor of mortality in the multivariate cox-regression model.A model including HCV was found to add predictive value to clinical and laboratory parameters.CONCLUSION In patients with COVID-19,history of HCV infection leads to an accentuated severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virulence,irrespective of baseline comorbidities,admission laboratory variables,or COVID-19-induced liver injury,which may be related to extrahepatic effects of HCV leading to enhanced ACE-2/TMPRSS mechanisms of SARS-CoV-2 viral entry,baseline cytokine-mediated pro-inflammation,and endothelial dysfunction.

关键词： Hepatitis C Acute liver injury Seropositive COVID-19 Mortality

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Patients with Clostridium difficile infection and prior appendectomy may be prone to worse outcomes

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World Journal of Gastrointestinal Surgery 2021年第11期13卷 1436-1447页

作者： Danial Haris Shaikh Harish Patel Rezwan Munshi haozhe sun Shehriyar Mehershahi Ahmed Baiomi Ahmed Alemam Usman Pirzada Iqra Nawaz Kamrun Naher Siddarth Hanumanthu Suresh Nayudu Division of Gastroenterology Department of MedicineBronxCare Health SystemBronxNY 10457United States Department of Medicine Nassau University Medical CenterNew YorkNY 11554United States Department of Medicine BronxCare Health SystemBronxNY 10457United States

BACKGROUND Clostridium difficile infection(CDI)occurs due to a dysbiosis in the colon.The appendix is considered a‘safe house’for gut microbiota and may help repopulate gut flora of patients with CDI.AIM To study the impact of prior appendectomy on the severity and outcomes of CDI.METHODS We retrospectively reviewed data of 1580 patients with CDI,admitted to our hospital between 2008 to 2018.Patients were grouped based on the presence or absence of the appendix.The primary aim was to(1)assess all-cause mortality and(2)the severity of CDI.Severity was defined as per the Infectious Diseases Society of America criteria.Logistic regression,and propensity score analysis using inverse probability of treatment weights(IPTW)was performed.RESULTS Of the 1580 patients,12.5%had a history of appendectomy.There was no statistical difference in mortality between patients with a prior appendectomy or without(13.7%vs 14%,P=0.877).However,a history of appendectomy affected the severity of CDI[odds ratio(OR)=1.32,95%confidence interval:1.01-1.75].On IPTW,this association remained significant(OR=1.59,P<0.05).On multivariable toxic megacolon(OR=5.37,P<0.05)and colectomy(OR=2.77,P<0.05).CONCLUSION Prior appendectomy may affect the severity of CDI,development of toxic megacolon and the eventual need for colectomy.Since treatment of CDI is governed by its severity,stronger antibiotic regimens or earlier use of fecal microbiota transplant may be a viable option for patients with prior appendectomy.

关键词： Appendectomy Clostridium difficile Toxic megacolon Colectomy Gut microbiome

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The Impact of the ＂Replace the Business Tax with VAT＂ on the Enterprises Tax Burden

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International English Education Research 2018年第4期 47-49页

作者： sun haozhe School of Management Shanghai University of Engineering Science shanghai 201620

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公务员正当行使“抵抗权”问题研究——以夏明旭、刘予勇滥用职权案为例

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法律适用 2022年第3期 134-142页

作者：孙昊哲路禹臻首都经济贸易大学首都经济贸易大学法学院

《公务员法》第60条规定了公务员执行上级有错误或者违法的命令时,可以根据上级命令的具体情况,做出不同的抉择并由此而产生相应的法律后果。这一制度设计,包含两层重要内容。其一,公务员作为特殊的公民主体,法律赋予其在执行公务行为... 详细信息

《公务员法》第60条规定了公务员执行上级有错误或者违法的命令时,可以根据上级命令的具体情况,做出不同的抉择并由此而产生相应的法律后果。这一制度设计,包含两层重要内容。其一,公务员作为特殊的公民主体,法律赋予其在执行公务行为时保障其权益的“抵抗权”。其二,公务员作为政府部门和相关机构中从事公共事务的专职人员,其权力行使势必受到法律约束,其公务行为触犯法律也应受到相应制裁。与此同时,公务人员大多是基于上级的命令而执行公务,这种行为关系实际上增加了违法追责的复杂性和难度。其中,焦点之一在于公务员执行上级明显违法命令时是否获罪又应如何追责。2017年发生的“夏明旭、刘予勇滥用职权案”(以下简称“夏案”)被称为全国首例公务员执行上级命令获罪案,该案为《公务员法》第60条更好地应用于司法实践以及相关法律制度的完善提供了很好的范例借鉴。本文以“夏案”为例,围绕“抵抗权”的法理依据、认知维度、有限性等相关法律问题展开深入分析,并针对司法实践中如何完善《公务员法》第60条,提出了上级决定或命令的发布形式、错误或者违法命令的界定、完善公务员问责体系以及加强“但书”司法解释等意见和建议。

关键词：公务员抵抗权明显违法命令权责一致

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Identification of new cotton fiber-quality QTL by multiple genomic analyses and development of markers for genomic breeding

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The Crop Journal 2024年第3期12卷 866-879页

作者： haozhe Tan Binghui Tang Mengling sun Qiulu Yin Yizan Ma Jianying Li Pengcheng Wang Zhonghua Li Guannan Zhao Maojun Wang Xianlong Zhang Chunyuan You Lili Tu National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina Cotton Research Institute Shihezi Academy of Agriculture ScienceShihezi 832000XinjiangChina

Cotton fiber is one of the main raw materials for the textile industry.In recent years,many cotton fiber quality QTL have been identified,but few were applied in breeding.In this study,a genome wide association study(GWAS)of fiber-quality traits in 265 upland cotton breeding intermediate lines(GhBreeding),combined with genome-wide selective sweep analysis(GSSA)and genomic selection(GS),revealed 25 QTL.Most of these QTL were ignored by only using GWAS.The CRISPR/Cas9 mutants of GhMYB_D13 had shorter fiber,which indicates the credibility of QTL to a certain extent.Then these QTL were verified in other cotton natural populations,5 stable QTL were found having broad potential for application in breeding.Additionally,among these 5 stable QTL,superior genotypes of 4 showed an enrichment in most improved new varieties widely cultivated currently.These findings provide insights for how to identify more QTL through combined multiple genomic analysis to apply in breeding.

关键词： Cotton fiber quality breeding GWAS Genome-wide selective sweep analysis Genomic selection InDel markers

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