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Tissue adhesive,ROS scavenging and injectable PRP-based‘plasticine’for promoting cartilage repair

Regenerative Biomaterials 2024年第1期3卷 94-107页

作者： Shiao li Dawei Niu haowei Fang Yancheng Chen Jinyan li Kunxi Zhang Jingbo Yin Peiliang Fu Department of Orthopedics Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003P.R.China Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444P.R.China

Platelet-rich plasma(PRP)that has various growth factors has been used clinically in cartilage repair.However,the short residence time and release time at the injury site limit its therapeutic effect.The present study fabricated a granular hydrogel that was assembled from gelatin microspheres and tannic acid through their abundant hydrogen bonding.Gelatin microspheres with the gelatin concentration of 10wt%and the diameter distribution of 1-10 lm were used to assemble by tannic acid to form the granular hydrogel,which exhibited elasticity under low shear strain,but flowability under higher shear strain.The viscosity decreased with the increase in shear rate.Meanwhile,the granular hydrogel exhibited self-healing feature during rheology test.Thus,granular hydrogel carrying PRP not only exhibited well-performed injectability but also performed like a‘plasticine’that possessed good plasticity.The granular hydrogel showed tissue adhesion ability and reactive oxygen species scavenging ability.Granular hydrogel carrying PRP transplanted to full-thickness articular cartilage defects could integrate well with native cartilage,resulting in newly formed cartilage articular fully filled in defects and well-integrated with the native cartilage and subchondral bone.The unique features of the present granular hydrogel,including injectability,plasticity,porous structure,tissue adhesion and reactive oxygen species scavenging provided an ideal PRP carrier toward cartilage tissue engineering.

关键词： cartilage regeneration granular hydrogel gelatin tannic acid PRP

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Robust reinforcement learning with UUB guarantee for safe motion control of autonomous robots

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Science China(Technological Sciences) 2024年第1期67卷 172-182页

作者： ZHANG RuiXian HAN YiNing SU Man liN ZeFeng li haowei ZHANG liXian School of Astronautics Harbin Institute of TechnologyHarbin 150001China School of Management Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Tracking and Telecommunication Technology Beijing 100094China

This paper addresses the issue of safety in reinforcement learning(RL)with disturbances and its application in the safety-constrained motion control of autonomous robots.To tackle this problem,a robust Lyapunov value function(rLVF)is proposed.The rLVF is obtained by introducing a data-based LVF under the worst-case disturbance of the observed state.Using the rLVF,a uniformly ultimate boundedness criterion is established.This criterion is desired to ensure that the cost function,which serves as a safety criterion,ultimately converges to a range via the policy to be designed.Moreover,to mitigate the drastic variation of the rLVF caused by differences in states,a smoothing regularization of the rLVF is introduced.To train policies with safety guarantees under the worst disturbances of the observed states,an off-policy robust RL algorithm is proposed.The proposed algorithm is applied to motion control tasks of an autonomous vehicle and a cartpole,which involve external disturbances and variations of the model parameters,respectively.The experimental results demonstrate the effectiveness of the theoretical findings and the advantages of the proposed algorithm in terms of robustness and safety.

关键词： motion control reinforcement learning robustness stability

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Resource-saving scheduling scheme for centralized target tracking in multiple radar system under automatic blanket jamming

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Chinese Journal of Aeronautics 2024年第5期37卷 349-362页

作者： Zhengjie li Yujie WEI Junwei XIE haowei ZHANG Yu TIAN Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China Air Force Xi’an Flying College Xi’an 710300China Air and Missile Defense Institute Air Force Research InstituteBeijing 100085China School of Economics and Management Beihang UniversityBeijing 100191China

This paper investigates the problem of Joint Radar Node Selection and Power Allocation(JRNSPA)in the Multiple Radar System(MRS)in the blanket jamming environment.Each radar node independently tracks moving target and subsequently transmits the raw observation data to the fusion center,which formulates a centralized tracking network structure.In order to establish a practical blanket jamming environment,we suppose that each target carries the self-defense jammer which automatically implements blanket jamming to the radar nodes that exceed the preset interception probability.Subsequently,the Predicted Conditional Cramer-Rao Lower Bound(PC-CRLB)is derived and utilized as the tracking accuracy criterion.Aimed at ensuring both the tracking performance and the Low Probability of Intercept(LPI)performance,the resource-saving scheduling model is formulated to minimize the transmit power consumption while meeting the requirements of tracking accuracy.Finally,the Modified Zoutendijk Method Of Feasible Directions(MZMFD)-based two-stage solution technique is adopted to solve the formulated non-convex optimization model.Simulation results show the effectiveness of the proposed JRNSPA scheme.

关键词： Multiple Radar System(MRS) Centralized target tracking Resource scheduling Blanket jamming Low Probability of Intercept(LPI)

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Current status,trends,and predictions in the burden of gallbladder and biliary tract cancer in China from 1990 to 2019

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Chinese Medical Journal 2022年第14期135卷 1697-1706页

作者： Shimin Chen Ke Han Yang Song Shaohua liu Xuehang li Shengshu Wang haowei li Rongrong li Jianhua Wang Yao He Miao liu Institute of Geriatrics Beijing Key Laboratory of Aging and GeriatricsNational Clinical Research Center for Geriatric DiseaseSecond Medical Center of Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Department of Gastroenterology First Medical Center of Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Graduate School Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China

Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data in China is lacking.This study was to determine the current status,trends,and predictions in the burden of GBTC over the past 30 years in China.Methods:This was a descriptive,epidemiological,secondary analysis of the Global Burden of Disease,Injuries,and Risk Factor Study 2019 data.Data including incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of GBTC in China by year,age,and sex were assessed.Joinpoint regression analysis was conducted to evaluate trends of disease burden due to GBTC from 1990 to 2019.Nordpred age-period-cohort analysis was applied for the projection of mortality and incidence due to GBTC from 2019 to 2044.Results:Nationally,there were 38,634(95%uncertainty interval[UI]:27,350-46,512)new cases and 47,278(95%UI:32,889-57,229)patients due to GBTC,causing 34,462(95%UI:25,220-41,231)deaths,and 763,584(95%UI:566,755-920,493)DALYs in 2019.Both cases and rates of burden owing to GBTC were heavier among males and at old age.From 1990 to 2019,the age-standardized rates of incidence,prevalence,mortality,and DALYs of GBTC generally increased from 1990 to 2019,with average annual percentage change at 0.8%(95%confidential interval[CI]:0.6-1.0%),1.3%(95%CI:1.1-1.5%),0.4%(95%CI:0.2-0.6%),and 0.2%(95%CI:0.1-0.4%),respectively.Even though the age-standardized incidence rate and agestandardized mortality rate in both sexes were predicted to decline gradually from 2019 to 2044,the number of new cases and deaths were expected to grow steadily.Conclusions:GBTC is becoming a major health burden in China,particularly among males and older individuals.Given the aging population and increasing burden,effective strategies and measurements are urged to prevent or reduce the number of new cases and deaths of GBTC.

关键词： Gallbladder cancer Biliary tract cancer Global burden of disease China Prediction Aging

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Natural variation of GmFNSII-2 contributes to drought resistance by modulating enzyme activity in soybean

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The Crop Journal 2024年第2期12卷 529-539页

作者： Huihui Gao Pengcheng Wei Yongzhe Gu Pengbin Tang Yifan Shen Lei Yang linxin Dong haowei Zheng Kuo Shu Mayamiko Masangano Bin Dong Long Miao Jiajia li lijuan Qiu Xiaobo Wang School of Agronomy Anhui Agricultural UniversityHefei 230036AnhuiChina State Key Laboratory of Crop Gene Resources and Breeding The National Key Facility for Crop Gene Resources and Genetic Improvement(NFCRI)/Key Laboratory of Crop Gene Resource and Germplasm Enhancement(MOA)Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

As an essential crop that provides vegetable oil and protein,soybean(Glycine max(L.)Merr.)is widely planted all over the world.However,the scarcity of water resources worldwide has seriously impacted on the quality and yield of soybean.To address this,exploring excellent genes for improving drought resistance in soybean is crucial.In this study,we identified natural variations of GmFNSII-2(flavone synthase II)significantly affect the drought resistance of soybeans.Through sequence analysis of GmFNSII-2 in 632 cultivated and 44 wild soybeans nine haplotypes were identified.The full-length allele GmFNSII-2^(C),but not the truncated allele GmFNSII-2^(A) possessing a nonsense nucleotide variation,increased enzyme activity.Further research found that GmDREB3,known to increase soybean drought resistance,bound to the promoter region of GmFNSII-2^(C).GmDREB3 positively regulated the expression of GmFNSII-2^(C),increased flavone synthase abundance and improved the drought resistance.Furthermore,a singlebase mutation in the GmFNSII-2^(C) promoter generated an additional drought response element(CCCCT),which had stronger interaction strength with GmDREB3 and increased its transcriptional activity under drought conditions.The frequency of drought-resistant soybean varieties with Hap 1(Pro:GmFNSII-2^(C))has increased,suggesting that this haplotype may be selected during soybean breeding.In summary,GmFNSII-2^(C) could be used for molecular breeding of drought-tolerant soybean.

关键词： Drought stress Flavone synthase GmFNSII-2 Natural variation Drought response element

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Tunable non-Hermiticity through reservoir engineering

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Photonics Research 2022年第9期10卷 2091-2098页

作者： XIN MENG ZHIWEI HU XINGDA LU WANXIA CAO XICHANG ZHANG haowei li YING HU WEI YI YANHONG XIAO Department of Physics State Key Laboratory of Surface Physics and Key Laboratory of Micro and Nano Photonic Structures(Ministry of Education)Fudan UniversityShanghai 200433China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China CAS Center For Excellence in Quantum Information and Quantum Physics Hefei 230026China

We experimentally demonstrate tunable non-Hermitian coupling in an atomic-vapor cell where atomic coherences in different optical channels are dissipatively coupled through atomic motion.Introducing a far-detuned light wall in the reservoir between the optical channels,we decorate the inter-channel coupling term so that it can be switched from dissipative to coherent.The tunable non-Hermiticity is then confirmed through measurements of the inter-channel light transport where the light-wall-induced phase shift is directly probed.Based on the tunable non-Hermiticity,we further discuss an exemplary scheme in which our setup can serve as a building block for the experimental study of exotic non-Hermitian criticality.

关键词： tunable switched channel

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匈塞铁路道口限速防护方案

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中国铁路 2024年第4期 92-97页

作者：李亮李铮郑泽熙刘皓玮李博范楷中国铁道科学研究院集团有限公司通信信号研究所北京100081 北京华铁信息技术有限公司北京100081

针对匈塞铁路道口通过速度的安全防护需求,以匈塞铁路匈牙利段使用的铁路道口为研究对象,提出满足匈牙利项目应用需求的铁路道口限速设计与实现方案。通过对道口通过速度防护的应用需求分析,设计基于欧标应答器和无线闭塞中心(RBC)的道... 详细信息

针对匈塞铁路道口通过速度的安全防护需求,以匈塞铁路匈牙利段使用的铁路道口为研究对象,提出满足匈牙利项目应用需求的铁路道口限速设计与实现方案。通过对道口通过速度防护的应用需求分析,设计基于欧标应答器和无线闭塞中心(RBC)的道口限速防护功能,包括功能定义、接口架构及详细设计方案等;对道口限速防护功能应用的安全性开展调查研究,从系统运营和逻辑防护等层面设计相应的安全条件和安全防护。通过研究欧洲先进铁路道口控制系统,有利于我国铁路道口设备提高安全性和自动化水平,为我国铁路道口控制系统及设备在欧洲国家铁路项目中推广应用奠定了基础。

关键词：匈塞铁路铁路道口限速防护欧标应答器 RBC

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一种防空服务质量模型下的集中式多输入多输出雷达三维机动跟踪功率分配方法

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兵工学报 2024年第4期45卷 1321-1331页

作者：李正杰陈红印谢军伟张浩为刘斌中国空气动力研究与发展中心高速空气动力研究所四川绵阳621000 空军研究院北京100085 空军工程大学防空反导学院陕西西安710051 国防大学联合作战学院北京100091

针对防空作战中现有多功能雷达功率资源利用率低的问题,提出一种基于服务质量(Quanlity of Service,QoS)模型的三维机动跟踪功率分配方法以差异化标准提升多目标跟踪性能。将目标三维机动模型建立为自适应当前统计模型,通过将加速度协... 详细信息

针对防空作战中现有多功能雷达功率资源利用率低的问题,提出一种基于服务质量(Quanlity of Service,QoS)模型的三维机动跟踪功率分配方法以差异化标准提升多目标跟踪性能。将目标三维机动模型建立为自适应当前统计模型,通过将加速度协方差与估计误差协方差矩阵相关联以实现自适应调整。在此基础上,对三维跟踪下的贝叶斯克拉美罗下界进行推导,并将其作为跟踪误差衡量指标。通过构建关于目标威胁度与期望跟踪精度的函数关系,建立防空QoS模型下的闭环功率优化分配机制。证明所构建功率优化分配模型是凸优化问题,并进一步转化为半正定规划问题进行求解。仿真结果表明,相对于传统功率分配方法,所提方法能显著提高全局跟踪效能。

关键词：集中式多输入多输出雷达功率分配三维机动跟踪防空作战凸优化

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基于行为克隆的高通量卫星通信频谱资源分配

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通信学报 2024年第5期45卷 101-114页

作者：秦浩李双益赵迪孟昊炜宋彬西安电子科技大学空天地一体化综合业务网全国重点实验室陕西西安710071 西安电子科技大学杭州研究院浙江杭州311200

为应对在高通量多波束卫星系统中,随着波束数量和用户规模的扩大,频谱资源分配问题的维度急剧增加和求解复杂度呈指数级上升这一挑战,提出了一种结合行为克隆与深度强化学习的两阶段算法。第一阶段基于行为克隆,利用已有卫星资源分配决... 详细信息

为应对在高通量多波束卫星系统中,随着波束数量和用户规模的扩大,频谱资源分配问题的维度急剧增加和求解复杂度呈指数级上升这一挑战,提出了一种结合行为克隆与深度强化学习的两阶段算法。第一阶段基于行为克隆,利用已有卫星资源分配决策数据对策略网络进行预训练,通过模仿专家行为减少盲目探索,加快算法收敛。第二阶段基于近端策略优化,进一步优化策略网络,并通过引入卷积注意力模块有效地提取用户业务状态特征,以提升算法整体性能。仿真结果表明,所提算法在收敛速度和算法稳定性方面均优于其他基准算法,并在系统时延、系统平均满意度和频谱效率等性能指标上表现更佳。

关键词：高通量卫星行为克隆深度强化学习近端策略优化卷积注意力模块

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白藜芦醇调控苹果响应轮纹病的差异表达基因分析

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山东农业科学 2024年第2期56卷 14-22页

作者：张洋红李爽陈昊伟李佳徐继忠河北农业大学园艺学院河北保定071000

为筛选苹果轮纹病抗性基因,以苹果轮纹病抗、感株系为材料,白藜芦醇处理后针刺法接种轮纹病菌,利用高通量测序技术对接菌0 h和96 h的样品进行差异表达基因分析。试验共构建了24个文库,转录组测序共检测到173.80 Gb Clean Data,各样品Cle... 详细信息

为筛选苹果轮纹病抗性基因,以苹果轮纹病抗、感株系为材料,白藜芦醇处理后针刺法接种轮纹病菌,利用高通量测序技术对接菌0 h和96 h的样品进行差异表达基因分析。试验共构建了24个文库,转录组测序共检测到173.80 Gb Clean Data,各样品Clean Data均达到6.05 Gb,Q30值在90.67%及以上。差异表达基因(DEGs)分析结果表明,白藜芦醇处理后抗病材料的DEGs多于感病材料,接菌96 h的DEGs多于接菌0 h的。KEGG代谢通路富集分析表明,抗病材料富集的通路远远多于感病材料,且富集到抗病相关通路如植物激素信号转导和植物-病原互作的基因也多于感病材料;此外,抗病材料还富集到与木质素合成相关的苯丙素生物合成途径以及类黄酮生物合成通路。可见,在白藜芦醇处理后接菌,抗病材料叶片内的防御机制变化更丰富,可以更好地应对轮纹病菌的侵染。本研究结果可为了解白藜芦醇影响苹果轮纹病抗性的分子机制以及选育苹果抗轮纹病新品种提供理论依据。

关键词：苹果轮纹病白藜芦醇转录组差异表达基因

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