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Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma

World Journal of Clinical Oncology 2024年第1期15卷 130-144页

作者： Yan Li William Lee Zhen-Gang Zhao Yi Liu hao Cui hao-yu wang Department of Gastroenterology Tianjin Third Central HospitalTianjin 300170China Biomedical Engineering Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide.Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival,growth,and evolution.Emerging evidence suggests the importance of fatty acid binding proteins(FABPs)in contribution to cancer progression and metastasis;however,how these FABPs are dysregulated in cancer cells,especially in HCC,and the roles of FABPs in cancer progression have not been well defined.AIM To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.METHODS We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma(LIHC)as well as patient cohorts with other cancer types in this study.We investigated genetic alterations of FABPs in various cancer types.mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome,enriched cancer hallmarks and oncogenes previously reported for patients with HCC.We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.RESULTS We discovered that a gene cluster including five FABP family members(FABP4,FABP5,FABP8,FABP9 and FABP12)is frequently co-amplified in cancer.Amplification,in fact,is the most common genetic alteration for FABPs,leading to overexpression of FABPs.FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues.High FABP5 expression correlates well with worse patient outcomes(P<0.05).FABP5 expression highly correlates with enrichment of G2M checkpoint(r=0.33,P=1.1e-10),TP53 signaling pathway(r=0.22,P=1.7e-5)and many genes in the gene sets such as CDK1(r=0.56,P=0),CDK4(r=0.49,P=0),and TP53(r=0.22,P=1.6e-5).Furthermore,FABP5 also correlates

关键词： Hepatocellular carcinoma Fatty acid binding protein Novel target Amplification Correlated expression

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Study of the multi-physics field-coupled model of the two-stage electrostatic precipitator

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Building Simulation 2024年第3期17卷 387-398页

作者： Wenjia hao yu Guo yukun wang Tao yu hao Gao Zhengwei Long Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityWeijin Road 92Tianjin300072China Wuhan Second Ship Design and Research Institute WuhanChin

The two-stage electrostatic precipitator is widely used to purify oil mist particles.However,there is limited research on the influences of relative humidity,particle deposition characteristics,and the generation of gaseous pollutants.Therefore,this paper established a numerical model of the electrostatic oil mist purifier and applied it to a two-stage electrostatic precipitator.Then the model was used to investigate the corona discharge characteristics under different relative humidity conditions in the charged zone,the particle deposition characteristics,the purification efficiency,the ozone concentration distribution,and the oil vapor concentration distribution in the collection zone.The results indicate that,with a constant temperature,the corona current decreases as relative humidity increase,and there is a quadratic relationship between relative humidity and current.The variation in relative humidity has little impact on the purification efficiency.The maximum ozone concentration occurs near the electrode line,and its concentration is influenced by the discharge current and inlet airflow velocity.The oil vapor concentration reaches its maximum value at the side plates,with a value of 19 ppb,while it reaches the minimum value at the collecting zone electrode plate,with a value of 2 ppb.The temperature is the main factor affecting the volatilization of the oil film,with higher temperatures resulting in higher oil vapor.

关键词： two-stage ESPs particle deposition corona discharge oil vapor

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Influence of carbides and pores on the localized deformation of nickel-based single-crystal superalloys

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Progress in Natural Science:Materials International 2024年第3期34卷 562-568页

作者： Rengeng Li yu Zhang haoyi Niu hao wang hao Wu Key Laboratory for Light-weight Materials Nanjing Tech University College of Materials Science and Engineering Chongqing University CRRC Qishuyan Institute Co.Ltd.

The carbides and pores play a critical role in the cracking tendencies of nickel-based single-crystal superalloys during deformation. In the present study, the deformation mechanism and local strain evolution behavior around carbides and pores were studied through in-situ tensile deformation experiments. The findings indicate that multiple slip systems are easily activated during tensile deformation in single-crystal alloys. Furthermore, the strain localization in carbides is influenced by their morphology, with rod-like and flake-like carbides demonstrating an increased likelihood of cracking during deformation. The strain localization adjacent to pores is markedly more intense, rendering these areas particularly susceptible to cracking. Our work therefore offers a theoretical foundation for enhancing the mechanical properties of nickel-based single-crystal superalloys by controlling carbide morphology and pore formation.

关键词： Carbides In-situ tensile Nickel-based single-crystal Pores Strain evolution

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Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： Kun Zhang Zhe Zhang Hailong Pan haoyu wang Xueting Zhao Ji Qi Zhao Zhang Ruiqi Song Chenyang yu Biaohong Huang Xujing Li Huaican Chen Wen Yin Changlong Tan Weijin Hu Michael Wüubbenhorst Jiangshui Luo Dehong yu Zhidong Zhang Bing Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost everywhere.Unlike electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of thermodynamics.Optical illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and unscalable.Here,we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol(AMP)to realize an affordable,easily manageable approach for thermal energy recycling.The supercooled state of AMP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 20 s.Furthermore,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of383.Such delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational

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Versatile MXene Gels Assisted by Brief and Low‑Strength Centrifugation

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Nano-Micro Letters 2024年第5期16卷 231-247页

作者： Weiyan yu Yi Yang yunjing wang Lulin Hu Jingcheng hao Lu Xu Weimin Liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006People’s Republic of China Key Laboratory of Colloid and Interface Chemistry and Key Laboratory of Special Aggregated Materials Shandong UniversityJinan 250100People’s Republic of China

Due to the mutual repulsion between their hydrophilic surface terminations and the high surface energy facilitating their ran-dom restacking,2D MXene nanosheets usually cannot self-assemble into 3D macroscopic gels with various applications in the absence of proper linking agents.In this work,a rapid spontaneous gelation of Ti3C2Tx MXene with a very low dispersion concentration of 0.5 mg mL^(-1) into multifunctional architectures under moderate centrifugation is illustrated.The as-prepared MXene gels exhibit reconfigurable internal structures and tunable rheological,tribological,electrochemical,infrared-emissive and photothermal-conversion properties based on the pH-induced changes in the surface chemistry of Ti_(3)C_(2)T_(x) nanosheets.By adopting a gel with optimized pH value,high lubrication,exceptional specific capacitances(~635 and~408 F g^(-1) at 5 and 100 mV s^(-1),respectively),long-term capacitance retention(~96.7%after 10,000 cycles)and high-precision screen-or extrusion-printing into different high-resolution anticounterfeiting patterns can be achieved,thus displaying extensive potential applications in the fields of semi-solid lubrication,control-lable devices,supercapacitors,information encryption and infrared camouflaging.

关键词： MXene Centrifugation-assisted rapid gelation Lubrication Supercapacitor Anti-counterfeiting applications

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A hybrid physics-informed data-driven neural network for CO_(2) storage in depleted shale reservoirs

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Petroleum Science 2024年第1期21卷 286-301页

作者： Yan-Wei wang Zhen-Xue Dai Gui-Sheng wang Li Chen yu-Zhou Xia yu-hao Zhou College of Construction Engineering Jilin UniversityChangchun130026JilinChina Institute of Intelligent Simulation and Early Warning for Subsurface Environment Jilin UniversityChangchun130026JilinChina School of Energy Resources China University of GeosciencesBeijing100083China Department of Safety Environmental Protection and Quality ManagementShengli OilfieldSinopecDongying257000ShandongChina Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an710049ShaanxiChina College of Computer Science and Technology China University of Petroleum(East China)Qingdao266580ShandongChina Department of Physics University of FribourgFribourg1700Switzerland

To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport processes.However,most current CO_(2) sequestration models do not adequately consider multiple transport mechanisms.Moreover,the evaluation of CO_(2) storage processes usually involves laborious and time-consuming numerical simulations unsuitable for practical prediction and decision-making.In this paper,an integrated model involving gas diffusion,adsorption,dissolution,slip flow,and Darcy flow is proposed to accurately characterize CO_(2) storage in depleted shale reservoirs,supporting the establishment of a training database.On this basis,a hybrid physics-informed data-driven neural network(HPDNN)is developed as a deep learning surrogate for prediction and inversion.By incorporating multiple sources of scientific knowledge,the HPDNN can be configured with limited simulation resources,significantly accelerating the forward and inversion processes.Furthermore,the HPDNN can more intelligently predict injection performance,precisely perform reservoir parameter inversion,and reasonably evaluate the CO_(2) storage capacity under complicated scenarios.The validation and test results demonstrate that the HPDNN can ensure high accuracy and strong robustness across an extensive applicability range when dealing with field data with multiple noise sources.This study has tremendous potential to replace traditional modeling tools for predicting and making decisions about CO_(2) storage projects in depleted shale reservoirs.

关键词： Deep learning Physics-informed data-driven neural network Depleted shale reservoirs CO_(2)storage Transport mechanisms

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Modelling the viscoplastic behaviour of Callovo-Oxfordian claystone with consideration of damage effect

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 303-316页

作者： hao wang yu-Jun Cui Minh Ngoc Vu Jean Talandier Ecole des Ponts ParisTech Laboratoire Navier/CERMES6 et 8 avenue Blaise PascalMarne La Vallée cedex 277455France Andra R&D DepartmentChâtenay-Malabry92290France

In order to evaluate the performance of deep geological disposal of radioactive waste,an underground research laboratory(URL)was constructed by Andra in the Callovo-Oxfordian(COx)claystone formation at the Meuse/Haute-Marne(MHM).The construction of URL induced the excavation damage of host formations,and the ventilation in the galleries desaturated the host formation close to the gallery wall.Moreover,it is expected that the mechanical behaviour of COx claystone is time-dependent.This study presents a constitutive model developed to describe the viscoplastic behaviour of unsaturated and damaged COx claystone.In this model,the unsaturation effect is considered by adopting the Bishop effective stress and the van Genuchten(VG)water retention model.In terms of the viscoplastic behaviour,the nonstationary flow surface(NSFS)theory for unsaturated soils is used with consideration of the coupled effects of strain rate and suction on the yield stress.A progressive hardening law is adopted.Meanwhile,a non-associated flow rule is used,which is similar to that in Barcelona basic model(BBM).In addition,to describe the damage effect induced by suction change and viscoplastic loading,a damage function is defined based on the crack volume proportion.This damage function contains two variables:unsaturated effective stress and viscoplastic volumetric strain,with the related parameters determined based on the mercury intrusion porosimetry(MIP)tests.For the model validation,different tests on COx claystone under different loading paths are simulated.Comparisons between experimental and simulated results indicated that the present model is able to well describe the viscoplastic behaviour of damaged COx claystone,including swelling/shrinkage,triaxial extension and compression,and triaxial creep.

关键词： Callovo-Oxfordian(COx)claystone Excavation damage Time-dependent behaviour Suction Viscoplastic model

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Enhancing hydrogen evolution and oxidation kinetics through oxygen insertion into nickel lattice

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Journal of Energy Chemistry 2024年第8期95卷 529-539页

作者： Wanli Liang Xiyu Gong Jinchang Xu Zixuan Dan Fanyan Xie Hulei yu hao-Fan wang Yanshuo Jin Hongjuan wang Yonghai Cao Hui Meng hao yu School of Chemistry and Chemical Engineering South China University of Technology Siyuan Laboratory Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy Materials Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Department of Physics Jinan University GBA Branch of Aerospace Information Research Institute Chinese Academy of Sciences Instrumental Analysis & Research Center Sun Yat-sen University School of Materials Science and Engineering South China University of Technology

Nickel-based materials,including metallic Ni and Ni oxide,have been widely studied in the exploration of non-precious-metal hydrogen electrocatalysts,but neither pure Ni nor NiO is ideal for the hydrogen evolution reaction（HER） and hydrogen oxidation reaction（HOR）.In this paper,an oxygen insertion strategy was applied on nickel to regulate its hydrogen electrocatalytic performance,and the oxygen-inserted nickel catalyst was successfully obtained with the assistance of tungsten dioxide support（denoted as O-Ni/WO2）.The partial insertion of oxygen in Ni maintains the face-centered cubic arrangement of Ni atoms,simultaneously expanding the lattice and increasing the lattice spacing.Consequently,the adsorption strength of*H and*OH on Ni is optimized,thus resulting in superior electrocatalytic performance of0-Ni/WO2in alkaline HER/HOR.The Tafel slope of O-Ni/WO2@NF for HER is 56 mV dec-1,and the kinetic current density of O-Ni/WO2for HOR reaches 4.85 mA cm-2,which is ahead of most currently reported catalysts.Our proposed strategy of inserting an appropriate amount of anions into the metal lattice could provide more possibilities for the design of high-performance catalysts.

关键词： Adsorption free energy Hydrogen evolution Hydrogen oxidation Nickel Oxygen insertion

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Electron engineering of nickel phosphide for Ni^(δ+) in electrochemical nitrate reduction to ammonia

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Nano Research 2024年第6期17卷 4864-4871页

作者： Jie Hu hao Huang Miao yu Shuang wang Jinping Li College of Environmental Science and Engineering Taiyuan University of TechnologyJinzhong 030600China School of Sustainable Energy Materials and Science Jinhua Advanced Research InstituteJinhua 321000China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China

The electrochemical reduction of nitrate to ammonia(ENRA)provides an efficient approach to remove nitrate pollution and achieve ammonia production simultaneously.Herein,inspired by bio-enzyme in denitrifying bacteria,a carbon-coated nickel phosphide(NiPC)nanosheet derived from metal-organic frameworks(MOFs)is proposed as an efficient catalyst for ENRA.Through electron engineering,controllable Ni^(δ+)in nickel phosphide is achieved by regulating the degree of phosphating,which enhances its activity for the hydrogenation of nitrate.As the result,Niδ+becomes one of dominating factors determining the efficiency of the ENRA reaction in nickel phosphide.The optimal NiPC catalyst exhibits impressive property toward ENRA:NH_(4)^(+)Faraday efficiency of 96.68%,NH4+selectivity of 99.04%,and nitrate conversion rate of 90.43%under low nitrate concentration(200 mg·L^(−1)).This work opens a new avenue for the design of next-generation catalysts through electron engineering for ENRA.

关键词： electron engineering transition metal phosphide nitrate reduction ammonia production metal-organic frameworks

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Bioengineered skin organoids:from development to applications

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Military Medical Research 2024年第3期11卷 449-466页

作者： Zi-Xuan Hong Shun-Tian Zhu hao Li Jing-Zhi Luo yu Yang Yang An Xi wang Kai wang Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China Department of Hepatopancreatobiliary Surgery the Third Affiliated Hospital of Soochow UniversityChangzhou 213000JiangsuChina Department of Plastic Surgery Peking University Third HospitalBeijing 100191China Clinical Stem Cell Research Center Peking University Third HospitalBeijing 100191China State Key Laboratory of Cardiovascular Disease Fuwai HospitalBeijing 100037China Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease Capital Medical UniversityBeijing 100050China

Signifcant advancements have been made in recent years in the development of highly sophisticated skin organoids.Serving as three-dimensional(3D)models that mimic human skin,these organoids have evolved into complex structures and are increasingly recognized as efective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional(2D)systems and ethical concerns.The inherent plasticity of skin organoids allows for their construction into physiological and pathological models,enabling the study of skin development and dynamic changes.This review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with appendages.Furthermore,it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques,such as 3D printing and microfuidic devices.The review also summarizes and discusses the diverse applications of skin organoids in developmental biology,disease modelling,regenerative medicine,and personalized medicine,while considering their prospects and limitations.

关键词： Skin organoid Organoid generation Skin appendage Tissue engineering Disease modelling Regenerative medicine

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