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P-cadherin和34βE12在乳腺导管内增生性病变及浸润性癌中的表达与鉴别意义

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山西医药杂志 2014年第14期43卷 1630-1632页

作者：李明雷焦艳赵长燕陈浩华才秋敏河北省秦皇岛市妇幼保健院病理科 066000

目的探讨P-cadherin、34βE12在乳腺导管内增生性病变和浸润性导管癌中的表达与意义。方法采用免疫组织化学S-P法观察P-cadherin、34βE12在各组病变中的表达。结果 P-cadherin的表达在乳腺普通型导管增生(UDH)与导管原位癌(DICS)组、UD... 详细信息

目的探讨P-cadherin、34βE12在乳腺导管内增生性病变和浸润性导管癌中的表达与意义。方法采用免疫组织化学S-P法观察P-cadherin、34βE12在各组病变中的表达。结果 P-cadherin的表达在乳腺普通型导管增生(UDH)与导管原位癌(DICS)组、UDH与浸润性导管癌(IDC)组、平坦型上皮非典型增生(FEA)与IDC组、非典型性导管增生(ADH)与IDC组的差异有统计学意义(P<0.05);34βE12的表达在UDH与FEA组、UDH与ADH组、UDH与DICS组、UDH与IDC组的差异有统计学意义(P<0.05)。结论 P-cadherin、34βE12可应用于乳腺导管内增生性病变和浸润性导管癌的鉴别诊断。

关键词：乳腺肿瘤导管内增生性病变 34βE12

Geometrical and electrical optimization of NS-SDBD streamwise plasma heat knife for aircraft anti-icing

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Chinese Journal of Aeronautics 2023年第2期36卷 87-99页

作者： Zhi SU Hua LIANG haohua ZONG Jun LI Xu FANG Biao WEI Jie chen Weiliang KONG Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi'an 710038China Institute of Aero-engine School of Mechanical EngineeringXi'an Jiaotong UniversityXi'an 710049China Northwest Institute of Nuclear Technology Xi'an 710024China The Green Aerotechnics Research Institute Chongqing Jiaotong UniversityChongqing 404100China

Ice accretion on aircraft encountering supercooled water droplets in clouds poses great risks to flight performance and *** the aim of optimizing the newly developed streamwise plasma heat knife method for anti-icing,a parametric investigation is carried out in this *** influence of the detailed voltage profile on the heating effects of a Surface Dielectric Barrier Discharge driven by Nanosecond Pulses(NS-SDBD)is investigated,and a comparison of the antiicing performance among different configurations of streamwise plasma heat knife is *** results show that columnar high-temperature regions produced by a multi-streamer discharge appear at small pulse rise time,but become diffuse as the pulse rise time *** optimal pulse rise time exists to provide a wide range and high value of temperature,which is found to be 150 ns for the setup in the present *** influence of the pulse fall time is much weaker than that of the rise *** range and value of the temperature decrease with increasing pulse fall time.A greater pulse width is found to improve the heating effect by increasing the discharge *** a spanwise electrode is placed connecting the streamwise electrodes of the streamwise plasma heat knife at the airfoil leading edge,the anti-icing performance becomes poorer,whereas good performance is achieved when the spanwise electrode is at the edge of the streamwise *** on this,a three-level configuration of the plasma heat knife is proposed,and its anti-icing performance is found to be much better than that of the original configuration.

关键词： Airfoil icing mitigation Dielectric barrier discharge Nanosecond pulse Voltage profile Plasma

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北京冬奥村暖通空调设计

暖通空调 2022年第6期52卷 82-87页

作者：沈逸赉陈浩华张辉王玉超段晓敏南天辰北京市建筑设计研究院有限公司北京

阐述了北京冬奥村人才公租房项目暖通空调设计。该项目需满足赛时及赛后2种使用要求,且需践行“节俭、健康、绿色”的理念。在绿色建筑设计的基础上,结合超低能耗被动房设计,考虑健康建筑特性,实现了可持续设计,可供集群式项目暖通空调... 详细信息

阐述了北京冬奥村人才公租房项目暖通空调设计。该项目需满足赛时及赛后2种使用要求,且需践行“节俭、健康、绿色”的理念。在绿色建筑设计的基础上,结合超低能耗被动房设计,考虑健康建筑特性,实现了可持续设计,可供集群式项目暖通空调设计参考。

关键词：冬奥村暖通空调绿色建筑超低能耗建筑健康建筑可持续

Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion

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Chinese Chemical Letters 2019年第9期30卷 1659-1662页

作者： haohua Deng Shaobin He Xiuling Lin Lu Yang Zhen Lin Ruiting chen Huaping Peng Wei chen Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province Department of Pharmaceutical Analysis Fujian Medical University

The development of efficient methods for the detection of hazardous and toxic elements is extremely important for environmental security and public health. In this work, we developed a facile colorimetric assaying system for Ag+ detection in aqueous solution. Chitosan-stabilized platinum nanoparticles(ChPtNPs) were synthesized and severed as an artificial oxidase to catalyze the oxidation of the substrate3,30,5,50-tetramethylbenzidine(TMB) and generate color signal. In the presence of Ag+, due to the strong metallophilic interactions between Ag+ and Pt2+ on the surface of Ch-PtNPs, Ag+ can weaken the affinity to the substrates and inactivate the catalytic activity of Ch-PtNPs, leading to decreased absorbance signal to varying degrees depending on Ag+ amount. Combing the specific binding between Ch-PtNPs and Ag+ with signal amplification procedure based on the Ch-PtNPs-catalyzed TMB oxidation, a sensitive,selective, simple, cost-effective, and rapid detection method for Ag+ can be realized. Ag+ ions in tap and lake waters have been successfully detected. We ensured that the proposed method can be a potential alternative for Ag+ determination in environmental samples.

关键词： Colorimetric detection Oxidase-like activity Platinum nanoparticle Tetramethylbenzidine Silver ion

An Optimization System for Intent Recognition Based on an Improved KNN Algorithm with Minimal Feature Set for Powered Knee Prosthesis

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Journal of Bionic Engineering 2023年第6期20卷 2619-2632页

作者： Yao Zhang Xu Wang haohua Xiu Lei Ren Yang Han Yongxin Ma Wei chen Guowu Wei Luquan Ren Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun130022People’s Republic of China Robotics Institute of NBUT Ningbo University of TechnologyNingbo315211People’s Republic of China Department of Mechanical Aerospace and Civil EngineeringThe University of ManchesterManchesterM139PLUK School of Mechanical Science and Aerospace Engineering Jilin UniversityChangchun130022People’s Republic of China School of Science Engineering and EnvironmentUniversity of SalfordSalfordM54WTUK

In this article,a new optimization system that uses few features to recognize locomotion with high classification accuracy is *** optimization system consists of three ***,the features of the mixed mechanical signal data are extracted from each analysis window of 200 ms after each foot contact ***,the Binary version of the hybrid Gray Wolf Optimization and Particle Swarm Optimization(BGWOPSO)algorithm is used to select ***,the selected features are optimized and assigned different weights by the Biogeography-Based Optimization(BBO)***,an improved K-Nearest Neighbor(KNN)classifier is employed for intention *** classifier has the advantages of high accuracy,few parameters as well as low memory *** on data from eight patients with transfemoral amputations,the optimization system is *** numerical results indicate that the proposed model can recognize nine daily locomotion modes(i.e.,low-,mid-,and fast-speed level-ground walking,ramp ascent/decent,stair ascent/descent,and sit/stand)by only seven features,with an accuracy of 96.66%±0.68%.As for real-time prediction on a powered knee prosthesis,the shortest prediction time is only 9.8 *** promising results reveal the potential of intention recognition based on the proposed system for high-level control of the prosthetic knee.

关键词： Intent recognition K-Nearest Neighbor algorithm Powered knee prosthesis Locomotion mode classification

城市轨道交通车载无线传输系统设计研究及实现探讨

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智慧轨道交通 2023年第5期60卷 36-40,46页

作者：管超孟彤杨康张欣萍滕俊青李华栋陈浩华吕方林中车青岛四方车辆研究所有限公司山东青岛266031 青岛地铁集团有限公司山东青岛266035 青岛城市轨道交通科技有限公司山东青岛266035

目前国内轨道交通行业正处于蓬勃发展时期,但运维新模式的技术应用、设备配置与规模增长不相匹配,运维的压力日益增大,这对正线故障事件的应对处理能力和运营网络自救能力提出了更高的要求。结合城市轨道交通车辆智能化发展需求,亟需开... 详细信息

目前国内轨道交通行业正处于蓬勃发展时期,但运维新模式的技术应用、设备配置与规模增长不相匹配,运维的压力日益增大,这对正线故障事件的应对处理能力和运营网络自救能力提出了更高的要求。结合城市轨道交通车辆智能化发展需求,亟需开展车载无线传输系统的研究与设计。首先分析了城市轨道交通车载无线传输系统的典型工作场景、功能要求,其次针对无线传输系统的车载数据流向、车地数据传输方式以及车地传输安全防护的现状和问题进行了重点分析,最后提出上述典型问题在实现层面的设计思路。

关键词：城市轨道交通车载无线传输系统设计研究及实现车载数据流向车地数据传输车地传输安全防护

Hawanoids A–E, unprecedented diterpenoids with PAF-induced platelet aggregation inhibitory activities from the deep-sea-derived fungus Paraconiothyrium hawaiiense

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Chinese Chemical Letters 2023年第2期34卷 416-419页

作者： Shushuai chen Hongxin Liu Saini Li Yuchan chen Wei Ye haohua Li Haibo Tan Dongli Li Zhaoming Liu Weimin Zhang State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020China Program for Natural Product Chemical Biology Key Laboratory Plant Resources Conservation and Sustainable UtilizationSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China

Hawanoids A–E(1–5), five highly cyclized diterpenoids were isolated from the deep-sea-derived fungus Paraconiothyrium hawaiiense FS482. Compounds 1 and 2 possessed an unprecedented tetracyclo[6.***.2.0^(2,7).0^(11,15)]cetane carbon skeleton while 3 and 4 possessed an unusual 11,14-macrocyclic ether moiety in phomactin family. Their structures including the stereo-chemistry were determined through spectroscopic analysis, X-ray diffractions and computational calculations. The plausible biosynthetic pathway was proposed based on the predicted biosynthetic gene cluster. All of the isolated compounds exhibited inhibitory activities against PAF-induced platelet aggregation. The molecular docking study was carried out understand the interaction between the PAF receptor and hawanoids with different skeletons.

关键词： Diterpenoids Deep-sea-derived fungus Biosynthetic pathway Platelet aggregation inhibition Molecular docking

Experimental study on plasma actuation characteristics of nanosecond pulsed dielectric barrier discharge

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Plasma Science and Technology 2022年第1期24卷 129-138页

作者： Hao ZHENG Hua LIANG Jie chen haohua ZONG Xiangzhe MENG Like XIE Yinghong LI Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi'an 710038People’s Republic of China Chinese Flight Test Establishment Xi’an 710089People’s Republic of China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Combining high-speed schlieren technology and infrared imaging technology,related research has been carried out on the influence of parameters such as actuation voltage,repetition frequency,and electrode size of an actuator on the discharge characteristics,induced flow field characteristics,and thermal characteristics of nanosecond pulsed dielectric barrier *** results show that increasing the value of the actuation voltage can significantly increase the actuation intensity,and the plasma discharge area is significantly *** the repetition frequency can increase the number of discharges per unit *** will cause more energy input and induce more changes in the flow *** effect of temperature rise is more *** width of the covered electrode will affect the potential distribution during the discharge process,which in turn will affect the extension process of the plasma discharge *** the same actuation intensity,the wider the covered electrode,the larger range the induced flow field and temperature rise *** experimental analyses of high-frequency actuation characteristics,temperature field characteristics,flow field characteristics and actuation parameter settings provide support for the parameter selection and partial mechanism analysis of plasma anti-icing.

关键词： NS-DBD actuation voltage repetition frequency induced flow field temperature rise

Natural variation of an autophagy-family gene among rice subspecies affects grain size and weight

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The Crop Journal 2024年第1期12卷 121-132页

作者： Shiying Huang Peng Wang Caijing Li Qingwen Zhou Tao Huang Yicong Cai Qin cheng Hui Wang Qi Zhong Zhihao chen Liping chen haohua He Jianmin Bian Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of Education.Jiangxi Agricultural UniversityNanchang 330045JiangxiChina Weill Cornell Medical Immunology and Microbiology1300 York AvenueBox 62New YorkNY 10065USA

Elucidating the genetic basis of natural variation in grain size and weight among rice varieties can help breeders develop high-yielding *** identified a novel gene,GW3a(Grain Weight 3a)(LOC_Os03g27350),that affects rice grain size and ***3a mutants showed higher total starch content and dry matter accumulation than the wild type(WT),Nipponbare,suggesting that GW3a negatively regulates grain size and ***,our study found that GW3a interacted with OsATG8 by cleaving it,suggesting that GW3a may be involved in the assembly of autophagosomes and starch degradation in *** haplotype analysis of GW3a showed functional differences between indica and japonica *** together,we conclude that GW3a is expressed in the autophagosome pathway regulating starch metabolism in rice,affecting yield-related traits,such as grain size,grain weight and thousand grain weight(TGW).Our findings also shed new light on autophagy-mediated yield trait regulation,proposing a possible strategy for the genetic improvement of high-yield germplasm in rice.

关键词： Grain size GW3a Autophagy Starch content