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济源太行山猕猴自然保护区鱼类资源初步调查

河南大学学报（自然科学版） 2013年第3期43卷 291-294页

作者：赵海鹏卢全伟苏豪杰李海涛路纪琪河南大学生命科学学院河南开封475004 安阳工学院生物与食品工程学院河南安阳455000 中国科学院水生生物研究所武汉430072 平顶山市水产技术推广站河南平顶山476000 郑州大学生物多样性与生态学研究所郑州450001

于2010年9月和11月,对济源太行山猕猴国家级自然保护区的鱼类资源进行了调查.共记录鱼类22种,隶属于5目7科22属.其中,鲤形目17种(以鲤科鱼类为主,14种),鲇形目2种,鳗鲡目、合鳃目和鲈形目各1种.区系分析表明:保护区鱼类含中国平原区系... 详细信息

于2010年9月和11月,对济源太行山猕猴国家级自然保护区的鱼类资源进行了调查.共记录鱼类22种,隶属于5目7科22属.其中,鲤形目17种(以鲤科鱼类为主,14种),鲇形目2种,鳗鲡目、合鳃目和鲈形目各1种.区系分析表明:保护区鱼类含中国平原区系复合体8种,占36.4%;晚第三纪早期区系复合体7种,占31.8%;北方平原区系复合体、北方山地区系复合体和南方平原区系复合体各2种,分别占9.1%;海水复合体鱼类1种,占4.5%.生态类型分析可见,保护区鱼类中静水定居性鱼类9种、溪流定居性鱼类11种、海淡水洄游性鱼类和江湖洄游性鱼类各1种.肉食性鱼类和杂食性鱼类各8种,植食性鱼类和碎屑食性鱼类各3种.

关键词：鱼类资源太行山猕猴自然保护区生态类型

长江下游湖泊水生植物现状及与水环境因子的关系

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湖泊科学 2015年第3期27卷 385-391页

作者：孔祥虹肖兰兰苏豪杰吴耀张霄林李中强湖北大学资源环境学院武汉430062 郑州幼儿师范高等专科学校郑州450002 中国科学院水生生物研究所东湖湖泊生态系统试验站武汉430072

研究水生植物分布与环境因子的关系可为富营养化湖泊的生态修复提供重要科学依据.通过对长江下游10个不同营养水平湖泊的水生植物群落组成和环境状况进行野外调查,研究了长江下游湖泊主要水生植物分布状况及水环境因子对水生植物分布的... 详细信息

研究水生植物分布与环境因子的关系可为富营养化湖泊的生态修复提供重要科学依据.通过对长江下游10个不同营养水平湖泊的水生植物群落组成和环境状况进行野外调查,研究了长江下游湖泊主要水生植物分布状况及水环境因子对水生植物分布的影响.调查发现长江下游10个代表性湖泊主要水生植物共计6科7属11种,主要生活型为沉水植物.水生植物群落组成与环境因子的冗余分析结果显示,总氮、pH值和水深是显著影响这些不同营养水平湖泊水生植物分布的主导因子.

关键词：水生植物环境因子营养水平主要因子冗余分析长江下游

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李达辨治原发性骨髓纤维化经验

山东中医杂志 2023年第1期42卷 62-66页

作者：苏浩杰戴晓峰吴建伟李达(指导) 广州中医药大学广东广州510403 蚌埠市中医院安徽蚌埠233080 江门市五邑中医院广东江门529099 不详

原发性骨髓纤维化(PMF)是一种恶性骨髓增殖性疾病,西医目前尚无特效疗法,中医药在改善症状、缓解病情、增效减毒方面独具优势。李达教授衷中参西,病证结合、多维辨析,认为瘀毒内蕴、脾肾两虚、正衰毒亢是PMF的基本病机,故临证以扶正祛... 详细信息

原发性骨髓纤维化(PMF)是一种恶性骨髓增殖性疾病,西医目前尚无特效疗法,中医药在改善症状、缓解病情、增效减毒方面独具优势。李达教授衷中参西,病证结合、多维辨析,认为瘀毒内蕴、脾肾两虚、正衰毒亢是PMF的基本病机,故临证以扶正祛邪为治则,提出健脾补肾、活血解毒、和解增效等治法,将内服与外敷有机结合,有效地改善了PMF患者贫血、巨脾及骨髓纤维化表现。附验案1则。

关键词：原发性骨髓纤维化病证结合青黛四黄散内服外敷李达

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脾虚湿阻型银屑病病证结合小鼠模型的系统评价研究

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中药新药与临床药理 2024年第10期35卷 1470-1482页

作者：刘凡露苏浩杰周攀宇张雅婷汪晴孙玥岳洪宇吴晶晶危建安韩凌广州中医药大学第二临床医学院广东广州510006 省部共建中医湿证国家重点实验室(广州中医药大学第二附属医院) 广东广州510120 广州中医药大学东莞医院(东莞市中医院) 广东东莞523127 广东省中医证候临床研究重点实验室广东广州510120 粤港澳中医药与免疫疾病研究联合实验室广东广州510120

目的构建脾虚湿阻型银屑病小鼠模型,并从多维度、多方向评价该模型,以期为中医药治疗脾虚湿阻型银屑提供研究支持。方法采用高脂饮食喂养建立脾虚湿阻证小鼠模型,外涂咪喹莫特乳膏建立银屑病小鼠模型,并二者结合构建病证结合小鼠模型。... 详细信息

目的构建脾虚湿阻型银屑病小鼠模型,并从多维度、多方向评价该模型,以期为中医药治疗脾虚湿阻型银屑提供研究支持。方法采用高脂饮食喂养建立脾虚湿阻证小鼠模型,外涂咪喹莫特乳膏建立银屑病小鼠模型,并二者结合构建病证结合小鼠模型。比较体质量、进食量和饮水量,评价脾虚湿阻证候指征。比较皮损面积、PASI评分、经皮水分丢失值、HE染色下皮肤病理学改变评价银屑病严重程度。流式细胞术检测各类细胞表达情况,评价炎症程度。观察脂肪指数、肝脏HE染色下肝脏病理学变化、RT-q PCR法检测肝脏和附睾脂肪的相关因子m RNA表达水平、Western Blot法检测皮肤ABCA1蛋白表达水平,评价脂代谢紊乱情况。结果与寻常型银屑病组小鼠比较,脾虚湿阻型银屑病组小鼠体质量升高(P0.05)。结论脾虚湿阻型银屑病小鼠模型可作为可靠的病证结合动物模型,为进一步探讨中医药治疗脾虚湿阻型银屑病提供参考。

关键词：银屑病脾虚湿阻证病证结合动物模型小鼠

废弃印刷电路板中有毒有害金属含量及浸出特征研究

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江汉大学学报（自然科学版） 2023年第5期51卷 47-53页

作者：谭芳张子荀费若凡郑紫薇刘艳琳苏浩杰江汉大学光电材料与技术学院湖北武汉430056 武汉城市学院医学部湖北武汉430070

针对废弃印刷电路板所含重金属的环境风险问题,对汽车、电视机、路由器等电路板中8种主要有毒有害金属含量进行分析,并在此基础上对各金属的赋存形态及浸出特征进行分析评价。实验结果显示:实验范围内电路板中各金属物质的含量差别较大... 详细信息

针对废弃印刷电路板所含重金属的环境风险问题,对汽车、电视机、路由器等电路板中8种主要有毒有害金属含量进行分析,并在此基础上对各金属的赋存形态及浸出特征进行分析评价。实验结果显示:实验范围内电路板中各金属物质的含量差别较大,Fe、Cu、Pb、Cr、Sb、Sn、Cd和As的含量在0.015~294.9 mg/g之间,Cd和As虽然含量较低,但毒性较高。电路板中Cu、As、Sn、Sb的主要赋存形态为残渣态,生态风险等级低;Pb以酸可提取态和氧化态为主,Fe、Cr和Cd以酸可提取态、可还原态、可氧化态和残渣态4种形态存在,生态风险等级高。在模拟中性和酸性降雨以及垃圾渗滤液的环境条件下,Cd、Cr、Cu、As、Fe、Sb和Sn均有浸出,Pb在模拟垃圾渗滤液浸出实验中浸出率较高,而As在模拟中性和酸性降雨的浸出率更高。各模拟环境条件下的浸出液中Cd、Cr、Cu、As、Fe、Sb和Sn浓度均超过GB/T 14848—2017《地下水质量标准》Ⅲ类指标限值。

关键词：废弃电路板重金属赋存形态浸出特征

Study on the surface-modification of nano-hydroxyapatite with lignin and the corresponding nanocomposite with poly (lactide-co-glycolide)

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Frontiers of Chemical Science and Engineering 2021年第3期15卷 630-642页

作者： haojie Ding Liuyun Jiang Chunyan Tang Shuo Tang Bingli Ma Na Zhang Yue Wen Yan Zhang Liping Sheng Shengpei su Xiang Hu National&Local Joint Engineering Laboratory for New Petro-Chemical Materials and Fine Utilization of Resources College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of sustainable Resources Processing and Advanced Materials College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory Developmental Biology of Freshwater Fish School Life ScienceHunan Normal UniversityChangsha 410081China

To obtain nano-hydroxyapatite/poly(lactideco-glycolide)(n-HA/PLGA)nanocomposite with superior mechanical properties,here,lignin was chosen to surfacemodify for n-HA through co-precipitation *** different reaction conditions of reaction time,phosphorus source,and the lignin addition amount were studied by fourier transformation infrared spectra,X-ray diffraction,the intuitionistic dispersion experiment,transmission electron microscope and thermal gravimetric *** reaction mechanism and the best appropriate reaction condition were *** importantly,the results of electromechanical universal tester,scanning electron microscope,differential scanning calorimetric analyzer,polarized optical microscopy and dynamic mechanical analysis confirmed that the obtained n-HA could greatly increase the mechanical strength of PLGA,owing to the excellent dispersion and promotion crystallization ***,in vitro cell culture experimental results indicated that the n-HA surface-modified by lignin was favorable to improve the cell biocompatibility of *** study suggested that the introduction of lignin was a novel method to acquire a highly dispersed n-HA,which would provide a new idea to achieve the n-HA/PLGA nanocomposite as bone materials in future,and it would pave the way towards a new application of lignin in biomedical field.

关键词： nanocomposite poly(lactide-co-glycolide) hydroxyapatite mechanical property

Ultra-small superparamagnetic iron oxide nanoparticles for intra-articular targeting of cartilage in early osteoarthritis

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Regenerative Biomaterials 2023年第1期10卷 1111-1121页

作者： Jun Wu Changqiang Wu Zhongyuan Cai haojie Gu Li Liu Chunchao Xia su Lui Qiyong Gong Bin Song Hua Ai Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu 610207China Medical Imaging Key Laboratory of Sichuan Province School of Medical ImagingNorth Sichuan Medical CollegeNanchong 637000China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Department of Radiology Huaxi MR Research Center(HMRRC)Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province Key Laboratory of Transplant Engineering and ImmunologyNHCResearch Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610064China Department of Radiology West China Xiamen Hospital of Sichuan UniversityFujianXiamen 361000China Department of Radiology Sanya People’s HospitalHainanSanya 572000China

Early diagnosis of osteoarthritis(OA)is critical for effective cartilage ***,lack of blood vessels in articular cartilage poses a barrier to contrast agent delivery and subsequent diagnostic *** address this challenge,we proposed to develop ultra-small superparamagnetic iron oxide nanoparticles(SPIONs,4 nm)that can penetrate into the matrix of articular cartilage,and further modified with the peptide ligand WYRGRL(particle size,5.9 nm),which allows SPIONs to bind to type II collagen in the cartilage matrix and increase the retention of *** II collagen in the cartilage matrix is gradually lost with the progression of OA,consequently,the binding of peptide-modified ultra-small SPIONs to type II collagen in the OA cartilage matrix is less,thus presenting different magnetic resonance(MR)signals in OA group from the normal *** introducing the AND logical operation,damaged cartilage can be differentiated from the surrounding normal tissue on T1 and T2 AND logical map of MR images,and this was also verified in histology ***,this work provides an effective strategy for delivering nanosized imaging agents to articular cartilage,which could potentially be used to diagnosis joint-related diseases such as osteoarthritis.

关键词： early osteoarthritis magnetic resonance imaging superparamagnetic iron oxide collagen type II targeting peptide

Kinetically inert manganese(II)-based hybrid micellar complexes for magnetic resonance imaging of lymph node metastasis

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Regenerative Biomaterials 2023年第1期10卷 1122-1134页

作者： Kai Chen Zhongyuan Cai Yingzi Cao Lingling Jiang Yuting Jiang haojie Gu Shengxiang Fu Chunchao Xia su Lui QiyongGong Bin Song Hua Ai National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Huaxi MR Research Center(HMRRC) Department of RadiologyFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province Key Laboratory of Transplant Engineering and ImmunologyNHCResearch Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityFujianXiamen 361000China Department of Radiology Sanya People’s HospitalSanya 572000China

The localization and differential diagnosis of the sentinel lymph nodes(SLNs)are particularly important for tumor staging,surgical planning and *** this work,kinetically inert manganese(II)-based hybrid micellar complexes(MnCs)for magnetic resonance imaging(MRI)were developed using an amphiphilic manganese-based chelate(C18-PhDTA-Mn)with reliable kinetic stability and self-assembled with a series of amphiphilic PEG-C18 polymers of different molecular weights(C18En,n=10,20,50).Among them,the probes composed by 1:10 mass ratio of manganese chelate/C18En had slightly different hydrodynamic particle sizes with similar surface charges as well as considerable relaxivities(∼13 mM^(−1)s^(−1)at 1.5 T).In vivo lymph node imaging in mice revealed that the MnC MnC-20 formed by C18E20 with C18-PhDTA-Mn at a hydrodynamic particle size of 5.5 nm had significant signal intensity brightening effect and shortened T1 relaxation *** an imaging probe dosage of 125μg Mn/kg,lymph nodes still had significant signal enhancement in 2 h,while there is no obvious signal intensity alteration in non-lymphoid *** 4T1 tumor metastatic mice model,SLNs showed less signal enhancement and smaller T1 relaxation time variation at 30 min post-injection,when compared with normal lymph *** was favorable to differentiate normal lymph nodes from SLN under a 3.0-T clinical MRI *** conclusion,the strategy of developing manganese-based MR nanoprobes was useful in lymph node imaging.

关键词： kinetically inert amphiphilic manganese chelate T1 contrast agent sentinel lymph node magnetic resonance imaging

End to End Motion Control for Mobile Robots

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End to End Motion Control for Mobile Robots