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Aggregate 2024年第3期5卷 421-428页

作者： Zhirong Zhu Xiaoyan Chen Hongze Liao Li Li haojian yang Qi Wang Wei-Hong Zhu Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina Department of Pathology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Research Center for Marine Drugs Department of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Laboratory Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Urinary microalbumin(mALB)serves as an exceptionally sensitive indicator for the early detection of kidney damage,playing a pivotal role in identifying chronic renal failure and kidney lesions in ***,the currentfluores-cent methodologies for point-of-care(POC)diagnosis of mALB in real urine still exhibit suboptimal ***,the development and synthesis of QM-N2,an albumin-activated near-infrared(NIR)aggregation-induced emission(AIE)fluorescent probe,are *** strategic incorporation and positioning of quaternary ammonium salts within the quinoline-malononitrile(QM)scaffold sig-nificantly influence solubility and luminescence ***,the quaternary ammonium salt-free variant,QM-OH,and the quaternary ammonium salt integrated at the donor function group(DFG)site,QM-N1,display limited solubility in aqueous solutions while demonstrating a distinctfluorescence ***,the incorporation of quaternary ammonium salt at the conformational functional group(CFG)site in QM-N2 imparts superior dispersibility in water and reduces the ***,the integration of a well-defined D-π-A struc-ture within QM-N2 enables itself with near-infrared emission,which is crucial for mitigating interference from autofluorescence present in urine *** inter-action with albumin,QM-N2 forms a tight bond with the IIA site of the subdomain of human serum albumin(HSA),inducing alterations in protein configuration and constraining the intrinsic motion offluorescent *** interaction inducesfluorescence,facilitating the sensitive detection of trace ***,QM-N2 is applied for POC testing of mALB using portable equipment,particularly in the diagnosis of mALB-related diseases,notably chronic renal *** positioning underscores its potential as an ideal candidate for self-health measurement at home or in community hospitals.

关键词： AIE-active probe kidney disease microalbuminuria point-of-care testing

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针刺联合熄风益肝汤加减对脑卒中恢复期患者细胞凋亡蛋白、抗氧化指标的影响

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吉林中医药 2021年第10期41卷 1383-1386页

作者：杨浩建房雪苏布衣倪金霞北京市密云区中医医院高血压老年病科北京101500 北京中医药大学东直门医院针灸科北京100700

目的观察针刺联合熄风益肝汤加减对脑卒中恢复期患者细胞凋亡蛋白、抗氧化指标的影响。方法选取我院于2019年7月-2021年3月收治的脑卒中恢复期患者108例,随机分为对照组和观察组,各54例。对照组给予常规治疗和康复训练,观察组在对照组... 详细信息

目的观察针刺联合熄风益肝汤加减对脑卒中恢复期患者细胞凋亡蛋白、抗氧化指标的影响。方法选取我院于2019年7月-2021年3月收治的脑卒中恢复期患者108例,随机分为对照组和观察组,各54例。对照组给予常规治疗和康复训练,观察组在对照组基础上给予针刺联合熄风益肝汤加减治疗。比较总有效率,细胞凋亡蛋白、抗氧化指标的变化情况,观察2组美国国立卫生院卒中量表(NIHSS)评分、Fugl-Meyer评分、脑卒中自我效能问卷(SSEQ)评分的差异。结果观察组总有效率92.59%,高于对照组的77.78%,差异有统计学意义(P<0.05)。与治疗前比较,2组治疗后SOD升高(P<0.05),Caspase-3、脂肪酸合成酶(Fas)及其配体FasL、MDA下降(P<0.05),观察组治疗后SOD、MDA、细胞凋亡蛋白较对照组改善更明显(P<0.05)。与治疗前比较,2组治疗后Fugl-Meyer评分、SSEQ评分升高(P<0.05),NIHSS评分下降(P<0.05),观察组较对照组改善更明显(P<0.05)。结论针刺联合熄风益肝汤加减治疗脑卒中恢复期可通过提高患者抗氧化能力,降低细胞凋亡蛋白的表达,达改善神经功能和运动功能的目的。

关键词：针刺熄风益肝汤脑卒中细胞凋亡蛋白抗氧化能力

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Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells

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Protein & Cell 2013年第3期4卷 186-196页

作者： haojian Zhang Shaoguang Li Division of Hematology/Oncology Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterMA 01605USA

Studies on chronic myeloid leukemia(CML)have served as a paradigm for cancer research and *** studies involve the identifi cation of the fi rst cancer-associated chromosomal abnormality and the subsequent development of tyrosine kinase inhibitors(TKIs)that inhibit BCR-ABL kinase activity in *** becomes clear that leukemia stem cells(LSCs)in CML which are resistant to TKIs,and eradication of LSCs appears to be extremely ***,one of the major issues in current CML biology is to understand the biology of LSCs and to investigate why LSCs are insensitive to TKI monotherapy for developing curative therapeutic *** from our group and others have revealed that CML LSCs form a hierarchy similar to that seen in normal hematopoiesis,in which a rare stem cell population with limitless self-renewal potential gives rise to progenies that lack such *** also possess biological features that are different from those of normal hematopoietic stem cells(HSCs)and are critical for their malignant *** this review,we summarize the latest progress in CML field,and attempt to understand the molecular mechanisms of survival regulation of LSCs.

关键词： molecular mechanisms chronic myeloid leukemia leukemia stem cell

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Proteomic analysis of nuclear matrix proteins during arsenic trioxide induced apoptosis in leukemia K562 cells

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Chinese Medical Journal 2005年第2期118卷 100-104页

作者： WANGZi-hui YUDing CHENYan haojian-zhong BeijingUniversity ShenzhenHospitalShenzhen518036China DepartmentofHematology UnionHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430022China

Background Arsenic trioxide (As2O3) has been identified as a very potent antiacute leukemic agent However its role in apoptosis needs to be elucidated As2O3 interferes with the proliferation and survival of tumor cells via a variety of mechanisms Drugtarget interactions at the level of nuclear matrix (NM) may be critical events in the induction of cell death by As2O3 This study dealt with As2O3-target interactions at the level of NM in chronic myelogenous leukemia cell line K562 by proteomics Methods K562 cells were cultured in MEM and treated with different concentrations of As2O3 The nuclear matrix proteins were analyzed by highresolution twodimensional gel electrophoresis and computerassisted image analysis Results As2O3 significantly inhibited the growth of chronic myelogenous leukemia cell line K562 at low concentrations While more than 200 protein spots were shared among the nuclear matrices, about 18 distinct spots in the nuclear matrices were found characteristic for As2O3 treated cells Conclusions: As2O3 induces apoptosis in K562 cells in a dose and timedependent manner Our results demonstrated that for the detection of the onset of apoptosis, the alteration in the composition of nuclear matrix proteins was a more sensitive indicator than nucleosomal DNA fragmentation test These results indicated that As2O3 might be clinically useful in the treatment of chronic myelogenous leukemia. The changes of nuclear matrix proteins in the treated cells can be used as a useful indicator for this treatment

关键词： Arsenic trioxide · nuclear matrix · chronic myelogenous leukemia · K562 cells · apoptosis · proteomics

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Hydrodynamic Coefficient Investigation on a Partial Permeable Stepped Breakwater Under Regular Waves

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Journal of Ocean University of China 2021年第6期20卷 1341-1352页

作者： YIN Zegao ZHENG Zihan YU Ning WANG haojian Engineering College Ocean University of ChinaQingdao 266100China Shandong Province Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China

Traditional breakwater takes the advantage of high protection performance and has been widely ***,it contributes to high wave reflection in the seaside direction and poor water exchange capacity between open seawater and an inside ***,a partially permeable stepped breakwater(PPSB)is proposed to ensure safety and good water exchange capacity for an inside harbor,and a 3-D computational fluid dynamics(CFD)mathematical model was used to investigate the hydrodynamic coefficients using Reynolds-Averaged Navier-Stokes equations,Re-Normalization Group(RNG)k-εequations,and the VOF technique.A series of experiments are conducted to measure the wave heights for validating the mathematical model,and a series of dimensionless parameters considering wave and PPSB effects were presented to assess their relationships with hydrodynamic coefficients,*** the increase in the reciprocal value of PPSB slope,incident wave steepness and permeable ratio below still water level(SWL),the wave reflection coefficient *** wave transmission coefficient decreases with an increase in the reciprocal value of the PPSB slope and incident wave steepness;however,it increases with the increase in the permeable ratio below *** increases in the reciprocal value of the PPSB slope,permeable ratio below SWL and incident wave steepness for relatively high wave period scenarios,the wave energy dissipation coefficient increases;however,it decreases slightly with increases in the incident wave steepness for the smallest wave period ***,simple prediction formulas are conducted for predicting the hydrodynamic coefficients and they are well validated with the related data.

关键词： regular waves partially permeable stepped breakwater wave reflection coefficient wave transmission coefficient wave energy dissipation coefficient mathematical model

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Structure and governance model of rural social space quality:A case study of Longxi County in the Loess Hilly Area of China

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Journal of Geographical Sciences 2022年第7期32卷 1297-1320页

作者： WU Shanshan MA Libang TAO Tianmin DOU haojian College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China Key Laboratory of Resource Environment and Sustainable Development of Oasis Gansu ProvinceLanzhou 730070China Northwest Institute of Urban-Rural Development and Collaborative Governance Lanzhou 730070China

The rural social space quality is an important indicator to measure the living standard and thinking ideas and so forth of rural residents in a certain *** this paper,213 administrative villages in Longxi County of the Loess Hilly Area,China are taken as evaluation units to construct the evaluation model of the rural social space *** paper deeply analyzed the variation patterns and their formation mechanism of the rural social space quality at a village scale,and proposed a governance model based on the rural social space *** results show that:(1)the social space quality levels of individual administrative villages show a gradually decreasing trend from the township seats to *** eastern part of Longxi County has a relatively high education level and living standard,and the western part has a relatively high population stability level and income level.(2)The rural social space quality is mainly in a ring structure,supplemented by the interlaced *** core area is the towns and their surrounding areas,while the transition area,marginal area,and other areas are expanded around the core area.(3)Social forces and spatial effects jointly shape the variation of the rural social space *** organizations provide a driving force for the allocation of elements,and interweaving with the spatial effects lead to the differences in the social space quality.(4)The governance models of the rural social space quality are constructed based on the principles of retaining the rural“people”,optimizing the rural“land”,and developing the rural“industry”,so as to improve the rural centripetal force,core force,inner thrust,and source power.

关键词： rural social space quality spatial structure formation mechanism governance model Longxi County in the Loess Hilly Area of China

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Robot-aided fN∙m torque sensing within an ultrawide dynamic range

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Microsystems & Nanoengineering 2021年第1期7卷 51-61页

作者： Shudong Wang Xueyong Wei haojian Lu Ziming Ren Zhuangde Jiang Juan Ren Zhan yang Lining Sun Wanfeng Shang Xinyu Wu Yajing Shen State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China Mechanical and Biomedical Engineering Department City University of Hong KongHong Kong SAR 999077China Department of Mechatronics Chang’an UniversityXi’an 710054China Robotics and Microsystems Center Soochow UniversitySuzhou 215021China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Shenzhen Research Institute City University of Hong KongShenzhen 440305China

In situ scanning electron microscope(SEM)characterization have enabled the stretching,compression,and bending of micro/nanomaterials and have greatly expanded our understanding of small-scale ***,as one of the fundamental approaches for material analytics,torsion tests at a small scale remain a major challenge due to the lack of an ultrahigh precise torque sensor and the delicate sample assembly ***,we present a microelectromechanical resonant torque sensor with an ultrahigh resolution of up to 4.78 fN∙m within an ultrawide dynamic range of 123 ***,we propose a nanorobotic system to realize the precise assembly of microscale specimens with nanoscale positioning accuracy and to conduct repeatable in situ pure torsion tests for the first *** a demonstration,we characterized the mechanical properties of Si microbeams through torsion tests and found that these microbeams were five-fold stronger than their bulk *** proposed torsion characterization system pushes the limit of mechanical torsion tests,overcomes the deficiencies in current in situ characterization techniques,and expands our knowledge regarding the behavior of micro/nanomaterials at various loads,which is expected to have significant implications for the eventual development and implementation of materials science.

关键词： torsion precise dynamic

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A Theoretical Method for Estimating Performance of Reed-Solomon Codes Concatenated with Orthogonal Space-Time Block Codes

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The Journal of China Universities of Posts and Telecommunications 2002年第1期9卷 30-34页

作者： LUOTao haojian-Jun 等 TelecommunicationEngineeringSchool BeijingUniversityofPostsandTelecommunicationsBeijing100876P.R.China TelecommunicationEngineeringSchool BeijingUniversityofPostsandTelecommunicationsBeijing100876

Based on the studies of Reed-Solomon codes and orthogonalspace-time block codes over Rayleigh fading channel, a theoreticalmethod for estimating performance of Reed-Solomon codes concatenatedwith orthogonal space- time block codes is presented in this *** an upper bound of the bit error rate is also obtained. It isshown through computer simulations that the signal-to-noise ratioreduces about 15 dB or more after orthogonal space-time block codesare concatenate with Reed-Solomon(15,6)codes over Rayleigh fadingchannel, when the bit error rate is 10^-4.

关键词： channel codes space-time codes concatenated codes diversity technology

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Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1024-1040页

作者： Hang Yu Hui Xu Xinyu yang Zhengwei Zhang Jiachun Hu Jinyue Lu Jie Fu Mengmeng Bu haojian Zhang Zhao Zhai Jingyue Wang Jiandong Jiang Yan Wang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing100050China

Specnuezhenide(SNZ)is among the main components of Fructus Ligustri Lucidi,which has antiinflammation,anti-oxidation,and anti-tumor *** low bioavailability makes it difficult to explain the mechanism of pharmacological effect of *** this study,the role of the gut microbiota in the metabolism and pharmacokinetics characteristics of SNZ as well as the pharmacological meaning were *** can be rapidly metabolized by the gut microbiome,and two intestinal bacterial metabolites of SNZ,salidroside and tyrosol,were *** addition,carboxylesterase may be the main intestinal bacterial enzyme that mediates its *** the same time,no metabolism was found in the incubation system of SNZ with liver microsomes or liver homogenate,indicating that the gut microbiota is the main part involved in the metabolism of *** addition,pharmacokinetic studies showed that salidroside and tyrosol can be detected in plasma in the presence of gut ***,tumor development was inhibited in a colorectal tumor mice model administered orally with SNZ,which indicated that SNZ exhibited potential to inhibit tumor growth,and tissue distribution studies showed that salidroside and tyrosol could be distributed in tumor *** the same time,SNZ modulated the structure of gut microbiota and fungal group,which may be the mechanism governing the antitumoral activity of ***,SNZ stimulates the secretion of short-chain fatty acids by intestinal flora in vitro and in *** the future,targeting gut microbes and the interaction between natural products and gut microbes could lead to the discovery and development of new drugs.

关键词： Specnuezhenide Pharmacokinetics Tumor Gut microbiota Fungi Metabolism

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Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1537-1553页

作者： Libin Pan Hang Yu Jie Fu Jiachun Hu Hui Xu Zhengwei Zhang Mengmeng Bu Xinyu yang haojian Zhang Jinyue Lu Jiandong Jiang Yan Wang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Received 5 September 2022Revised 8 November

At present,clinical interventions for chronic kidney disease are very limited,and most patients rely on dialysis to sustain their lives for a long ***,studies on the gut—kidney axis have shown that the gut microbiota is a potentially effective target for correcting or controlling chronic kidney *** study showed that berberine,a natural drug with low oral availability,significantly ameliorated chronic kidney disease by altering the composition of the gut microbiota and inhibiting the production of gut-derived uremic toxins,including ***,berberine reduced the content of pcresol sulfate in plasma mainly by lowering the abundance of g_Clostridium_sensu_stricto_1 and inhibiting the tyrosine—p-cresol pathway of the intestinal ***,berberine increased the butyric acid producing bacteria and the butyric acid content in feces,while decreased the renal toxic trimethylamine *** findings suggest that berberine may be a therapeutic drug with significant potential to ameliorate chronic kidney disease through the gut—kidney axis.

关键词： Chronic kidney disease Gut microbiota Berberine Gut—kidney axis Clostridium p-Cresol Uremic toxins p-Cresol sulfate

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