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Hippo(YAP)-autophagy axis protects against hepatic ischemia-reperfusion injury through JNK signaling

Chinese Medical Journal 2024年第6期137卷 657-668页

作者： Shuguang Zhu Xiaowen Wang haoqi chen Wenfeng Zhu Xuejiao Li Ruiwen Cui Xiaomeng Yi Xiaolong chen Hua Li Genshu Wang Department of Hepatic Surgery Liver TransplantationThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Hepatology lab The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of General Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Organ Transplantation The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Renal Transplantation Guangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdong 510630China Department of Surgical Intensive Care Unit The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Hepatic Surgery Liver TransplantationGuangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdong 510630China

Background:Hepatic ischemia-reperfusion injury(HIRI)remains a common complication during liver transplantation(LT)in *** a key downstream effector of the Hippo pathway,Yes-associated protein(YAP)has been reported to be involved in various physiological and pathological ***,it remains elusive whether and how YAP may control autophagy activation during ***:Human liver tissues from patients who had undergone LT were obtained to evaluate the correlation between YAP and autophagy *** an in vitro hepatocyte cell line and in vivo liver-specific YAP knockdown mice were used to establish the hepatic ischemia-reperfusion models to determine the role of YAP in the activation of autophagy and the mechanism of ***:Autophagy was activated in the post-perfusion liver grafts during LT in patients,and the expression of YAP positively correlated with the autophagic level of ***-specific knockdown of YAP inhibited hepatocytes autophagy upon hypoxia-reoxygenation and HIRI(P<0.05).YAP deficiency aggravated HIRI by promoting the apoptosis of hepatocytes both in the in vitro and in vivo models(P<0.05).Attenuated HIRI by overexpression of YAP was diminished after the inhibition of autophagy with *** addition,inhibiting autophagy activation by YAP knockdown exacerbated mitochondrial damage through increasing reactive oxygen species(P<0.05).Moreover,the regulation of autophagy by YAP during HIRI was mediated by AP1(c-Jun)N-terminal kinase(JNK)signaling through binding to the transcriptional enhanced associate domain(TEAD).Conclusions:YAP protects against HIRI by inducing autophagy via JNK signaling that suppresses the apoptosis of *** Hippo(YAP)-JNK-autophagy axis may provide a novel strategy for the prevention and treatment of HIRI.

关键词： YAP-signaling proteins Autophagy c-Jun N-terminal kinase Ischemia-reperfusion injury Liver transplantation

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Ultra-compact and broadband polarization-insensitive mode-order converting power splitter

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Chinese Optics Letters 2024年第3期22卷 36-41页

作者：陈浩琪姚润葵汪鹏君符强陈伟伟戴世勋孔德军林健金涛李军戴庭舸杨建义 Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China College of Electrical and Electronic Engineering Wenzhou UniversityWenzhou 325035China College of Science and Technology Ningbo UniversityNingbo 315211China Laboratory of Infrared Materials and Devices The Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211China Department of Information Science and Electronics Engineering Zhejiang UniversityHangzhou 310027China

A polarization-insensitive mode-order converting power splitter using a pixelated region is presented and investigated in this *** TE_(0)and TM_(0)modes are injected into the input port,they are converted into TE_(1)and TM_(1)modes,which evenly come out from the two output *** finite-difference time-domain method and direct-binary-search optimization algorithm are utilized to optimize structural parameters of the pixelated region to attain small insertion loss,low crosstalk,wide bandwidth,excellent power uniformity,polarization-insensitive property,and compact *** results reveal that the insertion loss,crosstalk,and power uniformity of the fabricated device at 1550 nm are 0.57,-19.67,and 0.094 d B in the case of TE polarization,while in the TM polarization,the relevant insertion loss,crosstalk,and power uniformity are 0.57,-19.40,and 0.11 d *** a wavelength range from 1520 to 1600 nm,for the fabricated device working at TE polarization,the insertion loss,crosstalk,and power uniformity are lower than 1.39,-17.64,and 0.14 *** the case of TM polarization,we achieved an insertion loss,crosstalk,and power uniformity less than 1.23,-17.62,and 0.14 dB.

关键词： integrated optics optical waveguide polarization-insensitive property mode-order converting power splitter

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基于稳定性分析的含酸/醇烃水体系相平衡计算

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化工学报 2024年第3期75卷 789-800页

作者：陈好奇史博会彭琪康琦宋尚飞姚海元陈海宏吴海浩宫敬中国石油大学(北京)油气管道输送安全国家工程实验室石油工程教育部重点实验室城市油气输配技术北京市重点实验室北京102249 中国石油大学(北京)碳中和示范性能源学院北京102249 清华大学深圳清华大学研究院广东深圳518057 中海油研究总院有限责任公司北京100028

油气开发的井流物多以油气水混相形式存在。对于酸性油气田,还常伴有硫化氢或二氧化碳等酸性气体。为了避免水合物生成堵塞管道,加注醇类防冻剂是常用的方法。因而油气田井流物易于呈现含酸、含醇的多相烃水混输状态。含酸/醇烃水体系... 详细信息

油气开发的井流物多以油气水混相形式存在。对于酸性油气田,还常伴有硫化氢或二氧化碳等酸性气体。为了避免水合物生成堵塞管道,加注醇类防冻剂是常用的方法。因而油气田井流物易于呈现含酸、含醇的多相烃水混输状态。含酸/醇烃水体系相平衡的准确计算,是预测其物性特征的基础,也是支持该复杂体系多相混输流动仿真的关键。但目前被广泛应用的基于经典立方型状态方程计算油气水体系相平衡的方法,存在对液烃及水相分布预测准确性不高的问题。为此,引入稳定性分析的方法,构建适用于含酸/醇烃水体系的稳定性检验方式,结合SRK-HV状态方程,建立了耦合稳定性分析的含酸/醇烃水多相多组分相平衡计算模型及算法。经多角度验证,本研究所提模型具有较高的准确性与稳定性。

关键词：相平衡热力学状态方程稳定性分析闪蒸计算

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Degradation of o-dichlorobenzene by DBD-NTP co-modified titanium gel catalyst

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Journal of Environmental Sciences 2024年第9期143卷 71-84页

作者： Wenbo Zhang Yi Xing Wei Su Jiaqing Wang haoqi Jia Yongkang Cui Jing chen Hui Zhang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science and Technology BeijingBeijing 100083China Guangdong Province Engineering Laboratory for Air Pollution Control Guangzhou 510530China College of Environmental and Resource Sciences Shanxi UniversityTaiyuan 030006China Sinosteel Maanshan Mine Research Institute Co.Ltd. Anhui 243071China

In order to study the degradation process of dioxins in industrial flue gas,the decomposition of o-dichlorobenzene(o-DCB)in a DBD plasma catalytic reactor was *** results showed that an NTP-catalyzed system,especially using the Cu Mn Ti Oxcatalyst,had better o-DCB degradation performance compared to plasma *** combination of the Cu Mn Ti Oxcatalyst with NTP can achieve a degradation efficiency of up to 97.2%for o-DCB;the selectivity of CO and CO_(2)and the carbon balance were 40%,45%,and 85%,*** dielectric constant and electrical property results indicated that the surface discharge capacity of the catalysts played a major role in the degradation of o-DCB,and a higher dielectric constant could suppress the plasma expansion and enhance the duration of the plasma discharge per discharge *** to the O1s XPS and O_(2)-TPD results,the conversion of CO to CO_(2)follows the M-v-K mechanism;thus,the active species on the catalyst surface play an important ***,the Cu Mn Ti Oxand NTP mixed system exhibited excellent stability,which is probably because Cu doping improved the lifetime of the *** work can provide an experimental and theoretical basis for research in the degradation of o-DCB by plasma catalyst systems.

关键词： o-dichlorobenzene(o-DCB) Non-thermal plasma catalysis Ozone concentration

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Constructing high-capacity and flexible aqueous zinc-ion batteries with air-recharging capability using organic cathodes

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Chinese Chemical Letters 2024年第3期35卷 468-472页

作者： Xiaojuan chen haoqi Su Baozhu Yang Xiaocen Liu Xiuting Song Lixin Su Gui Yin Qi Liu Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis Green Manufacturing Collaborative Innovation Center and School of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210093China

Flexible aqueous zinc-ion batteries(AZIBs)with air-recharging capability are a promising self-powered system applied in future wearable *** is desired to develop high-capacity air-rechargeable ***,we developed a flexible AZIB with air-recharging capability based on trinitrohexaazatrinaphthylene(TNHATN)cathode and a ZnSO_(4)*** flexible Zn//TNHATN battery exhibits high volumetric energy density(21.36 mWh/cm^3)and excellent mechanical ***,the discharged flexible Zn//TNHATN battery can be chemical self-charged via the redox reaction between TNHATN cathode and O_(2)from the *** oxidation in air for 15 h,such flexible Zn//TNHATN battery can deliver a high specific capacity of 320 mAh/g at 0.5 A/g,displaying excellent air-recharging ***,this flexible Zn//TNHATN battery also works well in chemical or/and galvanostatic charging mixed modes,showing *** work provides a new insight for designing flexible aqueous self-powered systems.

关键词： Aqueous zinc-ion battery Trinitrohexaazatrinaphthylene Organic cathode materials Flexible air-rechargeable battery Self-powered system

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Platelets:A review of their function and effects in liver diseases

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Liver Research 2020年第3期4卷 129-135页

作者： haoqi chen Xiaolong chen Genshu Wang Department of Hepatic Surgery Liver TransplantationThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Platelets are small fragments of the cytoplasm and are detached from the cytoplasm of mature *** play an important role in the function of blood coagulation in *** studies have shown that in addition to participating in hemostasis,platelets play a critical role in liver regeneration,liver inflammation,liver tumors,injury,and other liver diseases by regulating the activation of stellate cells and the interaction between Kupffer cells and sinusoidal endothelial *** platelets and their related molecules is a promising treatment strategy in the management of liver ***,we review the role of platelets and their related molecules in the development of liver diseases and the application of targeted drugs.

关键词： Platelets Hepatic fibrosis Hepatic ischemia-reperfusion injury Liver regeneration Liver diseases

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Multifunctional RGD coated a single-atom iron nanozyme:A highly selective approach to inducing ferroptosis and enhancing immunotherapy for pancreatic cancer

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Nano Research 2024年第6期17卷 5469-5478页

作者： haoqi Pan Xu chen Mingming Xiao He Xu Jiansheng Guo Zhiyi Lu Dong Cen Xianjun Yu Si Shi Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Key Laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Qianwan Institute of CNITECHNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Key Laboratory of Laparoscopic Technology of Zhejiang Province Department of General SurgerySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2)O_(2)via a traditional radical pathway and enhance cancer ***,short half-life period of hydroxyl radical(·OH)results in unsatisfied ***,we synthesized a single-atom iron nanozyme(Fe-SAzyme),which can activate H_(2)O_(2)via a non-radical pathway to generate Fe-based reactive oxygen species(ROS)(O=FeO_(3)=O)for promoting the ferroptosis of pancreatic cancer *** Fe-SAzyme could be specifically phagocytosed by pancreatic cancer cells,increasing ROS levels and inhibiting glutathione(GSH)synthesis,which activates *** magnetic resonance imaging(MRI)showed decreased T2 signal after intravenous injection of RGD@Fe-AC(AC=activated carbon).Moreover,RGD@Fe-AC promoted dendritic cell(DC)maturation,overcame Treg-mediated immunosuppression,activated T cells to trigger adaptive immune responses,and enhanced the efficacy ofα-PD-L1 *** research demonstrated that RGD@Fe-AC provided a straightforward,easily implemented,and selective approach for pancreatic cancer treatment and immunotherapy.

关键词： single-atom iron nanozyme pancreatic cancer immunotherapy ferroptosis

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基于动作捕捉与深度学习的跳跃荷载重构方法

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振动与冲击 2024年第5期43卷 231-238页

作者：王浩祺于秉仟陈隽同济大学土木工程学院上海200092

通过学科交叉,采用医学和运动生物力学中的动作捕捉技术开展了27人次的跳跃荷载试验,总计获得9 985条单次跳跃的反力时程曲线及其对应的人体特征点运动轨迹。利用卷积神经网络技术,以特征点轨迹作为网络输入,分别以地反力三参数模型和... 详细信息

通过学科交叉,采用医学和运动生物力学中的动作捕捉技术开展了27人次的跳跃荷载试验,总计获得9 985条单次跳跃的反力时程曲线及其对应的人体特征点运动轨迹。利用卷积神经网络技术,以特征点轨迹作为网络输入,分别以地反力三参数模型和多参数模型的目标参数作为输出,训练获得轨迹与地反力之间的高维非线性关系,实现了跳跃荷载重构。与实测荷载的对比表明,跳跃荷载三参数模型能较好地重构单次跳跃曲线的幅值,而多参数模型能更好地反映荷载的时频域特征,适用于不同的使用场合。该方法可作为一种新型的跳跃荷载间接测量手段,结合计算机视觉技术开展服役工程结构的人致荷载监测。

关键词：跳跃荷载动作捕捉卷积神经网络(CNN) 荷载重构振动舒适度

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Memristive switching in the surface of a charge-density-wave topological semimetal

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Science Bulletin 2024年第13期69卷 2042-2049页

作者： Jianwen Ma Xianghao Meng Binhua Zhang Yuxiang Wang Yicheng Mou Wenting Lin Yannan Dai Luqiu chen Haonan Wang haoqi Wu Jiaming Gu Jiayu Wang Yuhan Du Chunsen Liu Wu Shi Zhenzhong Yang Bobo Tian Lin Miao Peng Zhou Chun-Gang Duan Changsong Xu Xiang Yuan cheng Zhang State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Key Laboratory of Computational Physical Sciences(Ministry of Education) Institute of Computational Physical SciencesState Key Laboratory of Surface PhysicsDepartment of PhysicsFudan UniversityShanghai 200433China Shanghai Qi Zhi Institute Shanghai 200030China School of Physics Southeast UniversityNanjing 211189China Key Laboratory of Polar Materials and Devices(Ministry of Education) Department of ElectronicsEast China Normal UniversityShanghai 200241China Shanghai Center of Brain–inspired Intelligent Materials and Devices East China Normal UniversityShanghai 200241China State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China Frontier Institute of Chip and System Fudan UniversityShanghai 200433China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China

Owing to the outstanding properties provided by nontrivial band topology,topological phases of matter are considered as a promising platform towards low-dissipation electronics,efficient spin-charge conversion,and topological quantum *** ferroelectricity in topological materials enables the non-volatile control of the quantum states,which could greatly facilitate topological electronic ***,ferroelectricity is generally incompatible with systems featuring metallicity due to the screening effect of free *** this study,we report the observation of memristive switching based on the ferroelectric surface state of a topological semimetal(TaSe_(4))*** find that the surface state of(TaSe_(4))2I presents out-of-plane ferroelectric polarization due to surface *** the combination of ferroelectric surface and charge-density-wave-gapped bulk states,an electric-switchable barrier height can be achieved in(TaSe_(4))2I-metal *** employing a multi-terminal-grounding design,we manage to construct a prototype ferroelectric memristor based on(TaSe_(4))2I with on/off ratio up to 103,endurance over 103 cycles,and good retention *** origin of the ferroelectric surface state is further investigated by first-principles calculations,which reveal an interplay between ferroelectricity and band *** emergence of ferroelectricity in(TaSe_(4))2I not only demonstrates it as a rare but essential case of ferroelectric topological materials,but also opens new routes towards the implementation of topological materials in functional electronic devices.

关键词： Topological semimetal Schottky barrier Surface ferroelectricity Memristor

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Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

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