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Characterization of heat shock protein 90, 70 and their transcriptional expression patterns on high temperature in adult of Graphofita molesta （Busck）

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Insect Science 2014年第4期21卷 439-448页

作者： hao chen xiang-Li Xu Yi-Ping Li Jun-xiang Wu Key Laboratory of Plant Protection Resources and Pest Management (Northwest A&F University) Ministry of Education Key Laboratoryof Appfied Entomology Northwest A&F University Yangling Shaanxi China

Grapholita molesta （Busck） is a worldwide insect pest damaging stone and pome fruits. High temperature can significantly affect insect survival, development and fecundity. Heat shock protein （Hsp） genes were speculated to possess a pivotal function in response to high temperature stress. In this study, two full-length Hsp genes, Gmhsp90 and GmhspTO, were cloned from G. molesta using rapid amplification of complementary DNA ends （RACE）. The open reading frames of Gmhsp90 and Gmhsp70 obtained were 2 148 bp and 1 998 bp in length, respectively. Their deduced amino acids showed high homology to Hsp genes of other species. Subsequently, the transcriptional expression of Gmhsp90 and Gmhsp70 in G. molesta adults exposed at various temperatures （26, 29, 32, 35, 38, 41 and 44℃） for 1 h and at 41℃ for various time duration （0, 15, 30, 45, 60, 75, 90 and 105 min） were investigated via real time quantitative polymerase chain reaction （qPCR）. The relative expression levels of Gmhsp90 and Gmhsp70 in G. molesta adults were both up-regulated with the rise of temperature and time duration. In addition, the Gmhsp70 usually showed a higher transcription accumulation than Gmhsp90. Interestingly, Gmhsp90 and Gmhsp 70 in female adults could be induced much earlier than that in males, and the effective induction temperature in females was also lower than that in males. The distinct expression profiles of Gmhsp90 and Gmhsp 70 indicated that Gmhsp90 and Gmhsp 70 may play important roles in G. molesta adults responding to a thermal threat, and there is difference on induction between sexes.

关键词： Grapholita molesta heat shock protein high temperature sex difference

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Neural 3D reconstruction from sparse views using geometric priors

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Computational Visual Media 2023年第4期9卷 687-697页

作者： Tai-Jiang Mu hao-xiang chen Jun-Xiong Cai Ning Guo BNRist Department of Computer Science and TechnologyTsinghua UniversityBeijing 100084China Academy of Military Sciences Beijing 100091China

Sparse view 3D reconstruction has attracted increasing attention with the development of neural implicit 3D *** methods usually only make use of 2D views,requiring a dense set of input views for accurate 3D *** this paper,we show that accurate 3D reconstruction can be achieved by incorporating geometric priors into neural implicit 3D *** method adopts the signed distance function as the 3D representation,and learns a generalizable 3D surface reconstruction model from sparse ***,we build a more effective and sparse feature volume from the input views by using corresponding depth maps,which can be provided by depth sensors or directly predicted from the input *** recover better geometric details by imposing both depth and surface normal constraints in addition to the color loss when training the neural implicit 3D *** demonstrate that our method both outperforms state-of-the-art approaches,and achieves good generalizability.

关键词： sparse views 3D reconstruction volume rendering geometric priors neural implicit 3D representation

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NUMERICAL SIMULATION AND EXPERIMENTAL STUDY OF DRAGREDUCING SURFACE OF A REAL SHARK SKIN

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Journal of Hydrodynamics 2011年第2期23卷 204-211页

作者： ZHANG De-yuan LUO Yue-hao LI xiang chen Hua-wei School of Mechanical Engineering and Automation Beihang University Beijing 100191 China

It is well known that shark skin surface can effectively inhabit the occurrence of turbulence and reduce the wall friction, but in order to understand the mechanism of drag reduction, one has to solve the problem of the turbulent flow on grooved-scale surface, and in that respect, the direct numerical simulation is an important tool. In this article, based on the real biological shark skin, the model of real shark skin is built through high-accurate scanning and data processing. The turbulent flow on a real shark skin is comprehensively simulated, and based on the simulation, the drag reduction mechanism is discussed. In addition, in order to validate the drag-reducing effect of shark skin surface, actual experiments were carried out in water tunnel, and the experimental results are approximately consistent with the numerical simulation.

关键词： numerical simulation experimental study biomimetic surface shark skin drag reduction mechanism

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Graph-based Selection-Activation Reinforcement Learning for Heterogenous Multi-agent Collaboration

Graph-based Selection-Activation Reinforcement Learning for ...

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第43届中国控制会议

作者： hao-xiang chen Xi-Wen Zhang Jun-Nan Shen State Key Laboratory of Intelligent Control and Decision of Complex System School of Automation Beijing Institute of Technology Chongqing Innovation Center Beijing Institute of Technology

In practical applications of multi-agent systems, agents are often heterogeneous, and each type of them typically has different task objectives. For heterogeneous multi-agent reinforcement learning(HMARL), the diversity of agent types and the unbalanced agent number of each type can lead to the curse of dimensionality and non-stationary. Moreover, the increase in the number of heterogeneous agents may result in slow convergence during training. This paper proposes a graph-based selection-activation reinforcement learning(GSARL) method for training heterogenous multi-agent collaboration strategies. It first constructs agents based on their types, then extracts the global adjacency matrices and the ally adjacency matrices from the agents' observations, and calculates the global feature matrices. Afterwards, GSARL utilizes hierarchical graph convolutional network to sequentially convolve the global information and ally information, obtaining action logits based on agent types. By using the neural topology graph and the selection-activation method, the optimal multi-agent collaboration configuration is obtained through combinatorial optimization. Experiments are conducted in an adversarial combat simulation environment involving collaborative Unmanned Aerial Vehicles(UAVs) and Unmanned Ground Vehicles(UGVs). Simulation results show that the proposed method can accelerate convergence while allowing that each type of heterogeneous agents can leverage its unique advantages.

关键词： Multi-Agent System Hierarchical Graph Convolutional Network Heterogenous Multi-Agent Collaboration

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Responses of streamflow to climate change in the northern slope of Tianshan Mountains in Xinjiang: A case study of the Toutun River basin

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Science China Earth Sciences 2007年第S1期 42-48页

作者： LI WeiHong, chen YaNing, hao XingMing, HUANG xiang & chen YaPeng Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, ürümqi 830011, China

A case study on the responses of streamflow to climate change in the Toutun River basin was carried out based on data analysis of streamflow, precipitation, and temperatures during the past 50 years. Temporal series of the streamflow change in the Toutun River basin was analyzed and tested using the Mann-Kendall nonparametric test. Results revealed that the annual runoff of the Toutun River had been in a monotonic decreasing trend for the past 50 years. Compared with the 1950s and 1960s, the annual runoff in the 1990s decreased by 4.0×105 m3 and 7.2×105 m3. The precipitation did not show monotonic trend during the past 50 years, but the annual temperature increased by 1.12℃ since the 1950s. Further data analysis indicated that the monthly runoff of the Toutun River decreased significantly from August to October, with precipitation displaying the similar pattern of seasonal change. Analysis suggests that the reduction of streamflow in the Toutun River basin is possibly caused by the seasonal change of precipitation, especially the precipitation reduction in summer, and temperature increases.

关键词： streamflow climate change Mann-Kendall test the Toutun River northern slope of the Tianshan Mountains

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang Xuheng chen Junfang Bao Qiuyue hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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基于统计特征和显著度的光谱信号提取算法

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光谱学与光谱分析 2021年第7期41卷 2294-2300页

作者：吴江波贾云伟姚城斌郝晨翔王坤天津理工大学天津市先进机电系统设计与智能控制重点实验室天津300384

各类光谱信号都会受到噪声和基线畸变的影响,在提取光谱信号过程中若不考虑基线畸变和噪声的影响,将会严重影响信号提取的精度和准确性,所以需要在信号提取前消除噪声和基线畸变的影响。大多数信号提取算法的步骤是先提取整体基线,再提... 详细信息

各类光谱信号都会受到噪声和基线畸变的影响,在提取光谱信号过程中若不考虑基线畸变和噪声的影响,将会严重影响信号提取的精度和准确性,所以需要在信号提取前消除噪声和基线畸变的影响。大多数信号提取算法的步骤是先提取整体基线,再提取信号,这样难以保证基线的提取精度。为了降低信号提取过程中背景噪声、基线畸变等不利因素的影响,根据信号的存在总是会导致该区域的统计特征不同于背景的特点,提出了一种基于显著度和统计特征的光谱信号检测与提取算法(SSD算法)。首先,在待测数据的不同尺度空间中计算出信号在各尺度下的显著度,将检测出的显著信号点作为候选信号点;其次,利用信号特征去除候选信号点中的伪信号点;最后,对候选信号点所在区域采用二次多项式进行基线拟合以剔除伪信号区域并实现最终的信号提取。为验证SSD算法的综合性能,首先,通过仿真的方法对高斯信号和矩形信号在不同基线类型、不同信噪比下进行实验;然后将该算法与AirPLS算法、Wavelet算法以及DoG算法对两种信号在不同信噪比,不同基线类型下的提取结果进行比较。仿真实验结果表明:与其他算法相比,SSD算法信号提取结果基本不受信号类型和基线畸变类型的影响,且当信噪比大于40时基本不受信噪比的影响;在不同基线畸变类型下,SSD算法对两种信号提取结果的准确度、稳定性、离散度均较好,其他算法则只适用于某种基线畸变类型。从总体提取结果上看,SSD算法提取结果的绝对误差的均值仅为AirPLS算法的8.71%、Wavelet算法的3.52%、DoG算法的2.01%;绝对误差的均方根也仅为AirPLS算法的13.08%、Wavelet算法的5.45%、DoG算法的3.11%。因此,所提出的SSD算法在提取信号时具有良好的综合性能,能够在不同的信噪比及基线畸变情况下准确的提取出信号。

关键词：光谱信号信号提取信号检测基线畸变显著度统计特征

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光谱信号区域基线拟合算法

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光子学报 2020年第12期49卷 105-117页

作者：姚城斌贾云伟吴江波王坤郝晨翔天津理工大学天津市先进机电系统设计与智能控制重点实验室天津300384

为消除基线畸变对光谱信号后续处理产生的不利影响,提出了一种光谱信号区域基线拟合算法.首先,利用渐变惯性力和吸引力的思想,针对具有曲率突变的基线提出了GradSuck拟合算法,该算法弥补了多项式拟合算法在信号区域周围基线曲率发生突... 详细信息

为消除基线畸变对光谱信号后续处理产生的不利影响,提出了一种光谱信号区域基线拟合算法.首先,利用渐变惯性力和吸引力的思想,针对具有曲率突变的基线提出了GradSuck拟合算法,该算法弥补了多项式拟合算法在信号区域周围基线曲率发生突变时拟合基线不准确的不足;然后将这种算法与分段二次多项式拟合算法进行结合,提出了更具有普适性的信号区域基线拟合算法,同时将该算法与不同的基线拟合算法做了对比.实验结果表明,信号区域基线拟合算法在不同的基线类型和不同的信噪比下均具有较高的准确性和稳定性,其总体拟合精度的相对误差仅为分段二次多项式拟合的47.0%,为AirPLS拟合的35.6%,为Wavelet拟合的20%,且由于只对光谱信号区域进行基线拟合,因此具有较好的实时性.

关键词：信号区域基线拟合基线畸变二次多项式拟合分段拟合曲率突变

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： haonan Zhang cheng hao Tongtong Fu Dian Yu Jane Howe Kaiwen chen Ning Yan hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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