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Food Science and Human Wellness 2024年第3期13卷 1292-1302页

作者： Li Kong Xinyu Gao Lijuan Zhu Xing Lin You Huang Chunlin Huang Wenjiang Yang Yazhi Chen haoqiang zhao Jing Wu Zhihang Yuan Jin’e Yi Hunan Engineering Research Center of Livestock and Poultry Health Care College of Veterinary MedicineHunan Agricultural UniversityChangsha 410128China

F-2 toxin is an estrogenic mycotoxin that causes reproductive disorders in *** acid(BA)is a natural pentacyclic lupane-structure triterpenoid that has diverse pharmacological *** this study,the antioxidative and anti-inflammatory effects of BA and its underlying mechanism are explored in F-2 toxin-triggered mouse ovarian *** found that BA alleviated the F-2 toxin-induced ovarian impairment by stimulating follicle growth,reducing inflammatory cell infiltration,repairing damaged mitochondria and endoplasmic ***,BA not only reversed F-2 toxin-induced reduction of follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels in the serum,but also restrained the protein expression of the estrogen receptors a(ERa)and ERβ.Moreover,BA restored the balance of F-2 toxin-induced ovarian redox system ***,we found that 0.25 mg/kg BA played an anti-inflammatory role in the F-2 toxin-induced ovarian impairment by decreasing interleukin-1β(IL-1β).IL-6,and tumor necrosis factor-α(TNF-α)mRNA expression,as well as inhibiting p38 protein *** data demonstrated that BA exerts its protective effect on F-2 toxin-induced ovarian oxidative impairment and inflammation by inhibiting p38 expression,which implies a natural product-based medicine to ameliorate F-2 toxin-caused female reproductive toxicity and provides a detoxifying method for food contaminated by mycotoxin.

关键词： Betulinic acid F-2 toxin Ovarian damage p38 MAPK signaling pathway

Intelligent UAV Based Energy Supply for 6G Wireless Powered IoT Networks

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China Communications 2024年第9期21卷 321-337页

作者： Miao Jiansong Chen haoqiang Wang Pengjie Li Hairui zhao Yan Mu Junsheng Yan Shi School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and TelecommunicationsBeijing 100876China

In this paper,we develop a 6G wireless powered Internet of Things(IoT)system assisted by unmanned aerial vehicles(UAVs)to intelligently supply energy and collect data at the same *** our dual-UAV scheme,UAV-E,with a constant power supply,transmits energy to charge the IoT devices on the ground,whereas UAV-B serves the IoT devices by data collection as a base *** this framework,the system's energy efficiency is maximized,which we define as a ratio of the sum rate of IoT devices to the energy consumption of two UAVs during a fixed working *** the constraints of duration,transmit power,energy,and mobility,a difficult non-convex issue is presented by optimizing the trajectory,time duration allocation,and uplink transmit power of *** tackle the non-convex fractional optimization issue,we deconstruct it into three subproblems and we solve each of them iteratively using the descent method in conjunction with sequential convex approximation(SCA)approaches and the Dinkelbach *** simulation findings indicate that the suggested cooperative design has the potential to greatly increase the energy efficiency of the 6G intelligent UAV-assisted wireless powered IoT system when compared to previous benchmark systems.

关键词： 6G wireless powered network energy efficiency IoT intelligent network UAV communication

“学院+书院”双院制协同育人模式的研究与实践——以北京中医药大学中药学拔尖学生培养基地时珍书院为例

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中医教育 2024年第3期43卷 21-25页

作者：赵浩强窦津晶王运丽马家宝周天尹兴斌雷海民北京中医药大学中药学院北京102488

学院和书院协同育人模式是当前高等教育领域的一个重要创新,可有效提升拔尖学生的综合素质和竞争力。北京中医药大学时珍书院秉承“医药圆融重传承,药教协同求创新”的教育理念,通过“学院+书院”的协同育人模式,为中医药人才的培养探... 详细信息

学院和书院协同育人模式是当前高等教育领域的一个重要创新,可有效提升拔尖学生的综合素质和竞争力。北京中医药大学时珍书院秉承“医药圆融重传承,药教协同求创新”的教育理念,通过“学院+书院”的协同育人模式,为中医药人才的培养探索了一条新路。这一模式将专业学院的知识传授与书院的文化熏陶相结合,旨在提升学生的综合素质,增强其学术竞争力。在此框架下,时珍书院注重中医药传统的继承与发展,同时强调教育的创新实践,形成了具有特色的中药学拔尖学生培养方案。

关键词：双院制学院书院中医药人才培养

Relationships Between Meteorological Factors and Mongolian Gerbils and Its Flea Burdens—Xilingol League,Inner Mongolia Autonomous Region,China,2012–2021

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China CDC weekly 2024年第23期6卷 547-552,I0012-I0018页

作者： Ke Li Zhenxu Wang Xiaohui Wei haoqiang Ji Meng Shang Nan Chang Zihao Wang Chenran Guo Lei Xu Ning zhao Qiyong Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Cheeloo College of Medicine Shandong UniversitySchool of Public HealthJinan CityShandong ProvinceChina Vanke School of Public Health Tsinghua UniversityBeijingChina

Introduction:Plague is a significant global infectious disease,its spread is linked to host and flea *** conditions can impact flea populations and host densities,hence influencing plague *** the connection between meteorological factors,flea populations,and rodent densities in Inner Mongolia’s natural plague foci can aid in predicting and managing plague ***:Monthly data on flea index,rodent density,meteorological factors,and normalized difference vegetation index(NDVI)were collected for the study *** additive modeling(GAM)was used to analyze the non-linear and lag effects of meteorological factors on flea index and rodent *** equation modeling(SEM)was employed to investigate the relationships among meteorological factors,NDVI,flea index,and rodent ***:GAM analysis revealed that temperature,precipitation,relative humidity,and NDVI had significant linear,non-linear,and time-lagged impacts on the density of Mongolian gerbils and the flea *** analysis indicated that meteorological factors could directly influence the density and flea index of Mongolian gerbils,or indirectly impact NDVI,subsequently influencing gerbil density and the flea ***:Meteorological factors primarily influence gerbil density and flea index indirectly by affecting NDVI and the relationship between flea index and gerbil *** study offers additional support for the significance of meteorological factors and NDVI in influencing the vector-rodent system,offering valuable insights for predicting and managing plague outbreaks.

关键词： meteorological offering humidity

The transcription factor IbNAC29 positively regulates the carotenoid accumulation in sweet potato

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Horticulture Research 2023年第3期10卷 189-200页

作者： Shihan Xing Ruijie Li haoqiang zhao Hong Zhai Shaozhen He Huan Zhang Yuanyuan Zhou Ning zhao Shaopei Gao Qingchang Liu Key Laboratory of Sweet Potato Biology and Biotechnology Ministry of Agriculture and Rural Affairs/Beijing Key Laboratory of Crop Genetic Improvement/Laboratory of Crop Heterosis and UtilizationMinistry of EducationCollege of Agronomy&BiotechnologyChina Agricultural UniversityBeijing 100193China

Carotenoid is a tetraterpene pigment beneficial for human *** the carotenoid biosynthesis pathway has been extensively studied in plants,relatively little is known about their regulation in sweet ***,we conducted the transcriptome database of differentially expressed genes between the sweet potato(Ipomoea batatas)cultivar‘Weiduoli’and its high-carotenoid mutant‘HVB-3’.In this study,we selected one of these candidate genes,IbNAC29,for subsequent ***29 belongs to the plant-specific NAC(NAM,ATAF1/2,and CUC2)transcription factor *** IbNAC29 mRNA level in the HVB-3 storage roots was∼1.71-fold higher than *** experiments showed that the contents ofα-carotene,lutein,β-carotene,zeaxanthin,and capsanthin are obviously increased in the storage roots of transgenic sweet potato plants overexpressing ***,the levels of carotenoid biosynthesis genes in transgenic plants were also ***,yeast one-hybrid assays indicated that IbNAC29 could not directly bind to the promoters of these carotenoid biosynthesis ***,the level of IbSGR1 was down-regulated,whose homologous genes in tomato can negatively regulate carotene *** three-hybrid analysis revealed that the IbNAC29-IbMYB1R1-IbAITR5 could form a regulatory *** one-hybrid,electrophoretic mobility shift assay,quantitative PCR analysis of chromatin immunoprecipitation and dual-luciferase reporter assay showed that IbAITR5 directly binds to and inhibits the promoter activity of IbSGR1,up-regulating carotenoid biosynthesis gene *** together,IbNAC29 is a potential candidate gene for the genetic improvement of nutritive value in sweet potato.

关键词： roots sweet potato

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植物油体蛋白基因家族研究进展

遗传 2022年第12期44卷 1128-1140页

作者：赵浩强王小斐高少培中国农业大学教育部作物杂种优势研究与利用重点实验室/农业农村部甘薯生物学与生物技术重点实验室北京100193 中国农业大学食品科学与营养工程学院北京100083

油体也称脂滴或油滴,是植物细胞中一种重要的储藏油脂的细胞器。油体由单层磷脂膜包裹中性脂肪酸组成,膜上镶嵌有多种膜蛋白,包括油体蛋白、油体钙蛋白和油体固醇蛋白,其中油体蛋白占80%~90%。油体蛋白在影响油体大小与稳定性、油体形... 详细信息

油体也称脂滴或油滴,是植物细胞中一种重要的储藏油脂的细胞器。油体由单层磷脂膜包裹中性脂肪酸组成,膜上镶嵌有多种膜蛋白,包括油体蛋白、油体钙蛋白和油体固醇蛋白,其中油体蛋白占80%~90%。油体蛋白在影响油体大小与稳定性、油体形成和降解、脂质代谢、种子成熟及萌发等多种生命活动中都发挥着重要的生物学作用。本文结合近些年国内外关于植物油体蛋白基因家族的研究进展系统总结了油体蛋白序列与结构特征及在植物生长发育中所扮演的重要角色,讨论了油体蛋白作为一种新型植物蛋白在实际生产中的应用场景和油体蛋白研究及应用过程中仍存在的一些问题,以期为人们后期更加深入研究植物油体蛋白相关分子功能及在生产实践中应用提供有益的参考。

关键词：油体油体蛋白油体稳定性脂质代谢油脂合成

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基于属性关联的朴素贝叶斯分类算法

计算机工程 2018年第6期44卷 18-23页

作者：宁可孙同晶赵浩强杭州电子科技大学自动化学院杭州310018 浙江省电子信息产品检验所杭州310007

针对传统朴素贝叶斯分类算法处理多维连续型数据时准确率较低的问题,提出基于属性关联的改进算法。通过高斯分割对属性类别不同的多维连续型数据集进行离散化处理,并使用拉普拉斯校准、属性关联和属性加权方法改进朴素贝叶斯分类过程。... 详细信息

针对传统朴素贝叶斯分类算法处理多维连续型数据时准确率较低的问题,提出基于属性关联的改进算法。通过高斯分割对属性类别不同的多维连续型数据集进行离散化处理,并使用拉普拉斯校准、属性关联和属性加权方法改进朴素贝叶斯分类过程。实验结果表明,与基于拉普拉斯校准或属性加权的改进算法相比,该算法能够提高分类准确率,且提升幅度在一定范围内随着属性数量的增加而增加,适用于多维连续型数据的分类。

关键词：连续型数据数据分类关联规则朴素贝叶斯分类算法属性加权

New measurement of the neutron-induced total cross-sections of^(nat)Cr in a wide energy range on the Back-n at CSNS

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Chinese Physics C 2024年第10期48卷 168-175页

作者： Baoqian Li Min Xiao Yonghao Chen Jieming Xue Xinxiang Li Han Yi Pinjing Cheng Rong Liu Yiwei Yang Zijie Han Dajun zhao haoqiang Wang Jirong zhao Peng Luan Jing Liu Zijun Liu Chaomin Chen Wen Luo Bo Zheng Song Feng School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron total cross-section of ^(nat)Cr plays a crucial role in new nuclear engineering design and fundamental science.A new measurement of the neutron-induced total cross-sections of ^(nat)Cr was performed using the transmission method on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron Source(CSNS).The neutron energy was determined using the time-of-flight *** neutron total cross-sections of ^(nat)Cr were obtained across a broad energy range(0.3 eV−20 MeV)in one experiment for the first *** resulting effective total cross-sections were compared with the existing experimental data in different energy ranges,which revealed good agreement with the evaluated *** calculation of the total cross-section in the energy range of 1.5 to 20 MeV was then conducted using TALYS-1.96 and compared with the present *** measurement provides a high-quality total cross-section of ^(nat)Cr,including detailed uncertainty data across a wide energy range,offering a valuable reference for nuclear data re-evaluation and nuclear engineering design.

关键词： neutron total cross-section natural chromium Back-n white neutron beamline NTOX

环化及亚胺/酰胺部分氢化一锅法串联反应合成1,2,3,4⁃四氢喹喔啉

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高等学校化学学报 2020年第10期41卷 2239-2255,M0003页

作者：潘一骁李艳稳韩佳宏赵浩强冯宇丁相元徐立进范青华时茜中国人民大学化学系北京100872 中国科学院化学研究所北京100190 温州大学化学与材料工程学院温州325035

报道了一种利用价廉易得的邻苯二胺衍生物与α-酮酸酯经环化/钌催化的亚胺和酰胺氢化串联反应一锅法制备1,2,3,4-四氢喹喔啉的方法.该方法使用原位生成的Ru(acac)3/Triphos配合物和HBF4共催化剂组成的催化体系,高效制备了一系列2-取代的... 详细信息

报道了一种利用价廉易得的邻苯二胺衍生物与α-酮酸酯经环化/钌催化的亚胺和酰胺氢化串联反应一锅法制备1,2,3,4-四氢喹喔啉的方法.该方法使用原位生成的Ru(acac)3/Triphos配合物和HBF4共催化剂组成的催化体系,高效制备了一系列2-取代的1,2,3,4-四氢喹喔啉,官能团耐受性良好.在较低的氢气压力和不使用助催化剂的条件下,反应可停留在只生成3,4-二氢喹喔啉酮产物阶段.反应机理研究表明,钌催化剂仅用于还原亚胺和酰胺部分,而布朗斯台德酸助催化剂的选择对于酰胺部分去氧氢化至关重要.研究表明,布朗斯台德酸助催化剂通过活化酰胺部分参与催化过程.

关键词：四氢喹喔啉环化亚胺酰胺氢化

“四新”建设背景下中药学拔尖学生培养基地建设模式研究——以北京中医药大学中药学拔尖学生培养基地为例

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中医教育 2023年第5期42卷 81-87页

作者：赵浩强张薇吴清雷海民北京中医药大学中药学院北京102488

为深入贯彻习近平总书记关于推进“新医科、新工科、新农科、新文科”建设的重要指示精神,推动中医药文化创造性转化和创新性发展,北京中医药大学“拔尖计划2.0”中药学拔尖学生培养基地保持和发展“医药圆融重传承,药教协同求创新”的... 详细信息

为深入贯彻习近平总书记关于推进“新医科、新工科、新农科、新文科”建设的重要指示精神,推动中医药文化创造性转化和创新性发展,北京中医药大学“拔尖计划2.0”中药学拔尖学生培养基地保持和发展“医药圆融重传承,药教协同求创新”的培养特色,由前期摸索逐步走向模式变革,力求培养面向中医药传承创新与中医药产业升级的新型人才。以北京中医药大学中药学拔尖学生培养基地建设为例,从基地建设基本路线、建设目标与实施方案等方面进行了详细的分析与研究,期望本研究能为中医药院校中药学拔尖人才培养基地的建设提供参考。

关键词： “四新”建设中医药中药学拔尖学生培养基地拔尖计划2.0