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Alternative splicing and related RNA binding proteins in human health and disease

Signal Transduction and Targeted Therapy 2024年第3期9卷 839-871页

作者： Yining Tao Qi Zhang Haoyu Wang Xiyu Yang haoran mu Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of Medicine200000 ShanghaiChina Shanghai Bone Tumor Institution 200000 ShanghaiChina Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory for Tumor Microenvironment and InflammationShanghai Jiao Tong University School of Medicine200000 ShanghaiChina

Alternative splicing(AS)serves as a pivotal mechanism in transcriptional regulation,engendering transcript diversity,and modifications in protein structure and *** varying tissues,developmental stages,or under specific conditions,AS gives rise to distinct splice *** implies that these isoforms possess unique temporal and spatial roles,thereby associating AS with standard biological activities and *** these,AS-related RNA-binding proteins(RBPs)play an instrumental role in regulating alternative splicing *** physiological conditions,the diversity of proteins mediated by AS influences the structure,function,interaction,and localization of proteins,thereby participating in the differentiation and development of an array of tissues and *** pathological conditions,alterations in AS are linked with various diseases,particularly *** changes can lead to modifications in gene splicing patterns,culminating in changes or loss of protein *** instance,in cancer,abnormalities in AS and RBPs may result in aberrant expression of cancer-associated genes,thereby promoting the onset and progression of *** and RBPs are also associated with numerous neurodegenerative diseases and autoimmune ***,the study of AS across different tissues holds significant *** review provides a detailed account of the recent advancements in the study of alternative splicing and AS-related RNA-binding proteins in tissue development and diseases,which aids in deepening the understanding of gene expression complexity and offers new insights and methodologies for precision medicine.

关键词： organs alterations thereby

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Interface and surface engineering of black phosphorus: a review for optoelectronic and photonic applications

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Materials Futures 2022年第1期1卷 52-75页

作者： haoran mu Wenzhi Yu Jian Yuan Shenghuang Lin Guangyu Zhang Songshan Lake Materials Laboratory DongguanGuangdong 523808People’s Republic of China

Since being rediscovered as an emerging 2D material,black phosphorus(BP),with an extraordinary energy structure and unusually strong interlayer interactions,offers new opportunities for optoelectronics and ***,due to the thin atomic body and the ease of degradation with water and oxides,BP is highly sensitive to the surrounding ***,high-quality engineering of interfaces and surfaces plays an essential role in BP-based *** this review,begun with a review of properties of BP,different strategies of interface and surfaces engineering for high ON-OFF ratio,enhanced optical absorption,and fast optical response are reviewed and highlighted,and recent state-of-the-art advances on optoelectronic and photonic devices are ***,the opportunities and challenges for future BP-related research are considered.

关键词： black phosphorus interface engineering surface engineering optoelectronics photonics

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Boosting the efficiency of quantum dot–sensitized solar cells over 15%through light-harvesting enhancement

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SusMat 2023年第4期3卷 543-554页

作者： Han Song haoran mu Jian Yuan Baiquan Liu Gongxun Bai Shenghuang Lin Songshan Lake Materials Laboratory DongguanGuangdongChina Institute of Physics Chinese Academy of ScienceBeijingChina School of Electronics and Information Technology Sun Yat-Sen UniversityGuangzhouGuangdongChina Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province China Jiliang UniversityHangzhouChina

How to improve the capacity of light-harvesting is still an important point and essential strategy for the assembling of high-efficiency quantum dot–sensitized solar cells(QDSCs).A believable approach is to implant new light absorption materials into QDSCs to stimulate the charge ***,the few-layer black phosphorus quantum dots(BPQDs)are synthesized by electrochemical intercalation technology using bulk BP as *** the obtained BPQDs are deposited onto the surface of Zn–Cu–In–S–Se(ZCISSe)QD-sensitized TiO2 substrate to serve as another light-harvesting material for the first *** experimental results have shown that BPQDs can not only increase the absorption intensity by photoanode but also reduce unnecessary charge recombination processes at the interface of photoanode/*** optimizing the size and deposition process of BPQDs,the champion power conversion efficiency of ZCISSe QDSCs is increased to 15.66%(26.88 mA/cm2,Voc=0.816 V,fill factor[FF]=0.714)when compared with the original value of 14.11%(Jsc=25.41 mA/cm^(2),Voc=0.779 V,FF=0.713).

关键词： black phosphorus quantum dots high-efficiency light-harvesting quantum dot–sensitized solar cells

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Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis

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Cancer Biology & Medicine 2022年第9期19卷 1397-1409页

作者： haoran mu Dongqing Zuo Jie Chen Zhigang Liu Zhuo Wang Liu Yang Qihui Shi Yingqi Hua Shanghai Bone Tumor Institute and Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Key Laboratory of Systems Biomedicine(Ministry of Education) Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Medical Epigenetics and the International Co-laboratory of Medical Epigenetics and Metabolism(MOST) Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer(SMHC)and Institute of Fudan-Minhang Academic Health System Minhang HospitalFudan UniversityShanghai 201199China Shanghai Engineering Research Center of Biomedical Analysis Reagents Shanghai 201203China

Objective:Osteosarcoma(OS)is an aggressive,highly metastatic,relatively drug-resistant bone tumor with poor long-term survival *** presence and persistence of circulating tumor cells(CTCs)in the peripheral blood are believed to be associated with treatment inefficiency and distant metastases.A blood-based CTC test is thus greatly needed for monitoring disease progression and predicting clinical ***,traditional methods cannot detect CTCs from tumors of mesenchymal origin such as OS,and research on CTC detection in mesenchymal tumors has been hindered for ***:In this study,we developed a CTC test based on hexokinase 2,a metabolic function-associated marker,for the detection and surveillance of OS CTCs,and subsequently explored its clinical *** patients with OS were enrolled as the training cohort for serial CTC *** CTC counting,in combination with therapy evaluation and post-treatment follow-up,was used to establish a model for predicting post-chemotherapy evaluation and disease-free survival,and the model was further validated with a cohort of 8 patients with ***:Two dynamic CTC number patterns were identified,and the resulting predictive model exhibited 92%consistency with the clinical *** model suggested that a single CTC test has similar predictive power to serial CTC *** the validation cohort,the single CTC test exhibited 100%and 87.5%consistency with therapy response and disease-free survival,***:Our non-invasive test for detection and surveillance of CTCs enables accurate prediction of therapy efficiency and prognosis,and may be clinically valuable for avoiding inefficient therapy and prolonging survival.

关键词： Circulating tumor cells osteosarcoma hexokinase 2 single-cell sequencing mesenchymal tumor

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Wafer-scale patterned growth of type-II Dirac semimetal platinum ditelluride for sensitive room-temperature terahertz photodetection

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InfoMat 2023年第5期5卷 17-27页

作者： Zhuo Dong Wenzhi Yu Libo Zhang Liu Yang Luyi Huang Yan Zhang Zeqian Ren haoran mu Cheng Chen Junrong Zhang Jie Li Lin Wang Kai Zhang CAS Key Laboratory of Nanophotonic Materials and Devices&Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhouJiangsuthe People's Republic of China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefeiAnhuithe People's Republic of China Songshan Lake Materials Laboratory DongguanGuangdongthe People's Republic of China State Key Laboratory for Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghaithe People's Republic of China

As the lastly unexplored electromagnetic wave,terahertz(THz)radiation has been exploited in a plenty of contexts such as fundamental research,military and civil *** recently,representative two-dimensional(2D)topological semimetal,platinum ditelluride(PtTe_(2))has attracted considerable research interest in THz detection due to its unique physical ***,to achieve practical applications,the low-cost,large-scale,controllable synthesis and efficient patterning of 2D materials are key requirements,which remain a challenge for PtTe_(2)and its photodetectors(PDs).Herein,a facile approach is developed to obtain waferscale(2-inches)patterned PtTe_(2)arrays using one-step tellurium-vapor transformation method and micro-Nano ***_(2)PD arrays are fabricated with the as-grown PtTe_(2)arrays evenly distributed on a 2-inch wafer,exhibiting high conductivity(~2.7×105 S m^(-1))and good electrical *** by the Dirac fermions,PtTe_(2)PDs achieve a broadband(0.02-0.3 THz)response with a fast response speed(~4.7μs),a high sensitivity(~47 pW Hz^(-1/2))and high-resolution transmission THz-imaging capability,which displays the potential of large-area THz array *** results are one step towards the practical applications of integrated PD arrays based on 2D materials.

关键词： patterned growth photodetection platinum ditelluride terahertz wafer-scale

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Engineering applications and technical challenges of active array microsystems

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 342-368页

作者： Jiaguo LU haoran ZHU East China Research Institute of Electronic Engineering Hefei 230039China School of Electronic and Information Engineering Anhui UniversityHefei 230601China

In the post-Moore era,the development of active phased array antennas will inevitably trend towards active array *** this paper,the characteristics and composition of the active array antenna are briefly *** to the high efficiency,low profile,and light weight of the active array microsystems,the application prospects and advantages in the engineering of multi-functional airborne radar,spaceborne radar,and communication systems are ***,according to the characteristics of the post-Moore era of integrated circuits,scientific and technological problems in the active array microsystems are presented,including multi-scale,multi-signal,and multi-physics field *** challenges are also discussed,such as new architectures and algorithms,miniaturization of passive components,novel materials and processes,ultra-wideband technology,and new interdisciplinary technological *** paper is expected to inspire in-depth research on active array microsystems.

关键词： Microelectronics Heterogeneous integration Packaging materials Antenna array microsystems multi-functional radar Communication

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Bacterial Cellulose/Zwitterionic Dual-network Porous Gel Polymer Electrolytes with High Ionic Conductivity

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 596-605页

作者：侯朝霞 WANG haoran QU Chenying Liaoning Province Key Laboratory of Micro-nano Materials Research and Development School of Mechanical EngineeringShenyang UniversityShenyang 110044China

Bacterial cellulose(BC)was innovatively combined with zwitterionic copolymer acrylamide and sulfobetaine methacrylic acid ester[P(AM-co-SBMA)]to build a dual-network porous structure gel polymer electrolytes(GPEs)with high ionic *** dual network structure BC/P(AM-co-SBMA)gels were formed by a simple one-step polymerization *** results show that ionic conductivity of BC/P(AM-co-SBMA)GPEs at the room temperature are 3.2×10^(-2) S/cm@1 M H_(2)SO_(4),4.5×10^(-2) S/cm@4 M KOH,and 3.6×10^(-2) S/cm@1 M NaCl,*** active carbon(AC)as the electrodes,BC/P(AM-co-SBMA)GPEs as both separator and electrolyte matrix,and 4 M KOH as the electrolyte,a symmetric solid supercapacitors(SSC)(AC-GPE-KOH)was assembled and *** specific capacitance of AC electrode is 173 F/g and remains 95.0%of the initial value after 5000 cycles and 86.2%after 10,000 cycles.

关键词： bacterial cellulose zwitterion gel polymer electrolytes ionic conductivity dual-network structure

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Beyond the lab:a nanoimprint metalens arraybased augmented reality

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Light(Science & Applications) 2024年第5期13卷 801-802页

作者： Chi Li haoran Ren School of Physics and Astronomy Monash UniversityMelbourneVICAustralia

A see-through augmented reality prototype has been developed based on an ultrathin nanoimprint metalens array,opening up a full-colour,video-rate,and low-cost 3D near-eye display.

关键词： cost ens imprint

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Tailoring the Properties of Polyhydroxyalkanoates from Plastics to Elastomers via Stereoselective Copolymerizations of rac-β-Butyrolactone and β-Propiolactone

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Chinese Journal of Chemistry 2024年第9期42卷 963-972页

作者： haoran Zhang JiaojiaoQin Xiaoyan Tang Beijing National Laboratoryfor Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenterfor Soft Matter Science and EngineeringCollegeof Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Poly(3-hydroxybutyrate),a crucial member of the large biodegradable polyhydroxyalkanoate family,suffers from its *** enhance its performance,we employed a straightforward approach involving the ring-opening copolymerization of racemic-β-butyrolactone(rac-β-BL)andβ-propiolactone(β-PL)using the syndio-selective amino-alkoxy-bis(phenolate)-yttrium complex as a catalyst,thanks to the excellent ductility of poly(3-hydroxypropionate).Control over the rac-β-BL/β-PL feeding ratios and polymerization time yielded random or block copolymers with tunable thermal and mechanical properties comparable to traditional fossil-based ***,we achieved one-pot synthesis of hard-soft-hard triblock copolymers by exploiting monomers’different copolymerization rates and a bifunctional initiator,thus transforming polyhydroxyalkanoates from hard and tough plastics to soft and ductile thermoplastic elastomers.

关键词： Ring-opening(co-)polymerization Biodegradable polymers Polyhydroxyalkanoates Copolymers Plastics Elastomers

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Mega-Constellations Based TT&C Resource Sharing: Keep Reliable Aeronautical Communication in an Emergency

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China Communications 2024年第2期21卷 1-16页

作者： haoran Xie Yafeng Zhan Jianhua Lu Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China

With the development of the transportation industry, the effective guidance of aircraft in an emergency to prevent catastrophic accidents remains one of the top safety concerns. Undoubtedly, operational status data of the aircraft play an important role in the judgment and command of the Operational Control Center(OCC). However, how to transmit various operational status data from abnormal aircraft back to the OCC in an emergency is still an open problem. In this paper, we propose a novel Telemetry, Tracking,and Command(TT&C) architecture named Collaborative TT&C(CoTT&C) based on mega-constellation to solve such a problem. CoTT&C allows each satellite to help the abnormal aircraft by sharing TT&C resources when needed, realizing real-time and reliable aeronautical communication in an emergency. Specifically, we design a dynamic resource sharing mechanism for CoTT&C and model the mechanism as a single-leader-multi-follower Stackelberg game. Further, we give an unique Nash Equilibrium(NE) of the game as a closed form. Simulation results demonstrate that the proposed resource sharing mechanism is effective, incentive compatible, fair, and reciprocal. We hope that our findings can shed some light for future research on aeronautical communications in an emergency.

关键词： aeronautical emergency communication mega-constellation networked TT&C resource allocation stackelberg game

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