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Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4394-4402页

作者： Yan Wang Chong Zhang Yongbo Luo Xiaobin Ling Bingnan Luo Guowen Jia Dan Su haohao dong Zhaoming Su The State Key Laboratory of Biotherapy Frontiers Medical Center of Tianfu Jincheng LaboratoryDepartment of Geriatrics and National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610044China

Respiratory syncytial virus(RSV)is a nonsegmented,negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly,yet no effective vaccine or antiviral therapy is *** RSV genome encodes the nucleoprotein(N)that forms helical assembly to encapsulate and protect the RNA genome from degradation,and to serve as a template for transcription and *** crystal structure revealed a decameric ring architecture of N in complex with the cellular RNA(N-RNA)of 70 nucleotides(70-nt),whereas cryo-ET reconstruction revealed a low-resolution left-handed filament,in which the crystal monomer structure was docked with the helical symmetry applied to simulate a nucleocapsid-like assembly of ***,the molecular details of RSV nucleocapsid assembly remain unknown,which continue to limit our complete understanding of the critical interactions involved in the nucleocapsid and antiviral development that may target this essential process during the viral life *** we resolve the near-atomic cryo-EM structure of RSV N-RNA that represents roughly one turn of the helical assembly that unveils critical interaction interfaces of RSV nucleocapsid and may facilitate development of RSV antiviral therapy.

关键词： respiratory vaccine structure

Altered Neural Processing of Negative Stimuli in People with Internet Gaming Disorder: fMRI Evidence from the Comparison with Recreational Game Users

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Altered Neural Processing of Negative Stimuli in People with...

第二十二届全国心理学学术会议

作者： Jialin Zhang haohao dong Guangheng dong Department of Psychology Zhejiang Normal University Institute of Psychological and Brain Sciences Zhejiang Normal University

Background Abundant clinical studies have found that emotion dysregulation seems to be the essential pathogenesis for Internet gaming disorder(IGD). However, the neural mechanism of emotion regulation for IGD is still unclear. Methods Subjective evaluation and fMRI data were collected from 50 subjects(IGD: 24;recreational game use(RGU): 26) while they were performing an emotion reappraisal task. We collected and compared their brain features during emotion processing of different visual stimuli. Results Higher activation in the bilateral anterior cingulate cortex(ACC) and insula was observed in participants with IGD during emotional reappraisal relative to that of the RGU participants. A negative correlation between emotion reappraisal scores(lower scores indicating better regulation) and brain responses in the right insula was observed. In addition, the IGD group was found to have a significant negative correlation between the emotional reappraisal score and the right insula activity, while no significant correlation was found in the RGU group. Generalized psychophysiological interaction analysis also showed that IGD participants had stronger functional connectivity between the right insula and bilateral dorsolateral prefrontal cortex(DLPFC) than the RGUs. Conclusions The results suggest that negative stimuli have a more pronounced effect on IGD participants;at the same time, they could not downregulate their negative emotional experiences as efficiently as the RGU participants. These results revealed why individuals with IGD are vulnerable to emotional problems and provide a new perspective for interventions in IGD.

关键词： Internet gaming disorder Emotion regulation ACC Insula

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地对空雷达干扰系统有源无源联合发现概率

探测与控制学报 2017年第6期39卷 51-55页

作者：董豪豪刘雅奇齐锋龚燕解放军电子工程学院安徽合肥230037

针对目前地对空雷达干扰系统发现概率模型没有考虑有源侦察与无源侦察之间的指示情形,并且计算模型不完整的问题,提出了地对空雷达干扰系统有源无源联合发现概率建模方法。该方法分析了地对空雷达干扰系统的探测规律,在考虑了发现目标... 详细信息

针对目前地对空雷达干扰系统发现概率模型没有考虑有源侦察与无源侦察之间的指示情形,并且计算模型不完整的问题,提出了地对空雷达干扰系统有源无源联合发现概率建模方法。该方法分析了地对空雷达干扰系统的探测规律,在考虑了发现目标的完整过程下推导了有源侦察方位指示成功的概率、有方位指示和无方位指示情形下干扰站系统的发现概率,然后运用概率论思想建立了系统有源无源联合发现概率模型。仿真分析表明,有方位指示下系统的发现概率大于无指示独立探测的情形,并且指示的时刻越早,系统的联合发现概率增长越快。

关键词：地对空雷达干扰系统发现概率方位指示有源无源联合

Resonance mechanism of flapping wing based on fluid structure interaction simulation

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Chinese Journal of Aeronautics 2024年第5期37卷 243-262页

作者： Yueyang GUO Wenqing YANG Yuanbo dong dong XUE National Key Laboratory of Science and Technology on Aerodynamic Design and Research School of AeronauticsNorthwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China Yangtze River Delta Research Institute of Northwestern Polytechnical University Taicang 215400China

Certain insect species have been observed to exploit the resonance mechanism of their *** order to achieve resonance and optimize aerodynamic performance,the conventional approach is to set the flapping frequency of flexible wings based on the Traditional Structural Modal(TSM)***,there exists controversy among researchers regarding the relationship between frequency and aerodynamic *** that the structural response of wings can be influenced by the surrounding air vibrations,an analysis known as Acoustic Structure Interaction Modal(ASIM)is introduced to calculate the resonant *** this study,Fluid Structure Interaction(FSI)simulations are employed to investigate the aerodynamic performance of flapping wings at modal frequencies derived from both TSM and ASIM *** performance is evaluated for various mass ratios and frequency ratios,and the findings indicate that the deformation and changes in vortex structure exhibit similarities at mass ratios that yield the highest aerodynamic ***,the flapping frequency associated with the maximum time-averaged vertical force coefficient at each mass ratio closely aligns with the ASIM frequency,as does the frequency corresponding to maximum ***,the ASIM analysis can provide an effective means for predicting the optimal flapping frequency for flexible ***,it enables the prediction that flexible wings with varying mass ratios will exhibit similar deformation and vortex structure *** paper offers a fresh perspective on the ongoing debate concerning the resonance mechanism of Flexible Flapping Wings(FFWs)and proposes an effective methodology for predicting their aerodynamic performance.

关键词： Flexible Flapping Wing(FFW) Acoustic Structure Interaction Modal(ASIM) Fluid Structure Interaction(FSI) Resonance mechanism Aerodynamic performance

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多站协同对机载雷达的干扰压制空域研究

战术导弹技术 2019年第3期 48-52,58页

作者：董豪豪刘雅奇齐锋国防科技大学合肥230037

针对传统平面二维干扰压制区量化图难以表现出不同高度维上干扰压制区变化的问题,通过分析地对空雷达干扰站对抗机载雷达的空间关系,建立了多站协同干扰机载雷达的三维干扰压制空域模型和机载雷达天线模型,并计算了对常规脉冲雷达和脉... 详细信息

针对传统平面二维干扰压制区量化图难以表现出不同高度维上干扰压制区变化的问题,通过分析地对空雷达干扰站对抗机载雷达的空间关系,建立了多站协同干扰机载雷达的三维干扰压制空域模型和机载雷达天线模型,并计算了对常规脉冲雷达和脉冲多普勒雷达的干扰压制系数。通过仿真计算,得到了不同干扰站配置距离、对不同体制机载雷达干扰情形下的干扰压制空域,直观反映出不同情形下的干扰效果。仿真结果可用于地对空雷达干扰系统的干扰效能评估和实战运用。

关键词：机载雷达地对空雷达干扰多站协同干扰压制空域

Copper slag assisted coke reduction of phosphogypsum for sulphur dioxide preparation

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Chinese Journal of Chemical Engineering 2024年第1期65卷 43-53页

作者： dong Ma Qinhui Wang State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

The reduction of phosphogypsum(PG)to lime slag and SO_(2)using coke can effectively alleviate the environmental problems caused by ***,the PG decomposition temperature remains high and the product yield remains *** adding additives,the decomposition temperature can be further reduced and PG decomposition rate and product yield can be ***,the use of current additives such as Fe_(2)O_(3)and SiO_(2)brings the problem of increasing economic ***,it is proposed to use solid waste copper slag(CS)as a new additive to reduce PG to prepare SO2,which can reduce the cost and meet the environmental benefits at the same *** effects of proportion,temperature and thermostatic time on PG decomposition are investigated by experimental and kinetic analysis combined with FactSage thermodynamic calculations to optimize the roasting ***,the reaction mechanism is *** is found that adding CS to the coke and PG system can increase the rate of PG decomposition and SO_(2)yield while lowering the PG decomposition *** example,when the CS/PG mass ratio increases from 0 to 1,PG decomposition rate increases from 83.38%to 99.35%,SO_(2)yield increases from 78.62%to 96.81%,and PG decomposition temperature decreases from 992.4℃to 949.6℃.The optimal reaction parameters are CS/PG mass ratio of 1,Coke/PG mass ratio of 0.06 at 1100℃for 20 min with 99.35%PG decomposition rate and 96.81%SO_(2) *** process proceeds according to the following reactions:2CaSO_(4)+ 0.7C + 0.8Fe_(2)SiO_(4)→0.8Ca_(2)SiO_(4)+ 0.2Ca_(2)Fe_(2)O_(5)+ 0.4Fe_(3)O_(4)+2SO_(2)+ 0.7CO_(2)Finally,a process for decomposing PG with coke and CS is proposed.

关键词： Phosphogypsum Sulfur dioxide Copper slag Fluidized-bed Reduction Waste treatment

Resilient control of flexible hypersonic vehicles against unmatched distributed faults

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Chinese Journal of Aeronautics 2024年第5期37卷 60-70页

作者： dong ZHAO Wenjing REN School of Artificial Intelligence Anhui UniversityHefei 230601China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

This paper studies a robust fault compensation and vibration suppression problem of flexible hypersonic *** controlled plant is represented by a cascade system composed of a nonlinear Ordinary Differential Equation(ODE)and an Euler-Bernoulli Beam Equation(EBBE),in which the vibration dynamics is coupled with the rigid dynamics and suffers from distributed faults.A state differential transformation is introduced to transfer distributed faults to an EBBE boundary and a longitudinal dynamics is refined by utilizing T-S fuzzy IF-THEN rules.A novel T-S fuzzy based fault-tolerant control algorithm is developed and related stability conditions are *** robust exponential stability and well-posedness are proved by using the modified l_(0)-semigroup based Lyapunov direct approach.A simulation study on the longitudinal dynamics of flexible hypersonic vehicles effectively verifies the validity of the developed theoretical results.

关键词： Flexible hypersonic vehicles ODE-EBBE cascade Robust exponential stability Unmatched distributed fault compensation Vibration suppression

Finite-time Prescribed Performance Time-Varying Formation Control for Second-Order Multi-Agent Systems With Non-Strict Feedback Based on a Neural Network Observer

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1039-1050页

作者： Chi Ma Dianbiao dong the School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China

This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown *** eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the *** addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader *** address this problem,a neural network state observer based on the leader state information is ***,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite ***,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.

关键词： Finite-time control multi-agent systems neural network prescribed performance control time-varying formation control

Modeling urban scale human mobility through big data analysis and machinelearning

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Building Simulation 2024年第1期17卷 3-21页

作者： Yapan Liu Bing dong Department of Mechanical&Aerospace Engineering Syracuse University263 Link HallSyracuseNY 13244USA

In the United States,the buildings sector consumes about 76%of electricity use and 40% of all primary energy use and associated greenhouse gas *** behavior has drawn increasing research interests due to its impacts on the building energy ***,occupant behavior study at urban scale remains a challenge,and very limited studies have been *** an effort to couple big data analysis with human mobility modeling,this study has explored urban scale human mobility utilizing three months Global Positioning System(GPS)data of 93,o00 users at Phoenix Metropolitan *** research extracted stay points from raw data,and identified users'home,work,and other locations by Density-Based Spatial Clustering ***,daily mobility patterns were constructed using different types of *** propose a novel approach to predict urban scale daily human mobility patterns with 12-hour prediction horizon,using Long Short-Term Memory(LSTM)neural network *** shows the developed models achieved around 85%average accuracy and about 86%mean *** developed models can be further applied to analyze urban scale occupant behavior,building energy demand and flexibility,and contributed to urban planning.

关键词： urban human mobility big data analysis urban scale occupant behavior recurrent neural networks