检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

压片机充填过程影响因素的研究进展

中国医药工业杂志 2010年第8期41卷 610-614页

作者：虞雅萍陈岚施昊韫上海理工大学医疗器械与食品学院上海200093

压片机充填过程分为重力充填、强迫式充填和附加的吸入式充填,充填过程粉末颗粒的流动性决定片重差异。本文从实验研究和数值计算两方面综述影响以上几种充填过程粉末颗粒流动性的重要因素,包括粉末颗粒性质、充填环境、机器结构及运行... 详细信息

压片机充填过程分为重力充填、强迫式充填和附加的吸入式充填,充填过程粉末颗粒的流动性决定片重差异。本文从实验研究和数值计算两方面综述影响以上几种充填过程粉末颗粒流动性的重要因素,包括粉末颗粒性质、充填环境、机器结构及运行参数。

关键词：压片机充填过程粉末颗粒性质机器结构运行参数综述

强迫加料器叶轮转速对压片机充填影响的数值模拟和试验研究

在线全文

学校读者我要写书评

暂无评论

中国医药工业杂志 2011年第11期42卷 819-822页

作者：施昊韫陈岚虞雅萍陈露真上海理工大学医疗器械与食品学院上海200093 上海天祥.健台制药机械有限公司上海200040

以GZPK3037型高速旋转式压片机强迫加料器为研究对象,采用试验和数值模拟相结合的方式研究了强迫加料器不同叶轮转速对压片机充填性能的影响。选择欧拉法为气固两相流研究方法,采用有限体积法对欧拉方程进行离散,分析了叶轮转速变化对... 详细信息

以GZPK3037型高速旋转式压片机强迫加料器为研究对象,采用试验和数值模拟相结合的方式研究了强迫加料器不同叶轮转速对压片机充填性能的影响。选择欧拉法为气固两相流研究方法,采用有限体积法对欧拉方程进行离散,分析了叶轮转速变化对粉末充填的影响。计算和试验结果吻合较好,当叶轮转速为60 r/min时,粉末颗粒出口质量流量最大,片重差异最小,粉末颗粒流动性和充填效果最好。

关键词：压片机强迫加料器叶轮数值模拟粉末直接压片

Baseline radiologic features as predictors of efficacy in patients with pancreatic neuroendocrine tumors with liver metastases receiving surufatinib

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2023年第5期35卷 526-535页

作者： Jianwei Zhang Haibin Zhu Lin Shen Jie Li Xiaoyan Zhang Chunmei Bai Zhiwei Zhou Xianrui Yu Zhiping Li Enxiao Li Xianglin Yuan Wenhui Lou Yihebali Chi Nong Xu Yongmei Yin Yuxian Bai Tao Zhang Dianrong Xiu Jia Chen Shukui Qin Xiuwen Wang Yujie Yang haoyun shi Xian Luo Songhua Fan Weiguo Su Ming Lu Jianming Xu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Medical Oncology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastric Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510062China Department of Pancreatic and Hepatobiliary Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Abdominal Oncology West China HospitalSichuan UniversityChengdu 332001China Department of Medical Oncology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of General Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China Department of Medical Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology the First Affiliated Hospital of Zhejiang UniversityHangzhou 310009China Department of Medical Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Gastrointestinal Oncology Harbin Medical University Cancer HospitalHarbin 150081China Department of Oncology Union HospitalTongji Medical

Objective:Currently,pre-treatment prediction of patients with pancreatic neuroendocrine tumors with liver metastases(PNELM)receiving surufatinib treatment was *** objective was to examine the association between radiological characteristics and efficacy/***:We enrolled patients with liver metastases in the phase III,SANET-p trial(NCT02589821)and obtained contrast-enhanced computed tomography(CECT)*** and quantitative parameters including hepatic tumor margins,lesion volumes,enhancement pattern,localization types,and enhancement ratios were *** progression-free survival(PFS)and hazard ratio(HR)were calculated using Cox’s proportional hazard *** was analyzed by logistic-regression ***:Among 152 patients who had baseline CECT assessments and were included in this analysis,the surufatinib group showed statistically superior efficacy in terms of median PFS compared to placebo across various qualitative and quantitative *** the multivariable analysis of patients receiving surufatinib(N=100),those with higher arterial phase standardized enhancement ratio-peri-lesion(ASER-peri)exhibited longer PFS[HR=0.039;95%confidence interval(95%CI):0.003−0.483;P=0.012].Furthermore,patients with a high enhancement pattern experienced an improvement in the objective response ratio[31.3%vs.14.7%,odds ratio(OR)=3.488;95%CI:1.024−11.875;P=0.046],and well-defined tumor margins were associated with a higher disease control rate(DCR)(89.3%vs.68.2%,OR=4.535;95%CI:1.285−16.011;P=0.019)compared to poorlydefined ***:These pre-treatment radiological features,namely high ASER-peri,high enhancement pattern,and well-defined tumor margins,have the potential to serve as predictive markers of efficacy in patients with PNELM receiving surufatinib.

关键词： Neuroendocrine tumors liver metastases computed tomography surufatinib

在线全文

学校读者我要写书评

暂无评论

技术创新能破解国际分工低端锁定吗?

世界经济研究 2024年第4期 57-72,M0003页

作者：施贞怀石彦培赵浩云中国人民大学书报资料中心清华大学五道口金融学院中南大学商学院

出口企业自主创新是否有助于破解全球分工低端锁定?基于中国授权发明专利数据库、中国税收调查数据库、中国海关进出口数据库和作者测算得到的中国出口企业全球价值链位置数据库形成的多源匹配数据,文章首先对中国出口企业技术创新水平... 详细信息

出口企业自主创新是否有助于破解全球分工低端锁定?基于中国授权发明专利数据库、中国税收调查数据库、中国海关进出口数据库和作者测算得到的中国出口企业全球价值链位置数据库形成的多源匹配数据,文章首先对中国出口企业技术创新水平和企业全球价值链上游度进行了精准测度,在此基础上从创新数量和创新质量两个维度检验了出口企业技术创新对其全球价值链位置的影响,并检验了贸易方式、企业所有制、价值链升级方向等维度的异质性效应。同时,为了缓解反向因果带来的内生性问题,文章基于颗粒工具变量(GIVs)方法进行了内生性问题的处理,并从创新质量再测度、下游度、研发投入等角度进行了稳健性检验。研究发现:(1)中国出口企业技术创新有助于破解出口企业低端锁定,这同时体现在推动企业向全球价值链上游和下游攀升上;(2)就技术创新对企业全球价值链的影响而言,其质量效应显著高于数量效应;(3)技术创新对出口企业破解低端锁定的影响,在私营企业、一般贸易企业和下游主导型出口企业上体现得更加显著。上述结果在经过一系列内生性处理和稳健性检验后仍然成立。文章的研究丰富了技术创新和全球价值链等研究问题的内容和方法,也为探寻外贸高质量发展的可行路径提供了理论支撑。

关键词：技术创新全球价值链攀升低端锁定颗粒工具变量

基于修正Drucker-Prager Cap模型的片剂粉末压缩有限元分析

在线全文

学校读者我要写书评

暂无评论

中国医药工业杂志 2013年第1期44卷 88-94页

作者：佀国宁陈岚施昊韫谢蕴辉衡瑞林上海理工大学医疗器械与食品学院上海200093

采用修正Drucker-Prager Cap模型对乳糖的压缩过程进行了建模与有限元分析,系统研究了不同压缩速率和摩擦系数条件下的片剂特性。结果表明,压缩速率对片剂的上冲压力没有影响;压缩速度增大时,剪切应力增加,剪切应力带相应变大;当摩擦系... 详细信息

采用修正Drucker-Prager Cap模型对乳糖的压缩过程进行了建模与有限元分析,系统研究了不同压缩速率和摩擦系数条件下的片剂特性。结果表明,压缩速率对片剂的上冲压力没有影响;压缩速度增大时,剪切应力增加,剪切应力带相应变大;当摩擦系数减小时,粉末流动性增强,片剂密度更加均匀;当摩擦系数增大时,粉末与冲模之间的摩擦力变大,靠近冲模壁的粉末位移变小。通过对药物粉末压缩过程的研究,能预测片剂的性能,为片剂的实际生产提供理论参考。

关键词：修正Drucker-Prager Cap模型粉末压缩压缩速率摩擦系数有限元分析

在线全文

学校读者我要写书评

暂无评论

无线供电用植入式集成线圈建模

杭州电子科技大学学报（自然科学版） 2021年第1期41卷 25-30页

作者：石昊云程瑜华王高峰杭州电子科技大学电子信息工程学院浙江杭州310018

通过研究硅基集成线圈被多层介质包围下的线圈阻抗模型,提出新的精确寄生电容建模方法。先将多层介质简化成多个单层介质的叠加,再进行单层介质的等效介电常数拟合,从而提高线圈阻抗的建模精度。在硅基集成线圈的植入式无线供电系统中,... 详细信息

通过研究硅基集成线圈被多层介质包围下的线圈阻抗模型,提出新的精确寄生电容建模方法。先将多层介质简化成多个单层介质的叠加,再进行单层介质的等效介电常数拟合,从而提高线圈阻抗的建模精度。在硅基集成线圈的植入式无线供电系统中,系统工作频率通常选择最大线圈品质因数所对应的频率,提出的模型可以有效预测该频率。在实验仿真中,提出的精确寄生电容建模方法预测的最大线圈品质因数所对应的频率的精度在5%以内。

关键词：集成线圈植入式无线供电模型品质因素

Therapeutic effects of low-frequency phonophoresis with a Chinese herbal medicine versus sodium diclofenac for treatment of knee osteoarthritis: a double-blind, randomized, placebo-controlled clinical trial

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2016年第5期36卷 613-617页

作者： Zhao Jun Wang Qingfu Wu Ji shi Xinchao Qi Qingxue Zheng haoyun Lang Song Yang Lili Zhang Dong Department of Spinal Column and Joint the Third Affiliated Hospital of Beijing University of Chinese Medicine

OBJECTIVE: To evaluate the therapeutic effects of low-frequency phonophoresis with a Chinese herbal medicine(CHM) compared with sodium diclofenac(SD) for knee osteoarthritis(KOA).METHODS: In this double-blind, randomized, placebo-controlled trial, 100 KOA patients were assigned randomly to a placebo group, a CHM group,or SD group. Low-frequency phonophoresis was used to improve the efficiency of drug *** at rest [using a visual analog scale(VAS)], pain on movement(VAS), and range of motion(degrees) in the three groups were evaluated using the Western Ontario and Mc Master Universities Osteoarthritis Index(WOMACAI) scores. Safety assessments comprised emergency adverse events, aswell as laboratory tests of blood biochemistry, creatinine, blood urea nitrogen, alanine aminotransferase and aspartate ***: Significant improvements were found after treatment in all outcome measures except stiffness and range of motion in patients in the CHMP group and SDP group(P < 0.05). No significant differences in all outcome measures were found between the CHMP group and SDP ***: CHMP and SDP can show good therapeutic effects for KOA in terms of relieving pain and improving physical function.

关键词： Osteoarthritis knee Phonophoresis Drugs Chinese herbal Diclofenac Ultrasonography

Abstract Painting of Zhang Daqian

在线全文

学校读者我要写书评

暂无评论

China & The World Cultural Exchange 2011年第11期77卷 14-15页

作者： Zhu haoyun

Zhang Daqian is a master painter of Chinese traditional painting who enjoys worldwide reputation. He is also an artist with strong individuality and legendary experience. His artistic career can be divided into three different stages: following ancient masters before age 40, following the law of nature between age 40 and 60 and following mind after age 60. In his early years,

关键词：传统绘画张大千抽象艺术生涯法律性质艺术家中国画家

Nesfatin-1 Decreases Excitability of Dopaminergic Neurons in the Substantia Nigra

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nesfatin-1 Decreases Excitability of Dopaminergic Neurons in...