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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

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Negative Bias Temperature Instability ＂Recovery＂ under Negative Stress Voltage with Different Oxide Thicknesses

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Chinese Physics Letters 2011年第1期28卷 175-178页

作者： CAO Yan-Rong ma Xiao-Hua hao Yue ZHU Min-Bo tian Wen-Chao ZHANG Yue School of Electronical and machanical Engineering Xidian University Xi'an 710071 School of Technical Physics Xidian University Xi 'an 710071 Key Lab of Wide Band-Gap Semiconductor materials and Devices Xi'an 710071

Different phenomena are observed under negative gate voltage stress which is smaller than the previous degra- dation stress in PMOSFETs with different oxide thicknesses. We adopt the real time method to make a point of the drain current to study the degradation and recovery of negative bias temperature instability （NBTI）. For the device with thin oxide, recovery phenomenon appears when smaller negative voltage stress was applied, due to the more influencing oxide charges detrapping effects than the interface states. For the device with thick oxide, not recovery but degradation phenomenon comes forth. As many charges are trapped in the deeper position and higher energy level in the oxide, these charges can not be detrapped. Therefore, the effect of the charge detrapping is smaller than that of the interface states in the thick oxide. The degradation presents itself during the ＇recovery＇ time.

关键词： Electronics and devices Semiconductors

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Unraveling the impacts of intermolecular interaction on morphology evolution for highly efficient organic solar cells and modules

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Science China Chemistry 2025年第1期68卷 264-272页

作者： Xueqing ma Yingying Cheng Yuqiang Liu Xinming Zheng Guangliu Ran Hongxiang Li Xinyue Cui Andong Zhang Wenkai Zhang Pei Cheng Wenchao Huang Zhishan Bo Beijing Key Laboratory of Energy Conversion and Storage materials College of Chemistry Beijing Normal University College of Textiles and Clothing State Key Laboratory of Bio-fibers and Eco-textiles Qingdao University Key State Laboratory of Advanced Technology for materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of Technology Department of Physics and Applied Optics Beijing Area major Laboratory Center for Advanced Quantum Studies Beijing Normal University State Key Laboratory of Polymer materials Engineering College of Polymer Science and Engineering Sichuan University

Understanding the effect of intermolecular interaction on the growth dynamic of active layers is critical for advancing organic solar cells(OSCs). However, the diverse structure of donors and acceptors makes the research challenging. Additives with customizable structures and properties could simplify this complexity. Herein, we meticulously tailor two additives of 3,4-ethylenedioxythiophene(EDOT) and 2,5-dibromo-3,4-ethylenedioxythiophene(DBEDOT), possessing distinct intermolecular interaction features to elaborate the inherent relationship. It is found that varied interaction strengths can alter film formation processes. The enhanced intermolecular interaction between the DBEDOT and non-fullerene acceptor BTP-e C9-4F results in pre-aggregation and longer crystallization duration of BTP-e C9-4F, facilitating the formation of films with compact molecular packing and decent phase separation. Thus, exciton dissociation and charge transport become more efficient. Finally, devices processed with DBEDOT exhibit a remarkable power conversion efficiency of 19.35% in small-area OSCs and 14.11% in bladecoated 5 cm × 5 cm organic solar mini-modules. Especially, OSCs can maintain 80% of their initial efficiency after continuous annealing at 85 °C for over 2,100 h.

关键词： organic solar cell non-fullerene acceptor film growth molecular packing intermolecular interaction

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Regularity of Keldys-Fichera Boundary Value Problem for Degenerate Elliptic Equations

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Chinese Annals of mathematics,Series B 2010年第5期31卷 713-722页

作者： Limei LI tian ma Corresponding author. mathematical College Sichuan University Chengdu 610064 China. mathematical College Sichuan University Chengdu 610064 China.

The authors discuss the W1,p-solutions and the interior regularity of weak solutions for the Keldys-Fichera boundary value problem using the acute angle principle,the reversed Hlder inequality and the generalized po... 详细信息

关键词： Keldys-Fichera boundary value problem W1 p-regularity Interior regularity

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DYNAMIC BIFURCATION OF NONLINEAR EVOLUTION EQUATIONS

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Chinese Annals of mathematics,Series B 2005年第2期26卷 185-206页

作者： ma tian WANG Shouhong Department of mathematics Sichuan UniversityChengdu 610064China Department of mathematics Indiana UniversityBloomingtonIN 47405USA.

The authors introduce a notion of dynamic bifurcation for nonlinear evolution equa- tions, which can be called attractor bifurcation. It is proved that as the control pa- rameter crosses certain critical value, the system bifurcates from a trivial steady state solution to an attractor with dimension between m and m + 1, where m + 1 is the number of eigenvalues crossing the imaginary axis. The attractor bifurcation theory presented in this article generalizes the existing steady state bifurcations and the Hopf bifurcations. It provides a uni?ed point of view on dynamic bifurcation and can be applied to many problems in physics and mechanics.

关键词： Attractor bifurcation Steady state bifurcation Dynamic bifurcation Hopf bifurcation Nonlinear evolution equation

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基于静电纺丝的生物活性物质封装体系及其在食品抑菌包装中的应用进展

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食品科学 2025年第3期46卷 246-256页

作者：任洁谭中美田子豪武高云刘永辰王浩姜瞻梅马佳歌侯俊财东北农业大学食品学院黑龙江哈尔滨150030 贵阳学院食品与制药工程学院贵州贵阳550005

食源性致病菌和腐败微生物污染食品是导致食源性疾病的主要原因之一。因此,保障食品品质和延长其保质期已成为学者们迫切关注的问题。利用静电纺丝技术封装生物活性物质开发食品抑菌包装是一种保障食品安全的有效方法。本文首先概述了... 详细信息

食源性致病菌和腐败微生物污染食品是导致食源性疾病的主要原因之一。因此,保障食品品质和延长其保质期已成为学者们迫切关注的问题。利用静电纺丝技术封装生物活性物质开发食品抑菌包装是一种保障食品安全的有效方法。本文首先概述了静电纺丝制备食品抑菌包装的基本原理、分类、影响因素和材料,系统总结了封装在电纺纳米纤维中的生物活性物质及基于静电纺丝的生物活性物质共封装体系。最后论述了封装生物活性物质的电纺纳米纤维在禽畜肉、乳制品和果蔬抑菌包装方面的应用进展,总结并展望了基于静电纺丝的食品抑菌包装面临的挑战和发展趋势,旨在为食品工业中利用电纺纳米纤维封装生物活性物质从而有效抑制食源性致病菌和腐败微生物提供理论支撑和参考依据。

关键词：静电纺丝生物活性物质封装食品抑菌包装

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Metric of States

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Communications in Theoretical Physics 2008年第11期50卷 1069-1070页

作者： ma Zhi-hao Department of mathematics Shanghai Jiao Tong University Shanghai 200240 China

Metric of quantum states plays an important role in quantum information theory. In this letter, we find the deep connection between quantum logic theory and quantum information theory. Using the method of quantum logi... 详细信息

关键词： state density operator metric fidelity quantum information quantum logic

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Crossover Phenomena in Detrended Fluctuation Analysis Used in Financial markets

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Communications in Theoretical Physics 2009年第2期51卷 358-362页

作者： ma Shi-hao College of Physical Science and Technology Huazhong Normal University Wuhan 430079 China

A systematic analysis of Shanghai and Japan stock indices for the period of Jan. 1984 to Dec. 2005 is performed. After stationarity is verified by ADF （Augmented Dickey-Fuller） test, the power spectrum of the data exhibits a power law decay as a whole characterized by 1/f^β processes with possible long range correlations. Subsequently, by using the method of detrended fluctuation analysis （DFA） of the general volatility in the stock markets, we find that the long-range correlations are occurred among the return series and the crossover phenomena exhibit in the results ***, Shanghai stock market shows long-range correlations in short time scale and shows short-range correlations in long time scale. Whereas, for Japan stock market, the data behaves oppositely absolutely. Last, we compare the varying of scale exponent in large volatility between two stock markets. All results obtained may indicate the possibility of characteristic of multifractal scaling behavior of the financial markets.

关键词： financial market crossover phenomena detrended fluctuation analysis

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Minimum eigenvalue based adaptive fault compensation for hypersonic vehicles

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Journal of Systems Engineering and Electronics 2023年第2期34卷 492-500页

作者： ma Yajie JIANG Bin REN hao College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The attitude tracking control problem is addressed for hypersonic vehicles under actuator faults that may cause an uncertain time-varying control gain *** adaptive compensation scheme is developed to ensure system stability and asymptotic tracking properties,including a kinematic control signal and a dynamic control *** deal with the uncertainties of the control gain matrix,a new positive definite one is *** minimum eigenvalue of such a new control gain matrix is *** results of application to an X-33 vehicle model verify the effectiveness of the proposed minimum eigenvalue based adaptive fault compensation scheme.

关键词： actuator fault adaptive compensation hypersonic vehicle minimum eigenvalue

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Effects of Orthogonal Heat Treatment on Microstructure and Mechanical Properties of GN9 Ferritic/martensitic Steel

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Chinese Journal of Mechanical Engineering 2023年第6期36卷 289-300页

作者： Tingwei ma Xianchao hao Ping Wang Key Laboratory of Electromagnetic Processing of materials Ministry of EducationNortheastern UniversityShenyang 110004China Yingkou Institute of Technology Yingkou 115014China CAS Key Laboratory of Nuclear materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Microstructure and mechanical properties of GN9 Ferritic/martensitic steel for sodium-cooled fast reactors have been investigated through orthogonal design and *** electron microscopy(SEM),transmission electron microscopy(TEM),differential scanning calorimeter(DSC),tensile and impact tests were used to evaluate the heat treatment parameters on yield strength,elongation and ductile-to-brittle transition temperature(DBTT).The results indicate that the microstructures of GN9 steel after orthogonal heat treatments consist of tempered martensite,M23C6,MX carbides and MX *** average prior austenite grains increase and the lath width decreases with the austenitizing temperature increasing from 1000°C to 1080°*** temperature is the most important factor that influences the dislocation evolution,yield strength and elongation compared with austenitizing tempera-ture and cooling *** temperature,tempering temperature and cooling methods show interactive effects on *** morphology and distribution,which is influenced by austenitizing and tempering tempera-tures,is the critical microstructural factor that influences the Charpy impact energy and *** on the orthogo-nal design and microstructural analysis,the optimal heat treatment of GN9 steel is austenitizing at 1000°C for 0.5 h followed by air cooling and tempering at 760°C for 1.5 h.

关键词： Ferritic/martensitic steel Orthogonal design M23C6 carbide Ductile-to-brittle transition temperature

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