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骨形态发生蛋白/Wnt信号通路调控成骨:揭示骨骼形成和重塑的分子机制

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中国组织工程研究 2025年第3期29卷 563-571页

作者：刘淏文乔卫平孟志成李凯杰韩暄史鹏博河南中医药大学第一附属医院骨伤科一区河南省郑州市450000

背景:成骨细胞是负责骨骼形成和重塑的主要细胞类型,其功能的正常发挥受到多种信号通路的精密调控,其中,骨形态发生蛋白和Wnt信号通路在成骨过程中起着关键作用。目的:综述了骨形态发生蛋白/Wnt信号通路在调控成骨细胞功能中的作用,并... 详细信息

背景:成骨细胞是负责骨骼形成和重塑的主要细胞类型,其功能的正常发挥受到多种信号通路的精密调控,其中,骨形态发生蛋白和Wnt信号通路在成骨过程中起着关键作用。目的:综述了骨形态发生蛋白/Wnt信号通路在调控成骨细胞功能中的作用,并分析其在不同生理和病理条件下的变化,以期进一步揭示骨骼形成和重塑的分子机制。方法:以中文检索词“BMP信号通路,Wnt信号通路,成骨”及英文检索词“BMP signaling pathway,Wnt signaling pathway,osteogenesis”在中国知网、万方和PubMed数据库中检索研究原著,检索时限为各数据库建库至2023年6月的相关文献,最终筛选61篇文献进行分析总结。采用文献综述的方法,对骨形态发生蛋白/Wnt信号通路调控成骨作用的研究进行梳理和分析。结果与结论:①骨形态发生蛋白和Wnt信号通路在成骨细胞的分化、增殖和成熟过程中发挥重要作用。骨形态发生蛋白信号通路主要通过激活Smad蛋白来调控成骨相关基因的表达,Smad蛋白被激活后进入细胞核,调控与成骨相关的基因表达,与骨形态发生蛋白不同,Wnt信号通路主要依赖于β-catenin的激活来发挥生物学效应。②不同生理和病理状态下,骨形态发生蛋白/Wnt信号通路的调控作用会受到多种因素的影响。生长因子及激素及机械应力等会在一定程度上影响骨形态发生蛋白/Wnt信号通路的活性。③骨形态发生蛋白/Wnt信号通路在调控成骨过程中与其他信号通路相互作用,共同构成复杂的调控网络。④中药和天然化合物可以通过调控信号通路来促进骨骼健康,为中药治疗骨骼疾病提供了新的可能性。⑤未来研究可进一步探讨骨形态发生蛋白/Wnt信号通路与其他信号通路的相互作用以及其在不同生理和病理条件下的变化,解析此复杂网络中的关键节点和调控机制,为骨骼相关疾病的治疗提供更精确的靶点,也为揭示骨骼形成和重塑的分子机制提供新的思路。

关键词：骨形态发生蛋白信号通路 Wnt信号通路成骨骨骼基因表达分化增殖调控作用交互作用调控网络

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A flexible artificial solid-electrolyte interlayer supported by compactness-tailored carbon nanotube network for dendrite-free lithium metal anode

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Journal of Energy Chemistry 2022年第6期31卷 421-427,I0012页

作者： haowen liu Jifang Zhang Yang liu Yang Wei Shuaiyang Ren Ludi Pan Yi Su Jianhua Xiao Haiyan Fan Yitao Lin Yipeng Su Yuegang Zhang State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China

A dendrite-free lithium metal anode requires a stable interface designed for efficient and reversible lithium plating and stripping. In this work, we have devised a mechanically flexible artificial Li_(3)N solid-electrolyte interlayer supported by a dual-layer compactness-tailored carbon nanotube fiber network. The more compact side of the network ensures a full coverage of Li_(3)N, which prevents the reaction between electrolyte and lithium. The other side, with sparsely distributed nanotube fibers, provides mechanical flexibility for the film, and induces three-dimensional lithium deposition along its structure without any dendrite formation. The resulting full cell with NCM811 cathode has a high capacity retention of 95.1% for 160 cycles compared with less than 80% for the control.

关键词： Lithium metal anode Artificial SEI CNT network 3D deposition

“Buckets effect”in the kinetics of electrocatalytic reactions

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Journal of Energy Chemistry 2024年第2期89卷 388-396,I0010页

作者： haowen Cui Yan-Xia Chen Hefei National Laboratory for Physical Sciences at Microscale Department of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

In this study,we systematically investigated the effect of proton concentration on the kinetics of the oxygen reduction reaction(ORR)on Pt(111)in acidic *** results demonstrate a rectangular hyperbolic relationship,i.e.,the ORR current excluding the effect of other variables increases with proton concentration and then tends to a constant *** consider that this is caused by the limitation of ORR kinetics by the trace oxygen concentration in the solution,which determines the upper limit of ORR kinetics.A model of effective concentration is further proposed for rectangular hyperbolic relationships:when the reactant concentration is high enough to reach a critical saturation concentration,the effective reactant concentration will become a constant *** could be due to the limited concentration of a certain reactant for reactions involving more than one reactant or the limited number of active sites available on the *** study provides new insights into the kinetics of electrocatalytic reactions,and it is important for the proper evaluation of catalyst activity and the study of structureperformance relationships.

关键词： Oxygen reduction reaction Kinetics Zero order Rectangular hyperbolic relationship pH effect

Recent advances in molecular and nanoparticle probes for fluorescent bioanalysis

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Nano Research 2024年第7期17卷 6443-6474页

作者： haowen Luo Lejie Tian Yaoming Zhang Yang Wu Bin Li Jianxi liu State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Shandong Laboratory of Advanced Materials and Green ManufacturingYantai 264006China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

With the increasing emphasis on ecological safety and physical health,the detection and treatment of harmful substances and diseases are becoming more and more ***,efficiently monitoring these biological behaviors with high accuracy and sensitivity in real-time has shown prominent research *** use of fluorescent probes to analyze organisms has gained momentum in recent years,especially in the field of organ imaging and assisted cancer therapy,where fluorescent bioanalysis demonstrates significant *** this review,we explored the latest advancements in fluorescent molecular probes(e.g.,small-molecule,macro-molecule,supramolecule)and fluorescent nanoparticle probes(e.g.,quantum dots or nanoclusters,metal-organic frameworks,polymers,complexes)used as bioanalytical tools in various assays over the last three *** also delved into their detective mechanisms,specific application areas,and characterization tools for responsive *** review aims to showcase the most recent and comprehensive research progress in fluorescent bioanalysis based on molecular and nanoparticle probes,offering guidance for future developments in the design and fabrication of fluorescent probes and their potential applications.

关键词： fluorescent biosensing bioimaging disease diagnosis tumor detection and treatment

Deciphering the linear relationship in the activity of the oxygen reduction reaction on Pt electrodes:A decisive role of adsorbates

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Journal of Energy Chemistry 2024年第7期94卷 70-77页

作者： haowen Cui Yan-Xia Chen Hefei National Research Center for Physical Sciences at Microscale and Department of Chemical Physics University of Science and Technology of ChinaHefei 230026AnhuiChina

Despite substantial efforts in developing high-performance catalysts for the oxygen reduction reaction(ORR),the persistent challenge lies in the high onset overpotential of the ORR,and the effect of the elec-trolyte solution cannot be ***,we have systematically investigated the impact of adsorbate species and concentration,as well as solution pH,on the ORR activity on Pt(111)and Pt(poly)*** results all tend to establish a linear quantitative relationship between the onset potential for ORR and the adsorption equilibrium potential of the *** finding indicates the decisive role of adsorbates in the onset potential for ORR,suggesting that the adsorption potential of adsorbates can serve as an intuitive criterion for ORR *** support for this conclusion is derived from experimental results obtained from the oxygen evolution reaction on Pt(poly)with different adsorbate species and from the hydrogen evolution reaction on Pt(111)with iodine *** further propose both an empirical equation for the onset potential for ORR and the concept of a potential-regulated adsor-bate shielding effect to elucidate the influence of adsorbates on ORR *** study provides new insights into the high onset overpotential of the ORR and offers potential strategies for predicting and enhancingORRactivity inthefuture.

关键词： Oxygen reduction reaction Activity Adsorbate Equilibrium potential Pt(111)

Climatic implications in earlywood and latewood width indices of Chinese pine in north central China

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Journal of Forestry Research 2024年第3期35卷 143-153页

作者： Kaixuan Yang Junzhou Zhang haowen Fan Yuan Yan College of Geographic Sciences Qinghai Normal UniversityXining 810016People's Republic of China Key Laboratory of Tibetan Plateau Land Surface Processes and Ecological Conservation(Ministry of Education) Xining 810016People's Republic of China Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730030People's Republic of China Gansu Liancheng Forest Ecosystem Field Observation and Research Station Lanzhou UniversityLanzhou 730333People's Republic of China School of Geography and Information Engineering University of GeoscienceWuhan 430074People's Republic of China

Latewood width(LWW)indices of trees are considered a reliable proxy of summer precipitation in the Northern ***,the strong coupling and high correlation between earlywood width(EWW)and LWW indices often prevent registration of climate signals of the LWW *** this study,328-year-long earlywood width and latewood width chronologies were developed from Chinese pine at two sites in the Hasi Mountains,north central *** climate responses of these chronologies were analyzed and the LWW index used to derive sum-mer precipitation *** analyses showed that LWW was particularly influenced by earlywood growth and recorded stronger climate signals of the previous year as EWW,rather than those of the current year with infrequent summer climate ***,after removing the effect of earlywood growth using a simple regression model,the adjusted LWW chronology(LWW_(adj))showed a strong relationship with July precipitation in dry *** suggests that the LWW_(adj) chronology has the potential to be used to investigate long-term variability in summer precipitation in drought-limited regions.

关键词： Dendroclimatology Latewood width Climate response Summer precipitation Earlywood effect

A Practical Group Key Management Algorithm for Cloud Data Sharing with Dynamic Group

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China Communications 2016年第6期13卷 205-216页

作者： Wei Song Hua Zou haowen liu Jun Chen State Key Laboratory of Software Engineering Wuhan University School of Computer Wuhan University International School of Software Wuhan University Lab of Storage and quantum computing University of Pittsburgh

Cloud data sharing service, which allows a group of people to work together to access and modify the shared data, is one of the most popular and efficient working styles in the enterprises. However, the cloud server is not completely trusted, and its security could be compromised by monetary reasons or caused by hacking and hardware errors. Therefore, despite of having advantages of scalability and flexibility, cloud storage service comes with privacy and the security concerns. A straightforward method to protect the user's privacy is to encrypt the data stored at the cloud. To enable the authenticated users to access the encrypted cloud data, a practical group key management algorithm for the cloud data sharing application is highly desired. The existing group key management mechanisms presume that the server is trusted. But, the cloud data service mode does not always meet this condition. How to manage the group keys to support the scenario of the cloud storage with a semi-trusted cloud server is still a challenging task. Moreover, the cloud storage system is a large-scale and open application, in which the user group is dynamic. To address this problem, we propose a practical group key management algorithm based on a proxy re-encryption mechanism in this paper. We use the cloud server to act as a proxy tore-encrypt the group key to allow authorized users to decrypt and get the group key by their private key. To achieve the hierarchical access control policy, our scheme enables the cloud server to convert the encrypted group key of the lower group to the upper group. The numerical analysis and experimental results further validate the high efficiency and security of the proposed scheme.

关键词： proxy re-encryption group key management bilinear map encrypted cloud storage

Unraveling the complex roles of macrophages in obese adipose tissue:an overview

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Frontiers of Medicine 2024年第2期18卷 205-236页

作者： Chang Peng Jun Chen Rui Wu haowen Jiang Jia Li Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou310000China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200011China

Macrophages,a heterogeneous population of innate immune cells,exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic *** activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects,inducing insulin resistance through increased inflammation,impaired thermogenesis,and adipose tissue ***,adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis,facilitating the clearance of dead adipocytes,and promoting mitochondrial *** the heterogeneity of macrophages in obese adipose tissue is crucial for unraveling the pathogenesis of obesity and holds significant potential for targeted therapeutic ***,the dual effects and some potential regulatory mechanisms of macrophages in adipose tissue have been elucidated using single-cell *** this review,we present a comprehensive overview of the intricate activation mechanisms and diverse functions of macrophages in adipose tissue during obesity,as well as explore the potential of drug delivery systems targeting macrophages,aiming to enhance the understanding of current regulatory mechanisms that may be potentially targeted for treating obesity or metabolic diseases.

关键词： obesity inflammation adipose tissue macrophages adipose tissue homeostasis

Modelling the water diversion of a sustainable cover system under humid climates

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2429-2440页

作者： haowen Guo Charles Wang Wai Ng Qi Zhang Chuanxiang Qu Liwen Hu Shenzhen Research Institute of Hong Kong University of Science and Technology Shenzhen518057China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong SAR999077China CCCC Fourth Harbor Engineering Institute Co. LtdGuangzhou510230China

Extreme rainfall significantly threatens the safety of the landfill cover system,especially under humid *** study aims to provide design recommendations for a sustainable landfill cover system consisting of a low-permeability soil layer underlying a two-layer capillary barrier for humid ***,the numerical back-analysis was conducted for verification against a series of flume model ***,a parametric study was performed to investigate the effects of inclination angle,particle size and layer thickness on the lateral diversion length(DL)of the three-layer cover system under the 100-year return period rainfall of humid *** results show that the water lateral DL of the cover system can be greatly enhanced by increasing the inclination angle from 3°to 18°.Moreover,the bottom layer of the cover system with a coarser d10 was more susceptible to the impact of the heavy rainfall,while this can be alleviated by increasing the thickness of the bottom layer.A dimensionless number,defined as the ratio of thickness and d_(10) of the bottom layer,is proposed for designing lateral diversion of the three-layer cover system under humid *** preserve the maximum DL,it is suggested that the proposed dimensionless number should be larger than 95 and 110 for the design of rainfall events with 50-year and 100-year return periods for humid climates,respectively.

关键词： Unsaturated soil Recycling Construction waste Three-layer landfill cover Water infiltration