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Changes of paired-pulse evoked responses during the development of epileptic activity in the hippocampus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 704-711页

作者： Zhou-yan FENG Xiao-jing ZHENG Cong TIAN Yang WANG hao-yu xing Ministry of Education Key Lab of Biomedical Engineering College of Biomedical Engineering & Instrument ScienceZhejiang UniversityHangzhou 310027China

Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons,thereby inducing epileptic *** aim of the paper is to investigate the effects of successive excitatory inputs on the epileptic activity induced in the absence of ***-pulse orthodromic and antidromic stimulations were used to test the changes in the evoked responses in the ***(PTX),γ-aminobutyric acid(GABA) type A(GABA A) receptor antagonist,was added to block the inhibitory synaptic transmission and to establish the epileptic *** evoked population spike(PS) was recorded in the CA1 region of the *** results showed that the application of PTX induced a biphasic change in the paired-pulse ratio of PS amplitude.A short latency increase of the second PS(PS2) was later followed by a reappearance of PS2 *** type of depression was observed in both orthodromic and antidromic paired-pulse responses,whereas the GABAergic PS2 depression [called paired-pulse depression(PPD)] during baseline recordings only appeared in orthodromic-evoked *** addition,the depression duration at approximately 100 ms was consistent with a relative silent period observed within spontaneous burst discharges induced by prolonged application of *** conclusion,the neurons may ignore the excitatory inputs and intrinsically generate bursts during epileptic *** depolarization block could be the mechanisms underlying the PPD in the absence of GABA A *** distinct neuronal responses to stimulations during different epileptic stages may implicate the different antiepileptic effects of electrical stimulation.

关键词： Epilepsy Paired-pulse depression γ-Aminobutyric acid(GABA) Picrotoxin(PTX) CA1 region In-vivo

Transcriptome response of wheat Norin 10 to long-term elevated CO_2 under high yield field condition

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Journal of Integrative Agriculture 2016年第9期15卷 2142-2152页

作者： LIN yue-bing SHEN Cheng-guo LIN Er-da hao xing-yu HAN Xue Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences/Key Laboratory of Agricultural Environment Ministry of Agriculture Bioinformatics Unit Source Bio Science College of Agronomy Shanxi Agricultural University

The increasing atmospheric carbon dioxide concentration, caused by fossil fuel combustion and deforestation, plays an important role in plant growth and development. Wheat, as a major staple crop, adapts to climate change by tuning its inherent molecular mechanism, which is not well understood. The present study employed the RNA-Seq method to generate transcriptome profiles of the wheat Norin 10 in response to elevated CO_2 in comparison with ambient CO_2. The 10 895 787 high-quality clean reads of Norin 10 were assembled de novo using Trinity（without a reference genome） resulting in a total of 18 206 candidate transcripts with significant BLAST matches. GO enrichment analysis of Norin 10 at different CO_2 concentrations showed that some functional genes related to plastids, precursor metabolites, and energy, thylakoid and photosynthesis were apparently enriched at elevated CO_2（550 μmol mol^–1） in contrast to that at ambient CO_2（400 μmol mol^–1）; these findings were further confirmed by RT-PCR analysis. The findings demonstrated the specific effects of elevated CO_2 during long-term period in free air CO_2 enrichment（FACE） on transcriptome response of the high yielding wheat variety, Norin 10, which has a large spike.

关键词： Norin 10 transcriptome response wheat long term elevated carbon dioxide GO enrichment

Leaf photosynthesis and yield components of mung bean under fully open-air elevated[CO_2]

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Journal of Integrative Agriculture 2015年第5期14卷 977-983页

作者： GAO Ji HAN Xue Saman Seneweera LI Ping ZONG yu-zheng DONG Qi LIN Er-da hao xing-yu Key Laboratory of Ministry of Agriculture on Agro-Environment and Climate Change Institute of Environment and Sustainable Development in Agriculture(IEDA)Chinese Academy of Agricultural Sciences College of Agriculture Shanxi Agricultural University Centre for Systems Biology University of Southern Queensland

Mung bean（Vigna radiata L.） has the potential to establish symbiosis with rhizobia,and symbiotic association of soil micro flora may facilitate the photosynthesis and plant growth response to elevated[CO2].Mung bean was grown at either ambient CO2 400 μmol mol^（-1） or[CO2]（（550＋17） μmol mol^（-1）） under free air carbon dioxide enrichment（FACE） experimental facility in North ***[CO2]increased net photosynthetic rate（Pn）,water use efficiency（WUE） and the non-photochemical quenching（NPQ） of upper most fully-expanded leaves,but decreased stomatal conductance（Gs）,intrinsic efficiency of PSII（Fv ＇/Fm＇）,quantum yield of PSII（φ（PSll）） and proportion of open PSII reaction centers（qp）.At elevated[CO2],the decrease of Fv＇/Fm＇,φ（PSII）,qp at the bloom stage were smaller than that at the pod *** the other hand,Pn was increased at elevated[CO2]by 18.7 and 7.4%at full bloom（R2） and pod maturity stages（R4）,*** these findings,we concluded that as a legume despite greater nutrient supply to the carbon assimilation at elevated[CO2],photosynthetic capacity of mung bean was still suppressed under elevated[CO2]particularly at pod maturity stage but plant biomass and yield was increased by 11.6 and 14.2%,***,these findings suggest that even under higher nutrient acquisition systems such as legumes,nutrient assimilation does not match carbon assimilation under elevated[CO2]and leads photosynthesis down-regulation to elevated[CO2].

关键词： photosynthesis photosynthetic elevated stomatal PSII maturity nutrient assimilation ambient facility

Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： xing-yu Chen Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

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气候变化对大豆影响的研究进展

应用生态学报 2010年第10期21卷 2697-2706页

作者：郝兴宇韩雪居煇林而达中国农业科学院农业环境与可持续发展研究所农业部农业环境与气候变化重点实验室北京100081 山西农业大学农学院山西太谷030801

工业革命以来,全球大气中CO2等温室气体浓度急剧升高,导致全球气温升高和降水格局发生变化.大气CO2浓度升高、全球变暖、水分状况的变化将对大豆的生长发育、产量、品质等产生影响,未来气候变化下大豆生产将发生很大变化.大豆是世界及... 详细信息

工业革命以来,全球大气中CO2等温室气体浓度急剧升高,导致全球气温升高和降水格局发生变化.大气CO2浓度升高、全球变暖、水分状况的变化将对大豆的生长发育、产量、品质等产生影响,未来气候变化下大豆生产将发生很大变化.大豆是世界及我国重要的粮食和油料作物之一,未来气候变化下大豆生产的变化将会影响全球粮油安全.本文从大气CO2浓度升高、温度升高、水分胁迫三方面综述了气候变化对大豆影响的研究,并对未来的相关研究做了展望,为了解未来大豆的生产情况以及制定应对气候变化对大豆生产影响的相关政策提供依据.

关键词：气候变化 CO2浓度升高气候变暖水分胁迫大豆产量品质

基于对偶双环滑模的空间翻滚目标相对绕飞控制

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导弹与航天运载技术 2018年第5期 57-63,97页

作者：郝宇星申麟李扬中国运载火箭技术研究院研究发展中心北京100076

针对空间翻滚目标相对绕飞问题,采用基于旋量、对偶四元数的方法建立了相对动力学模型。以在轨翻滚航天器作为任务对象进行了相对绕飞的对偶双环滑模控制器设计,不仅保证了追踪航天器相对距离的稳定,还使其姿态能够与翻滚目标保持时刻... 详细信息

针对空间翻滚目标相对绕飞问题,采用基于旋量、对偶四元数的方法建立了相对动力学模型。以在轨翻滚航天器作为任务对象进行了相对绕飞的对偶双环滑模控制器设计,不仅保证了追踪航天器相对距离的稳定,还使其姿态能够与翻滚目标保持时刻同步。数值仿真验证了控制器的有效性。

关键词：空间翻滚目标对偶四元数双环滑模控制

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空间翻滚目标位姿耦合建模与运动特性分析

导弹与航天运载技术 2019年第1期 74-79页

作者：郝宇星申麟李扬中国运载火箭技术研究院研究发展中心北京100076

空间失效航天器与空间碎片与正常运行的航天器发生碰撞会产生严重的后果,其不能提供自身的姿轨信息,可能会有翻滚等复杂运动状态,使空间操作的安全性受到威胁。以空间翻滚目标为研究对象,由相关任务带来的目标识别以及运动估计问题,引... 详细信息

空间失效航天器与空间碎片与正常运行的航天器发生碰撞会产生严重的后果,其不能提供自身的姿轨信息,可能会有翻滚等复杂运动状态,使空间操作的安全性受到威胁。以空间翻滚目标为研究对象,由相关任务带来的目标识别以及运动估计问题,引入了位姿耦合建模方法,推导了空间翻滚目标位姿耦合形式的对偶牛顿——欧拉方程,对翻滚目标的耦合性、运动特征进行分析,并以在轨翻滚目标为例仿真归纳了各类翻滚目标的主要运动形式。根据分析,空间翻滚目标的姿态运动可分为3类,并且根据其运动特征可以反推其质量特性,这对空间目标运动的识别与参数估计拥有重要参考意义。

关键词：空间翻滚目标运动特性位姿耦合对偶四元数

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da Long Xiao yu Zhi-Xiang xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

大气CO_(2)浓度和气温升高对大豆叶片光合特性及氮代谢的影响

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中国农业气象 2021年第5期42卷 426-437页

作者：刘昭霖宗毓铮张东升郝兴宇李萍山西农业大学农学院山西太谷030801

以大豆品种“中黄35”为材料,利用人工气候室,设置对照CK(CO_(2)浓度和气温与外界测定值相同)、EC(CO_(2)浓度为外界测定值+200μmol·mol–1,气温与外界测定值相同)、ET(CO_(2)浓度与外界测定值相同,气温为外界测定值+2℃)、ECT(CO_(2... 详细信息

以大豆品种“中黄35”为材料,利用人工气候室,设置对照CK(CO_(2)浓度和气温与外界测定值相同)、EC(CO_(2)浓度为外界测定值+200μmol·mol–1,气温与外界测定值相同)、ET(CO_(2)浓度与外界测定值相同,气温为外界测定值+2℃)、ECT(CO_(2)浓度为外界测定值+200μmol·mol–1,气温为外界大气测定值+2℃)共4个处理。大豆整个生育期均种植在人工气候室内,在大豆鼓粒期(8月12日)利用相对叶绿素仪测定大豆叶片相对叶绿素含量,利用便携式气体交换系统测定光合参数,利用便携式光合测量系统测定光响应曲线和CO_(2)响应曲线,并测定叶片氮代谢相关指标,以研究CO_(2)浓度升高200μmol·mol–1和气温升高2℃对鼓粒期大豆叶片的光合特性和氮代谢关键指标的影响。结果表明:(1)ET处理鼓粒期大豆叶片相对叶绿素含量(SPAD)显著增加,EC和ECT处理对其影响不明显。(2)各处理鼓粒期大豆叶片气孔导度(Gs)均显著下降。ET处理中,叶片净光合速率(Pn)、水分利用效率(WUE)显著下降,EC处理对其影响不大,但是可以提高叶片水分利用效率(WUE),改善气温升高对叶片的负面影响。(3)EC和ET处理鼓粒期大豆叶片最大净光合速率(Pnmax)均显著下降,ECT处理对其影响不显著。(4)EC处理中,鼓粒期大豆叶片CO_(2)补偿点(Γ)、饱和胞间CO_(2)浓度(Cisat)、光呼吸速率(Rp)均显著增加,ET和ECT对其影响不大。各处理均使鼓粒期大豆叶片最大净光合能力(Amax)下降。(5)EC处理鼓粒期大豆叶片硝酸还原酶(NR)活性和可溶性蛋白含量均显著下降,但是ET和ECT处理叶片可溶性蛋白含量显著增加,硝酸还原酶(NR)活性变化不显著,各处理均降低了谷氨酰胺合成酶(GS)的活性。总之,CO_(2)浓度升高200μmol·mol–1可以改善气温升高2℃对鼓粒期大豆叶片光合作用的负面影响,但对氮代谢有抑制作用,而气温升高2℃可以一定程度上缓解CO_(2)浓度升高200μmol·mol–1对鼓粒期大豆叶片氮代谢的抑制作用。

关键词： CO_(2)浓度升高气温升高大豆光合特性氮代谢