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Development of a novel staging classification for Siewert Ⅱ adenocarcinoma of the esophagogastric junction after neoadjuvant chemotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2541-2554页

作者： Jian Zhang hao Liu Hang Yu Wei-xiang xu Department of Gastrointestinal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Stage classification for Siewert Ⅱ adenocarcinoma of the esophagogastric junction(AEG)treated with neoadjuvant chemotherapy(NAC)has not been *** To investigate the optimal stage classification for Siewert Ⅱ AEG with *** A nomogram was established based on Cox regression model that analyzed variables associated with overall survival(OS)and disease-specific survival(DSS).The nomogram performance in terms of discrimination and calibration ability was evaluated using the likelihood-ratio test,Akaike information criterion,Harrell concordance index,time-receiver operating characteristic curve,and decision curve *** Data from 725 patients with Siewert type Ⅱ AEG who underwent neoadjuvant therapy and gastrectomy were obtained from the Surveillance,Epidemiology,and End Results *** and multivariate analyses revealed that sex,marital status,race,ypT stage,and ypN stage were independent prognostic factors of OS,whereas sex,race,ypT stage,and ypN stage were independent prognostic factors for *** factors were incorporated into the OS and DSS *** novel nomogram model performed better in terms of OS and DSS prediction compared to the 8th American Joint Committee of Cancer pathological staging system for esophageal and gastric ***,a user-friendly web application was developed for clinical *** The nomogram established specifically for patients with Siewert type Ⅱ AEG receiving NAC demonstrated good prognostic *** using external data is warranted before its widespread clinical application.

关键词： Stage classification Prognosis Esophagogastric junction cancer Neoadjuvant chemotherapy Siewert type

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua xu Miao Yu Yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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Science China Chemistry 2025年第01期 10-11页

作者： Zhoumei Tan Kun xu Chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by International Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (DC).

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New Allele of HL6 Regulates Trichome Elongation in Rice

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Rice science 2020年第6期27卷 480-492页

作者： Shang Fei Mou Wenbin Wu hao xu Furong xiang Chunyan Wang Jianfei State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China Yunnan University of Chinese Medicine Kunming 650500China

Trichomes are specialized epidermal cells that plav multiple roles in plant ***,knowledge about the molecular mechanism of trichome development in rice is *** this study,a hairy leaf locus HL6SWWR of rice variety Suwangwanger(SWWR)was identified by map-based *** complementation and knock-out mutation demonstrated that HL6SWWR regulated trichomes on leaves and expression levels of HL6SWWR affected trichome *** experiments of PROswwr:HL6nipand PROnip:HL6swwr indicated that the promoter and coding sequences of HL6swwr were indispensable for trichome *** alignment of the promoter and coding regions of HL6 in 22 varieties showed that some c/s-binding elements in the promoter region may be related to trichome development,while no decisive variation was found in the coding ***,RNA-sequencing analysis revealed that 1415 differential expression genes(DEGs)were detected in hl6SWWR mutant vs wild type and that 1010 DEGs were found in HL6SWWR complementary transgenic line vs wild *** Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that most of the DEGs were involved in metabolite pathway,secondary metabolite biosynthesis,plant pathogen interaction and phytohormone signal transduction in both the two *** results indicated that these enhanced pathways are critical during trichome development in *** together,our results provided new views into the regulatory mechanism of trichome formation in rice.

关键词： map-based cloning rice RNA-sequencing analysis trichome elongation

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香薷组织培养及快速繁殖的研究

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山东科学 2011年第4期24卷 11-14页

作者：黄亮孙颖颢刘祥徐娜姜长阳辽宁师范大学生命科学学院辽宁大连116029

以香薷的嫩茎段为材料,对生长点生长,生长芽分化,试管苗生根、移栽和移植进行了研究,成功地建立起香薷快速繁殖技术。试验结果表明:1/3MS+KT 0.1 mg.L-1+IAA 0.1 mg.L-1是生长点生长培养的理想培养基;MS+6-BA 0.6 mg.L-1+NAA 0.1 mg.L-... 详细信息

以香薷的嫩茎段为材料,对生长点生长,生长芽分化,试管苗生根、移栽和移植进行了研究,成功地建立起香薷快速繁殖技术。试验结果表明:1/3MS+KT 0.1 mg.L-1+IAA 0.1 mg.L-1是生长点生长培养的理想培养基;MS+6-BA 0.6 mg.L-1+NAA 0.1 mg.L-1是生长芽分化培养的理想培养基;White+IBA 0.1 mg.L-1+IAA 0.3 mg.L-1培养基是生长分化芽生根培养、试管苗生根继代培养和快速繁殖的理想培养基。

关键词：香薷组织培养无性系

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Ectopic opening of the common bile duct into the duodenal bulb with recurrent choledocholithiasis: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5332-5338页

作者： hao xu Xin Li Ke-xiang Zhu Wen-Ce Zhou The Fourth Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medical School of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Ectopic opening of the common bile duct is a condition with low *** with an ectopic common bile duct opening have a high incidence of common bile duct stones and acute *** with atypical symptoms and imaging findings are easily misdiagnosed;moreover,it is difficult to retrieve stones by endoscopic retrograde cholangiopancreatography,and common bile duct stones are prone to postsurgical *** SUMMARY A 45-year-old male patient presented with“intermittent upper abdominal pain and elevated liver enzymes for 1 wk”.Transabdominal ultrasound indicated dilation of the common bile duct and the presence of *** resonance imaging showed that the common bile duct was dilated with stones and that its opening was *** retrograde cholangiopancreatography revealed an abnormal opening of the common bile duct into the duodenal bulb and the presence of common bile duct *** extrahepatic choledochectomy and hepatoenteric anastomosis were *** surgery,the patient recovered well and was *** patient has been followed up for 2 years since the *** has not experienced stone recurrence,and his liver function and quality of life are *** Improved understanding of ectopic opening of the common bile duct is needed for clinicians to provide patients with appropriate treatment.

关键词： Ectopic opening of the common bile duct Choledocholithiasis Cholangiojejunostomy Treatment Laparoscopic surgery Case report

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Advancing to the era of cancer immunotherapy

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Cancer Communications 2021年第9期41卷 803-829页

作者： Yun Wang Min Wang hao-xiang Wu Rui-Hua xu Department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhouGuangdong 510060P.R.China Department of Clinical Research Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Cancer greatly affects the quality of life of humans worldwide and the number of patients suffering from it is continuously *** the last century,numerous treatments have been developed to improve the survival of cancer patients but substantial progress still needs to be made before cancer can be truly *** recent years,antitumor immunity has become the most debated topic in cancer research and the booming development of immunotherapy has led to a new epoch in cancer *** this review,we describe the relationships between tumors and the immune system,and the rise of ***,we summarize the characteristics of tumor-associated immunity and immunotherapeutic strategies with various molecular mechanisms by showing the typical immune molecules whose antibodies are broadly used in the clinic and those that are still under *** also discuss important elements from individual cells to the whole human body,including cellular mutations and modulation,metabolic reprogramming,the microbiome,and the immune *** addition,we also present new observations and technical advancements of both diagnostic and therapeutic methods aimed at cancer ***,we discuss the controversies and challenges that negatively impact patient outcomes.

关键词： adverse effects cancer hyperprogressive disease immune checkpoints immunity immunotherapy metabolic reprogramming microbiome mutation

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang xuan Cheng Hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Evaluation of the production-living-ecology space function suitability of Pingshan County in the Taihang mountainous area,China

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Journal of Mountain Science 2020年第10期17卷 2562-2576页

作者： YU Shu-hui DENG Wei xu You-xin ZHANG Xia xiang hao-lin Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu610041China College of Geography Resource Sciences Sichuan Normal UniversityChengdu610101China Hebei GEO University Shijiazhuang050031China Weifang University of Science and Technology Weifang262700China

A rational utilization of land is a matter of importance in sustainable development of mountainous *** land function in mountainous areas has a close connection with space structure of ecology,production and *** promote a harmonious development of the relationship between people and nature in mountainous areas,it is necessary to coordinate their relationships of space *** evaluation of basic unit function associated with multi-scale space analysis is a prerequisite to a reasonable optimization of land function *** this study,an optimized evaluation index system of combination functions was introduced into the assessment of ecological spatial functional suitability in ecological fragile regions by adding three indicators,namely,soil erosion sensitivity,landscape ecological risk and ecological *** principle of"taking high"(referred to a function with high suitability to be regarded as the main function of an evaluation unit)and ecological priority(referred to the case,supposing the suitability of a unit’s three functions is consistent,the main function is determined to be the ecological function)were used to determine the main function of an evaluation *** County,China,located at the eastern foot of the Taihang Mountain,was targeted in this case *** production-livingecology space(PLES)function in Pingshan was identified by applying our improved valuation ***,the functional suitability distribution of the combination of elements was obtained by using overlapping comprehensive analysis method,considering the tradeoff of the functional suitability of combination *** regions suitable for production/living were distributed in relatively flat piedmont plains,whereas the regions suitable for ecology were distributed in the mountain areas of middle and low ***,to maintain a sustainable development in mountainous areas,an improved scheme of development for Pingshan should be

关键词： Taihang Mountain Area Space of production-living-ecology Functional tradeoff Suitability evaluation

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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

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