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Open Journal of Nursing 2021年第6期11卷 489-496页

作者： Lihua Zheng Beixi Wu Hongmei Pan Xiumei Zhong Qiong Shu haotong xu Shuxian Jiang Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong

Objective: We assess the application effect of the “3 + 1” mode in the COVID-19 epidemic prevention and control at the infection ward of a designated comprehensive hospital for COVID-19 treatment. Method: Based on the features of the inpatients of the infection ward and their relatives, a “3 + 1” mode for the COVID-19 prevention and control is developed to conform to the demands for epidemic prevention and control and the overall prevention and control scheme of the whole hospital. Here, “3” stands for the epidemic prevention and control system, personnel management, and prevention and control measures;“1” stands for COVID-19 testing. Result: From March 1, 2020 to March 31, 2021, a total of 3056 patients were hospitalized in the three infection wards. Among them, 265 patients had a fever, and 113 patients had respiratory symptoms. None of them were infected with COVID-19. The participation rate of the test about the knowledge related to COVID-19 and the knowledge mastery rate were both 100% among the medical staff. None of the inpatients and their companions or the medical staff was diagnosed with COVID-19. Conclusion: Thus the “3 + 1” mode proves successful for avoiding nosocomial infection and the spread of the epidemic.

关键词： COVID-19 Comprehensive Hospital Infection Department Epidemic Prevention and Control

Application of Five-in-One Community Management Mode plus Wuhan’s Regional WeChat Platform in the Novel Coronavirus Control

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Open Journal of Nursing 2020年第3期10卷 252-259页

作者： Shunwen Pan Lihua Zheng Xiaoyan Zheng Zimei Zheng Guili Chen Lili Li Hongmei Pan haotong xu Beixi Wu Shuxian Jiang The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China

In this study, the five-in-one community mass prevention and mass treatment group established in Wuhan to curb novel coronavirus outbreak in 2019 to 2020 is introduced. Various public health propaganda methods are used, including community loudspeakers and community bulletin boards. In the meantime, WeChat platform account named “Wuhan neighborhood on WeChat” is registered and opened, and a Group Chat on WeChat is created for grid management. A diversity of on-line and off-line countermeasures against the novel coronavirus outbreak are implemented via the WeChat platform: three-early measures (early discovery, early reporting, and early treatment), centralized management, community-based reporting, hierarchical diagnosis, and treatment system, isolation of mild patients at designated facilities, diagnosis and treatment appointment system for patients with fever, patient transferral in special vehicles, terminal disinfection at homes, psychological support and daily caring plan for special populations. This WeChat platform allows for an all-region, all-around, all-time and entire population-coverage control of novel coronavirus outbreak, with the extension and strengthening of health propaganda, guidance for seeking medical assistance, mass prevention and mass treatment, and health self-management among the community residents. Great effect has been achieved in novel coronavirus control so far. The five-in-one community management mode of Wuhan plus “Wuhan neighborhood on WeChat” plays an important role in relieving the shortage of health service resources and resolving the problem of limited service scope of professional medical staff in Wuhan, and ultimately contributes to the overall novel coronavirus control.

关键词： COVID-19 Five-in-One Community Management Mode Regional WeChat Platform Community Management

Application of DDG-3300K Liver Reserve Function Analyzer and Relevant Nursing Procedures at the Department of Infectious Diseases

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Open Journal of Nursing 2019年第2期9卷 120-124页

作者： Lihua Zheng Cheng Hu Yubao Zheng Qiong Shu Xiang Yin Hongmei Pan haotong xu Beiqian Wu Ying Liu Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China Department of Urology The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China

Objective: To discuss some key points about nursing in the use of DDG-3300K liver reserve function analyzer in patients at the department of infectious diseases. Method: DDG-3300K liver reserve function analyzer was applied to 5464 patients at the department of infectious diseases. The reasons for failed detection and complications related to the detection were analyzed, and the measures for improving the nursing procedures were proposed. Result: Among the 5464 patients, the detections were successful at the first attempt in 5458 patients;2 patients had leakage of liquid;2 patients were poorly prepared, and 1 case failed because of mistaken selection of CO mode, which led to adverse drug reactions;1 case did not finish the detection due to anaphylactic shock;8 patients had nausea and 6 patients had skin rash on the four limbs and torso during the detection. Conclusion: It is necessary to formulate the nursing procedures for the use of DDG-3300K liver reserve function analyzer. Moreover, preparatory work, health education, refined nursing procedures and skillful operations are closely related to the success rate and accuracy of the detection.

关键词： DDG-3300K Liver Reserve Function Analyzer Liver Function Reserve Indocyanine Green (ICG) Nursing

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肝脏外伤与肝脏病变继发出血的介入治疗价值

成都医学院学报 2019年第2期14卷 207-210,270页

作者：刘书林徐浩铜成都医学院第一附属医院放射科成都610500

目的探讨经肝动脉栓塞治疗不同原因致肝破裂出血的临床效果及安全性。方法选取2008至2016年于成都医学院第一附属医院行肝动脉栓塞治疗肝破裂出血的28例患者作为试验组。随机选取同时段单纯行外科手术的肝破裂出血患者21例作为对照组,... 详细信息

目的探讨经肝动脉栓塞治疗不同原因致肝破裂出血的临床效果及安全性。方法选取2008至2016年于成都医学院第一附属医院行肝动脉栓塞治疗肝破裂出血的28例患者作为试验组。随机选取同时段单纯行外科手术的肝破裂出血患者21例作为对照组,评估两种术式的临床疗效及安全性。结果试验组28例患者中,肝癌破裂出血21例,肝外伤出血4例,肝血管畸形出血3例。21例肝癌患者中,巨块型14例,结节型5例,弥漫性2例。经肝动脉介入栓塞术后,20例患者即时止血成功,1例肝顶部巨块型肝癌患者于4d后再出血,急诊数字减影血管造影(DSA)发现右膈下动脉供血,予以栓塞后出血停止;4例肝外伤出血患者中,3例采用明胶海绵和弹簧圈栓塞,1例用明胶海绵栓塞,栓塞后血压、脉搏逐渐趋于稳定;3例肝血管畸形出血患者中,肝动脉畸形1例与肝动静脉畸形2例经PVA颗粒及明胶海绵栓塞治疗后,平均随访13个月,疗效确切,未发生严重并发症。对照组21例患者中:肝癌16例,10例肿瘤位于右肝,6例肿瘤位于左肝;肝外伤5例。对照组显效13例,愈后良好5例,疗效较差3例。试验组患者在愈后情况、手术时间、住院时间和并发症方面均优于对照组患者,差异有统计学意义(P<0.05)。结论选择合适的栓塞材料栓塞出血责任血管,对肝癌、外伤肝破裂及肝血管畸形等原因导致的肝出血有确切的疗效。

关键词：肝破裂出血血管栓塞术疗效

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脯氨酰羟化酶抑制剂治疗肾性贫血的研究进展

攀枝花学院学报 2021年第2期38卷 11-21页

作者：郑守军魏巍徐浩铜攀枝花学院医学院四川攀枝花617000

贫血是慢性肾病(CKD)患者最常见的并发症之一,且随肾功能下降发生率增高。目前治疗CKD贫血的主导药物是红细胞生成刺激剂(ESAs),但心血管等严重不良事件限制了ESAs的应用。从1992年低氧诱导因子首次被发现到2018年罗沙司他以first-in-cl... 详细信息

贫血是慢性肾病(CKD)患者最常见的并发症之一,且随肾功能下降发生率增高。目前治疗CKD贫血的主导药物是红细胞生成刺激剂(ESAs),但心血管等严重不良事件限制了ESAs的应用。从1992年低氧诱导因子首次被发现到2018年罗沙司他以first-in-class新药身份在中国首发上市,新型低氧诱导因子脯氨酰羟化酶(HIF-PHD)抑制剂日益受到越来越多研究者的关注。本文围绕新型HIF-PHD抑制剂的作用机制、临床应用效果、研究进展以及潜在风险等进行综述,并探讨其在未来治疗CKD贫血的潜力。

关键词：慢性肾病贫血低氧诱导因子脯氨酰羟化酶低氧诱导因子脯氨酰羟化酶抑制剂

慢性胰腺炎脾门假性囊肿分类及其与SPH关系的影像学研究

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中国临床解剖学杂志 2023年第6期41卷 652-656页

作者：徐浩铜徐万宇吴毅何明静雷秀兵田伏洲攀枝花学院基础医学院解剖学教研室四川攀枝花617000 西部战区总医院全军普外中心成都610083 陆军军医大学生物医学工程与影像医学系数字医学教研室重庆400038

目的为鉴别脾门假性囊肿与脾内假性囊肿、脾周局灶性积液,运用影像学和2号中国可视人(second Chinese Visible Human,CVH2)数据库归纳脾门假性囊肿分类,探究脾门假性囊肿和左侧区域性门静脉高压(sinistral portal hypertation,SPH)的潜... 详细信息

目的为鉴别脾门假性囊肿与脾内假性囊肿、脾周局灶性积液,运用影像学和2号中国可视人(second Chinese Visible Human,CVH2)数据库归纳脾门假性囊肿分类,探究脾门假性囊肿和左侧区域性门静脉高压(sinistral portal hypertation,SPH)的潜在关系。方法采集2019年291例慢性胰腺炎患者CT或MRI图像,归纳脾门假性囊肿分类,在CVH2图像上模拟本影像学脾门假性囊肿分类法,分析脾门假性囊肿与SPH之间的潜在关系。结果脾门假性囊肿可分为3类:胰尾假性囊肿扩张至脾门,并进一步伸入脾实质形成脾门假性囊肿;主胰管瘘发展成脾门假性囊肿;胰尾假性囊肿和胰瘘共同形成脾门假性囊肿。脾门假性囊肿是SPH的重要风险预测指标(OR=7.88,P<0.001)。结论运用可视化技术归纳并虚拟展示脾门假性囊肿分类法,对后续治疗方案的选择起指导作用。

关键词：脾门假性囊肿胰瘘左侧区域性门静脉高压可视化中国可视人

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一种基于区块链的联邦学习贡献评价方案

计算机应用研究 2023年第8期40卷 2258-2265页

作者：徐浩曈刘立新王静宇张晓琳王永平内蒙古科技大学信息工程学院内蒙古包头014017 中国人民大学信息学院北京100872

为了实现联邦学习中公平的收益分配,需要有一个指标来量化每个数据提供者对联合模型的贡献。针对现有的贡献评价方案存在的隐私泄露、不透明和依赖中心服务器等问题,提出一种基于区块链的透明的联邦学习贡献评价方案。首先,提出基于改进... 详细信息

为了实现联邦学习中公平的收益分配,需要有一个指标来量化每个数据提供者对联合模型的贡献。针对现有的贡献评价方案存在的隐私泄露、不透明和依赖中心服务器等问题,提出一种基于区块链的透明的联邦学习贡献评价方案。首先,提出基于改进的Paillier安全聚合算法,通过联合解密避免了在模型聚合阶段对用户本地数据的推断。其次,提出一种基于用户累计提交的梯度来近似计算其贡献的方法,解决了现有贡献评估方案存在的隐私泄露问题。此外,将贡献的评估融入到区块链的共识过程中,使其评估结果具备了可审计性。最后,基于MNIST数据集进行的实验表明,所提出的方法可以有效地评估贡献。

关键词：区块链联邦学习公平贡献评估透明隐私

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui Hong Su xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan xu Liang Wu Zhihui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide