检索结果-南通市图书馆

Unsupervised multi-modal image translation based on the squeeze-and-excitation mechanism and feature attention module

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Technology Letters 2024年第1期30卷 23-30页

作者：胡振涛 HU Chonghao yang haoran SHUAI Weiwei School of Artificial Intelligence Henan UniversityZhengzhou 450046P.R.China 95795 Troops of the PLA Guilin 541003P.R.China

The unsupervised multi-modal image translation is an emerging domain of computer vision whose goal is to transform an image from the source domain into many diverse styles in the target ***,the multi-generator mechanism is employed among the advanced approaches available to model different domain mappings,which results in inefficient training of neural networks and pattern collapse,leading to inefficient generation of image *** address this issue,this paper introduces a multi-modal unsupervised image translation framework that uses a generator to perform multi-modal image ***,firstly,the domain code is introduced in this paper to explicitly control the different generation ***,this paper brings in the squeeze-and-excitation(SE)mechanism and feature attention(FA)***,the model integrates multiple optimization objectives to ensure efficient multi-modal *** paper performs qualitative and quantitative experiments on multiple non-paired benchmark image translation datasets while demonstrating the benefits of the proposed method over existing ***,experimental results have shown that the proposed method is versatile and scalable.

关键词： multi-modal image translation generative adversarial network(GAN) squeezeand-excitation(SE)mechanism feature attention(FA)module

NG2 expression in rats with acute T_(10) spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2012年第5期7卷 359-362页

作者： haoran Lv Jinshun yang Zhuangwen Liao Yu Zhao Yan Huang Department of Orthopedic Surgery Second Affiliated Hospital of Guangzhou Medical College Guangzhou 510260 Guangdong ProvinceChina

Rat models of T10 spinal cord injury were established with a clamp method. NG2 expression was detected with immunohistochemical staining and western blot. Ten days after spinal cord injury, the number of NG2-positive cells in the damaged areas and NG2 absorbance were both significantly increased. The findings indicate that acute T10 spinal cord injury in rats can lead to upregulation of NG2 protein expression in damaged areas.

关键词： NG2 protein spinal cord injury immunohistochemistry western blot neural regeneration

Enhanced thermal performance from liquid metal in copper/graphite filled elastomer

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第21期152卷 247-255页

作者： Yisimayili Tuersun Xu Huang Mingdeng Huang Weiguang Lin Pingjun Luo haoran yang Sheng Chu School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510006China

With the increasing integration level of modern electronics,thermal management becomes an urgent issue for guaranteeing the work efficiency and lifespan of *** the basis of intrinsic high thermal conductivity nature,highly ordered graphite and copper stripes are densely aligned in the silicone gel pads in vertical(VCuGr)and oblique(@15°CuGr)directions to couple the high thermal conductivity and mechanical *** wetting nature of liquid metal(LM)on the chemically treated Cu surface is utilized to form a LM layer on the two surfaces of thermal *** obtained LM-pad TIMs possessed ultrahigh through-plane thermal conductivity(VCuGr:71.4 W/(m K),@15°CuGr:62.5 W/(m K))under the normal packaging *** thermal resistance decreased from 0.69 cm^(2) K/W to 0.25 cm^(2) K/W with the surface modification with *** simulation and practical thermal dissipation test results further demonstrate the excellent thermal management capability of these composites in high-power electronics.

关键词： Vertical copper/graphite High thermal conductivity Liquid metal modification Low thermal resistance Excellent thermal management

Rational design, synthesis, and biological evaluation of novel C6-modified geldanamycin derivatives as potent Hsp90 inhibitors and anti-tumor agents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第2期34卷 434-439页

作者： Ruxuan Wang Rentao Zhang haoran yang Nina Xue Xiaoguang Chen Xiaoming Yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Heat shock protein 90(Hsp90) is an appealing anticancer drug target that provoked a tremendous wave of investigations. Geldanamycin(GA) is the first identified Hsp90 inhibitor that exhibited potent anticancer activity, but the off-target toxicity associated with the benzoquinone moiety hampered its clinical application. Until now, structure optimization of GA is still in need to fully exploit the therapeutic value of Hsp90. Due to the structural complexity and synthetic challenge of this compound family, conventional optimization is bound to be costly but high efficiency is expected to be reachable by combining the art of rational design and total synthesis. Described in this paper is our first attempt at this approach aiming at rational modification of the C6-position of GA. The binding affinities towards Hsp90 of compound 1(C6-ethyl) and 2(C6-methyl) were designed and predicted by using Discovery Studio. These compounds were synthesized and further subjected to a thorough in vitro biological evaluation. We found that compounds1 and 2 bind to Hsp90 protein with the IC_(50) of 34.26 nmol/L and 163.7 nmol/L, respectively. Both compounds showed broad-spectrum antitumor effects. Replacing by ethyl, compound 1 exhibited more potent bioactivity than positive control GA, such as in G2/M cell cycle arrest, cell apoptosis and client proteins degradations. The results firstly indicated that the docking study is able to provide a precise prediction of Hsp90 affinities of GA analogues, and the C6 substituent of GA is not erasable without affecting its biological activity.

关键词： Hsp90 inhibitors Geldanamycin derivatives Total synthesis Structure-activity relationship Anticancer

Prediction of Low-Permeability Reservoirs Performances Using Long and Short-Term Memory Machine Learning

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2022年第5期18卷 1521-1528页

作者： Guowei Zhu Kangliang Guo haoran yang Xinchen Gao Shuangshuang Zhang School of Geosciences Yangtze UniversityWuhan430100China

In order to overcome the typical limitations of numerical simulation methods used to estimate the production of low-permeability reservoirs,in this study,a new data-driven approach is proposed for the case of water-driven hypo-permeable *** particular,given the bottlenecks of traditional recurrent neural networks in handling time series data,a neural network with long and short-term memory is used for such a *** method can reduce the time required to solve a large number of partial differential *** such,it can therefore significantly improve the efficiency in predicting the needed production *** examples about water-driven hypotonic reservoirs are provided to demonstrate the correctness of the method and its ability to meet the requirements for practical reservoir applications.

关键词： Water flooding flow in porous media data-driven LSTM CFD

Numerical investigation on fire-induced indoor and outdoor air pollutant dispersion in an idealized urban street canyon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2022年第4期15卷 597-614页

作者： Shengzhong Zhao haoran yang Chaorui Li Imad Obadi Fei Wang Wenjun Lei Tiantian Xu Miaocheng Weng School of Thermal Engineering Shandong Jianzhu UniversityJinanChina School of Architecture Design and PlanningThe University of SydneySydneyAustralia School of Civil Engineering Chongqing UniversityChongqingChina

Fire-induced pollutant dispersion under the influence of buoyancy in urban street canyons has attracted wide attention given its adverse impact on human *** study analyzes the influences of fire source location and crossflowing wind(perpendicular to the canyon centerline)on indoor and outdoor air pollutant dispersion in an idealized urban street canyon by employing large eddy *** fire scenarios are defined according to the transverse location of the fire source:near the windward building(scenario 1),in the middle of the canyon(scenario 2),and near the leeward building(scenario 3).Results show that a re-entrainment phenomenon appears when the wind velocity reaches a critical value in scenarios 1 and 2,but it doesn't occur in scenario *** source location significantly influences the critical re-entrainment *** critical velocity in scenario 1 is approximate 1.2-1.5 m/s larger than that in scenario *** the heat release rate is large,the critical Fr numbers are less sensitive to changes in HRR,and remain approximately constant with values of 0.47(scenario 1)and 0.37(scenario 2).When the wind velocity is large,more compartments are expected to be affected in the upper floors in all of the three scenarios,and smoke is distributed in an inverted triangle within the *** indoor/outdoor temperature and pollutant concentrations are also *** findings can provide valuable information for both human and property safety in relation to urban street canyons and their surrounding buildings.

关键词： air pollutant dispersion fire smoke street canyon critical re-entrainment velocity fire source location

Productivity Prediction Model of Perforated Horizontal Well Based on Permeability Calculation in Near-Well High Permeability Reservoir Area

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy Engineering 2024年第1期121卷 59-75页

作者： Shuangshuang Zhang Kangliang Guo Xinchen Gao haoran yang Jinfeng Zhang Xing Han College of the Earth Science Yangtze UniversityWuhan430100China PetroChina Changqing Oilfield Fifth Oil Production Plant Xi’an710201China Sinopec Jianghan Oilfield Information Center Wuhan430100China

To improve the productivity of oil wells,perforation technology is usually used to improve the productivity of horizontal wells in oilfield *** the perforation operation,the perforation channel around the wellbore will form a near-well high-permeability reservoir area with the penetration depth as the radius,that is,the formation has different permeability characteristics with the perforation depth as the dividing ***,the permeability is measured by the permeability tester,but this approach has a high workload and limited *** this paper,according to the reservoir characteristics of perforated horizontal wells,the reservoir is divided into two areas:the original reservoir area and the near-well high permeability reservoir *** on the theory of seepage mechanics and the formula of open hole productivity,the permeability calculation formula of near-well high permeability reservoir area with perforation parameters is *** to the principle of seepage continuity,the seepage is regarded as the synthesis of two directions:the horizontal plane elliptic seepage field and the vertical plane radial seepage field,and the oil well productivity prediction model of the perforated horizontal well is established by *** model comparison demonstrates that the model is reasonable and *** calculate and analyze the effect of oil well production and the law of influencing factors,actual production data of the oilfield are substituted into the oil well productivity *** can effectively guide the technical process design and effect prediction of perforated horizontal wells.

关键词： Perforated horizontal well permeability productivity model sensitivity analysis

Selection of the appropriate reference genes by quantitative real-time PCR in leopard coral groupers Plectropomus leopardus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2023年第3期41卷 1084-1099页

作者： Han ZHANG haoran yang Pengsuo LI Na ZHAO Xiaojuan CHEN Yongcan ZHOU Zhenjie CAO Yun SUN State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikou 570228China Key Laboratory of Tropical Hydrobiology and Biotechnology of Hainan Province Haikou 570228China Department of Aquaculture College of Marine SciencesHainan UniversityHaikou 570228China

Leopard coral groupers(Plectropomus leopardus),commercially bred in South China,are a significant economical fish *** this study,by means of quantitative real-time PCR(qRT-PCR)technology,we assessed the stability of six common reference genes expression and selected the appropriate reference genes in leopard coral groupers with or without Vibrio harveyi stimulation at different time *** data produced by qRT-PCR was handled via the geNorm,NormFinder,and BestKeeper *** results revealed all the examined reference genes had manifest tissue-specific expression in different *** to *** stimulation,RPL13 gene was the appropriate reference gene among eleven tissue types(blood,spleen,hepatopancreas,kidney,stomach,gill,heart,skin,muscle,intestine,brain)in leopard coral *** *** stimulation,the most reliable reference genes varied from tissue to tissue and were closely hinged upon different time *** 6-h post-bacterial injection,the appropriate reference genes in hepatopancreas,spleen,kidney,and gill were Actin,B2M,UBCE,and Actin,*** 9-and 12-h post-bacterial injection,the appropriate reference genes in hepatopancreas,spleen,kidney,and gill were RPL13,Actin,Actin,and Actin,*** one reference gene was preferable,RPL13,Actin,Actin,and Actin could be selected as the reference gene in hepatopancreas,spleen,kidney,and gill of leopard coral groupers after *** infection,*** profiles of two target genes(IL-6 and NK-lysin)were used to further validate reliability of these selected appropriate *** study will lay a solid foundation for the future research on qRTPCR analysis of gene expression in leopard coral groupers.

关键词： Plectropomus leopardus reference genes Vibrio harveyi stimulation

Highly efficient synthesis of boron nitride nanotubes by catalytic chemical vapor deposition of boron/nickel containing precursors

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2022年第6期8卷 1199-1204页

作者： Heng Wang haoran yang Yongzhi Peng Yulin Zheng Dongying Huang Pu Hu Yawei Li Zhengyi Fu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Key Laboratory of Green Chemical Engineering Process of Ministry of EducationWuhan Institute of TechnologyWuhan430205China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081China

High-purity and high-yield boron nitride nanotubes with large aspect ratio were prepared by a facile two-step process,including the synthesis of boron/nickel containing precursors by precipitation reactions and subsequent thermally catalytic chemical vapor deposition *** influence of catalyst content and annealing temperature on the phase composition and microstructure of the products were *** results show that it is difficult to exert the catalytic effect of nickel-based catalyst at low temperatures(<1400℃).At appropriate temperatures(1400-1500℃),highly crystalline boron nitride nanotubes with a length of more than 50 mm and a diameter of 50 nm are *** content of catalyst in the precursor mainly affects the morphology of the boron nitride *** the content is too low,it is easy to form boron nitride particles;while high catalyst content can easily lead to catalyst aggregation and form a submicron one-dimensional boron nitride with unregular *** on microstructural evolutions,phase changes,and thermodynamic analysis,the vapor-liquid-solid(V-L-S)growth mechanism of the tip growth mode dominates the formation of boron nitride nanotubes has also been verified.

关键词： Boron nitride nanotubes Highly efficient synthesis Boron/nickel containing precursors Growth mechanism