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The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： Shan-Shan Jiang Zi-Ran Kang Ying-xuan Chen Jing-yuan Fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity

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Effective suppression of surface cation segregations on double perovskite oxides through entropy engineering

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Journal of Rare Earths 2025年第2期43卷 345-353页

作者： Zhe Wang Mengke yuan Juntao Gao Hongru hao Jingwei Li Lingling Xu Zhe Lv Bo Wei School of Physics Harbin Institute of Technology Faculty of Engineering University of Bayreuth State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences Key Laboratory of Photonic and Electric Band Gap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal University

Cation segregation on cathode surfaces plays a key role in determining the activity and operational stability of solid oxide fuel cells（SOFCs）.The double perovskite oxide PrBa0.8Ca0.2Co2O5+δ（PBCC） has been widely studied as an active cathode but still suffer from serious detrimental *** enhance the cathode stability,a PBCC derived A-site medium-entropy Pr0.6La0.1Nd0.1Sm0.1Gd0.1Ba0.8Ca0.2Co2O5+δ（ME-PBCC） oxide was prepared and its segregation behaviors were investigated under different *** with initial PBCC oxide,the segregations of BaO and Co3O4on the surface of ME-PBCC material are significantly suppressed,especially for Co3O4,which is attributed to its higher configuration *** results also confirm the improved electrochemical performance and structural stability of ME-PBCC material,enabling it as a promising cathode for SOFCs.

关键词： Cathode Cation segregation Configuration entropy Double perovskite Rare earths Solid oxide fuel cells

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Heat transfer prediction modeling method combining threedimensional high-precision and one-dimensional real-time dynamic simulations

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Science China Technological Sciences 2025年第3期68卷 86-100页

作者： xuanang ZHANG Ping yuan Gequn SHU xuan WANG Hua TIAN State Key Laboratory of Engines Tianjin University Department of Thermal Science and Energy Engineering University of Science and Technology of China

Heat exchangers are the core components of energy transfer and conversion and are widely used in the energy,chemical, and other fields. In an actual operational process, load changes lead to variations in the operating conditions of the heat exchanger. Evaluating the heat-transfer performance is crucial for the safe and efficient operation of the system. To realize high-precision heat transfer prediction through simulations, instead of using traditional solid equipment, this study proposed a heat transfer prediction modeling method that combines three-dimensional high-precision and one-dimensional real-time dynamic simulations. This method combines the high-precision advantage of three-dimensional simulation with the real-time advantage of one-dimensional simulation. To verify the feasibility of the modeling method, a heat transfer prediction model was constructed based on the heat transfer channel structure of a CO2mixture heat transfer characteristic experimental test *** steady-state and dynamic heat transfer characteristics of CO2/R32 mixtures were simulated and experimentally ***, the real-time operational capability of the heat transfer prediction model was verified using a real-time simulator. The results showed that the heat transfer prediction model modeling method proposed in this study could improve the accuracy by 1.75–4.64 times compared with the conventional one-dimensional dynamic model. The established heat transfer prediction model exhibited good accuracy for both dynamic and steady-state processes. The average relative errors with the experimental results were in the range of 0.91%–2.83% under six sets of experimental tests. Thus, the proposed heat transfer prediction model can predict the heat transfer process in real-time under all experimental heat source conditions.

关键词： heat transfer prediction model CO2 mixture heat exchanger real-time simulation

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun hao-Ming yuan Guo-Da Zhang Chao Wang Shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

Mapping the landscape of gastric cancer immunotherapy:Bibliometric insights into advances and hotspots

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 349-370页

作者： Zhen yuan Jing-Hang Wang hao Cui Shu-yuan Wang Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer(GC).A comprehensive review of advancements,current status,and research trends in GC immunotherapy is essential to inform future investigative *** To delineate the trends,advancements,and focal points in immunotherapy for *** We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20,2023,indexed in the Web of Science Core *** analysis and visualization were facilitated by CiteSpace(6.1.6R),VOSviewer v.1.6.17,and GraphPad Prism *** There has been an increase in the annual publication rate of GC immunotherapy *** leads in publication volume,while the United States demonstrates the highest citation *** University is notable for its citation frequency and publication ***-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis,the tumor microenvironment(TME),and integrative immunotherapy with targeted *** research areas include gastroesophageal junction cancer,adoptive immunotherapy,and the role of Treg cell in *** GC immunotherapy research is an expanding field attracting considerable scientific *** the clinical adoption of immunotherapy in GC,the primary goals are to enhance treatment efficacy and patient *** hematological malignancies,GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer *** instance,although CAR-T therapy is effective in hematological malignancies,it has underperformed in GC *** research is centered on overcoming immunosuppression within the TME,with a focus on combinations of targeted therapy,adoptive immunotherapy,Treg cell dynamics,and precise prognosis prediction in ***,immunotherapy's role in treating gastroesophageal junctio

关键词： Bibliometrics Gastric cancer Immunotherapy Immune checkpoint inhibitor Tumor microenvironment

Encapsulating lipase on the surface of magnetic ZIF-8 nanosphers with mesoporous SiO2 nano-membrane for enhancing catalytic performance

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Chinese Chemical Letters 2025年第2期36卷 279-283页

作者： Guang-Xu Duan Queting Chen Rui-Rui Shao Hui-Huang Sun Tong yuan Dong-hao Zhang College of Pharmaceutical Science Hebei University Affiliated Hospital of Hebei University Key Laboratory of Pharmaceutical Quality Control of Hebei Province College of Pharmaceutical ScienceHebei University Institute of Life Science and Green Development Hebei University

The preparation of immobilized enzyme with excellent performance is one of the difficulties that restrict the application of enzyme catalysis technology. Here, Candida rugosa lipase（CRL） was firstly adsorbed on the surface of magnetic zeolitic imidazolate framework-8（ZIF-8） nanospheres, which was further encapsulated with a mesoporous SiO2nano-membrane formed by tetraethyl orthosilicate（TEOS） polycondensation. Consequently, lipase could be firmly immobilized on carrier surface by physical binding rather than chemical binding, which did not damage the active conformation of enzyme. There were mesopores on the silica nano-membrane, which could improve the accessibility of enzyme and its apparent catalytic activity. Moreover, silica membrane encapsulation could also improve the stability of enzyme, suggesting an effective enzyme immobilization strategy. It showed that TEOS amount and the encapsulation time had significant effects on the thickness of silica membrane and the enzyme activity. The analysis in enzyme activity and protein secondary structure showed that lipase encapsulated in silica membrane retained the active conformation to the greatest extent. Compared with the adsorbed lipase, the encapsulated lipase increased its thermostability by 3 times and resistance to chemical denaturants by 7 times. The relative enzyme activity remained around 80% after 8 repetitions, while the adsorbed lipase only remained at7.3%.

关键词： Encapsulation Enzyme immobilization Lipase activity Mesoporous silica membrane ZIF-8

Establishment and verification of anthropogenic speciated VOCs emission inventory of Central China

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Journal of Environmental Sciences 2025年第3期149卷 406-418页

作者： xuan Lu Dong Zhang Lanxin Wang Shefang Wang Xinran Zhang Yali Liu Keying Chen Xinshuai Song Shasha Yin Ruiqin Zhang Shanshan Wang Minghao yuan College of Chemistry Zhengzhou UniversityZhengzhou 450001China Research Institute of Environmental Sciences Zhengzhou UniversityZhengzhou 450001China School of Ecology and Environment Zhengzhou UniversityZhengzhou 450001China Zhengzhou Ecological Environment Monitoring Center of Henan Province Zhengzhou 450000China

Improving the accuracy of anthropogenic volatile organic compounds(VOCs)emission inventory is crucial for reducing atmospheric pollution and formulating control policy of air *** this study,an anthropogenic speciated VOCs emission inventory was established for Central China represented by Henan Province at a 3 km×3 km spatial resolution based on the emission *** 2019 VOCs emission in Henan Provincewas 1003.5 Gg,while industrial process source(33.7%)was the highest emission source,Zhengzhou(17.9%)was the city with highest emission and April and August were the months with the more *** VOCs emission regions were concentrated in downtown areas and industrial *** and aromatic hydrocarbons were the main VOCs contribution *** species composition,source contribution and spatial distribution were verified and evaluated through tracer ratio method(TR),Positive Matrix Factorization Model(PMF)and remote sensing inversion(RSI).Results show that both the emission results by emission inventory(EI)(15.7 Gg)and by TRmethod(13.6 Gg)and source contribution by EI and PMF are *** spatial distribution of HCHO primary emission based on RSI is basically consistent with that of HCHO emission based on EI with a R-value of *** verification results show that the VOCs emission inventory and speciated emission inventory established in this study are relatively reliable.

关键词： VOCs verification Species composition Tracer ratio PMF Remote sensing inversion

Metallized polymer current collector as “stress acceptor” for stable micron-sized silicon anodes

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Journal of Energy Chemistry 2025年第2期101卷 786-794页

作者： Ziyi Cao haoteng Sun Yi Zhang Lixia yuan Yaqi Liao Haijin Ji Shuaipeng hao Zhen Li Long Qie Yunhui Huang State Key Laboratory of Material Processing and Die & Mold Technology School of Materials Science and Engineering Huazhong University of Science and Technology Department of Chemistry Brown University

Micron-sized silicon（μSi） is a promising anode material for next-generation lithium-ion batteries due to its high specific capacity,low cost,and abundant ***,the volume expansion that occurs during cycling leads to the accumulation of undesirable stresses,resulting in pulverization of silicon microparticles and shortened lifespan of the ***,a composite film of Cu-PET-Cu is proposed as the current collector（CC） for μSi anodes to replace the conventional Cu ***-PET-Cu CC is prepared by depositing Cu on both sides of a polyethylene terephthalate（PET） *** PET layer promises good ductility of the film,permitting the Cu-PET-Cu CC to accommodate the volumetric changes of silicon microparticles and facilitates the stress release through ductile *** a result,the μSi electrode with Cu-PET-Cu CC retains a high specific capacity of 2181 mA h g-1,whereas the μSi electrode with Cu CC（μSi/Cu） exhibits a specific capacity of 1285 mA h g-1after 80 *** stress relieving effect of CuPET-Cu was demonstrated by in-situ fiber optic stress monitoring and multi-physics *** work proposes an effective stress relief strategy at the electrode level for the practical implementation of μSi anodes.

关键词： Electrode design Metallized polymer current collector Micron-sized Si anodes Stress relieving

Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3) Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie Zhao Yicheng Sun Chaoxin Pei Xing Yin Xinyi Li Yi hao Mengru Zhang Meng yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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