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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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生物质育苗钵热压成型特性试验分析

农机使用与维修 2023年第1期 1-5页

作者：马永财滕达王汉羊毛欣李昊庭吕卓黑龙江八一农垦大学工程学院黑龙江大庆163319

为解决农牧业有机废弃物污染,提高可再生资源综合利用率。以水稻秸秆和发酵牛粪为原料,采用热压成型技术制备生物质育苗钵,并对生物质育苗钵成型特性进行试验研究。结果表明,成型压力、成型温度、秸秆含量、含水率对成型特性具有显著影... 详细信息

为解决农牧业有机废弃物污染,提高可再生资源综合利用率。以水稻秸秆和发酵牛粪为原料,采用热压成型技术制备生物质育苗钵,并对生物质育苗钵成型特性进行试验研究。结果表明,成型压力、成型温度、秸秆含量、含水率对成型特性具有显著影响。当成型温度在120℃、140℃,秸秆含量为8%、7%,含水率为16%时,成型育苗钵抗破坏强度和耐久度均达到峰值,成型压力与抗破坏强度和耐久度呈正相关。研究结果可为农牧有机废弃物资源化、综合化利用提供参考。

关键词：水稻秸秆发酵牛粪育苗钵成型特性

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong Hu Wenyi lian Kang Hu Qiuju li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

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洪涝灾害早中期疾病发生情况的Meta分析

武警医学 2021年第10期32卷 889-894页

作者：李浩庭王欣桂婧秦璐范娟初晨曹德康苏彬武警特色医学中心研究部天津300162

目的运用Meta分析研究洪涝灾害早中期疾病发生情况,了解疾病发生的特点,为洪涝灾害早中期医学救援提供依据。方法检索PubMed、中国知网等数据库中有关洪涝灾害早中期疾病发生情况的文献,使用STATA 16.0软件对洪涝灾害发生早中期疾病占... 详细信息

目的运用Meta分析研究洪涝灾害早中期疾病发生情况,了解疾病发生的特点,为洪涝灾害早中期医学救援提供依据。方法检索PubMed、中国知网等数据库中有关洪涝灾害早中期疾病发生情况的文献,使用STATA 16.0软件对洪涝灾害发生早中期疾病占比进行合并,检验异质性并选择相应的效应模型,通过JBI量表识别发表偏倚,进行偏倚风险分析,并对同质性结果进行Meta分析;同时对洪涝灾害疾病发生的不同人群进行亚组分析。结果纳入文献20篇,合计111099例研究对象。Meta分析结果显示,洪涝灾害早中期各系统疾病分布情况分别为:皮肤疾病(30.8%)、呼吸系统疾病(24.1%)、消化系统疾病(13.1%)、损伤与中毒(12.6%)、循环系统疾病(4.0%)、视觉系统疾病(3.1%)、传染病(2.9%)、泌尿生殖系统疾病(0.5%)。结论洪涝灾害早中期皮肤疾病、呼吸系统疾病、消化系统疾病、损伤与中毒等疾病占比较高,受灾人员和救灾人员各疾病比例不同。

关键词：洪涝灾害疾病 Meta分析

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng li Meifeng Cai Shengjun Miao Yuan li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

基于电阻抗扫描成像的乳腺癌新辅助化疗疗效评价的仿真研究

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中国医疗设备 2020年第2期35卷 31-35页

作者：王瑞青马航李昊庭史学涛刘本源季振宇空军军医大学军事生物医学工程学院陕西西安710032 解放军陆军82集团军医院医学工程科河北保定071000

目的研究乳腺癌新辅助化疗期间,乳腺电阻抗扫描(Electrical Impedance Scanning,EIS)成像系统检测乳腺癌组织变化的能力。方法构建精细化乳腺电阻抗仿真模型,分析新辅助化疗期间EIS系统检测癌组织尺寸和电导率变化的能力,并对仿真数据... 详细信息

目的研究乳腺癌新辅助化疗期间,乳腺电阻抗扫描(Electrical Impedance Scanning,EIS)成像系统检测乳腺癌组织变化的能力。方法构建精细化乳腺电阻抗仿真模型,分析新辅助化疗期间EIS系统检测癌组织尺寸和电导率变化的能力,并对仿真数据进行曲线拟合得到对应的回归方程,最终得到衡量EIS系统检测癌组织变化的指标。结果EIS系统检测癌组织变化的能力与癌组织的长径和电导率变化均呈线性关系。当EIS系统检测阈值为0.05时,EIS系统可检测到的癌组织长径的最小变化量为2.17 mm,癌组织电导率的最小变化量为0.78 S/m。结论EIS系统能够实现对癌组织尺寸和电导率变化的敏感检测,仿真结果可为EIS应用于乳腺癌新辅助化疗疗效评价提供理论指导。

关键词：乳腺癌电阻抗扫描成像新辅助化疗仿真

Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong li Faqin li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni li Haojie An Shiyi Zeng Chunyan Wang li Yang Cheng Long School of life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission