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Roles of Cu doping in YbZn_(2)Sb_(2) for thermoelectric performance enhancement

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Rare Metals 2024年第6期43卷 2869-2875页

作者： Xiong Zhang Hai-Hui Li Xiao-Liang Cao Bin Zhang Hong Wu Yu Zhang guang Han guo-Yu Wang hao-shuang gu Xiao-Yuan Zhou College of Physics and Electronic Science Hubei Normal UniversityHuangshi 435002China Analytical and Testing Center Chongqing UniversityChongqing401331China School of Science Chongqing University of Posts and Telecommunications.Chongqing 400065 China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials-Hubei Key Laboratory of Ferro&Piezoelectric Materials and Devices Faculty of Physical and Electronic SciencesHubei UniversityWuhan 430062China College of Physics Chongqing UniversityChongqing 401331China

Recent research shows that increasing the carrier density after orbital alignment in AZn_(2)Sb_(2) (A=Ca,Yb,Eu,Sr,Mg)Zintl compounds yields remarkable results with regard to enhanced thermoelectric ***,research on carrier density increase via doping in these compounds is *** this study,we introduced Cu into the Zn sites in YbZn_(2)Sb_(2) and examined the thermoelectric properties.

关键词： properties doping performance

Enhanced thermoelectric performance of Cu_(2)SnSe_(3) via synergistic effects of Cd-doping and CuGaTe_(2) alloying

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Rare Metals 2022年第10期41卷 3466-3474页

作者： Yi-Jing Fan Kun-Ling Peng Yu-Ling Huang Hui-Jun Liao Zheng-Yong Huang Jian Li Yan-Ci Yan hao-shuang gu Bin Zhang Yong-Ming Hu Xu Lu Xiao-Yuan Zhou Faculty of Physics and Electronic Sciences Hubei Key Laboratory of Ferro and Piezoelectric Materials and DevicesHubei UniversityWuhan430062China College of Physics Chongqing UniversityChongqing400044China State Key Laboratory of Power Transmission Equipment and System Security and New Technology Chongqing UniversityChongqing400044China School of Science Chongqing University of Posts and TelecommunicationsChongqing400065China Analytical and Testing Center Chongqing UniversityChongqing400044China

In this work,we show significantly enhanced thermoelectric performance in Cu_(2) SnSe_(3) via a synergistic effect of Cd-doping and CuGaTe_(2) alloying in the temperature range of 300-823 *** the electron and phonon transport properties can be simultaneously regulated by Cd doping at Sn site,leading to a higher quality ***,a maximum figure of merit(zT) value of ~0.68 was obtained for Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3) sample at823 K,which is about four times higher than that of the pristine sample(zT=0.18 at 773 K).Furthermore,Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3) was alloyed with CuGaTe_(2) to reduce the lattice thermal conductivity in the high-temperature ***,a further enhanced zT value(0.77,823 K) was achieved in the(Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3))_(0.94)(CuGaTe_(2))_(0.06) sample,with a high average zT(zT_(ave)) value of0.30 between 300 and 823 *** results demonstrate that Cd-doping combined with CuGaTe2 alloying could be an effective method to enhance zT values of Cu_(2) SnSe_(3) based compounds.

关键词： Cu_(2)SnSe_(3) Synergistic optimization Alloying Quality factor Thermoelectric

ENHANCED MULTIFERROIC PROPERTIES OF La-DOPED BiFeO_(3)NANOTUBES FABRICATED THROUGH ANODIC ALUMINA TEMPLATE METHOD

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Journal of Advanced Dielectrics 2011年第3期1卷 325-330页

作者： ZHENG-LONG HU YAN WANG JI-YAN DAI DI ZHOU YONG-MING HU hao-shuang gu KARIM Z.BABA-KISHI Department of Applied Physics and Materials Research Centre The Hong Kong Polytechnic University Hong KongP.R.China Faculty of Physics and Electronic Technology Hubei University 430062 WuhanP.R.China

Bi_(0.85)La_(0.15)FeO_(3)(BLFO)nanotubes with an average diameter of about 200 nm and wall thickness of about 20 nm are fabricated by solgel alumina template technique,and their room-temperature multiferroic properties are *** and ferroelectricity in the BLFO nanotubes are revealed by piezoresponse force microscopy study of individual *** the BiFeO_(3)nanotubes with La reduces the crystallization temperature and results in a reduced lose of Bi and therefore improved multiferroic properties of the *** weak ferromagnetism is also observed,and it is attributed to the nano-crystalline structure of the nanotubes.

关键词： Bi_(0.85)La_(0.15)FeO_(3) nanotube ferroelectricity piezoelectricity perovskite

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Effects of extracellular vesicles from mesenchymal stem cells on oxygen-glucose deprivation/reperfusioninduced neuronal injury

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World Journal of Emergency Medicine 2021年第1期12卷 61-67页

作者： shuang-shuang gu Xiu-wen Kang Jun Wang Xiao-fang guo hao Sun Lei Jiang Jin-song Zhang Department of Emergency the First Affi liated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Modern Toxicology Ministry of EducationDepartment of ToxicologySchool of Public HealthNanjing Medical UniversityNanjing 211166China

BACKGROUND: Small extracellular vesicles (sEVs) from bone marrow mesenchymal stemcells (BMSCs) have shown therapeutic potential for cerebral ischemic diseases. However, themechanisms by which BMSC-derived sEVs (BMSC-sEVs) protect neurons against cerebral ischemia/reperfusion (I/R) injury remain unclear. In this study, we explored the neuroprotective effects ofBMSC-sEVs in the primary culture of rat cortical neurons exposed to oxygen-glucose deprivation andreperfusion (OGD/R) ***: The primary cortical neuron OGD/R model was established to simulate the processof cerebral I/R in vitro. Based on this model, we examined whether the mechanism through whichBMSC-sEVs could rescue OGD/R-induced neuronal ***: BMSC-sEVs (20 μg/mL, 40 μg/mL) significantly decreased the reactive oxygenspecies (ROS) productions, and increased the activities of superoxide dismutase (SOD) and glutathioneperoxidase (GPx). Additionally, BMSC-sEVs prevented OGD/R-induced neuronal apoptosis in vivo, asindicated by increased cell viability, reduced lactate dehydrogenase (LDH) leakage, decreased terminaldeoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) staining-positivecells, down-regulated cleaved caspase-3, and up-regulated Bcl-2/Bax ratio. Furthermore, Westernblot and flow cytometry analysis indicated that BMSC-sEV treatment decreased the expression ofphosphorylated calcium/calmodulin-dependent kinase II (p-CaMK II)/CaMK II, suppressed the increaseof intracellular calcium concentration ([Ca2+]i) caused by OGD/R in ***: These results demonstrate that BMSC-sEVs have signifi cant neuroprotectiveeff ects against OGD/R-induced cell injury by suppressing oxidative stress and apoptosis, and Ca2+/CaMK II signaling pathways may be involved in this process.

关键词： Oxygen-glucose deprivation and reperfusion Cortical neurons Oxidative stress Small extracellular vesicles

Protective effect of mesenchymal stem cell-derived exosomal treatment of hippocampal neurons against oxygen-glucose deprivation/reperfusion-induced injury

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World Journal of Emergency Medicine 2022年第1期13卷 46-53页

作者： Xiao-fang guo shuang-shuang gu Jun Wang hao Sun Yu-juan Zhang Peng-fei Yu Jin-song Zhang Lei Jiang Department of Emergency the First Affi liated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Modern Toxicology Ministry of EducationDepartment of ToxicologySchool of Public HealthNanjing Medical UniversityNanjing 211166China Key Laboratory of Modern Toxicology Ministry of EducationDepartment of Environmental GenomicsSchool of Public HealthNanjing Medical UniversityNanjing 211166China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaShanghai 201203China

BACKGROUND:Individuals who survive a cardiac arrest often sustain cognitive impairments due to ischemia-reperfusion *** stem cell(MSC)transplantation is used to reduce tissue damage,but exosomes are more stable and highly conserved than *** study was conducted to investigate the therapeutic effects of MSC-derived exosomes(MSC-Exo)on cerebral ischemia-reperfusion injury in an in vitro model of oxygen-glucose deprivation/reperfusion(OGD/R),and to explore the underlying ***:Primary hippocampal neurons obtained from 18-day Sprague-Dawley rat embryos were subjected to OGD/R treatment,with or without MSC-Exo *** integration,cell viability,mitochondrial membrane potential,and generation of reactive oxygen species(ROS)were *** deoxynucleotidyl transferase-mediated 2’-deoxyuridine 5’-triphosphate nickend labeling(TUNEL)staining was performed to detect neuronal ***,mitochondrial function-associated gene expression,Nrf2 translocation,and expression of downstream antioxidant proteins were ***:MSC-Exo attenuated OGD/R-induced neuronal apoptosis and decreased ROS generation(Pgulation of mitochondrial function-associated genes in hippocampal ***,MSCExo might be a potential therapeutic strategy to preven

关键词： Mesenchymal stem cells Exosomes Oxygen-glucose deprivation/reperfusion Reactive oxygen species Mitochondria

New Progress on Binocular Disparity in Higher Visual Areas Beyond V1

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Neuroscience Bulletin 2020年第10期36卷 1236-1238页

作者： Xiangwen hao Yu gu State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200032China

Binocular disparity,resulting from the differences between the retinal images of the two eyes,plays a fundamental role in the formation of stereoscopic vision and depth perception[1].Generally,a greater difference(disparity)between the two images indicates that the objects are closer to each other(Fig.1A).The brain uses binocular disparity to extract depth information from the two-dimensional retinal images,and the subtle differences between the images received by each eye allow us to perceive stereoscopic depth,which is important for the visual perception of the three-dimensional space[2].

关键词： Visual closer visual

Pushing the activity of CO2 electroreduction by system engineering

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Science Bulletin 2019年第24期64卷 1805-1816页

作者： hao Shen Zhengxiang gu Gengfeng Zheng Laboratory of Advanced Materials Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University

As a promising technology that may solve global environmental challenges and enable intermittent renewable energy storage as well as zero-carbon-emission energy cycling, the carbon dioxide reduction reaction has been extensively studied in the past several years. Beyond the fruitful progresses and innovations in catalysts, the system engineering-based research on the full carbon dioxide reduction reaction is urgently needed toward the industrial application. In this review, we summarize and discuss recent works on the innovations in the reactor architectures and optimizations based on system engineering in carbon dioxide reduction reaction. Some challenges and future trends in this field are further discussed, especially on the system engineering factors.

关键词： CO2 reduction Electrocatalysis Flow-cell electrolyzer Catalytic reactor engineering Artificial photosynthesis

Prediction of cutting forces in flank milling of parts with non-developable ruled surfaces

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Chinese Journal of Aeronautics 2019年第7期32卷 1788-1796页

作者： Liping WANG hao SI Liheng gu Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Beijing Beiyi Machine Tool Co.Ltd. Beijing101300China

Predicting the cutting forces required for five-axis flank milling is a challenging task due to the difficulties involved in determining the Undeformed Chip Thickness(UCT) and CutterWorkpiece Engagement(CWE). To solve these problems, this paper presents a new mechanistic cutting force model based on the geometrical analysis of a flank milling process. In the model,the part feature and corresponding cutting location data are taken as input information. The UCT considering cutter runout is calculated according to the instantaneous feed rate of the element cutting edges. A solid-discrete-based method is used to precisely and efficiently identify the CWE between the end mill and the surface being machined. Then, after calibrating the specific force coef-ficients, the mechanistic milling force can be obtained. During the validation process, two practical operations, three-axis flank milling of a vertical surface and five-axis flank milling of a nondevelopable ruled surface, are conducted. Comparisons between predicted and measured cutting forces demonstrate the reliability of the proposed cutting force model.

关键词： Chip thickness Cutting force Five-axis flank milling Machining Ruled surface