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[Determination of eight phthalate metabolites in urine of pregnant women and evaluation of neonatal birth outcomes based on solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 60-67页

作者： Zi-hao Wang Meng-Fei Xu Bei-Ni li Ping Wu Wei Wu Hubei University of Chinese Medicine Wuhan 430065 China.

Phthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs. While the concentrations of PAEs in urine reflect recent exposure levels in humans, urinary levels of phthalate metabolites (mPAEs) are commonly used as biomarkers of internal exposure owing to the relatively short biological half-lives of PAEs (lid-phase extraction-high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS) method for simultaneously detecting eight mPAEs in the urine of pregnant women. Urine samples were enzymatically hydrolyzed with -glucosidase and then purified using the Bond Elut Plexa SPE column, with subsequent elution, concentration, and redissolved performed prior to HPLC-MS/MS. Separation was achieved using an Agilent Eclipse Plus C18 column (100 mm×3 mm, 3.5 μm), with gradient elution performed using 0.1% acetic acid aqueous solution and 0.1% acetic acid acetonitrile as mobile phases. Multiple reaction monitoring (MRM) mode was used for detection, with quantification performed using the internal-standard method. Good linearities were obtained in the range of 0.1-200 ng/mL for the eight mPAEs, with limits of detection (LODs) and quantification (LOQs) of 0.015-0.048 and 0.050-0.160 ng/mL, respectively. The eight mPAEs exhibited recoveries of 80.2%-99.7% at three spiked levels (1, 10, and 50 ng/mL). This method was subsequently used to analyze the eight mPAEs levels in urine samples of 497 pregnant women from the Ezhou Maternity and Child Health Care Hospital. The participants exhibited widespread exposure t

关键词： birth outcomes high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) phthalate metabolites (mPAEs) urine samples of pregnant women

IBEA-SVM: An Indicator-based Evolutionary Algorithm Based on Pre-selection with Classification Guided by SVM

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Applied Mathematics(A Journal of Chinese Universities) 2019年第1期34卷 1-26页

作者： li hao-ran HE Fa-zhi YAN Xiao-hu School of Computer Science and Technology Wuhan University State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University

Multi-objective optimization has many important applications and becomes a challenging issue in applied science. In typical multi-objective optimization algorithms, such as Indicator-based Evolutionary Algorithm(IBEA), all of parents and offspring need to be evaluated in every generation, and then the better solutions of them are selected as the next generation candidates. This leads to a large amount of calculation and slows down convergence rate for IBEA related applications. Our discovery is that the evaluation of evolutionary algorithm is a binary classi?cation in nature and a meaningful preselection method will accelerate the convergence rate. Therefore this paper presents a novel preselection approach to improve the performance of the IBEA, in which a SVM(Support Vector Machine) classi?er is adopted to sort the promising solutions from unpromising solutions and then the newly generated solutions are conversely added as train sample to increase the accuracy of the classi?er. Firstly, we proposed an online and asynchronous training method for SVM model with empirical kernel. The initial population is randomly generated among population size, which is used as initial training. In the process of training, SVM classi?er is modi?ed and perfected to adapt to the evolutionary algorithm sample. Secondly, the classi?er divides all the new generated solutions from the whole solution spaces into promising solutions and unpromising ones. And only the promising ones are forwarded for evaluation. In this way, the evaluation time can be greatly reduced and the solution quality can be obviously improved. Thirdly, the promising and unpromising solutions are labeled as new train samples in next generation to re?ne classi?er model. A number of experiments on benchmark functions validates the proposed approach. The results show that IBEA-SVM can signi?cantly outperform previous works.

关键词： multi-objective optimization SVM IBEA training classification

Pore and fracture characteristics of Cretaceous tight reservoir and its control effect on hydrocarbon accumulation in the liuhe Basin

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Petroleum Science 2022年第5期19卷 1939-1949页

作者： Wen-hao li Er-Qiang Yang Min Wang Yan-ran Huang Laboratory of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong266580China School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China Hunan Provincial Key Laboratory of Shale Gas Resource Utilization Hunan University of Science and TechnologyXiangtanHunan411201China

Tight oil and gas in the Cretaceous has been found in the liuhe Basin,but the rules of tight reservoir and oil and gas accumulation are not *** paper discusses the developmental characteristics and evolution law of pores and fractures in the Cretaceous tight reservoir in the liuhe Basin,and reveals its controlling effect on tight oil and gas *** results show that intercrystalline pores,intergranular pores and dissolution pores are scattered and only developed in shallow tight reservoirs,while microfractures are developed in both shallow and deep layers,which are the main type of reservoir space in the study *** results of mercury intrusion porosimetry and nitrogen gas adsorption show that with the increase of depth,the proportion of macropores(microcracks)increases,while the proportion of micropores *** are two stages of microfractures developed in the study area,corresponding to the initial fault depression stage from late Jurassic to early late Cretaceous and compressional uplift at the end of late *** to the principle of“inversion and back-stripping method”,combined with the data of optical microscopy and inclusions,the time of each key diagenesis and its contribution to porosity are revealed,and the porosity evolution history of reservoirs in different diagenetic stages is quantitatively *** porosity reduction rate of compaction can reach more than 80%,which is the main reason for reservoir *** relationship between pore evolution history and oil and gas accumulation history reveals that during the oil and gas filling period of the Xiahuapidianzi Formation(90-85 Ma),the reservoir porosity is only 1.15%,but the development of microfractures in the first stage of the reservoir is conducive to oil and gas accumulation.

关键词： Tight reservoir Microscopic pore structure Microfracture Porosity evolution Hydrocarbon accumulation the liuhe Basin

Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

An analytical model for water-oil two-phase flow in inorganic nanopores in shale oil reservoirs

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Petroleum Science 2021年第6期18卷 1776-1787页

作者： ran li Zhangxin Chen Keliu Wu Xing hao Jinze Xu Department of Chemical and Petroleum Engineering University of CalgaryCalgaryAlbertaT2N 1N4Canada State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Illinois Institute of Technology ChicagoIL60616United States

The existence of water phase occupies oil flow area and impacts the confined oil flow behavior at the solid substrate in inorganic nanopores of shale oil reservoirs,resulting in a completely different flow pattern when compared with the single oil phase *** study proposes an analytical model to describe the water-oil two-phase *** this model,water slippage at the solid substrate is considered while oil slip is introduced to calculate the oil movement at the solid-oil boundary in dry *** is proven that the oil flow profiles of both the two-phase model and single-phase model show parabolic shapes,but the oil flow capacity drops when water takes up the flow space and the impact of water is more significant when the pore dimension is smaller than 30 ***,the oil flow velocity at a pore center is found to drop linearly given a larger water saturation in wet *** effects of surface wettability and oil properties on water-oil flow are also *** with the existing singlephase models,this model describes oil flow pattern in the wet condition with the incorporation of the influence of nanopore properties,which better predicts the oil transport in actual reservoir ***-oil relative permeability curves are also obtained to improve oil yield.

关键词： Shale oil Water films Two-phase flow Nanopore

A game-theoretic approach for federated learning:A trade-off among privacy,accuracy and energy

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Digital Communications and Networks 2024年第2期10卷 389-403页

作者： lihua Yin Sixin lin Zhe Sun ran li Yuanyuan He Zhiqiang hao Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China China Industrial Control Systems Cyber Emergency Response Team Beijing100040China

Benefiting from the development of Federated Learning(FL)and distributed communication systems,large-scale intelligent applications become *** devices not only provide adequate training data,but also cause privacy leakage and energy *** to optimize the energy consumption in distributed communication systems,while ensuring the privacy of users and model accuracy,has become an urgent *** this paper,we define the FL as a 3-layer architecture including users,agents and *** order to find a balance among model training accuracy,privacy-preserving effect,and energy consumption,we design the training process of FL as game *** use an extensive game tree to analyze the key elements that influence the players’decisions in the single game,and then find the incentive mechanism that meet the social norms through the repeated *** experimental results show that the Nash equilibrium we obtained satisfies the laws of reality,and the proposed incentive mechanism can also promote users to submit high-quality data in *** the multiple rounds of play,the incentive mechanism can help all players find the optimal strategies for energy,privacy,and accuracy of FL in distributed communication systems.

关键词： Federated learning Privacy preservation Energy optimization Game theory Distributed communication systems

Nanostructured amorphous Fe_(29)Co_(27)Ni_(23)Si_(9)B_(12) high-entropy-alloy:an efficient electrocatalyst for oxygen evolution reaction

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Journal of Materials Science & Technology 2021年第9期68卷 191-198页

作者： Hongyan Wang ran Wei Xiumin li Xuli Ma Xiaogang hao Guoqing Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Department of Environmental Science and Engineering Taiyuan University of Technology.Taiyuan 030024China Department of Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China Energy Con version Engineering Laboratory Institute of Regional InnovationHirosaki University2-1-3 MatsubaraAomori 030-0813Japan

Proximal configu ration of dissimilar metal atoms in amorphous high-entropy-alloys(HEAs) always re sult in interatomic d-band ligand effect,dense defect distribution,coordinatively unsaturated sites,high potential energy,and loose atom ***,nanostructured amorphous Fe_(29)Co_(27)Ni_(23)Si_(9)B_(12) HEA ribbon is fabricated via a melt spinning method combined with electrochemical corrosion etching process,which is applied as the potential oxygen evolution reaction *** is found that there are micro/nano pits on the surface of etched amorphous Fe_(29)Co_(27)Ni_(23)Si_(9)B_(12) *** elements of HEAs bond with each other to form a highly disordered configu ration,which could result in an optimized bonding energy and enhanced intrinsic catalytic *** electrocatalysis activity measurements indicate that the amorphous HEA endows a much higher activity than the crystalline one,which is further improved by the electrochemical etching ***,the HEA ribbon etched for 3 h requires a low overpotential of 230 mV to afford 10 mA cm^(-2) current *** addition,density functional theory calculations demonstrate that the amorphous structure can weaken the interaction between the surface of Fe_(29)Co_(27)Ni_(23)Si_(9)B_(12) alloy and the intermediates,leading to an optimized adsorption Gibbs free energy.

关键词： Water splitting High-entropy-alloys Oxygen evolution reaction Electro-catalyst

铁路轨道养护维修计算机辅助决策系统中几个技术问题的研究

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上海铁道大学学报 2000年第10期21卷 26-31页

作者：许玉德李浩然李海峰同济大学铁道建筑系上海200331

在分析国内外有关轨道养护维修辅助决策系统的基础上 ,提出建立我国辅助决策系统需解决的几个技术问题 ,并对轨道高低不平顺预测模型的建立进行了深入的分析。

关键词：养护维修铁路轨道辅助决策系统技术问题国内外基础预测模型计算机辅助决策中国

Surface-engineering of layered liNi_(0.815)Co_(0.15)Al_(0.035)O_2 cathode material for high-energy and stable li-ion batteries

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Journal of Energy Chemistry 2018年第2期27卷 559-564页

作者： Yugang li Haifeng Yu Yanjie Hu hao Jiang Chunzhong li Key Laboratory for Ultrafine Materials of Ministry of Education & School of Materials Science and Engineering East China University of Science and Technology

Surface engineering is an effective strategy to restrain the generation of rocksalt NiO phase on surface of layered liNi0.815Co0.15Al0.035O2（NCA） primary nanoparticles, a representative Ni-rich layered oxides cathode materials. Herein, we demonstrate the kilogram-scale synthesis of few-layer reduced graphene oxide（rGO） conformably coated NCA primary nanoparticles cathode materials by a mechanical wet ball-milling strategy. The lightening rGO coating layer effectively avoids the direct contact of electrolyte and NCA with rapid electrons transfer. As a result, the as-obtained NCA@rGO hybrids with only 1.0 wt% rGO content can deliver a high specific capacity（196 mAh g-1 at 0.2 C） and fast charge/discharge capability（127 mAh g-1 at 5 C）, which is much higher than the corresponding NCA nanoparticles（95 mAh g-1 at 5 C）. Even after100 cycles at 1 C, 91.7% of initial reversible capacity is still maintained. Furthermore, a prismatic pouch cell（240 mAh） is also successfully assembled with the commercial graphite anode.

关键词： Layered materials Cathode Reduced graphene oxide Energy density li-ion batteries