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Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy

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Cancer Biology & Medicine 2024年第2期21卷 125-131页

作者： Jilong Yang Jin Xu haotian liu Wanyi Xiao Gengpu Zhang Department of Bone and Soft Tissue Tumor Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Molecular Cancer EpidemiologyTianjin 300060China Department of Anaesthesiology Tianjin University Tianjin HospitalTianjin 300211China

Bod et al.1 recently published a study in Nature that garnered attention to B cell-associated anti-tumor immunity and immunotherapy of melanoma and other tumors1.As a promising supplemental immunotherapy to mainstream... 详细信息

关键词： immunotherapy immunity

Hierarchical model updating strategy of complex assembled structures with uncorrelated dynamic modes

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Chinese Journal of Aeronautics 2022年第3期35卷 281-296页

作者： Chengwei FEI haotian liu Rhea PATRICIA LIEM Yatsze CHOY Lei HAN Department of Aeronautics and Astronautics Fudan UniversityShanghai 200433China Department of Mechanical and Aerospace Engineering Hong Kong University of Science and TechnologyHong Kong 999077China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHong Kong 999077China

In structural simulation and design,an accurate computational model directly determines the effectiveness of performance evaluation.To establish a high-fidelity dynamic model of a complex assembled structure,a Hierarchical Model Updating Strategy(HMUS)is developed for Finite Element(FE)model updating with regard to uncorrelated modes.The principle of HMUS is first elaborated by integrating hierarchical modeling concept,model updating technology with proper uncorrelated mode treatment,and parametric modeling.In the developed strategy,the correct correlated mode pairs amongst the uncorrelated modes are identified by an error minimization procedure.The proposed updating technique is validated by the dynamic FE model updating of a simple fixed–fixed beam.The proposed HMUS is then applied to the FE model updating of an aeroengine stator system(casings)to demonstrate its effectiveness.Our studies reveal that(A)parametric modeling technique is able to build an efficient equivalent model by simplifying complex structure in geometry while ensuring the consistency of mechanical characteristics;(B)the developed model updating technique efficiently processes the uncorrelated modes and precisely identifies correct Correlated Mode Pairs(CMPs)between FE model and experiment;(C)the proposed HMUS is accurate and efficient in the FE model updating of complex assembled structures such as aeroengine casings with large-scale model,complex geometry,high-nonlinearity and numerous parameters;(D)it is appropriate to update a complex structural FE model parameterized.The efforts of this study provide an efficient updating strategy for the dynamic model updating of complex assembled structures with experimental test data,which is promising to promote the precision and feasibility of simulation-based design optimization and performance evaluation of complex structures.

关键词： Aeroengine casings Assembled structures Correlated mode pair Hierarchical model updating Objective function Uncorrelated modes

Dynamic parametric modeling-based model updating strategy of aeroengine casings

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Chinese Journal of Aeronautics 2021年第12期34卷 145-157页

作者： Chengwei FEI haotian liu Shaolin LI Huan LI Liqiang AN Cheng LU Department of Aeronautics and Astronautics Fudan UniversityShanghai 200433China School of Energy and Power Engineering Beihang UniversityBeijing 100083China Beijing Key Laboratory of Aero-Engine Structure and Strength Beijing 100083China Department of Mechanical Engineering North China Electric Power UniversityBaoding 071003China

For accurate Finite Element(FE)modeling for the structural dynamics of aeroengine casings,Parametric Modeling-based Model Updating Strategy(PM-MUS)is proposed based on efficient FE parametric modeling and model updating techniques regarding uncorrelated/correlated mode shapes.Casings structure is parametrically modeled by simplifying initial structural FE model and equivalently simulating mechanical characteristics.Uncorrelated modes between FE model and experiment are reasonably handled by adopting an objective function to recognize correct correlated modes pairs.The parametrized FE model is updated to effectively describe structural dynamic characteristics in respect of testing data.The model updating technology is firstly validated by the detailed FE model updating of one fixed–fixed beam structure in light of correlated/uncorrelated mode shapes and measured mode data.The PM-MUS is applied to the FE parametrized model updating of an aeroengine stator system(casings)which is constructed by the proposed parametric modeling approach.As revealed in this study,(A)the updated models by the proposed updating strategy and dynamic test data is accurate,and(B)the uncorrelated modes like close modes can be effectively handled and precisely identify the FE model mode associated the corresponding experimental mode,and(C)parametric modeling can enhance the dynamic modeling updating of complex structure in the accuracy of mode matching.The efforts of this study provide an efficient dynamic model updating strategy(PM-MUS)for aeroengine casings by parametric modeling and experimental test data regarding uncorrelated modes.

关键词： Aeroengine casings Correlated mode pair Model updating Parametric modeling Structural dynamics Uncorrelated modes

Whole-process design and experimental validation of landing gear lower drag stay with global/local linked driven optimization strategy

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Chinese Journal of Aeronautics 2021年第2期34卷 318-328页

作者： Chengwei FEI haotian liu Zhengzheng ZHU Liqiang AN Shaolin LI Cheng LU Department of Aeronautics and Astronautics Fudcm UniversityShanghai 200433China School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072Xi'anChina Department of Mechanical Engineering North China Electric Power UniversityBaoding 071003China School of Energy and Power Engineering Beihang UniversityBeijing 100083China Beijing Key Laboratory of Aero-Engine Structure and Strength Beijing 100083China

Landing gear lower drag stay is a key component which connects fuselage and landing gear and directly effects the safety and performance of aircraft takeoff and landing. To effectively design the lower drag stay and reduce the weight of landing gear, Global/local Linked Driven Optimization Strategy(GLDOS) was developed to conduct the overall process design of lower drag stay in respect of optimization thought. The whole-process optimization involves two stages of structural conceptual design and detailed design. In the structural conceptual design, the landing gear lower drag stay was globally topologically optimized by adopting multiple starting points algorithm. In the detailed design, the local size and shape of landing gear lower drag stay were globally optimized by the gradient optimization strategy. The GLDOS method adopts different optimization strategies for different optimization stages to acquire the optimum design effect. Through the experimental validation, the weight of the optimized lower dray stay with the developed GLDOS is reduced by 16.79% while keeping enough strength and stiffness, which satisfies the requirements of engineering design under the typical loading conditions. The proposed GLDOS is validated to be accurate and efficient in optimization scheme and design cycles. The efforts of this paper provide a whole-process optimization approach regarding different optimization technologies in different design phases, which is significant in reducing structural weight and enhance design tp wid 1 precision for complex structures in aircrafts.

关键词： Global/local linked driven optimization Landing gear Lower drag stay Optimization Whole-process design

High sulfur loading and shuttle inhibition of advanced sulfur cathode enabled by graphene network skin and N,P,F-doped mesoporous carbon interfaces for ultra-stable lithium sulfur battery

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Nano Research Energy 2023年第1期2卷 148-156页

作者： haotian liu Fan liu Zehua Qu Jieling Chen Hui liu Yiqing Tan Jiabao Guo Yan Yan Shuang Zhao Xinsheng Zhao Xinming Nie Xin Ma Zengxia Pei Mingkai liu School of Chemistry&Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional MaterialsJiangsu Normal UniversityXuzhou 221116China School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjing 210044China School of Chemical and Biomolecular Engineering The University of SydneySydneyNew South Wales 2006Australia

Achieving high loading of active sulfur yet rational regulating the shuttle effect of lithium polysulfide(LiPS)is of great significance in pursuit of high-performance lithium-sulfur(Li-S)battery.Herein,we develop a free-standing graphene nitrogen(N),phosphorus(P)and fluorine(F)co-doped mesoporous carbon-sulfur(G-NPFMC-S)film,which was used as a binder-free cathode in Li-S battery.The developed mesoporous carbon(MC)achieved a high specific surface area of 921 m^(2)·g^(-1)with a uniform pore size distribution of 15 nm.The inserted graphene network inside G-NPFMC-S cathode can effectively improve its electrical conductivity and simultaneously restrict the shuttle of LiPS.A high sulfur loading of 86%was achieved due to the excellent porous structures of graphene-NPFMC(G-NPFMC)composite.When implemented as a freestanding cathode in Li-S battery,this G-NPFMC-S achieved a high specific capacity(1,356 mAh·g^(-1)),favorable rate capability,and long-term cycling stability up to 500 cycles with a minimum capacity fading rate of 0.025%per cycle,outperforming the corresponding performances of NPFMC-sulfur(NPFMC-S)and MC-sulfur(MC-S).These promising results can be ascribed to the featured structures that formed inside G-NPFMC-S film,as that highly porous NPFMC can provide sufficient storage space for the loading of sulfur,while,the N,P,F-doped carbonic interface and the inserted graphene network help hinder the shuttle of LiPS via chemical adsorption and physical barrier effect.This proposed unique structure can provide a bright prospect in that high mass loading of active sulfur and restriction the shuttle of LiPS can be simultaneously achieved for Li-S battery.

关键词： lithium sulfur battery high sulfur loading shuttle inhibition heteroatoms doped interface graphene network barrier

川东红星地区中上二叠统页岩气勘探成果及方向展望

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岩性油气藏 2024年第4期36卷 12-24页

作者：包汉勇赵帅张莉刘皓天中国石油化工股份有限公司江汉油田分公司勘探开发研究院武汉430223

基于构造、岩心、测井等资料,采用电镜扫描、低温N2吸附实验、高压压汞实验、盆地模拟等手段,系统分析了川东红星地区中上二叠统页岩的沉积演化、储层特征及页岩气富集模式,明确了勘探有利区,总结了勘探成果及意义。研究结果表明:(1)红... 详细信息

基于构造、岩心、测井等资料,采用电镜扫描、低温N2吸附实验、高压压汞实验、盆地模拟等手段,系统分析了川东红星地区中上二叠统页岩的沉积演化、储层特征及页岩气富集模式,明确了勘探有利区,总结了勘探成果及意义。研究结果表明:(1)红星地区中上二叠统的沉积演化表现为:栖霞组—茅口组三段为开阔台地相;茅四段底部为台地-陆棚相,相带变化快,茅四段顶部为斜坡-陆棚相,地层被剥蚀、南厚北薄;吴家坪组一段(吴一段)底部为海陆过渡滨岸沼泽-潟湖相,吴一段顶部为台地-斜坡-陆棚相,斜坡-陆棚相带分布范围小、相变快;吴二段为斜坡-陆棚相沉积,从早至晚依次受控于古气候、火山活动和古气候、火山活动,沉积中—晚期古生产力较高,TOC均值大于8.00%。(2)研究区茅四段及吴二段陆棚相区发育2套优质页岩,具有“高有机碳-高灰质”的特征,富有机质页岩厚度分别为19 m和25 m,孔隙类型以有机孔为主,结构以微孔和介孔为主;富碳凝灰岩薄夹层混合质页岩岩相、高碳凝灰岩薄夹层硅质页岩为优质岩相,孔隙度分别为6.27%和6.43%,TOC值分别为10.11%和9.35%,含气饱和度分别为92.59%和91.81%,脆性指数分别为55.24%和61.19%,是地质和工程的双“甜点”段。(3)研究区二叠系广泛发育的层状藻为主要有机质来源;在侏罗纪主排烃期,其构造稳定、二叠系烃源岩排烃较少,中侏罗纪—早白垩纪早期为主生气期,构造活动较弱,页岩气的保存条件好,现今已完成生气过程,处于成熟—过成熟阶段,Ro值约2.1%,勘探潜力巨大。(4)建南、龙驹坝、三星区块为有利勘探区,其中建南区块潜力最大;茅四段(3)小层及吴二段(3)小层为优质层系的靶窗层段。

关键词：深层页岩气沉积演化有机孔斜坡-陆棚 “高有机碳-高灰质”页岩吴家坪组茅口组中上二叠统川东红星地区

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陆相页岩岩相非均质性及储层孔隙发育特征:以四川盆地自流井组东岳庙段页岩为例

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地质科技通报 2024年第2期43卷 1-15页

作者：舒志国舒逸陈绵琨彭伟刘皓天肖雄中国石油化工股份有限公司江汉油田分公司湖北潜江433124 中国石油化工股份有限公司江汉油田分公司勘探开发研究院武汉430223

继四川盆地复兴地区涪页10井取得勘探突破后,侏罗系自流井组东岳庙段页岩油气表现出良好的勘探潜力。东岳庙段页岩发育独特的介壳灰岩夹层、黏土矿物含量高(质量分数最高可达60%),储层孔隙类型多样,纵向上具有很强的非均质性。以兴页X... 详细信息

继四川盆地复兴地区涪页10井取得勘探突破后,侏罗系自流井组东岳庙段页岩油气表现出良好的勘探潜力。东岳庙段页岩发育独特的介壳灰岩夹层、黏土矿物含量高(质量分数最高可达60%),储层孔隙类型多样,纵向上具有很强的非均质性。以兴页X井为例,结合测录井资料、岩心观察、氩离子抛光扫描电镜等技术手段,重点剖析了东岳庙段陆相页岩岩相特征及其孔隙发育特征。建立了“夹层+矿物三端元”的陆相页岩岩相划分原则,将东岳庙段陆相页岩纵向上划分为6种岩相,即:介屑纹夹层型黏土页岩相;介屑纹夹层型混合页岩相;介屑灰岩相;粉砂介屑互层型混合页岩相;粉砂介屑互层型黏土页岩相;介壳韵律型混合页岩相。通过氩离子抛光扫描电镜观察发现,该套陆相页岩具有特殊的有机黏土复合体孔,其中介屑纹夹层型黏土页岩相有机孔类型最为发育,而介屑灰岩相有机孔不发育,主要发育粒内溶孔。压汞-氮气吸附联测结果显示6种岩相页岩的孔径分布无明显差异性。综合分析认为,有机质和黏土矿物在成岩演化过程中的相互作用是东岳庙段陆相页岩孔隙发育的主要因素。

关键词：陆相页岩岩相非均质性有机黏土复合体孔侏罗系东岳庙段四川盆地

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川东红星地区二叠系茅口组页岩气勘探突破及富集主控因素

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中国石油勘探 2024年第1期29卷 65-75页

作者：包汉勇赵帅王必金郭战峰刘皓天张莉朱志芳中国石化江汉油田分公司勘探开发研究院中国石化江汉油田分公司中国石化江汉油田分公司工程院

四川盆地二叠系页岩气具有良好的成藏条件和勘探潜力,继二叠系吴家坪组获得勘探突破后,将低勘探程度层系——茅口组“高灰”页岩气作为重要的勘探接替方向。利用HYM-1等井的岩心、测录井和分析化验资料,系统开展茅口组页岩气藏条件与富... 详细信息

四川盆地二叠系页岩气具有良好的成藏条件和勘探潜力,继二叠系吴家坪组获得勘探突破后,将低勘探程度层系——茅口组“高灰”页岩气作为重要的勘探接替方向。利用HYM-1等井的岩心、测录井和分析化验资料,系统开展茅口组页岩气藏条件与富集特征的研究,认为茅口组四段一亚段页岩具有高碳、高灰、高孔隙度、高含气性、高杨氏模量、薄储层、多夹层的“五高一薄一多”的典型地质特征;与五峰组—龙马溪组等页岩相比,茅四段页岩碳酸盐矿物含量更高、黏土矿物含量更低,储集空间类型以有机质孔为主,无机孔较少,孔隙度平均4.27%,整体表现为高孔隙度;茅四段一亚段平均含气量为4.96m^(3)/t,具备较高的含气量。综合分析认为,富藻高碳页岩的发育、良好的储集能力和保存条件,以及页岩储层的可压裂性,是茅四段页岩气富集高产的主控因素。

关键词：四川盆地川东红星地区二叠系茅口组海相页岩地质特征富集控制因素

A Study on the Relationship Between Corporate Social Responsibility to Employee and Corporate Operating Performance in China： Evidence From New Era Health Industry （Group） Co., Ltd.

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Economics World 2017年第1期5卷 1-8页

作者： Song bai liu haotian liu BeijingNormalUniversity ZhuhaiChina