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Biphase-to-monophase structure evolution of Na_(0.766+x)Li_(x)Ni_(0.33-x)Mn_(0.5)Fe_(0.1)Ti_(0.07)O_(2) toward ultradurable Na-ion batteries

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Carbon Energy 2024年第9期6卷 66-79页

作者： Mengting Liu Zhiwei Cheng Xu Zhu haojie dong Tianran Yan Liang Zhang Lu Zheng Hu-Rong Yao Xian-Zuo Wang Lianzheng Yu Bing Xiao Yao Xiao Peng-Fei Wang State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringCenter of Nanomaterials for Renewable EnergyXi'an Jiaotong UniversityXi'anShaanxiChina Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhouJiangsuChina Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials College of Physics and EnergyFujian Normal UniversityFuzhouFujianChina Wenzhou Key Laboratory of Sodium-Ion Batteries Institute for Carbon NeutralizationWenzhou University Technology InnovationWenzhouZhejiangChina

Layered composite oxide materials with O3/P2 biphasic crystallographic structure typically demonstrate a combination of high capacities of the O3 phase and high operation voltages of the P2 ***,their practical applications are seriously obstructed by difficulties in thermodynamic phase regulation,complicated electrochemical phase transition,and unsatisfactory cycling ***,we propose an efficient structural evolution strategy from biphase to monophase of Na_(0.766+x)Li_(x)Ni_(0.33-x)Mn_(0.5)Fe_(0.1)Ti_(0.07)O_(2) through Li+*** role of Li+substitution not only simplifies the unfavorable phase transition by altering the local coordination of transition metal(TM)cations but also stabilizes the cathode–electrolyte interphase to prevent the degradation of TM cations during battery *** a result,the thermodynamically robust O_(3)-Na_(0.826)Li_(0.06)Ni_(0.27)Mn_(0.5)Fe_(0.1)Ti_(0.07)O_(2) cathode delivers a high capacity of 139.4 mAh g^(-1) at 0.1 C and shows prolonged cycling life at high rates,with capacity retention of 81.6%at 5 C over 500 *** work establishes a solid relationship between the thermodynamic structure evolution and electrochemistry of layered cathode materials,contributing to the development of long-life sodium-ion batteries.

关键词： electrochemistry Li+substitution Na-ion batteries O_(3)phase phase transition

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青海地区大气加权平均温度模型精度优化

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导航定位学报 2024年第3期12卷 72-80页

作者：董浩杰杨维芳李小刚李得宴兰州交通大学测绘与地理信息学院/地理国情监测技术应用国家地方联合工程研究中心/甘肃省地理国情监测工程实验室兰州730070 青海省基础测绘院西宁810001 海军工程大学武汉430033

针对当前大气加权平均温度(T_(m))模型在青海省各地区的适用性较差,气象要素顾及较少等问题,提出一种青海地区大气加权平均温度模型精度优化方法:利用青海省4个探空站2014—2018年5 a的数据,通过线性回归的方法构建适用于青海省西宁、... 详细信息

针对当前大气加权平均温度(T_(m))模型在青海省各地区的适用性较差,气象要素顾及较少等问题,提出一种青海地区大气加权平均温度模型精度优化方法:利用青海省4个探空站2014—2018年5 a的数据,通过线性回归的方法构建适用于青海省西宁、都兰、郭勒木得及玉树4个地区的本地化单因子T_(m)模型和多个气象因子参与的本地化多因子T_(m)模型;并通过反演的大气可降水量(PWV)与贝维斯(Bevis)模型和龚绍琦全国模型反演的PWV结果进行对比分析。结果表明,所构建的模型精度均优于现有模型,在反演PWV精度方面也要优于现有模型,可为提高青海地区全球卫星导航系统(GNSS)水汽反演精度提供参考。

关键词：大气加权平均温度(T_(m)) 全球卫星导航系统(GNSS)气象学精密单点定位(PPP) 大气可降水量(PWV) 模型区域化

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Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs

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Acta Pharmaceutica Sinica B 2021年第1期11卷 30-54页

作者： Kai Yuan Xiao Wang haojie dong Wenjian Min Haiping Hao Peng Yang State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization China Pharmaceutical UniversityNanjing 210009China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 210009China

The sustained cell proliferation resulting from dysregulation of the cell cycle and activation of cyclin-dependent kinases(CDKs)is a hallmark of *** inhibition of CDKs is a highly promising and attractive strategy for the development of anticancer *** particular,third-generation CDK inhibitors can selectively inhibit CDK4/6 and regulate the cell cycle by suppressing the G1 to S phase transition,exhibiting a perfect balance between anticancer efficacy and general *** date,three selective CDK4/6 inhibitors have received approval from the *** and Drug Administration(FDA),and 15 CDK4/6 inhibitors are in clinical trials for the treatment of *** this perspective,we discuss the crucial roles of CDK4/6 in regulating the cell cycle and cancer cells,analyze the rationale for selectively inhibiting CDK4/6 for cancer treatment,review the latest advances in highly selective CDK4/6 inhibitors with different chemical scaffolds,explain the mechanisms associated with CDK4/6inhibitor resistance and describe solutions to overcome this issue,and briefly introduce proteolysis targeting chimera(PROTAC),a new and revolutionary technique used to degrade CDK4/6.

关键词： CDK4/6 Cell cycle Cancer Selectivity Drug resistance PROTAC

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Species-specific responses to drought,salinity and their interactions in Populus euphratica and *** seedlings

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Journal of Plant Ecology 2020年第5期13卷 563-573页

作者： Lei Yu haojie dong Zhijun Li Zhanjiang Han Helena Korpelainen Chunyang Li Department of Ecology College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang College of Life SciencesTarim UniversityAlar 843300China Department of Agricultural Sciences Viikki Plant Science CentrePO Box 27FI-00014 University of HelsinkiFinland

Aims Drought and salinity are severe abiotic stress factors,which limit plant growth and productivity,particularly in desert *** this study,we employed two desert poplars,Populus euphratica Oliver and Populus pruinosa Schrenk seedlings,to compare their tolerance to drought,salinity and combined *** We investigated species-specific responses of *** and *** in growth,photosynthetic capacity and pigment contents,nonstructural carbohydrate concentrations,Cl−allocation,osmotic regulation and the accumulation of reactive oxygen species(ROS)under drought,salinity and the combined *** Findings Populus pruinosa exhibited greater growth inhibitory effects,photosynthesis decline,stomatal closure and ROS accumulation,and lower antioxidant enzyme activities and osmotic regulation compared with *** under drought,salinity and especially under their combined *** the other hand,salt-stressed *** plants restricted salt transportation from roots to leaves,and allocated more Cl−to coarse roots and less to leaves,whereas salt-stressed *** allocated more Cl−to *** was shown that there is species-specific variation in these two desert poplars,and *** suffers greater negative effects compared with *** under drought,salinity and especially under the combined ***,in ecological restoration and afforestation efforts,species-specific responses and tolerances of these two poplar species to drought and salinity should be considered under climate change with increasing drought and soil salinity developing.

关键词： desert poplars drought and salinity Cl−allocation and transportation coarse and fine roots tolerance

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岷江冷杉和紫果云杉对增加温度和CO_(2)浓度的物种特异性的生长、形态和生理响应

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Journal of Plant Ecology 2023年第1期16卷 214-228页

作者： haojie dong Zongdi Huang Wen Li Lei Yu Department of Ecology College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China

尽管许多研究评估了植物对增加的大气二氧化碳浓度(CO_(2))和增温的生理生态响应,但探究这两个因素交互作用的研究较少,尤其是更敏感的高海拔树种。为了解决这个问题,我们选用岷江冷杉(Abies faxoniana)和紫果云杉(Picea purpurea)幼苗... 详细信息

尽管许多研究评估了植物对增加的大气二氧化碳浓度(CO_(2))和增温的生理生态响应,但探究这两个因素交互作用的研究较少,尤其是更敏感的高海拔树种。为了解决这个问题,我们选用岷江冷杉(Abies faxoniana)和紫果云杉(Picea purpurea)幼苗来评估增加CO_(2)浓度(CeTa,700 ppm)、增温(CaTe,高于环境温度2°C)以及增加CO_(2)浓度和增温(CeTe)交互作用对植物生长、形态和生理的影响。我们的研究发现CaTe处理下,这两种针叶树总干重、比根长、净光合速率以及^(15)NH_(4)+和^(15)NO_(3)−的转运速率均升高,但CeTe处理下植株的响应更强烈(岷江冷杉的净光合速率除外)。这些结果表明,增加CO_(2)浓度加剧了增温对植物生长和生理反应的影响。此外,CeTe对紫果云杉生理特征的影响更大,其总干重、比叶面积、水分利用效率(δ^(13)C)、δ^(15)NO_(3)^(−)-N水平、15NH4+和15NO3−的转运速率和非结构碳水化合物浓度均高于岷江冷杉。总体而言,这些研究结果表明,在评估针叶树种对未来气候的响应时,应考虑CO_(2)×温度的交互作用。

关键词：增温增加CO_(2)浓度非结构性碳水化合物 15N 示踪针叶树

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Elucidation of the sodium kinetics in layered P-type oxide cathodes

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Science China Chemistry 2022年第10期65卷 2005-2014页

作者： Lianzheng Yu haojie dong Yu-Xin Chang Zhiwei Cheng Kang Xu Yi-Hu Feng Duo Si Xu Zhu Mengting Liu Bing Xiao Peng-Fei Wang Sailong Xu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Center of Nanomaterials for Renewable Energy State Key Laboratory of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049China

Sodium-ion intercalation oxides generally possess high compositional diversity according to their different stacking *** sodium diffusion pathway in layered P-type materials used in sodium-ion batteries is open,which can increase their rate capability by directly transmitting Na+between adjacent triangular prismatic channels,rather than passing through an intermediate tetrahedral site in O-type ***,how the structure chemistry of the P-type oxides determines their electrochemical properties has not been fully understood ***,by comparing the crystalline structures,electrochemical behaviors,ion/electron transport dynamics of a couple of P-type intercalation cathodes,P2-Na_(2/3)Ni1/3Mn_(2/3)O_(2)and P3-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)with the same compositions,we demonstrate experimentally and computationally that the P2 phase delivers better cycling stability and rate capability than the P3 counterpart due to the predominant contribution of the faster intrinsic Na diffusion kinetics in the P2 *** also point out that it is the electronic conductivity that captures the key electrochemistry of layered P3-type materials and makes them possible to enhance the sodium storage *** results reveal that the correlation between stacking structure and functional properties in two typical layered P-type cathodes,providing new guidelines for preparing and designing alkali-metal layered oxide materials with improved battery performance.

关键词： sodium-ion batteries cathode P2 phase P3 phase kinetics

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Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4446-4457页

作者： Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang haojie dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization China Pharmaceutical UniversityNanjing 210009China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Department of Pharmacology School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Beijing Institute of Clinical Pharmacy Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Physics Chemistry and PharmacyUniversity of Southern DenmarkCampusvej 555230 OdenseDenmark Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer *** the inherent advantages of small-molecule inhibitors over antibodies,the discovery of small-molecule inhibitors has fallen behind that of antibody *** on docking studies between small molecule inhibitor and PD-L1 protein,changing the chemical linker of inhibitor from a flexible chain to an aromatic ring may improve its binding capacity to PD-L1 protein,which was not reported before.A series of novel phthalimide derivatives from structure-based rational design was synthesized.P39 was identified as the best inhibitor with promising activity,which not only inhibited PD-1/PD-L1 interaction(IC_(50)=8.9 nmol/L),but also enhanced killing efficacy of immune cells on cancer ***-crystal data demonstrated that P39 induced the dimerization of PD-L1 proteins,thereby blocking the binding of PD-1/***,P39 exhibited a favorable safety profile with a LD_(50)>5000 mg/kg and showed significant in vivo antitumor activity through promoting CD8^(+)T cell *** these data suggest that P39 acts as a promising small chemical inhibitor against the PD-1/PD-L1 axis and has the potential to improve the immunotherapy efficacy of T-cells.

关键词： PD-1/PD-L1 Small-molecule inhibitor Immunotherapy Co-crystal structure

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The regulation of angiogenin on miR-141 expression and its role in angiogenesis

The regulation of angiogenin on miR-141 expression and its r...

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华东六省一市生物化学与分子生物学学会2014年学术交流大会暨浙江省第十一届学会会员代表大会

作者： haojie dong Chunhua Weng Rongpan Bai Zhengping Xu Research Center of Molecular Medicine Zhejiang University School of Medicine

Angiogenesis is a key event in tumor growth and ***(RNase-5,ANG),one of angiogenic factors,can induce angiogenesis and promote tumor ***,itsunderlying mechanism of action is poorly ***(miRNAs),a class of highly conserved noncoding small RNA molecules that repress target gene expression post-transcriptionally,are believed playing regulatory roles in angiogenesis and *** investigate ANG-responsive and angiogenesis-related miRNAs,we did a miRNA array screening and found 21 ANG responsive miRNAs,in which miR-141 was one of the most down-regulated *** analysis showed miR-141 could inhibit HUVECproliferation,migration and tube formation in vitro,as well as angiogenesis in *** assay indicated that ANG enhanced tube formation in vitro in miR-141overexpressed HUVECs,suggesting that ANG could induce angiogenesis through down-regulation of *** explore the molecular mechanism of miR-141 in inhibition of angiogenesis,six target genes of miR-141,which related to angiogenesis,were screened out by in *** RT-qPCR,western blot and dual-luciferase report assays identified that five out of the six genes were targets of ***,we found ANG could regulate the expression of these target genes by down-regulation of ***,our studyelucidate a novel mechanism of ANG in regulation of angiogenesis through down regulating a miRNA-miR-141.

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Identification and functional analysis of angiogenin-specific microRNAs

Identification and functional analysis of angiogenin-specifi...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Chunhua Weng haojie dong Jinghao Sheng Yixing Zhai Zhengping Xu Bioelectromagnetics Laboratory Zhejiang University School of Medicine

Angiogenin(ANG) is a critical factor involved in angiogenesis and *** can translocate to the nucleus of target cells and bind to the genomic DNA,but the mechanism of ANG-induced angiogenesis or tumorigenesis is still *** this study,ANG-specific microRNAs including ANG-regulated and ANG-targeting microRNAs were explored to elucidate the relationship between ANG and microRNAs.

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Angiogenin degrades miR-141 as an endonuclease and modulates its multiple targets to promote angiogenesis

Angiogenin degrades miR-141 as an endonuclease and modulates...

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华东地区生物化学与分子生物学学会联合会2017年学术交流会暨安徽省生物化学与分子生物学学会理事会议

作者： Chunhua Weng haojie dong Xiaoliang Shi Rongpan Bai Zhengping Xu Institute of Environmental Health Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University

Currently,the understanding of microRNA(miRNA) decay is limited,and there is no endonuclease reported to play a role in miRNA *** a member of ribonuclease A,angiogenin(ANG) holds low but essential enzymatic activity and has been found to regulate rRNA processing and tiRNA production by cleaving pre-rRNA at AO site and tRNA at 3’-CCA termini or the anticodon loop *** this study,we found ANG exclusively down-regulated mature miR-141 without affecting pri-or pre-miR-141,and its ribonucleolytic activity was *** in vitro data showed ANG preferably cleaved miR-141 as an *** analysis revealed that miR-141 inhibited HUVECs proliferation,migration and tube formation in vitro,as well as angiogenesis in vivo,and could be rescued by ANG *** targets of miR-141 involved in angiogenesis were also identified and demonstrated to be modulated by ANG through down-regulating ***,we identified ANG as the first endoribonuclease in modulating miRNA turnover and elucidated a pathway of ANG,miR-141 and targets of miR-141 in inducing *** findings suggest the presence of a novel mode of miRNA turnover in mammalian cells and demonstrate a new mechanism of ANG in promotion of angiogenesis.

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