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Effective-constituent compatibility-based analysis of Bufei Yishen formula, a traditional herbal compound as an effective treatment for chronic obstructive pulmonary disease

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Journal of Integrative Medicine 2020年第4期18卷 351-362页

作者： Jian-sheng Li Xue-fang Liu hao-ran dong Wan-chun Zheng Su-xiang Feng Yan-ge Tian Peng Zhao Jin-di Ma Zhou-xin Ren Yang Xie Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R.China Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina

Objective:Critical effective constituents were identified from Bufei Yishen formula(BYF),a traditional herbal compound and combined as effective-constituent compatibility(ECC)of BYF I,which may have potential bioactive equivalence to ***:The active constituents of BYF were identified using four cellular models and categorised into Groups 1(Bufeiqi),2(Bushen),3(Huatan)and 4(Huoxue)according to Chinese medicinal *** orthogonal design and a combination method were used to determine the optimal ratios of effective constituents in each group and the ratios of‘‘Groups 1 to 4"according to their pharmacological *** also comprehensively assessed bioactive equivalence between the BYF and the ECC of BYF I in a rat model of chronic obstructive pulmonary disease(COPD).Results:We identified 12 active constituents in *** numbers of constituents in Groups 1 to 4 were 3,2,5 and 2,*** identified the optimal ratios of effective constituents within each *** Group1,total ginsenosides:Astragalus polysaccharide:astragaloside IV ratio was 9:5:*** Group 2,icariin:schisandrin B ratio was 100:*** Group 3,nobiletin:hesperidin:peimine:peiminine:kaempferol ratio was4:30:6.25:0:*** Group 4,paeoniflorin:paeonol ratio was 4:*** orthogonal design was then used to establish the optimal ratios of Group 1,Group 2,Group 3 and Group 4 in ECC of BYF *** ratio for total ginsenosides:Astragalus polysaccharide:astragaloside IV:icariin:schisandrin B:nobiletin:hesperidin:peimine:paeoniflorin:paeonol was determined to be 22.5:12.5:5:100:12.5:4:30:6.25:25:6.25.A comprehensive evaluation confirmed that ECC of BYF I presented with bioactive equivalence to the original ***:Based on the ECC of traditional Chinese medicine formula method,the effective constituents of BYF were identified and combined in a fixed ratio as ECC of BYF I that was as effective as BYF itself in treating rats with COPD.

关键词： Effective-constituent compatibility Bufei Yishen formula Chronic obstructive pulmonary disease

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Precise separation and efficient recovery of Pd(Ⅱ)from high-level liquid waste by XAD-based adsorbents

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Rare Metals 2024年第10期43卷 5372-5390页

作者： hao-ran dong Shun-Yan Ning Zeng-Yuan Li Si-Zhi Xu Feng-Tao Hu Feng Gao You-Bin Wang Li-Feng Chen Xiang-Biao Yin Toyohisa Fujita Mohammed FHamza Yue-Zhou Wei School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China School of Nuclear Science and Technology University of South ChinaHengyang 421001China

Efficient separation of palladium(Pd(Ⅱ))from high-level liquid waste(HLLW)not only helps the safe disposal of nuclear waste,but also is a vital importan supplement to Pd(Ⅱ)***,16 kinds of nove Amberlite XAD resins-based adsorbents were prepared by vacuum impregnation method for the separation of Pd(Ⅱ)from simulated HLLW,and the MMBT/XAD7HP prepared using 4-methyl-2-mercaptobenzothiazole(MMBT)as ligand and Amberlite XAD7HP resin(XAD7HP)as the carrier was selected as the optimal research *** analysis experiments proved the successful preparation of MMBT/XAD7HP,which exhibited ultrahigh adsorption selectivity for Pd(Ⅱ)(distribution coefficient(K_d)≥12584.5 ml·g^(-1),separation factor(SF_(Pd/M))≥2818.4)and superior adsorption capacity(Q≥130.1 mg·g^(-1)).The adsorption kinetics and adsorption isotherms for Pd(Ⅱ)matched with pseudo-secondorder(PSO)kinetics model and Langmuir model,indicating that the adsorption mode for Pd(Ⅱ)by MMBT/XAD7 HP was monolayer chemical *** dynamic column experiments showed that MMBT/XAD7 HP achieved efficiently separation of Pd(Ⅱ)from simulated HLLW,and the recovery rate was nearly 100% The adsorption mechanism was analyzed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and density functional theory(DFT),and the ultrahigh selectivity of MMBT/XAD7 HP is attributed to the preferred affinity of the soft-N,S donor atoms in MMBT for Pd(Ⅱ).MMBT has the shortest frontline molecular orbital energy band gap(HOMO-LUMO)among the four ligands,which makes it easier to become an electron donor to attract Pd^(2+)to participate in ***_(3)^(-)participates in the adsorption to keep charge *** summary,MMBT/XAD7 HP has broad application prospects for the treatment of Pd(Ⅱ)in HLLW.

关键词： XAD Palladium HLLW Adsorption Column experiments

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi dong Bangxiang Xie Qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Composite membranes

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亚甲基蓝对黄颡鱼鱼卵高卵壳裂解酶(HCE)表达的影响

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淡水渔业 2017年第5期47卷 53-57页

作者：李浩然董亚萍杨柳胡鲲杨先乐国家水生动物病原库水产动物遗传育种中心上海市协同创新中心水产科学国家级实验教学示范中心(上海海洋大学) 上海201306 上海长峰房地产开发有限公司上海200042

鱼卵高卵壳裂解酶(HCE)是鱼类孵化酶中的一种,在水生生物胚胎发育过程中起非常重要的作用,其表达可能会受到化学药物的影响。以黄颡鱼(Pelteobagrus fulvidraco)受精卵为研究对象,采用免疫组织化学方法研究了亚甲基蓝对黄颡鱼鱼卵高卵... 详细信息

鱼卵高卵壳裂解酶(HCE)是鱼类孵化酶中的一种,在水生生物胚胎发育过程中起非常重要的作用,其表达可能会受到化学药物的影响。以黄颡鱼(Pelteobagrus fulvidraco)受精卵为研究对象,采用免疫组织化学方法研究了亚甲基蓝对黄颡鱼鱼卵高卵壳裂解酶表达的影响。以15 mg/L亚甲基蓝浸泡黄颡鱼受精卵,同时设置不做任何药物处理的空白对照组,分别在受精后0、1、2、4、8、12、24 h取黄颡鱼受精卵或胚胎,4%多聚甲醛固定,石蜡切片,免疫组织化学方法染色,倒置显微镜观察,Image-Pro Plus6.0软件分析每张照片的累积光密度值。结果表明,亚甲基蓝实验组与空白对照组中均有HCE表达,但是亚甲基蓝实验组中HCE的相对表达量显著高于其相应的空白对照组。不同受精时间的对照组和实验组之间HCE的相对表达量无统计学差异。亚甲基蓝明显促进HCE的分泌,可能与鱼卵的代偿或应激反应有关,由此推测亚甲基蓝对胚胎有一定的毒性。

关键词：亚甲基蓝黄颡鱼胚胎鱼卵高卵壳裂解酶免疫组织化学

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颗粒特性对离心泵叶轮叶片的磨损分析

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水动力学研究与进展（A辑） 2022年第2期37卷 181-189页

作者：王田田池晓清杨具瑞谢汭之董浩然喻黎明昆明理工大学农业与食品学院昆明650500

为了预测离心泵叶轮叶片的磨损位置和计算磨损量的大小,利用有限元软件Ansys-FLUENT和离散元软件EDEM基于计算流体动力学(CFD)和离散单元法(DEM)耦合的方法,探究了颗粒体积分数(2%、3%和4%)、粒径(1 mm、2 mm和3 mm)、形状(球形、类球... 详细信息

为了预测离心泵叶轮叶片的磨损位置和计算磨损量的大小,利用有限元软件Ansys-FLUENT和离散元软件EDEM基于计算流体动力学(CFD)和离散单元法(DEM)耦合的方法,探究了颗粒体积分数(2%、3%和4%)、粒径(1 mm、2 mm和3 mm)、形状(球形、类球形和三角形)对离心泵叶轮叶片的磨损影响。结果表明离心泵内部压强最大处为隔舌部位,出口管道的滞留区域与大涡量区域分布一致,管道涡具有滞留作用;随着颗粒体积分数的增加,颗粒最大速度增加,最小速度减小,叶轮叶片磨损量增大,磨损分布不变;当粒径增大时,颗粒最大速度与最小速度同时增大,磨损增加,磨损最严重的位置由尾部变为头部,颗粒尖锐程度的增加也使得磨损加剧。

关键词： CFD-DEM 离心泵颗粒特性磨损

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Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： Yi Jing Xin-ran Liu Xing-Hua Wang Hui Han Sha-Sha Liang Xi-Meng Chen dong-Hui Wei Lai-Sheng Wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： Yan dong Wenzheng An Zihu Wang dongzhi Zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

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