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Facile Synthesis of Polyisothioureas via Alternating Copolymerization of Aziridines and Isothiocayanates

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Chinese Journal of Polymer Science 2024年第3期42卷 292-298,I0005页

作者： hao-tian zhang Ming-Xin Niu Qi zhang Chen-Yang Hu Xuan Pang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Materials Science and Engineering Jilin UniversityChangchun 130025China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Isothiourea is an important class of sulfur-containing molecules showing unique catalytic and biological activities. As such,polyisothiourea is envisioned to be an interesting type of polymer that potentially exhibits a number of interesting properties. However, there is no access to synthesizing well-defined polyisothiourea, and currently isothiourea-containing polymers are mainly prepared by immobilizing onto other polymer's side chain. Herein, we report the first facile synthesis of polyisothioureas via alternating copolymerization of aziridines and isothiocayanates. Mediated by the catalytic system of phosphazene superbases/alcohol, a broad scope of aziridines and isothiocayanates could be transformed into polyisothioureas with adjustable substitutions(11 examples). The structures of obtained polyisothioureas were fully characterized with ^(1)H-NMR, ^(13)C-NMR, and ^(1)H-^(13)C HMBC NMR. Moreover, the polyisothioureas show tunable thermal properties depending on substitutions on the isothiourea linkages. The novel structure of these polyisothioureas will enable a powerful platform for the discovery of nextgeneration functional plastics.

关键词： Polyisothioureas Alternative copolymer Aziridines Isothiocayanates

Isolation of Trichoderma reesei pyrG Negative Mutant by UV Mutagenesis and Its Application in Transformation

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Chemical Research in Chinese Universities 2008年第5期24卷 565-569页

作者： LONG hao WANG tian-hong zhang Ying-kuan State Key Laboratory of Microbial Technology Shandong University Jinan 250100 P. R. China

Two uridine auxotrophic mutants of Trichoderma reesei were isolated by resistance to 5-fluoroorotic acid after UV mutagenesis. One mutant, called M23, was complemented with the Aspergillus niger pyrG gene carried by plasmid pAB4-1. A mutated pyrG gene of M23 was cloned and DNA sequencing analysis indicated that a cytosine was inserted into the 934―939 oligo dC position of the pyrG coding region, resulted in a frameshift mutation. Transformation efficiency was approximately 200―300 transformants per microgram of DNA with plasmid pAB4-1. Stable transformants were obtained by monosporic culture and showed to be prototroph after successive propagation. Vitreoscilla hemoglobin expression plasmid pUCVHb was cotransformed with plasmid pAB4-1 and attained a transformation efficiency of 71.8% or of 26.1% with pAN7-1. Southern blot analysis of the transformants demonstrated that plasmid pUCVHb was integrated into the chromosomal DNA. The experimental results demonstrated that the pyrG-based system was more efficient and timesaving than the conventional hygromycin B resistance-based transformation system.

关键词： Trichoderma reesei UV mutagenesis pyrG negative strain pyrG-based transformation system

Image-based clothes changing system

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Computational Visual Media 2017年第4期3卷 337-346页

作者： Zhao-Heng Zheng hao-tian zhang Fang-Lue zhang Tai-Jiang Mu Computer Science and Engineering University of Michigan Computer Science Department Stanford University School of Engineering and Computer Science Victoria University of Wellington TNList Tsinghua University

Current image-editing tools do not match up to the demands of personalized image manipulation,one application of which is changing clothes in usercaptured images. Previous work can change single color clothes using parametric human warping *** this paper, we propose an image-based clothes changing system, exploiting body factor extraction and content-aware image warping. Image segmentation and mask generation are first applied to the user ***, we determine joint positions via a neural network. Then, body shape matching is performed and the shape of the model is warped to the user's shape. Finally, head swapping is performed to produce realistic virtual results. We also provide a supervision and labeling tool for refinement and further assistance when creating a dataset.

关键词： clothing try-on image warping human segmentation

Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway

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Journal of Integrative Medicine 2023年第5期21卷 496-508页

作者： Yuan-yuan Ding Feng Xu Ya-feng Wang Lin-lin Han Shi-qian Huang Shuai Zhao Lu-lin Ma tian-hao zhang Wen-jing Zhao Xiang-dong Chen Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

Objective This work explores the impact of electroacupuncture(EA)on acute postoperative pain(APP)and the role of stimulator of interferon genes/type-1 interferon(STING/IFN-1)signaling pathway modulation in the analgesic effect of EA in APP *** The APP rat model was initiated through abdominal surgery and the animals received two 30 min sessions of EA at bilateral ST36(Zusanli)and SP6(Sanyinjiao)***,thermal and cold sensitivity tests were performed to measure the pain threshold,and electroencephalograms were recorded in the primary somatosensory cortex to identify the effects of EA treatment on *** blotting and immunofluorescence were used to examine the expression and distribution of proteins in the STING/IFN-1 pathway as well as neuroinflammation.A STING inhibitor(C-176)was administered intrathecally to verify its role in *** APP rats displayed mechanical and thermal hypersensitivities compared to the control group(P<0.05).APP significantly reduced the amplitude ofθ,αandγoscillations compared to their baseline values(P<0.05).Interestingly,expression levels of proteins in the STING/IFN-1 pathway were downregulated after inducing APP(P<0.05).Further,APP increased pro-inflammatory factors,including interleukin-6,tumor necrosis factor-αand inducible nitric oxide synthase,and downregulated anti-inflammatory factors,including interleukin-10 and arginase-1(P<0.05).EA effectively attenuated APP-induced painful hypersensitivities(P<0.05)and restored theθ,αandγpower in APP rats(P<0.05).Meanwhile,EA distinctly activated the STING/IFN-1 pathway and mitigated the neuroinflammatory response(P<0.05).Furthermore,STING/IFN-1 was predominantly expressed in isolectin-B4-or calcitonin-gene-related-peptide-labeled dorsal root ganglion neurons and superficial laminae of the spinal dorsal *** of the STING/IFN-1 pathway by intrathecal injection of C-176 weakened the analgesic and anti-inflammatory effects of EA on APP(P<0.05).Conclusion

关键词： Electroacupuncture Inflammation Pain Primary sensory neurons Stimulator of interferongenes Type-1 interferon

Nucleus accumbens-linked executive control networks mediating reversal learning in tree shrew brain

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Zoological Research 2022年第4期43卷 528-531页

作者： Ting-Ting Pan Chao Liu De-Min Li Bin-Bin Nie tian-hao zhang Wei zhang Shi-Lun Zhao Qi-Xin Zhou Hua Liu Gao-Hong Zhu Lin Xu Bao-Ci Shan School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Animal Models and Human Disease Mechanisms and KIZ-SU Joint Laboratory of Animal Model and Drug Developmentand Laboratory of Learning and MemoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China CAS Centre for Excellence in Brain Science and Intelligent Technology Shanghai 200031China

DEAR EDITOR,Cognitive flexibility is crucial for animal survival but is frequently impaired in neuropsychiatric *** many brain structures and functional networks are involved in cognitive flexibility,the neural mechanisms underlying cooperation among specific functional networks remain unclear from a global *** this study,[^(18)F]-fluorodeoxyglucose positron emission tomography(FDG-PET)was performed on 19 male tree shrews after four different visual discrimination tasks,including baseline,learning expert(LE),reversal naive(RN),and reversal expert(RE).

关键词： networks EDIT tree

开环聚合催化剂用于脂肪族聚酯合成的研究进展

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高分子学报 2022年第9期53卷 1057-1071页

作者：张昊天胡晨阳李莉莉庞烜吉林大学材料科学与工程学院汽车材料教育部重点实验室长春130025 中国科学院长春应用化学研究所中科院生态环境高分子材料重点实验室长春130022

与广泛使用的聚烯烃材料相比,脂肪族聚酯由于其独特的生物相容性和可降解性,在电子、包装和生物医学等领域都有广泛的应用.开环聚合(ROP)是目前合成脂肪族聚酯的主要方法,本文针对催化开环聚合用于合成脂肪族聚酯,总结了该领域所涉及的... 详细信息

与广泛使用的聚烯烃材料相比,脂肪族聚酯由于其独特的生物相容性和可降解性,在电子、包装和生物医学等领域都有广泛的应用.开环聚合(ROP)是目前合成脂肪族聚酯的主要方法,本文针对催化开环聚合用于合成脂肪族聚酯,总结了该领域所涉及的2类主要催化体系,即金属基催化剂和无金属有机催化剂,同时对新兴的酶催化体系做了初步介绍.列举了相关重要催化体系的化学结构,旨在揭示各类体系的催化反应特点,重点关注和评述了催化剂结构对催化效率、可控性、分子量和立体选择性的影响.金属基催化剂主要包括中心金属与N-杂环卡宾、硫脲等配位生成的配合物,其在结构上具有较大的可调性,可根据催化的需要选择不同的结构;而无金属有机催化剂如有机碱催化剂(如磷腈碱和N-杂环卡宾等),有机酸催化剂(如磷酸和方酸等),往往具有高效催化效率、摩尔质量控制和立体选择性的优点;除此以外脂肪酶催化剂具有反应范围广、反应温和以及无金属污染残留的特点.

关键词：开环聚合脂肪族聚酯金属基催化剂有机催化剂

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Treatment of rat metastatic liver cancer by hepatic artery injection of recombinant adenovirus expressing cytokines

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中国实验血液学杂志 1997年第3期5卷 295-296页

作者： Qiang hao, Jiunming tian, Weiping zhang,Xuetao Cao Department of Radiology, Changhai Hospital, Shanghai 200433 Department of Immunologv, The Second Millitarv Medical University, Shanghai200433

In recent years, great enthusiasm is given to theresearches of cancer gene therapy, which seems to bea promising novel strategy for cancer *** are several strategies to deliver target genes intobodies. Among them, adenovirus-mediated genetransfection exhibits great advantages including highgene transfer efficiency and high expression level. Butthe optimal route of gene delivery is still uncertain.

关键词： metastatic adenovirus expressing uncertain cytokines deliver potentially staining administration detectable

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-hao Hu Dong-Yi Yan Ke-Hui zhang Di zhang Xi-Mao Cui Xiao-Hua Jiang Shun zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： haonan zhang Cheng hao Tongtong Fu Dian Yu Jane Howe Kaiwen Chen Ning Yan hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors