检索结果-南通市图书馆

Dynamic Frequency Support and DC Voltage Regulation Approach for VSC-MTDC Systems

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2023年第2期9卷 645-658页

作者： Chongru liu haoyu liu Siwen Jiang Le Zheng State Key Laboratory for Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

When an additional frequency control is implemented in the voltage source converter-based multi-terminal high voltage direct current(VSC-MTDC)system,the DC grid is capable of responding to a frequency disturbance in the AC system.However,the original additional frequency control may cause the DC voltage to exceed the limit when providing power for a severe frequency disturbance,threatening the security of the DC system.A novel dynamic additional frequency control strategy for the VSC-MTDC system is developed based on the relationship between the DC voltage and the frequency droop coefficient.A dynamic frequency droop coefficient is designed to adaptively adjust the support power of the DC grid,balancing the frequency regulation of the disturbed AC system and the voltage stability of the DC grid.A DC voltage recovery method based on multi-converter cooperation is proposed to cope with the DC voltage deviation caused by the additional frequency control.Simulations validate the advantages and satisfactory performance of the proposed method during power disturbances with different severities and for the process of DC voltage recovery.

关键词： Additional frequency control DC voltage recovery module dynamic frequency droop coefficient VSCMTDC

Water boosted CO_(2)/C_(2)H_(2)separation in L-arginine functionalized metal–organic framework

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2023年第5期16卷 6113-6119页

作者： Hejin Zhu Wenjuan Xue Hongliang Huang Lvyun Chen haoyu liu Chongli Zhong State Key Laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China Country School of Chemistry and Chemical Engineering Tiangong UniversityTianjin 300387China School of Material Science and Engineering Tiangong UniversityTianjin 300387China

The separation of CO_(2)/C_(2)H_(2)mixture by CO_(2)-selective sorbents is an energy-efficient C_(2)H_(2)purification technique,but is strategically challenging due to their similar molecular size and physicochemical properties.Meanwhile,water is inevitable in CO_(2)/C_(2)H_(2)mixture and it is usually a significant barrier because of its competitive adsorption with CO_(2).To address this challenge,herein,we report the first example of metal–organic framework(MOF)that exhibits water-boosted CO_(2)adsorption and CO_(2)/C_(2)H_(2)separation by anchoring L-arginine(ARG)on the Zr6 cluster of MOF-808.The CO_(2)affinity and capacity in the resulting MOF-808-ARG are markedly facilitated by the presence of water,while the C_(2)H_(2)adsorption is significantly suppressed.Specifically,CO_(2)adsorption capacities in adsorption isotherm and breakthrough measurement are increased to 143%and 184%,respectively.In addition,the wet MOF-808-ARG exhibits the record CO_(2)/C_(2)H_(2)selectivity of 1,180 under zero coverage.Breakthrough experiments reveal that CO_(2)/C_(2)H_(2)mixture can be completely separated and the result of mass spectrometry indicates that the C_(2)H_(2)purity in the outlet is up to 99.9%.In situ infrared(IR)results and density functional theory(DFT)calculations reveal the water-promoted CO_(2)adsorption mechanism that the formation of bicarbonate products in the presence of water is thermodynamically and kinetically more favorable than that without water.Moreover,MOF-808-ARG also possesses excellent water stability and excellent regeneration of CO_(2)adsorption.This work provides a new paradigm by transforming the negative effects of water into positive ones for CO_(2)/C_(2)H_(2)separation.

关键词： metal–organic frameworks L-arginine moisture acetylene(C_(2)H_(2))purification CO_(2)adsorption

Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第6期10卷 2383-2392页

作者： Zhongrui Ma Xinxing Lyu Ning Qin haoyu liu Mengrui Zhang Yongchao Lai Bo Dong Peiyuan Lu Medical Research Center The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250014China Department of Immunology Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250117China Department of Biochemistry and Molecular Biology School of Basic MedicineShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250117China Department of Cardiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250021China

Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins to regulate gene transcription. CARM1 has been found to play important roles in cell differentiation and development, cell cycle progression, autophagy, metabolism, pre-mRNA splicing and transportation, and DNA replication. In this review, we describe the molecular characteristics of CARM1 and summarize its roles in the regulation of cell differentiation and development in mammals.

关键词： Arginine methylation CARM1 Cell differentiation Development Epigenetic regulation

The inducible secreting TLR5 agonist,CBLB502,enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2023年第9期20卷 662-681页

作者： Xiaohui Wang Wei Qiu haoyu liu Min He Wei He Zhan Li Zhiqiang Wu Xiang Xu Ping Chen College of Biotechnology Southwest UniversityChongqing 400715China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042China Department of Dermatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035China Department of Biotherapeutics The First Medical CenterChinese PLA General HospitalBeijing 100038China

Objective:CAR-T/NK cells have had limited success in the treatment of solid tumors,such as colorectal cancer(CRC),in part because of the heterogeneous nature of tumor-associated antigens that lead to antigen-negative relapse after the initial response.This barrier might be overcome by enhancing the recruitment and durability of endogenous immune cells.Methods:Immunohistochemistry and flow cytometry were used to assess the expression of CD133 antigen in tissue microarrays and cell lines,respectively.Retroviral vector transduction was used to generate CBLB502-secreting CAR133-NK92 cells(CAR133-i502-NK92).The tumor killing capacity of CAR133-NK92 cells in vitro and in vivo were quantified via LDH release,the RTCA assay,and the degranulation test,as well as measuring tumor bioluminescence signal intensity in mice xenografts.Results:We engineered CAR133-i502-NK92 cells and demonstrated that those cells displayed enhanced proliferation(9.0×10^(4)cells vs.7.0×10^(4)cells)and specific anti-tumor activities in vitro and in a xenogeneic mouse model,and were well-tolerated.Notably,CBLB502 secreted by CAR133-i502-NK92 cells effectively activated endogenous immune cells.Furthermore,in hCD133+/hCD133−mixed cancer xenograft models,CAR133-i502-NK92 cells suppressed cancer growth better than the counterparts(n=5,P=0.0297).Greater T-cell infiltration was associated with greater anti-tumor potency(P<0.0001).Conclusions:Armed with a CBLB502 TLR5 agonist,CAR133-NK92 cells were shown to be capable of specifically eliminating CD133-positive colon cancer cells in a CAR133-dependent manner and indirectly eradicating CD133-negative colon cancer cells in a CBLB502-specific endogenous immune response manner.This study describes a novel technique for optimizing CAR-T/NK cells for the treatment of antigenically-diverse solid tumors.

关键词： TLR5 agonist CBLB502 CAR133 endogenous immune response colorectal cancer

Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2023年第2期14卷 792-805页

作者： Qiufang Zong Huan Qu Yahui Zhao haoyu liu Shenglong Wu Shuai Wang Wenbin Bao Demin Cai College of Animal Science and Technology Yangzhou UniversityYangzhou 225009PR China Joint International Research Laboratory of Agriculture&Agri‑Product Safety Yangzhou UniversityYangzhou 225009PR China Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070PR China.

Background:Cholesterol is an essential component of lipid rafts in cell plasma membrane,which exerts a hepatoprotective role against mycotoxin exposure in pigs,and cholesterol metabolism is vulnerable to epigenetic histone acetylation.Therefore,our present study aimed to investigate whether a histone deacetylase inhibitor(sodium butyrate [NaBu]) could protect the porcine liver from deoxynivalenol(DON) exposure by modulating cholesterol metabolism.Herein,we randomly divided 28 pigs into four groups,which were fed an uncontaminated basal diet,contaminated diet(4 mg DON/kg),uncontaminated diet supplemented with 0.2% NaBu or 4 mg/kg DON contaminated diet(4 mg DON/kg) supplemented with 0.2% NaBu for 28 d.Results:We found that the serum alanine transaminase(ALT),aspartate transaminase(AST),and alkaline phosphatase(ALP) were all increased in pigs exposed to DON,indicative of significant liver injury.Furthermore,the cholesterol content in the serum of DON-exposed pigs was significantly reduced,compared to the healthy Vehicle group.Transcriptome analysis of porcine liver tissues revealed that the cholesterol homeostasis pathway was highly enriched due to DON exposure.In which we validated by qRT-PCR and western blotting that the cholesterol program was markedly activated.Importantly,NaBu effectively restored parameters associated with liver injury,along with the cholesterol content and the expression of key genes involved in the cholesterol biosynthesis pathway.Mechanistically,we performed a ChIP-seq analysis of H3K27ac and showed that NaBu strongly diminished DON-increased H3K27ac genome-wide enrichment.We further validated that the elevated H3K27ac and H3K9ac occupancies on cholesterol biosynthesis genes were both decreased by NaBu,as determined by ChIP-qPCR analysis.Notably,nuclear receptor RORγ,a novel regulator of cholesterol biosynthesis,was found in the hyperacetylated regions.Again,a remarkable increase of RORγ at both mRNA and protein levels in DON-exposed porcine livers was drastically reduced by NaBu.Consistent

关键词： Cholesterol biosynthesis DON Histone acetylation RORγ Sodium butyrate

推进中国式现代化的“人民至上”价值旨向及逻辑遵循

在线全文

学校读者我要写书评

暂无评论

河南社会科学 2024年第6期32卷 52-59页

作者：刘皓昱熊友华湖北大学马克思主义学院湖北武汉430061

从马克思主义唯物史观来看,人民是现代化建设的主体和动力,推进中国式现代化需要从理论认知和实践发展上深化其人民性这一本质属性。在其价值意涵上,“人民至上”是社会主义现代化人本价值的深层体现,是中国式现代化建设探索发展的成功... 详细信息

从马克思主义唯物史观来看,人民是现代化建设的主体和动力,推进中国式现代化需要从理论认知和实践发展上深化其人民性这一本质属性。在其价值意涵上,“人民至上”是社会主义现代化人本价值的深层体现,是中国式现代化建设探索发展的成功密码,也是人的现代化在本质上延展的生动诠释。在其内生逻辑上,要从物质现代化的跃迁把握“人民至上”的逻辑必然,从精神现代化的演进认识“人民至上”的旨趣应然,从制度现代化的变革审视“人民至上”的实效使然。在其实践遵循上,只有在继续践行党的初心使命中深化“人民至上”的根本价值立场,在推进全体人民共同富裕中优化“人民至上”的具体行动落实,在超越西方的现代化道路中强化“人民至上”的主体自觉意识,才能把“人民至上”贯穿于全面建成社会主义现代化强国的全过程和各方面。

关键词：中国式现代化人民至上以人为本

Well-Drilling and Groundwater Monitoring Network Construction:Taking Changde City as an Example

在线全文

学校读者我要写书评

暂无评论

Journal of World Architecture 2023年第4期7卷 17-21页

作者： haoyu liu Gang liu Changwu Li Aerospace Kaitian Environmental Technology Co. Ltd.Changsha 410100Hunan ProvinceChina

Entrusted by the Environmental Protection Bureau of Changde City,we conducted drilling,sampling survey and constructed a monitoring network for groundwater in several counties and districts of Changde City.This article introduces the drilling technology,detection method and detection network layout plan adopted in the project,and expounds the problems that occurred while executing the project,in order to provide reference for similar groundwater capacity supervision and construction projects.

关键词： Groundwater Well-drilling Monitoring network Changde City

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

空战目标轨迹预测技术研究综述

航空兵器 2024年第2期31卷 32-43页

作者：郭正玉刘浩宇苏雨中国空空导弹研究院河南洛阳471009 西北工业大学航天学院西安710072 空基信息感知与融合全国重点实验室河南洛阳471009

信息化空战对抗中,快速获取和有效利用对手信息的一方,能够准确地预测对手的运动轨迹,更加迅速地完成OODA循环,进而取得空战优势。本文研究空战目标轨迹预测技术,以时序变化特征为研究视角,分别对基于物理、机器学习和深度学习的轨迹预... 详细信息

信息化空战对抗中,快速获取和有效利用对手信息的一方,能够准确地预测对手的运动轨迹,更加迅速地完成OODA循环,进而取得空战优势。本文研究空战目标轨迹预测技术,以时序变化特征为研究视角,分别对基于物理、机器学习和深度学习的轨迹预测技术开展分析和总结,进一步归纳物理因素、空战因素和交互因素等作为轨迹预测模型的输入,单模态轨迹、多模态轨迹和行为意图三类作为模型的输出,并对未来智能化空战中的目标轨迹预测技术进行展望。

关键词：信息化空战 OODA循环目标轨迹预测空战对抗机动决策

Chicory(Cichorium intybus L.) and cereals differently affect gut development in broiler chickens and young pigs

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2014年第2期5卷 230-235页

作者： haoyu liu Emma Ivarsson Torbjrn Lundh Jan Erik Lindberg Department of Animal Nutrition and Management Swedish University of Agricultural SciencesP.O.Box 7024Uppsala SE-750 07Sweden

Dietary fiber, resistant to host-mediated digestion in the small intestine due to lack of endogenous enzymes, impacts many facets of animal health and is associated with gut development especially in young monogastrics. Furthermore, it can be used as in-feed antibiotic alternative. Chicory （Cichorium intybus L.） forage with high content of pectin （uronic acids as building blocks） is a novel class of dietary fiber that is chemically different from cereal grains （with high content of arabinoxylans）. In the present study, we investigated effects of dietary inclusion of chicory forage on digestibility, gut morphology and microbiota in broilers and young pigs. In the chicken experiment, 160 1-d old broiler chicks were fed 3 nutritionally balanced diets for 30 d including a cereal-based diet and 2 diets with part of the cereals substituted with 60 and 120 g/k9 chicory forage （CF60 and CF120], whereas in the pig experiment, 18 seven-wk old Yorkshire pigs were fed 3 diets for 18 d including a cereal-based diet and 2 diets with 80 and 160 g/kg chicory forage inclusion （CF80 and CF160）. Our results showed that young pigs were capable to utilize chicory forage well with higher total tract apparent digestibility （TTAD） of all fiber fractions, particularly uronic acid, compared with the control （P 〈 0.01）. In contrast, a decreased TTAD of all fiber fractions was observed in chickens fed on diet CF120 （P 〈 0.05）. Moreover, diet induced changes in gut morphology were observed in the large intestine of chickens. The alteration of cecal mucosal thickness was further positively correlated with TTAD of non-starch polysaccharides （NSP） and its constituent sugars （P 〈 0.05）. In addition, in pigs, terminal restriction fragment length polymorphism （T-RFLP） analysis of intestinal microbiota revealed substantial dietary effects （cereal control diet vs. chicory forage inclusion） on the relative abundance of 2 dominant bacterial phylotypes （Prevotella sp. vs. Roseburia sp.） respectively （P 〈 0.05）. In conclusion, our data showed that chico

关键词： Broiler Cereal arabinoxylans Chicory uronic acids Digestibility Gut development Microbiota Pectin Young pigs